Current position
Education
- 2003-2008 Postgraduate Studies leading to a Ph.D. degree in Microbiology (Faculty of Food and Biochemical Technology, Institute of Chemical Technology Prague)
- 1998-2003 Biomedical Engineering (Faculty of Food and Biochemical Technology, Institute of Chemical Technology Prague)
Work experience
- 2019 Research associate – Assoc. Prof. in Biochemistry
- 2015-2019 Research assistant in the Department of Biochemical Sciences, Faculty of Pharmacy, Charles University
- 2012-2014 Postdoctoral position in the Department of Biochemical Sciences, Faculty of Pharmacy, Charles University (Postdoci na UK)
- 2012 Postdoctoral research stay in Max Planck Institute for Chemical Ecology, Jena, Germany (6 months)
- 2010-2012 Maternity leave
- 2008-2009 Postdoctoral position at the University of Exeter, School of Biosciences, Exeter, UK (14 months)
- 2002-2008 Institute of Organic Chemistry and Biochemistry AS CR, Prague (research assistant as a postgraduate student in the laboratory of Biochemistry)
- 2005-2006 DAAD fellowship: D32-CZ21/05-05 Exchange program in Max Planck Institute of Chemical Ecology, Jena, Germany (two 2-months stays as a postgraduate student)
Research interest
- expression, function and post-transcriptional regulation of drug metabolizing and antioxidant enzymes
- bioinformatics - database search, alignments, phylogenetics, python scripting
- epigenetics – microRNA interactions, DNA methylation
- ecotoxicology
Teaching
- Introduction to applied bioinformatics
- Xenobiochemistry
- Practical classes in molecular biology
Grants Received
- 2018-2020 Charles University (PRIMUS/17/SCI/4: miRNA role in the drug resistance of nematodes)
- 2017-2019 Czech Science Foundation (17-95411Y: UDP-glycosyltransferases in Haemonchus contortus –players in drug-resistance?)
- 2016 Internal Research project (Inclusion of new subject: Introduction to Applied Bioinformatics)
Other scientific achievements
- 2020-2021 FaF coordinator: Erasmus+ project “Bioinformatics centre Hradec Králové” KA203-7BA9D4F2
- 2016 Patent application: Kunke D., Matoušková P. iPSCs PCR array card - UKLFHK-160518
Other notable information
- 2019 - present Czech Society for Parasitology membership
- 2019 Medal of the dean of the Faculty of Pharmacy for the scientific contribution
- 2021 Member of organising committee of 26th Helminthological Days
Summary of publication activity
> 50 papers in international peer-reviewed journals (sum of IF > 180), 684 times cited (Scopus),
h-index: 14
Publications over the last three years:
- Dimunová D., Matoušková P., Navrátilová M., ...Szotáková B., Skálová L. Environmental circulation of the anthelmintic drug albendazole affects expression and activity of resistance-related genes in the parasitic nematode Haemonchus contortus. (2022) Science of the Total Environment 822, 153527
- Zajíčková M., Prchal L., Navrátilová M., Matoušková P., ...Nguyen L.T., Skálová L. Sertraline as a new potential anthelmintic against Haemonchus contortus: toxicity, efficacy, and biotransformation. (2021) Veterinary Research 52(1), pp. 143
- Hanousková B., Vávrová G., Ambrož M., ...Skálová L., Matoušková P*. MicroRNAs mediated regulation of glutathione peroxidase 7 expression and its changes during adipogenesis. (2021) Biochimica et Biophysica Acta - Gene Regulatory Mechanisms 1864(10), 194734.
- Navrátilová M., Raisová Stuchlíková L., Matoušková P., ...Szotáková B., Skálová L. Proof of the environmental circulation of veterinary drug albendazole in real farm conditions. (2021) Environmental Pollution 286, 117590.
- Nguyen L.T., Zajíčková M., Mašátová E., Matoušková P., Skálová L. The ATP bioluminescence assay: a new application and optimization for viability testing in the parasitic nematode Haemonchus contortus. (2021) Veterinary Research 52(1), 124.
- Kellerová P., Navrátilová M., Nguyen L.T., ...Skálová L., Matoušková P. UDP-Glycosyltransferases and Albendazole Metabolism in the Juvenile Stages of Haemonchus contortus. (2020) Frontiers in Physiology 11, 594116.
- Kellerová P., Raisová Stuchlíková L., Matoušková P., ...Szotáková B., Skálová L. Sub-lethal doses of albendazole induce drug metabolizing enzymes and increase albendazole deactivation in Haemonchus contortus adults. (2020) Veterinary Research 51(1), 94.
- Zajíčková M., Nguyen L.T., Skálová L., Raisová Stuchlíková L., Matoušková P*. Anthelmintics in the future: current trends in the discovery and development of new drugs against gastrointestinal nematodes. (2020) Drug Discovery Today 25(2), pp. 430–437.