RNDr. Miloslav Macháček, Ph.D.

Previous Education and Professional Experience

• 2017 - six months as a visiting research scholar at the University at Buffalo, Department of Biomedical Engineering, Jonathan Lovell's lab (April - October)
   
• 2014 - 2016 - assistant at the Department of Biochemical Sciences, Charles University in Prague, Faculty of Pharmacy in Hradec Králové
   
• 2012 - 2016 - Ph.D. study of Pathobiochemistry and Xenobiochemistry, Charles University in Prague, Faculty of Pharmacy in Hradec Kralove.
  Thesis: Study of the novel phthalocyanine and azaphthalocyanine photosensitisers for photodynamic therapy of cancer.
  Under the supervision of prof. PharmDr. Tomáš Šimůnek, Ph.D. and Doc. PharmDr. Veronika Nováková, Ph.D.
   
• 2010 - 2012 - graduated from the Faculty of Pharmacy in Hradec Kralove (Master's degree)
  Thesis: Study of cytoprotective properties of novel oxidative stress-activated aroylhydrazone pro-chelators of iron.
  Under the supervision of prof. PharmDr. Tomáš Šimůnek, Ph.D.
   
• 2007 - 2010 - graduated from the Faculty of Pharmacy in Hradec Králové (Bachelor’s degree)
  Thesis: The possibilities of determination of biologically active compounds in dietary products (chondroitine suplhate).
  Under the supervision of Doc. RNDr. Dalibor Šatínský, Ph.D.
   
• 1999 - 2007 - Gymnázium Mnichovo Hradiště (high school)

Research Interests

• photodynamic therapy of cancer
• photochemical internalisation
• light-triggered druh release from liposomes
• antimicrobial photodynamic therapy
• mode of cellular death
• oxidative stress on cellular and molecular level
• evaluation of toxicological and pharmacological properties of novel phthalocyanine, azaphthalocyanine (tetrapyrazinoporphyrazine and tetrapyridoporphyrazine), subphthalocyanine and BODIPy photosensitizers
• fluorescence and confocal microscopy
   
• list of publications , see below

Grant projects

• principal investigator, Czech Health Research Council, AZV NW24J-05-00016 (May 2024 - 2027),
  “Employment of photosensitizer-based therapy to combat notorious multi-drug resistant bacterial deliquents from the group ESKAPE responsible for skin and wound infections.”
• principal investigator, Czech Science Foundation, GAČR 19-14758Y (2019 - Jun 2022, evaluation: "Fulfilled"),
  “Novel photosensitizers for vascular targeted photodynamic therapy.”
• principal investigator, Charles University Grant Agency, GAUK 1916214 (2014 - 2016, evaluation: "Exceptionally good"),
  “Study of the novel phthalocyanine and azaphthalocyanine photosensitizers for photodynamic therapy of tumors on cellular and molecular level.”
• member of the team in other research grants and projects:
  1× ERC-CZ – LL2318
  7× Czech Science Foundation – GAČR 21-14919J, 20-09212S, 19-09600S,  18-08169S, 13-27761S, 13-15008S, 13-23891S
  1× Charles University – PRIMUS/20/SCI/013
  1× University Centre of Excellence – UNCE 204019/304019/2012
  1× Johannes Amos Comenius Programme – P JAC CZ.02.01.01/00/22_008/0004607
  3× Charles University Grant Agency – GAUK 367911, 1404213, 88615
• supervisor of Charles University Grant Agency projects:
  • Mgr. Marie Halašková, Ph.D.; GAUK 1620219 (2019 - 2021, evaluation: "Fulfilled") "Complex analysis of biological properties of novel photodynamically active hydrophilic and amphiphilic anionic phthalocyanine derivatives"
  • RNDr. Monika Rohlíčková; GAUK 1312220 (2020, 2024, 2025) "Study of the effectiveness of (aza)phthalocyanine-based photosensitizers for use in photochemical internalization of biologically active agents"
  • Mgr. Magdaléna Kozlíková; GAUK 157524 (2024 - 2025) "Development of 3D heterotypic tumor models for the study of photodynamic therapy"

Professional membership

• since 2013 – Society of Porphyrins and Phthalocyanines
• since 2015 - International Society for the Study of Xenobiotics
• since 2019 - International Photodynamic Association
• since 2020 - Charles University Grant Agency, member of the board – section C (Medical Sciences)

Educational activities

• supervisor of 4 disertation theses (since 2018; 1 already defended)
• supervisor of 12 B.Sc. and 28 M.Sc. (Pharmacy and Medical Bioanalytics) diploma theses (since 2014)
• Pathobiochemistry - lectures, seminaries (since 2014), exams (since 2018)
• Molecular Biology – practice (since 2012), exams (since 2018)
• General Biochemistry - practice (since 2013)
• Biophysics - practice (2012-2013)

Hobbies / Personal Interests

• natural sciences
• nature photography in general - wild-life and macrophotography, landscape photography, astrophotography etc.
• nature protection, conservation & preservation, collecting minerals and fossils, growing carnivorous plants

Two baby European tree frogs (Hyla arborea) waiting for dusk during their first day out of the water. Czech Republic, 2021	IC 1396 is young open star cluster surrounded  with HII region and containgn also Elephant's Trunk Nebula - a concentration of interstellar gas. Czech Republic, 2022	Black grouse (Tetrao tetrix) wading through frozen grass during mating season. Czech Republic, 2020

The spirit of an old-growth forests - the ghost orchid (Epipogium aphyllum). Very rare and hard to find. Czech Republic, 2020	American Pika (Ochotona princeps) watching its surroundings vigilantly while residing in scree under the cliff on alpine area in Washington, USA, 2019	First light of the day struggling through clouds. View from the top of the peak Mesolina. Dolomites, Italy, 2018

Serene sunrise from the rim of an antient caldera over pristine waters of Crater Lake. Oregon, USA, 2017	Creek running through thick temperate rainforest in Oregon's wilderness. USA, 2017	Dark skies in Death Valley shortly after dusk with the Milky Way disappearing over the horizon. California, USA, 2017
Gray Treefrog (Hyla versicolor) climbing sprig of bog laurel (Kalmia polifolia). Western New York, 2017	European mantis (Mantis religiosa). Czech Republic, 2016	Critically endangered European ground squirrel alias European souslik (Spermophilus citellus). Czech Republic, 2015

Publications

• author and co-author of 42 publications in international peer-reviewed journals; cumulative IF > 214
• 892 / 929 citations (WoS / Scopus; October 2024)
• 785 / 859 citations excluding self-citations (WoS / Scopus; October 2024)
• H-index: 19 / 19 (WoS / Scopus)
• green marked publications - photoactive compounds and PDT articels :-)

 

2024

• Boltnarova Barbora, Durinová Anna, Jandova Lenka, Micuda Stanislav, Kucera Otto, Pavková Ivona, Machacek Miloslav, Nemecková Ivana, Vojta Marek, Dusek Jan, Nachtigal Petr, Pavek Petr, Holas Ondrej. 
  Dexamethasone Acetate-Loaded PLGA Nanospheres Targeting Liver Macrophages.
  Macromolecular Bioscience. 2024; accepted
  [Impact factor 2023: 4.413 - Q2; Article Influence Score: 0.777 - Q1]

• Demuth J, Kaushik R, Kozlikova M, Rando C, Machacek M, Novakova V, Šindelář V, Zimcik P. 
  BODIPY-Cucurbituril Complexes: Supramolecular Approach toward Improvement of Photodynamic Activity.
  Materials Advances. 2024; 5; 3915 - 3920; DOI: 10.1039/D3MA01164J 
  [Impact factor 2022: 4.977; Article Influence Score: 0.850]

• Dwivedi A, Mazumder A, Pullmannová P, Paraskevopoulou A, Opálka L, Kováčik A, Macháček M, Jančálková P, Svačinová P, Peterlik H, Maixner J, Vávrová K. 
  Lipid monolayer on cell surface protein templates functional extracellular lipid assembly.
  Small. 2024; 2307793; DOI: 10.1002/smll.202307793
  [Impact factor 2022: 13.256 - D1; Article Influence Score: 2.545 - Q1]

• Al-Hamdan NS, Hussain A, Kozlikova M, Alfred A, Machacek M, Ganesan A, Zimcik P, Makhseed S. 
  Enhanced Photodynamic Activity of Asymmetric Non-Ionic Zn(II) Phthalocyanine Amphiphiles: Effect of Molecular Design on In Vitro Activity.
  Dyes and Pigments. 2024; 221; 111809; DOI: 10.1016/j.dyepig.2023.111809
  [Impact factor 2022: 4.454 - Q1; Article Influence Score: 0.509 - Q1]

2023

• Chelminiak-Dudkiewicz D, Macháček M, Dlugaszewska J, Wujak M, Smolarkiewicz-Wyczachowski A, Bocian S, Mylkie K, Goslinski T, Marszall MP, Ziegler-Borowska M.
  Fabrication and characterization of new levan@CBD biocomposite sponges as potential materials in natural, non-toxic wound dressing applications.
  International Journal of Biological Macromolecules. 2023; 253(3); 126933; DOI: 10.1016/j.ijbiomac.2023.126933
  [Impact factor 2022: 8.163 - Q1; Article Influence Score: 0.918 - Q1]

• Pavkova I, Kopeckova M, Link M, Vlcak E, Filimonenko V, Lecova L, Zakova J, Laskova P, Sheshko V, Machacek M, Stulik J.
  Francisella tularensis Glyceraldehyde-3-Phosphate Dehydrogenase is Secreted during Intracellular Infection and Reveals Pleiotropic Effect on Cellular Pathogenesis.
  Cells. 2023; 12(4); 607; DOI: 10.3390/cells12040607
  [Impact factor 2022: 6.040 - Q2; Article Influence Score: 1.275 - Q2]

• Kociscakova L; Rando C; Kozlikova M; Machacek M; Novakova V; Šindelář V; Zimcik P.
  Monomerization of Phthalocyanines in Water via Their Supramolecular Interactions with Cucurbiturils.
  Journal of Organic Chemistry. 2023; 88; 2; 988–1002; DOI: 10.1021/acs.joc.2c02413
  [Impact factor 2022: 3.608 - Q1; Article Influence Score: 0.683 - Q1]

2022

• Kopečná M, Macháček M, Roh J, Vávrová K.
  Proline, hydroxyproline, and pyrrolidone carboxylic acid derivatives as highly efficient but reversible transdermal permeation enhancers.
  Scientific Reports. 2022; 12:19495; DOI: 10.1038/s41598-022-24108-6
  [Impact factor 2021: 4.996 - Q2; Article Influence Score: 1.207 - Q1]

• Halaskova M, Kostelansky F, Demuth J, Hlbocanova I, Miletin M, Zimcik P, Machacek M, Novakova V.
  Amphiphilic cationic phthalocyanines for photodynamic therapy of cancer.
  ChemPlusChem. 2022; 26; 87(9):e202200133; DOI: 10.1002/cplu.202200133
  [Impact factor 2021: 3.210 - Q3; Article Influence Score: 0.533 - Q2]

• Gemuh CV; Macháček M; Solich P; Horstkotte B.
  Renewable Sorbent Dispersive Solid Phase Extraction Automated by Lab-In-Syringe Using Magnetite-Functionalized Hydrophilic-Lipophilic Balanced Sorbent Coupled Online to HPLC for Determination of Surface Water Contaminants.
  Analytica Chimica Acta. 2022; 1210:339874; DOI: 10.1016/j.aca.2022.339874
  [Impact factor 2021: 6.911 - Q1; Article Influence Score: 0.948 - Q1]

• Hympanova M; Oliver-Urrutia C; Vojta M; Macháček M; Krupka P; Kukla R; Celko L; Montufar EB, Marek J.
  Assessment of Streptococcus mutans Biofilm Formation on Calcium Phosphate Ceramics: the role of crystalline composition and microstructure.
  Biomaterials Advances. 2022; 135:212750; DOI: 10.1016/j.bioadv.2022.212750
  [Impact factor 2020: 7.328; Article Influence Score: 0.902]

2021

• Demuth J; Gallego L; Kozlikova M; Machacek M; Kucera R; Torres T; Martínez-Díaz MV; Novakova V.
  Subphthalocyanines as efficient photosensitizers with nanomolar photodynamic activity against cancer cells.
  Journal of Medicinal Chemistry. 2021; 64(23); 17436–17447; DOI: 10.1021/acs.jmedchem.1c01584
  [Impact factor 2021: 8.039 - D1; Article Influence Score: 1.579 - D1]

• Krzemien W, Rohlickova M, Machacek M, Novakova V, Piskorz J, Zimcik P.
  Tuning Photodynamic Properties of BODIPY Dyes, Porphyrins´ Little Sisters.
  Molecules. 2021; 26(14):4194; DOI: 10.3390/molecules26144194
  [Impact factor 2021: 4.927 - Q2; Article Influence Score: 0.671 - Q2]

• Bavlovič-Piskáčková H; Kollárová-Brázdová P; Kučera R; Macháček M, Pedersen-Bjergaard S; Štěrbová-Kovaříková P.
  The electromembrane extraction of pharmaceutical compounds from animal tissues.
  Analytica Chimica Acta. 2021; 1177:338742; DOI: 10.1016/j.aca.2021.338742
  [Impact factor 2021: 6.911 - Q1; Article Influence Score: 0.948 - Q1]

• Halaskova M; Rahali A; Almeida-Marrero V; Machacek M; Kucera R; Jamoussi B; Torres T; Novakova V; de la Escosura A; Zimcik P.
  Peripherally crowded cationic phthalocyanines as efficient photosensitizers for photodynamic therapy.
  ACS Medicinal Chemistry Letters. 2021; 12(3); 502–507; DOI: 10.1021/acsmedchemlett.1c00045
  [Impact factor 2021: 4.632 - Q2; Article Influence Score: 0.916 - Q1]

2020

• Kollar J; Machacek M; Halaskova M; Lenco J; Kucera R; Demuth J; Stekla M; Hasonova K; Miletin M; Novakova V; Zimcik P.
  Cationic versus Anionic Phthalocyanines for Photodynamic Therapy: What a Difference the Charge Makes.
  Journal of Medicinal Chemistry. 2020; 63(14); 7616-7632; DOI: 10.1021/acs.jmedchem.0c00481
  [Impact factor 2021: 8.039 - D1; Article Influence Score: 1.579 - D1]

• Husain A, Ganesan A, Machacek M, Cerveny L, Kubat P, Ghazal B, Zimcik P, Makhseed S.
  Dually Directional Glycosylated Phthalocyanines as Extracellular Red-Emitting Fluorescent Probes.
  Dalton Transactions. 2020; 49; 9605-9617; DOI: 10.1039/d0dt01180k
  [Impact factor 2021: 4.569 - D1; Article Influence Score: 0.626 - Q1]

2019

• Kopečná M, Macháček M, Nováčková A, Paraskevopoulos G, Roh J, Vávrová K.
  Esters of terpene alcohols as highly potent, reversible, and low toxic skin penetration enhancers.
  Scientific Reports. 2019; 9; 14617; DOI: 10.1038/s41598-019-51226-5
  [Impact factor 2021: 4.996 - Q2; Article Influence Score: 1.207 - Q1]

• Applová L, Karlíčková J, Warncke P, Macáková K, Hrubša M, Macháček M, Tvrdý V, Fischer D, Mladěnka P.
  4-Methylcatechol, a flavonoid metabolite with potent antiplatelet effects.
  Molecular Nutrition & Food Research. 2019; 63(20); e1900261; DOI: 10.1002/mnfr.201900261
  [Impact factor 2021: 6.575 - Q1; Article Influence Score: 1.008 - Q1]

• Lochman L, Machacek M, Miletin M, Uhlířová Š, Lang K, Kirakci  K, Zimcik P, Novakova V.
  Red-emitting fluorescence sensors for metal cations: the role of counter anions and sensing of SCN- in biological materials.
  ACS Sensors. 2019; 4(6); 1552-1559; DOI: 10.1021/acssensors.9b00081
  [Impact factor 2021: 9.618 - D1; Article Influence Score: 1.619 - D1]

• Reimerová P, Stariat J, Bavlovič-Piskáčková H, Jansová H, Roh J, Kalinowski D, Macháček M, Šimůnek T, Richardson D, Sterbova-Kovarikova P.
  Novel SPME fibers based on a plastic support for determination of plasma protein binding of thiosemicarbazone metal chelators: A case example of DpC, an anti-cancer drug that entered clinical trials.
  Analytical and Bioanalytical Chemistry. 2019; 411(11); 2383-2394; DOI: 10.1007/s00216-019-01681-w
  [Impact factor 2021: 4.478 - Q2; Article Influence Score: 0.700 - Q2]

• Vicen M, Vitverova B, Havelek R, Blazickova K, Machacek M, Rathouska J, Najmanová I, Dolezelova E, Prasnicka A, Sternak M, Bernabeu C, Nachtigal P.
  Regulation and role of endoglin in cholesterol-induced endothelial/vascular dysfunction in vivo and in vitro.
  FASEB Journal. 2019; 33(5); 6099-6114; DOI: 10.1096/fj.201802245R
  [Impact factor 2021: 5.834 - Q1; Article Influence Score: 1.304 - Q1]

• Kopecna M, Kováčik A, Kucera O, Machacek M, Sochorova M, Audrlicka P, VavrovaK.
  Fluorescent Penetration Enhancers Reveal Complex Interactions among the Enhancer, Drug, Solvent, and Skin.
  Molecular Pharmaceutics. 2019; 16(2); 886-897; DOI: 10.1021/acs.molpharmaceut.8b01196
  [Impact factor 2021: 5.364 - Q1; Article Influence Score: 0.812 - Q2]

• Kollar J, Macháček M, Jancarova A, Kubat P, Kucera R, Miletín M, Novakova V, ZimcikP.
  Effect of bovine serum albumin on the photodynamic activity of sulfonated tetrapyrazinoporphyrazine.
  Dyes and Pigments. 2019; 162; 358-366; DOI: 10.1016/j.dyepig.2018.10.051
  [Impact factor 2022: 4.454 - Q1; Article Influence Score: 0.509 - Q1]

2018

• Macháček M, Carter K, Kostelanský F, Miranda D, Seffouh A, Ortega J, Šimůnek T, Zimčík P, Lovell J.
  Binding of an amphiphilic phthalocyanine to pre-formed liposomes confers light-triggered cargo release.
  Journal of Materials Chemistry B. 2018; 6: 7298-7305; DOI: 10.1039/C8TB01602J
  [Impact factor 2021: 7.571 - Q1; Article Influence Score: 0.940 - Q1]

2017

• Kopečná M, Macháček M, Prchalová E, Štěpánek P, Drašar P, Kotora M, Vávrová K.
  Galactosyl Pentadecene Reversibly Enhances Transdermal and Topical Drug Delivery.
  Pharmaceutical Research. 2017; 34(10): 2097–2108; DOI: 10.1007/s11095-017-2214-3
  [Impact factor 2021: 4.580 - Q2; Article Influence Score: 0.765 - Q2]

• Ghazal B, Machacek M, Shalaby M, Novakova V, Zimcik P, Makhseed.
  Phthalocyanines and tetrapyrazinoporphyrazines with two cationic donuts: high photodynamic activity as a result of rigid spatial arrangement of peripheral substituents.
  Journal of Medicinal Chemistry. 2017; DOI: 10.1021/acs.jmedchem.7b00272
  [Impact factor 2021: 8.039 - D1; Article Influence Score: 1.579 - D1]

• Němeček J, Sychra P, Macháček M, Benková M, Karabanovich G, Konečná K, Kavková V, Stolaříkov J, Hrabálek A, Vávrová K, Soukup O, Roh J, Klimešová V.
  Structure-activity relationship studies on 3,5-dinitrophenyl tetrazoles as antitubercular agents.
  European Journal of Medicinal Chemistry. 2017; 130(21): 419–432; DOI: 10.1016/j.ejmech.2017.02.058
  [Impact factor 2021: 7.008 - Q1; Article Influence Score: 0.868 - Q1]

• Kopečná M, Macháček M, Prchalová E, Štěpánek P, Drašar P, Kotora M, Vávrová K.
  Dodecyl amino glucoside enhances transdermal and topical drug delivery via reversible interaction with skin barrier lipids.
  Pharmaceutical Research. 2017; 34(3): 640-653; DOI: 10.1007/s11095-016-2093-z
  [Impact factor 2021: 4.580 - Q2; Article Influence Score: 0.765 - Q2]

2016

• Machacek M, Demuth J, Cermak P, Vavreckova M, Hruba L, Jedlickova A, Kubat P, Simunek T, Novakova V, Zimcik P.
  Tetra(3,4-pyrido)porphyrazines caught in the cationic cage: toward nanomolar active photosensitizers.
  Journal of Medicinal Chemistry. 2016; 59(20): 9443–9456; DOI: 10.1021/acs.jmedchem.6b01140
  [Impact factor 2021: 8.039 - D1; Article Influence Score: 1.579 - D1]

• Haškova P, Jansova H, Bureš J, Macháček M, Jirkovská A, Franz KJ, Kovaříkova P, Šimůnek T.
  Cardioprotective effects of iron chelator HAPI and ROS-activated boronate prochelator BHAPI against catecholamine-induced oxidative cellular injury.
  Toxicology. 2016; 371: 17-28; DOI: 10.1016/j.tox.2016.10.004
  [Impact Factor 2021: 4.571 - Q1; Article Influence Score: 0.753 - Q2]

• Jansová H, Bureš J, Macháček M, Hašková P, Jirkovská A, Roh J, Wang Q, Franz KJ, Kovaříková P, Šimůnek T.
  Characterization of cytoprotective and toxic properties of iron chelator SIH, prochelator BSIH and their degradation products.
  Toxicology. 2016; 250: 15-24; DOI: 10.1016/j.tox.2016.03.004
  [Impact Factor 2021: 4.571 - Q1; Article Influence Score: 0.753 - Q2]

• Machacek M, Kollár J, Miletin M, Kučera R, Kubát P, Simunek T, Novakova V, Zimcik P.
  Anionic hexadeca-carboxylate tetrapyrazinoporphyrazine: synthesis and in vitro photodynamic studies of water-soluble non-aggregating photosensitizer.
  RSC Advances. 2016; 6:10064-10077; DOI: 10.1039/C5RA25881B
  [Impact factor 2021: 4.036 - Q2; Article Influence Score: 0.519 - Q2]

2015

• Potůčková E, Roh J, Macháček M, Stariat J, Šesták V, Jansová H, Hašková P, Jirkovská A, Vávrová A, Kovaříková P, Richardson DR, Šimůnek T.
  In vitro characterization of pharmacological properties of the anticancer iron chelator Bp4eT and its phase I metabolites.
  PLoS One. 2015; 10(10): e0139929. DOI:10.1371/journal.pone.0139929
  [Impact factor 2021: 3.752 - Q2; Article Influence Score: 0.973 - Q2]

• Jirkovská-Vávrová A, Roh J, Lenčová-Popelová O, Jirkovský E, Hrušková K, Potůčková-Macková E, Jansová H, Hašková P, Martinková P, Eisner T, Kratochvíl M, Šůs J, Macháček M, Vostatková-Tichotová L, Geršl V, Muller MT, Richardson DR, Vávrová K, Štěrba M, Šimůnek T.
  Synthesis and analysis of novel analogues of dexrazoxane and its open-ring hydrolysis product for protection against anthracycline cardiotoxicity in vitro and in vivo.
  Toxicology Research. 2015; 4: 1098-1114; DOI: 10.1039/C5TX00048C
  [Impact factor 2021: 2.680 - Q3; Article Influence Score: 0.437 - Q3]

• Vachova L, Machacek M, Kucera R, Demuth J, Cermak P, Kopecky K, Miletin M,  Jedlickova A, Simunek T, Novakova V and Zimcik P.
  Heteroatom-substituted tetra(3,4-pyrido)-porphyrazines: a stride toward near-infrared-absorbing macrocycles.
  Organic & Biomolecular Chemistry. 2015; DOI: 10.1039/c5ob00651a
  [Impact factor 2021: 3.890 - Q1; Article Influence Score: 0.657 - Q2]

• Machacek M, Cidlina A, Novakova V, Svec J, Rudolf E,Miletin M, Kučera R, Simunek T, Zimcik P.
  Far-red absorbing cationic phthalocyanine photosensitizers: Synthesis and evaluation of the photodynamic anti-cancer activity and the mode of cell death induction.
  Journal of Medicinal Chemistry. 2015; 58(4): 1736–1749; DOI: 10.1021/jm5014852
  [Impact factor 2021: 8.039 - D1; Article Influence Score: 1.579 - D1]

2014

• Potůčková E, Hrušková K, Bureš J, Kovaříková P, Špirková IA, Pravdíková K, Kolbabová L, Hergeselová T, Hašková P, Jansová H, Macháček M, Jirkovská A, Richardson V, Lane DJR, Kalinowski DS, Richardson DR, Vávrová K, Šimůnek T. 2014.
  Structure-activity relationships of novel salicylaldehyde isonicotinoyl hydrazone (SIH) analogs: iron chelation, anti-oxidant and cytotoxic properties.
  PLoS One. 2014; 9(11): e112059; DOI: 10.1371/journal.pone.0112059
  [Impact factor 2021: 3.752 - Q2; Article Influence Score: 0.973 - Q2]

• Jansová H, Macháček M, Wang Q, Hašková P, Vávrová A, Potůčková E, Kielar F, Franz KJ, Šimůnek T. 2014.
  Comparison of various iron chelators and prochelators as protecting agents against cardiomyocyte oxidative injury.
  Free Radical Biology & Medicine. 2014. DOI: 10.1016/j.freeradbiomed.2014.06.019.
  [Impact factor 2021: 8.101 - Q1; Article Influence Score: 1.423 - Q1]

• Potuckova E, Jansova H, Machacek M, Vavrova A, Haskova P, Tichotova L, Richardson V, Kalinowski DS, Richardson DR, Simunek T..
  Quantitative analysis of the anti-proliferative activity of combinations of selected iron-chelating agents and clinically used anti-neoplastic drugs. 
  PLoS One. 2014. 9(2). e88754. DOI: 10.1371/journal.pone.0088754.
  [Impact factor 2021: 3.752 - Q2; Article Influence Score: 0.973 - Q2]

2013

• Makhseed S, Machacek M, Alfadly W, Tuhl A, Vinodh V, Simunek T, Novakova V, Kubat P, Rudolf E a Zimcik P.
  Water-soluble non-aggregating zinc phthalocyanine and in vitro studies for photodynamic therapy.
  Chemical Communications. 2013. 49(95): 11149-51; DOI: 10.1039/C3CC44609C
  [Impact factor 2021: 6.065 - Q1; Article Influence Score: 1.124 - Q1]

• Vávrová A, Jansová H, Macková E, Macháček M, Hašková P, Tichotová L, Štěrba M, Šimůnek T.
  Catalytic inhibitors of topoisomerase II differentially modulate the toxicity of anthracyclines towards cardiac and cancer cells.
  PLoS ONE. 2013. 8(10): 1-13; DOI: 10.1371/journal.pone.0076676
  [Impact factor 2021: 3.752 - Q2; Article Influence Score: 0.973 - Q2]