Prof. PharmDr. Přemysl Mladěnka, Ph.D.

Vzdělání

• 2020 Prof., Univerzita Karlova, obor: Humánní a veterinární farmakologie 
• 2014 doc., Univerzita Karlova v Praze, Farmaceutická fakulta v Hradci Králové, obor: Humánní a veterinární farmakologie
• 2008 Ph.D., Univerzita Karlova v Praze, Farmaceutická fakulta v Hradci Králové, studijní program: Farmacie, obor: Farmakologie a toxikologie
• 2003 Mgr., Univerzita Karlova v Praze, Farmaceutická fakulta v Hradci Králové, studijní program: Farmacie
• 1998 maturita, Gymnázium Petra Bezruče ve Frýdku-Místku

Zaměstnání

• Od r. 2006 Univerzita Karlova v Praze, Farmaceutická fakulta v Hradci Králové, Katedra farmakologie a toxikologie

Ocenění

• 2009 Cena ministryně školství, mládeže a tělovýchovy pro vynikající studenty a absolventy studia ve studijním programu
• 2009 Fakultní medaile Farmaceutické fakulty Univerzity Karlovy
• 2011 Cena mladého vědce institutu Danone za nejlepší práci v oboru výživy
• 2012 Medaile statutárního města Hradce Králové
• 2014 vybrán pro 64. Setkání s nositeli Nobelovy ceny v Lindau (the 64th Lindau Nobel Laureate Meeting)
• 2014 posterová cena za mimořádný vědecký výsledek v oblasti výzkumu volných radikálů získaná na setkání evropské sekce Společnosti pro výzkum volných radikálů (Society for Free Radical Research - Europe)
• 2019 Cena Arnošta z Pardubic za vynikající počin ve vzdělávací činnosti na Univerzitě Karlově

Odborné stáže

• 2004 výzkumný pobyt na Katedře farmakologie přírodních látek a všeobecné fyziologie Univerzity „La Sapienza“ v Římě (5 měsíců)
• 2002 - 2003 diplomová práce vypracována na Katedře farmakologie přírodních látek a všeobecné fyziologie Univerzity „La Sapienza“ v Římě (5 měsíců)

Členství v odborných a profesních společnostech, komisích grantových agentur

• od r. 2007 člen International Society for Heart Research
• od r. 2009 člen International BioIron Society
• od r. 2018 člen odborného panelu P02 - Choroby oběhové soustavy Agentury pro zdravotnický výzkum ČR

Publikační aktivita

• v současné době autor 118 recenzovaných publikací (114 s IF, souhrnný IF 455, průměrný IF u impaktovaných publikací 3,99)

• H-index: 26 (bez autocitací, SCOPUS)

• orcid No.: 0000-0002-6076-6900

• Scopus Author ID: 12244999600

• reseacher ID: S-5929-2017

2025

• Harčárová P, Lomozová Z, Kallivretaki M, Karlíčková J, Kučera R & Mladěnka P. Different behavior of food-related benzoic acids toward iron and copper, Food Chem 2025;462: 141014 (IF₂₀₂₃ 8,5; D1_IF/AIS in FOOD SCIENCE & TECHNOLOGY)

2024

• Bencsik T, Balázs VL, Farkas Á, Csikós E, Horváth A, Ács K, Kocsis M, Doseděl M, Bittner Fialová S, Czigle S, Nagy M, Tóth J, Protti M, Mercolini L, Mladěnka P, Szentpéteri J & Horváth G. Herbal drugs in chronic venous disease treatment: An update,
  Fitoterapia2024; 179: 106256 (IF₂₀₂₃ 2,5; Q3_AIS/IF in Pharmacology and toxicology)
• Alva-Gallegos R, Jirkovský E, Mladěnka P & Carazo A. Small phenolic compounds as potential endocrine disruptors interacting with estrogen receptor alpha. Frontiers in Endocrinology 2024;15:1440654 (IF₂₀₂₃ 3,9; Q2_AIS/IF in Frontiers in Endocrinology)
• Konecny L, Lomozová Z, Karabanovich G, Roh J, Vavrová K & Mladěnka P. Rapid method for screening of both calcium and magnesium chelation with comparison of 21 known metal chelators. J Biol Inorg Chem 2024, in press (IF₂₀₂₃ 2,7; Q1_AIS v CHEMISTRY, INORGANIC & NUCLEAR)
• Dias P, Salam R, Pourová J, Vopršalová M, Konečný L, Jirkovský E, Tebbens JD & Mladěnka P. The quercetin metabolite 4-methylcatechol causes vasodilation via voltage-gated potassium (KV) channels. Food Funct 2024: 15, 11047-11059 (IF₂₀₂₃ 5,1; Q1_IF/AIS in FOOD SCIENCE & TECHNOLOGY)
• Dias P, Salam R, Moravcová M, Saadat S, Pourová J, Vopršalová M, Jirkovský E, Tebbens JF & Mladěnka P. 3-methoxycatechol causes vasodilation likely via KV channels: Ex vivo, in silico docking and in vivo study. Vasc Pharmacol 2024;156: 107418 (IF₂₀₂₃ 3,5; Q2_IF/AIS in PHARMACOLOGY & PHARMACY)
• Mandrioli R, Cirrincione M, Saladini B, Girotti S, Mladěnka P, Protti M & Mercolini L. Development of an accelerated ageing protocol for the study of phytocannabinoid stability in Cannabis sativa L.  J Pharm Biomed Anal 2024; 116422.  (IF₂₀₂₃ 3,1, Q2_IF/AIS in CHEMISTRY, ANALYTICAL)
• Moravcová M, Siatka T, Krčmová LK, Matoušová K & Mladěnka P. Biological properties of vitamin B₁₂. Nutrition Research Reviews 2024, in press (IF₂₀₂₃ 5,7; Q1_IF/AIS in NUTRITION & DIETETICS)
• Palano S, Turoňova D, Protti M, Krčmová LK, Sardella R, Mladěnka P, Mandrioli R, Girotti S & Mercolini L. Next generation microsampling towards sustainable forensic analysis: volumetric DBS for cocaine and metabolites. Microchem J 2024;  203: 110937 (IF₂₀₂₃ 4,8; Q1_IF in ANALYTICAL CHEMISTRY)
• Rassu G, Vlčková HK, Giunchedi P, Dias P, Cossu M, Pourová J, Harčárová P, Lomozová Z, Nováková L, Gavini E & Mladěnka P. A water-soluble preparation for intravenous administration of isorhamnetin and its pharmacokinetics in rats. Chem Biol Interact. 2024;396:111064 (IF₂₀₂₃ 5,1; Q1_IF in PHARMACOLOGY & PHARMACY)
• Carazo A, Hrubša M, Konečný L, Gunaseelan C, Fadraersada J, Skořepa P, Paclíková M, Musil F, Karlíčková J, Javorská L, Matoušová K, Kujovská-Krčmová L,  Šmahelová A, Blaha V & Mladěnka P. Correlations among different platelet aggregation pathways in a group of healthy volunteers. Platelets 2024;35(1): 2336093 (IF₂₀₂₃ 3,3; Q2_AIS in HEMATOLOGY)
• Fadraersada J, Alva‑Gallegos R, Skořepa P, Musil F, Javorská L, Matoušová K, Krčmová LK, Paclíková M, Carazo A, Blaha V & Mladěnka P. Head‑to‑head ex vivo comparison of clinically used direct anticoagulant drugs. Naunyn Schmiedebergs Arch Pharmacol 2024; 397: 4461–4470 (IF₂₀₂₃ 3,6; Q2_IF in PHARMACOLOGY & PHARMACY
• Mrštná K, Matoušová K, Krčmová LK, Carazo A, Pourová J, Mladěnka P, Matysová L, Švec F. Analysis of vitamin K₁ and major K₂ variants in rat/human serum and lipoprotein fractions by a rapid, simple, and sensitive UHPLC-MS/MS method. J Chromatogr A 2024;1714: 464548 (IF₂₀₂₂ 4,1; Q2_IF/Q3_AIS in CHEMISTRY, ANALYTICAL and BIOCHEMICAL RESEARCH METHODS)
• Konečný L, Hrubša M, Karlíčková J, Carazo A, Javorská L, Matoušová K, Kujovská Krčmová L, Blaha V, Bláha M & Mladěnka P. The impact of convertase subtilisin/kexin type 9 monoclonal antibodies with and without apheresis on platelet aggregation in familial hypercholesterolemia.  Cardiovasc Drugs Ther  2024;38: 959–970 (IF₂₀₂₁ 3,9; Q1_2021/AIS in PHARMACOLOGY & PHARMACY;  Q2_2021/AISCARDIAC & CARDIOVASCULAR SYSTEMS)

2023

• Moravcová M, Lomozová Z, Kučera R, Mladěnka P. 3-hydroxyflavone is a mildly active and safe cobalt chelator while cobalt markedly enhances baicalein toxicity toward erythrocytes. RSC Adv 2023;13: 29242-29251 (IF₂₀₂₂ 3,9; Q2 in CHEMISTRY, MULTIDISCPIPLINARY)
• Czigle S, Nagy M, Mladěnka P, Tóth J. Pharmacokinetic and pharmacodynamic herb-drug interactions – Part I. Herbal medicines of the central nervous system. PeerJ 2023; 11:e16149 (IF₂₀₂₂ 2,7; Q2 in MULTIDISCIPLINARY SCIENCE)
• Pourova J, Dias P, Pour M, Bittner Fialová S, Czigle S, Nagy M, Tóth J, Balázs VL, Horváth A, Csikós E, Farkas Á, Horváth G, Mladěnka P. Proposed mechanisms of action of herbal drugs and their biologically active constituents in the treatment of coughs: overview. PeerJ 2023;11:e16096  (IF₂₀₂₂ 2,7; Q2 in MULTIDISCIPLINARY SCIENCE)
• Konečný L, Hrubša M, Karlíčková J, Carazo A, Javorská L, Matoušová K, Krčmová LK, Šmahelová A, Blaha V, Bláha M, Mladěnka P. The Effect of 4-Methylcatechol on Platelets in Familial Hypercholesterolemic Patients Treated with Lipid Apheresis and/or Proprotein Convertase Subtilisin Kexin 9 Monoclonal Antibodies. Nutrients. 2023; 15(8):1842 (IF₂₀₂₁ 6,7; Q1_2021/IF in Nutrition & Dietetics, Q2_2021/AIS in Nutrition & Dietetics)
• Alva R, Carazo A, Mladěnka P. Toxicity overview of endocrine disrupting chemicals interacting in vitro with the oestrogen receptor. Environ Toxicol Phar 2023; 99: 104089 (IF₂₀₂₁ 5,8;  Q1_IF/Q2_AIS  in PHARMACY AND PHARMACOLOGY and TOXICOLOGY)
• Sisa M, Konečný L, Temml V, Carazo A, Mladěnka P, Landa P. SC-560 and mofezolac isosteres as new potent COX-1 selective inhibitors with antiplatelet effect. Arch Pharm (Weinheim). 2023;356(5): e2200549 (IF₂₀₂₁ 4,6;  Q2_IF  in PHARMACY AND PHARMACOLOGY; CHEMSITRY, MEDICAL; and CHEMISTRY, MULTIDISCIPLINARY)
• Tvrdý V, Dias P, Nejmanová I, Carazo A, Jirkovský E, Pourová J, Fadraersada J, Moravcová M, Peterlin Mašič L, Sollner Dolenc M & Mladěnka P. The effects of bisphenols on the cardiovascular system ex vivo and in vivo. Chemosphere 2023;313: 137565  (IF₂₀₂₁ 8,9;  Q1_2021/IF,  Q2_2021/AIS in ENVIRONMENTAL SCIENCES)
• Carazo A, Hrubša M, Konečný L, Skořepa P, Paclíková M, Musil F, Karlíčková J, Javorská L, Matoušová K, Kujovská Krčmová L, Parvin MS, Šmahelová A, Blaha V & Mladěnka P.Sex-related differences in platelet aggregation: a literature review supplemented with local data from a group of generally healthy individuals. Semin Thromb Hemost 2023; 49(5):488-506 /IF₂₀₂₁ 6,4/ (Q1_IF2021 in Peripheral Vascular Disease, Q2_IF2021 in Hematology)
• Moravcová M, Hrubša M, Lomozová Z, Catapano MC, Argento R, Jirkovský E, Kučera R, Mercolini L & Mladěnka M. A complex methodological approach for the screening of efficient and safe cobalt chelators. Med Chem 2023;19(5): 495 - 507 (IF₂₀₂₁ 2,3)

2022

• Costa VM, Grando LGR, Milandri E, Nardi J, Teixeira P, Mladěnka P & Remião F, on behalf of The OEMONOM. Natural Sympathomimetic Drugs: From Pharmacology to Toxicology. Biomolecules. 2022; 12(12):1793 (IF₂₀₂₁ 6,0;  Q2_2021/AIS in BIOCHEMISTRY & MOLECULAR BIOLOGY)

• Hrubša M, Konečný L, Paclíková M, Parvin MS, Skořepa P, Musil F, Karlíčková J, Javorská L, Matoušová K, Krčmová LK, Carazo A, Šmahelová A, Blaha V, Mladěnka P. The Antiplatelet Effect of 4-Methylcatechol in a Real Population Sample and Determination of the Mechanism of Action. Nutrients. 2022; 14(22):4798 (IF₂₀₂₁ 6,7; Q1_2021/IF in Nutrition & Dietetics, Q2_2021/AIS in Nutrition & Dietetics)

• Parvin MS, Chlebek J, Hošťálková A, Catapano MC, Lomozová Z, Macáková K, Mladěnka P. Interactions of Isoquinoline Alkaloids with Transition Metals Iron and Copper. Molecules. 2022; 27(19):6429 (IF₂₀₂₁ 4,9; Q2_IF2021 in BIOCHEMISTRY & MOLECULAR BIOLOGY and CHEMISTRY, MULTIDISCIPLINARY)

• Mandrioli R, Cirrincione M, Mladěnka P, Protti M & Mercolini L. Green analytical chemistry (GAC) applications in sample preparation for the analysis of anthocyanins in products and by-products from plant sources. Adv Sample Prep 2022;3:100037 (bez IF)

• Parvin MS, Hrubša M, Fadraersada J, Carazo A, Karlíčková J, Cahlíková L, Chlebek J, Macáková K, Mladěnka P. Can Isoquinoline Alkaloids Affect Platelet Aggregation in Whole Human Blood? Toxins 2022; 14(7):491 /IF₂₀₂₁ 5,0/ (Q1_IF2021 in Toxicology, Q2_IF2021 in Food Science & Technology)

• Lomozová Z, Hrubša M, Conte PF, Papastefanaki E, Moravcová M, Catapano MC, Proietti Silvestri I, Karlíčková J, Kučera R, Macáková K & Mladěnka P. The effect of flavonoids on the reduction of cupric ions, the copper-driven Fenton reaction and copper-triggered haemolysis. Food Chem 2022;394: 133461 /IF₂₀₂₀ 7,5/ (1^th decile in Nutrition & Dietetics; Food Science & Technology and Chemistry, Applied)

• Hrubša M, Tvrdý V, Kutý M, Valentová K, Křen V & Mladěnka M. Interaction of flavonoids with zinc and zinc-containing enzymes.  J Agric Food Chem 2022;70(20): 6134–6144 /IF₂₀₂₀  = 5,3/ (Q1_2020/IF/AIS Food Science & Technology, 1^st decile_IF/2020 Agriculture, multidiscipilinary, Q1_IF/AIS/2020 Chemistry, applied)

• Janoušek J, Pilařová V, Macáková K, Nomura A, Veiga-Matosc J, Dias da Silva D, Remião F, Saso L, Malá-Ládová K, Malý J, Nováková L & Mladěnka P. Vitamin D: Sources, physiological role, biokinetics, deficiency, therapeutic use, toxicity, and overview of analytical methods for detection of vitamin D and its metabolites. Crit Rev Clin Lab Sci 2022;59(8): 517-54 /IF₂₀₂₀ = 6,2/ (1^st decile_2020/AIS in Medical Laboratory Technology)

• Roque Bravo R, Faria AC, Brito-da-Costa AM, Carmo H, Mladěnka P, Dias da Silva D, Remião F, on behalf of The OEMONOM Researchers. Cocaine: An Updated Overview on Chemistry, Detection, Biokinetics, and Pharmacotoxicological Aspects including Abuse Pattern. Toxins. 2022; 14(4):278 /IF₂₀₂₀= 4,5/ (Q1_2020/AIS in Food Science & Technology, Q2_2020/AIS in Toxicology)

• Mladěnka, P. Special Issue “Dietary (Poly)Phenols and Health”. Nutrients 2022; 14: 1402 /IF₂₀₂₀=5,7/  (Q2_2020/AIS in Nutrition & Dietetics)

• Dias P, Tvdrý V, Jirkovský E, Solner Dolenc M, Peterlin Mašič L & Mladěnka P. The effects of bisphenols on the cardiovascular system. Crit Rev Toxic 2022;52(1): 66-87 /IF₂₀₂₀=5,6/ (1^th decile_2020/AIS in Toxicology) 

• Hrubša M, Siatka T, Nejmanová I, Vopršalová M, Kujovská Krčmová L, Matoušová K, Javorská L, Macáková K, Mercolini L, Remião F, Máťuš M, Mladěnka P, on behalf of the OEMONOM. Biological Properties of Vitamins of the B-Complex, Part 1: Vitamins B1, B2, B3, and B5. Nutrients 2022; 14(3):484. /IF₂₀₂₀=5,7/  (Q2_2020/AIS in Nutrition & Dietetics)

• Silva B, Soares J, Rocha-Pereira C, Mladěnka P, Remião F, on behalf of The OEMONOM Researchers. Khat, a Cultural Chewing Drug: A Toxicokinetic and Toxicodynamic Summary. Toxins 2022; 14(2):71  /IF₂₀₂₀= 4,5/ (Q1_2020/AIS in Food Science & Technology, Q2_2020/AIS in Toxicology)

• Dias P, Pourová J, Vopršalová M, Nejmanová I, Mladěnka P. 3-Hydroxyphenylacetic Acid: A Blood Pressure-Reducing Flavonoid Metabolite. Nutrients. 2022; 14(2):328 /IF₂₀₂₀=5,7/  (Q2_2020/AIS in Nutrition & Dietetics)

• Hrubša M, Alva R, Parvin MS, Macáková K, Karlíčková J, Fadraersada J, Konečný L, Moravcová M, Carazo A, Mladěnka P. Comparison of Antiplatelet Effects of Phenol Derivatives in Humans. Biomolecules. 2022; 12(1):117 /IF₂₀₂₀ 4,9/ (Q2_AIS,2020 in Biochemistry & Molecular Biology)

• Hrubša M, Nurjamal K, Carazo A, Nayek N, Karlíčková J, Applová L, Karmakar I, Parvin S, Fadraersada J, Macáková K & Mladěnka P, Brahmachari G. Screening of Synthetic Heterocyclic Compounds as Antiplatelet Drugs. Med Chem. 2022;18(5):536-543 /IF₂₀₂₀ 2,7/

• Mladěnka P, Macáková K, Kujovská Krčmová L, Javorská L, Mrštná K, Carazo A, Protti M, Remião F & Nováková L. Vitamin K - Sources, Physiological role, Kinetics, Deficiency, Detection, Therapeutic use and Toxicity. Nutrition Reviews 2022; 80(4): 677–698 /IF₂₀₂₀ 7,1/ (1^st decile in Nutrition & Dietetics)

• Sirakanyan SN, Hrubša M, Spinelli D, Dias P, Kartsev V, Carazo A, Hovakimyan AA, Pourová J, Hakobyan EK, Karlíčková J, Parvin S, Fadraersada J, Macáková K, Geronikaki A & Mladěnka P. Synthesis of 3,3-dimethyl-6-oxopyrano[3,4-c]pyridines and their antiplatelet and vasodilatory activity.  J Pharm Pharmacol 2022;74(6): 887–895 /IF₂₀₁₉ 2,6/ (Q3₂₀₁₉ in Pharmacology & Pharmacy)

2021

• Zveaghintseva M, Stingaci E, Pogrebnoi S, Smetanscaia A, Valica V, Uncu L, Kravtsov V, Melenic E, Petrou A, Glamočlija J, Soković M, Carazo A, Mladěnka P, Poroikov V, Geronikaki A, Macaev FZ. Chromenol Derivatives as Novel Antifungal Agents: Synthesis, In Silico and In Vitro Evaluation. Molecules. 2021; 26(14):4304 /IF₂₀₂₀ 4,4/ (Q2₂₀₂₀ Biochemistry and Molecular Biology, Q2₂₀₂₀ Chemistry, multidisciplinary)

• Kamoutsis C, Fesatidou M, Petrou A, Geronikaki A, Poroikov VV, Ivanov M, Soković M, Ćirić A, Carazo A & Mladěnka P. Triazolo Based-Thiadiazole Derivatives. Synthesis, Biological Evaluation and Molecular Docking Studies. Antibiotics 2021; 10(7): 804  /IF₂₀₁₉ 3,9/ (Q1₂₀₁₉ in Pharmacology & Pharmacy and in Infectious diseases)

• Tvrdý V, Hrubša M, Jirkovský E, Biedermann D, Kutý M, Valentová K, Křen V, Mladěnka P. Silymarin Dehydroflavonolignans Chelate Zinc and Partially Inhibit Alcohol Dehydrogenase. Nutrients. 2021; 13(12):4238 /IF₂₀₁₉=5,7/  (Q2_2020/AIS in Nutrition & Dietetics)

• Kenda M, Vegelj J, Herlah B, Perdih A, Mladěnka P and  Sollner Dolenc M. Evaluation of Firefly and Renilla Luciferase Inhibition in Reporter-Gene Assays: A Case of Isoflavonoids. Int J Mol Sc. 2021; 22(13): 6927 /IF₂₀₁₉ 4,6/ (Q1₂₀₁₉ in Biochemistry & Molecular Biology, Q2₂₀₁₉ in Chemistry, multidisciplinary)

• Carazo A, Macáková K, Matoušová K, Krčmová LK, Protti M, Mladěnka P. Vitamin A Update: Forms, Sources, Kinetics, Detection, Function, Deficiency, Therapeutic Use and Toxicity. Nutrients 2021;13(5): 1703 /IF₂₀₁₉=4,5/  (Q1₂₀₁₉ in Nutrition & Dietetics)

• Lomozová Z, Catapano MC, Hrubša M, Karlíčková J, Macáková K, Kučera R & Mladěnka P. Chelation of iron and copper by quercetin B-ring methyl metabolites, isorhamnetin and tamarixetin, and their effect on metal-based Fenton chemistry. J Agric Food Chem 2021;  69(21): 5926–5937 /IF₂₀₁₉ 4,2/ (1^st decile in Agriculture, mutlidisciplinary;  Q1₂₀₁₉ in Food Science and Technology and Q1₂₀₁₉ Chemistry, applied)

• Lomozová Z, Tvrdý V, Hrubša M, Catapano MC, Macáková K, Biedermann D, Kučera R, Křen V, Mladěnka P, Valentová K. Dehydroflavonolignans from Silymarin Potentiate Transition Metal Toxicity In Vitro but Are Protective for Isolated Erythrocytes Ex Vivo. Antioxidants 2021; 10(5):679 /IF₂₀₁₉ 5,0/ (Q1₂₀₁₉ in Biochemistry & Molecular Biology; Q1₂₀₁₉ in Food Science & Technology; Q1₂₀₁₉ in Chemistry, Medicinal)

• Catapano MC, Parsons DS, Kotuniak R, Mladěnka P, Bal W & Maret W. Probing the Structure and Function of the Cytosolic Domain of the Human Zinc Transporter ZnT8 with Nickel(II) Ions. Int J Mol Sci 2021; 22(6):2940. /IF₂₀₁₉ 4,6/ (Q1₂₀₁₉ in Biochemistry & Molecular Biology, Q2₂₀₁₉ in Chemistry, multidisciplinary)

• Vlčková HK, Catapano MC, Mitašík L, Kotland O, Nejmanová I, Pourová J, Mladěnka P & Nováková L. Featuring ultimate sensitivity of high resolution LC-MS analysis of phenolics in rat plasma. J Sep Sci 2021;44(9): 1893-1903 /IF₂₀₁₉ 2,8/ (Q2₂₀₁₉ in Analytical Chemistry)

• Haroun M,  Tratrat C, Kolokotroni A, Petrou A, Geronikaki A, Ivanov M, Kostic M, Sokovic M, Carazo A, Mladěnka P, Harsha S, Venugopala KN, Nair AB & Elsewedya HS. 5-Benzyliden-2-(5-methylthiazol-2-ylimino)thiazolidin-4-ones as Antimicrobial Agents. Design, Synthesis, Biological Evaluation and Molecular Docking Studies. Antibiotics 2021;10(3):309 /IF₂₀₁₉ 3,9/ (Q1₂₀₁₉ in Pharmacology & Pharmacy and in Infectious diseases)

• Tvrdý V, Pourová J, Jirkovský E, Křen V, Valentová K & Mladěnka P. Systematic review of pharmacokinetics and potential pharmacokinetic interactions of flavonolignans from silymarin. Med Res Rev 2021; 41:2195–2246 /IF₂₀₁₉ 9,3/ (1^st decile in Pharmacology & Pharmacy and in Medicinal chemistry)

• Doseděl M, Jirkovský E, Macáková K, Kujovská Krčmová L, Javorská L, Pourová J, Mercolini L, Remião F, Nováková L & Mladěnka P. Vitamin c - sources, physiological role, kinetics, deficiency, use, toxicity, and determination. Nutrients 2021;13(2): 615 /IF₂₀₁₉=4,5/  (Q1₂₀₁₉ in Nutrition & Dietetics)

2020

• Fliszár-Nyúl E, Mohos V, Csepregi R, Mladěnka P & Poór M. Inhibitory effects of polyphenols and their colonic metabolites on CYP2D6 enzyme using two different substrates, Biomed. Pharmacother 2020;131: 110732 /IF₂₀₁₉=4,5/
• Mladěnka, P.; Karlíčková, J.; Hrubša, M.; Veljović, E.; Muratović, S.; Carazo, A.; Shivling Mali, A.; Špirtović-Halilović, S.; Saso, L.; Pour, M.; Durić, K. Interaction of 2,6,7-Trihydroxy-Xanthene-3-Ones with Iron and Copper, and Biological Effect of the Most Active Derivative on Breast Cancer Cells and Erythrocytes. Appl Sci 2020; 10: 4846 /IF₂₀₁₉=2,5/
• Migkos T, Pourová J, Vopršalová M, Auger C, Schini-Kerth V & Mladěnka P. Biochanin A, the most potent of 16 isoflavones, induces relaxation of the coronary artery through the calcium channel and cGMP-dependent pathway. Planta Medica 2020; 86(10): 708-716 /IF₂₀₁₈=2,7/
• Mohos V, Fliszár-Nyúl E, Lemli B, Zsidó BZ, Hetényi C, Mladěnka P, Horký P, Pour M & Poór M. Testing the Pharmacokinetic Interactions of 24 Colonic Flavonoid Metabolites with Human Serum Albumin and Cytochrome P450 Enzymes. Biomolecules 2020;10: 409 /IF₂₀₁₈=4,7/  
• Najmanová I, Pourová J & Mladěnka P. Mixture of phenolic metabolites of quercetin can decrease elevated blood pressure of spontaneously hypertensive rats even in low doses. Nutrients 2020;12(1): 213 /IF₂₀₁₈=4,2/  
• Skledara DG, Tvrdý V, Kenda M, Zega A, Mladěnka P, Dolenca MS, Peterlin Mašič L. Applicability of the OECD 455 in-vitro assay for determination of hERa agonistic activity of isoflavonoids. Toxicol Appl Pharmacol 2020; 386: 114831 /IF₂₀₁₈=3,6/ 
• Najmanová I,Vopršalová M, Saso L & Mladěnka P. The pharmacokinetics of flavanones. Crit Rev Food Sci Nutr 2020; 60 (18): 3155-3171 /IF₂₀₁₈=6,7/  

2019

• Carazo A, Mladěnka P & Pávek P. Marine Ligands of the Pregnane X Receptor (PXR): An Overview. Mar. Drugs 2019, 17(10), 554 /IF₂₀₁₈=3,8/  
• Pourová J, Applová L, Macáková K, Vopršalová M, Migkos T, Bentanachs R, Biedermann D, Petrásková L, Tvrdý V, Hrubša M, Karlíčková J, Křen V, Valentová K & Mladěnka P. The Effect of Silymarin Flavonolignans and Their Sulfated Conjugates on Platelet Aggregation and Blood Vessels Ex Vivo. Nutrients 2019;11(10): 2286 /IF₂₀₁₈=4,2/  
• Catapano MC, Protti M, Fontana T, Mandrioli R, Mladěnka P & Mercolini L. An Original HPLC Method with Coulometric Detection to Monitor Hydroxyl Radical Generation via Fenton Chemistry. Molecules 2019; 24(17): 3066 /IF₂₀₁₈=3,1/  
• Applová L, Karlíčková J, Warncke P, Macáková K, Hrubša M, Macháček M, Tvrdý V, Fischer D & Mladěnka P. 4-Methylcatechol, a Flavonoid Metabolite with Potent Antiplatelet Effects. Mol Nutr Food Res. 2019; 63 (20): 1900261 /IF₂₀₁₇=5,2/
• Migkos T, Applová L, Horký P, Tvrdý V, Karlíčková J, Macáková K, Hrubša M, Catapano MC, Tomanek M, Pour M & Mladěnka P. The influence of microbial isoflavonoid specific metabolites on platelets and transition metals iron and copper. Phytomedicine 2019;62:152974 /IF₂₀₁₇=3,6/
• Mladěnka A, Mladěnka P, Šimetka O & Klát J. Intra-operative and postoperative complications depend on operating approach and body mass index in patients with malignant uterus body neplasm. Eur J Gynaecol Oncol 2019;40(4):593-8 /IF₂₀₁₆=0,7/
• Mohos V, Pánovics A, Fliszár-Nyúl E, Schilli G, Hetényi C, Mladěnka P, Needs PW, Kroon PA, Pethő G & Poór M. Inhibitory effects of quercetin as well as its human and microbial metabolites on xanthine oxidase enzyme. Int J Mol Sci 2019;20(11): 2681 /IF₂₀₁₇=3,7/
• Macáková K, Afonso R, Saso L & Mladěnka P. The influence of alkaloids on oxidative stress and related signaling pathways. Free Rad Biol Med 2019;134: 429-444 /IF₂₀₁₇=6,0/
• Macáková K, Catapano MC, Tvrdý V, Klimková K, Karlíčková J & Mladěnka P. Hematoxylin assay of cupric chelation can give false positive results. J Trace Elem Med Biol 2019;52: 29-36 /IF₂₀₁₇=3,8/

2018

• Pourová J, Najmanová I, Voršalová M, Migkos T, Pilařová V, Applová L, Nováková L & Mladěnka P. Two flavonoid metabolites, 3,4-dihydroxyphenylacetic acid and 4-methylcatechol, relax arteries ex vivo and decrease blood pressure in vivo. Vasc Pharmacol 2018;111: 36-43 /IF₂₀₁₇=3,6/
• Tvrdý V, Catapano MC, Rawlik T, Karlíčková J, Biedermann D, Křen V, Mladěnka P & Valentová K. Interaction of isolated silymarin flavonolignans with iron and copper. J Inorg Biochem 2018; 189: 115-123 /IF₂₀₁₇=3,0/
• Navrátilová L, Applová L, Horký P, Mladěnka P, Pávek P & Trejtnar F. Interaction of soy isoflavones and their main metabolites with hOATP2B1 transporter. Naunyn Schmiedebergs Arch Pharmacol. 2018;391(10): 1063-1071 /IF₂₀₁₆=2,6/
• Pilařová V, Plachká K, Chrenková L, Najmanová I, Mladěnka P, Švec F, Novák O & Nováková L. Simultaneous determination of quercetin and its metabolites in rat plasma by using ultra-high performance liquid chromatography tandem mass spectrometry. Talanta 2018,185: 71-79  /IF₂₀₁₆=4,2/ 
• Porcu EP, Cossu M, Rassu G, Giunchedi P, Cerri G, Pourová J, Najmanová I, Migkos T, Pilařová V, Nováková L, Mladěnka P  & Gavini E. Aqueous injection of quercetin: an approach for confirmation of its direct in vivo cardiovascular effects. Int J Pharmaceut 2018; 541(1-2):224-233  /IF₂₀₁₆=3,6/
• Mladěnka A, Šimetka O, Mladěnka P & Klát J. Gynekologická nádorová triplicita. Čes Gynek 2018; 83 (6):445-447
• Mladěnka P, Applová L, Patočka J, Costa VM, Remiao F, Pourová J, Mladěnka A, Karlíčková J, Jahodář L, Vopršalová M, Varner KJ & Štěrba M. TOX-OER and CARDIOTOX Hradec Králové researchers and collaborators. Comprehensive review of cardiovascular toxicity of drugs and related agents. Med Res Rev 2018;38(4): 1332-1403 /IF₂₀₁₆=8,8/
• Catapano MC, Tvrdý V, Karlíčková J, Mercolini L & Mladěnka P. A simple, cheap but reliable method for evaluation of zinc chelating properties. Bioorg Chem 2018;77: 287-292 /IF₂₀₁₆=3,2/
• Catapano MC, Karlíčková J, Tvrdý V, Sharma S,  Prasad AK,  Saso L,  Chhillar AK, Kuneš J,  Pour M,  Parmard, VS & Mladěnka P. Mono and Dihydroxy Coumarin Derivatives: Copper Chelation and Reduction Ability. J Trace Elem Med Biol 2018;46 :88-95 /IF₂₀₁₆=3,2/

• Applová L, Veljovic E, Muratovic S, Karlíčková J, Macáková K, Završnik D, Saso L, Duric K, Hrdina R & Mladěnka P. 9-(4'-dimethylaminophenyl)-2,6,7-trihydroxy-xanthene-3-one is a potentially novel antiplatelet drug antagonizing the effect of thromboxane A2, Med Chem 2018;14(2): 200-209 /IF₂₀₁₆=2,3/

2017

• Catapano MC, Tvrdý V, Karlíčková J, Migkos T, Valentová K, Křen V & Mladěnka P. The Stoichiometry of Isoquercitrin Complex with Iron or Copper Is Highly Dependent on Experimental Conditions. Nutrients 2017, 9, 1193 /IF₂₀₁₆=3,6/
• Applová L, Karlíčková J, Říha M, Filipský T, Macáková K, Spilková J & Mladěnka P. The isoflavonoid tectorigenin has better antiplatelet potential than acetylsalicylic acid. Phytomedicine 2017;35:11-7 /IF₂₀₁₆=3,5/
• Navrátilová L, Mandíková JR, Pávek P, Mladěnka P & Trejtnar F. Honey flavonoids inhibit hOATP2B1 and hOATP1A2 transporters and hOATP-mediated rosuvastatin cell uptake in vitro, Xenobiotika 2017; 26:1-34 /IF₂₀₁₆=1,9/
• Hloch K, Mladěnka P, Doseděl M, Adriani W & Zoratto F. The current clinical knowledge on the treatment of gambling disorder: a summary. Synapse 2017; 71(8): e21976 /IF₂₀₁₆=2,1/
• Filipský T, Říha M, Hašková P, Pilařová V, Nováková L, Semecký V, Vávrová J, Holečková M, Palicka V, Šimůnek T, Hrdina R & Mladěnka P. Intravenous rutin in rat exacerbates isoprenaline-induced cardiotoxicity likely due to intracellular oxidative stress. Redox Rep 2017;22(2):78-90 /IF₂₀₁₅=2,6/

2016

• Mladěnka P, Říha M, Martin J, Gorová B, Matějíček A & Spilková J. Fruit extracts of 10 varieties of elderberry (Sambucus nigra L.)  interact differently with iron and copper. Phytochem Lett  2016; 18:232-8  /IF₂₀₁₅=1,4/
• Najmanová I, Pourová J, Vopršalová M, Pilařová V, Semecký V, Nováková L & Mladěnka P. The flavonoid metabolite 3-(3-hydroxyphenyl)propionic acid formed by human microflora decreases arterial blood pressure in rat. Mol Nutr Food Res 2016;60(5):981-91  /IF₂₀₁₄=4,6/
• Říha M, Hašková P, Martin J, Filipský T, Váňová K, Vávrová J, Holečková M, Homola P, Vítek L, Palicka V, Šimůnek T& Mladěnka P. Protective Effects of D-Penicillamine on Catecholamine-Induced Myocardial Injury. Oxid Med Cell Longev 2016; 2016: article ID 5213532 /IF₂₀₁₄=3,5/
• Karlíčková J, Říha M, Filipský T, Macáková K, Hrdina R & Mladěnka P. Antiplatelet effects of flavonoids mediated by inhibition of arachidonic acid based pathway. Planta Med 2016; 82(01/02):76-83 /IF₂₀₁₄=2,2/
• Martin J, Mladěnka P, Saso L & Kostova I. Lanthanide(III) complexes are more active inhibitors of the Fenton reaction than pure ligands. Redox Rep 2016; 21(2):84-9 /IF₂₀₁₃=1,5/

2015

• Karlíčková J, Macáková K, Říha M, Pinheiro LMT, Filipský T, Horňasová V, Hrdina R & Mladěnka P. Isoflavones Reduce Copper with Minimal Impact on Iron In Vitro. Oxid Med Cell Longev 2015; 2015: article ID 437381 /IF₂₀₁₄=3,5/
• Najmanová I, Doseděl M, Hrdina R, Anzenbacher P, Filipský T, Říha M & Mladěnka P. Cardiovascular Effects of Coumarins Besides their Antioxidant Activity. Curr Top Med Chem. 2015;15(9):830-49 /IF₂₀₁₃=3,5/
• Filipský T, Říha M, Macáková K, Anzenbacherová E, Karlíčková J & Mladěnka P. Antioxidant Effects of Coumarins Include Direct Radical Scavenging, Metal Chelation and Inhibition of Ros-Producing Enzymes. Curr Top Med Chem. 2015;15(5):415-31 /IF₂₀₁₃=3,5/

2014

• Bureš J, Jansová H, Stariat J, Filipský T, Mladěnka P, Šimůnek T, Kučera R, Klimeš J, Wang Q, Franz KJ & Kovaříková P. LC-UV/MS methods for the analysis of prochelator-Boronyl salicylaldehyde isonicotinoyl hydrazone (BSIH) and its active chelator salicylaldehyde isonicotinoyl hydrazone (SIH). J Pharm Biomed Anal. 2014;105C:55-63 /IF₂₀₁₃=2,8/
• Říha M, Karlíčková J, Filipský T, Macáková K, Rocha L, Bovicelli P, Proietti Silvestri I, Saso L, Jahodář L, Hrdina R & Mladěnka P. In vitro evaluation of copper-chelating properties of flavonoids. RSC Adv 2014;4 (62): 32628 - 32638 /IF₂₀₁₃=3,7/
• Mladěnka P, Hrdina R, Filipký T, Říha M & Palicka V. Is a Highly Linear Relationship Between the Dose of Quercetin and the Pharmacological Effect Possible? — A Comment on Liu, et al. Evaluation of Antioxidant and Immunity Activities of Quercetin in Isoproterenol-Treated Rats. Molecules 2012, 17, 4281–4291. Molecules 2014, 19(7), 9606-9609 /IF₂₀₁₂=2,4/
• Říha M, Vopršalová M, Pilařová V, Semecký V, Holečková M, Vávrová J, Palicka V, Filipský T, Hrdina R, Nováková L & Mladěnka P. Oral administration of quercetin is unable to protect against isoproterenol cardiotoxicity. Naunyn Schmiedebergs Arch Pharmacol 2014;387: 823-35  /IF₂₀₁₂=2,1/
• Stariat J, Suprunová V, Roh J, Sesták V, Eisner T, Filipský T, Mladěnka P, Nobilis M, Šimůnek T, Klimeš J, Kalinowski DS, Richardson DR & Kovaříková P. Simultaneous determination of the novel thiosemicarbazone anti-cancer agent, Bp4eT, and its main phase I metabolites in plasma: Application to a pilot pharmacokinetic study in rats. Biomed Chromatogr. 2014;28(5):621-9 /IF₂₀₁₂=1,9/

2013

• Filipský T, Říha M, Hrdina R, Vávrová K & Mladěnka P. Mathematical calculations of iron complex stoichiometry by direct UV-Vis spectrophotometry. Bioorg Chem 2013; 49:1-8 /IF₂₀₁₂=1,7/
• Mladenka P, Zatloukalova L, Filipsky T, Vavrova J, Holeckova M, Palicka V & Hrdina R. Common biomarkers of oxidative stress do not reflect cardiovascular dys/function in rats. Biomed Pap 2013;157(2):146-152 /IF₂₀₁₂=1,0/
• Říha M, Karlíčková J, Filipský T, Macáková K,  Hrdina R & Mladěnka P. Novel method for rapid copper chelation assessment confirmed low affinity of D-penicillamine for copper in comparison with trientine and 8-hydroxyquinolines. J Inorg Bioch 2013; 123: 80-7  /IF₂₀₁₁=3,4/
• Janůšová B, Školová B, Tükörová K, Wojnarová L, Šimůnek T, Mladěnka P, Filipský T, Říha M, Roh J, Palát K, Hrabálek A & Vávrová K. Amino acid derivatives as transdermal permeation enhancers. J Control Release 2013, 165(2):91-100 /IF₂₀₁₁ = 6,5/

2012

• Macáková K, Řeháková Z, Mladěnka P, Karlíčková J, Filipský T, Říha M, Prasad AK, Parmar VS, Jahodář L, Pávek P, Hrdina R & Saso L. In vitro platelet antiaggregatory properties of 4-methylcoumarins. Biochimie 2012; 94(12): 2681-6 /IF₂₀₁₁=3,0/ 
• Macáková K, Mladěnka P, Filipský T,  Říha M,  Jahodář L,   Trejtnar F,  Bovicelli P,  Proietti Silvestri I, Hrdina R & Saso L. Iron reduction potentiates hydroxyl radical formation only in flavonols. Food Chem 2012; 135(4): 2584–92. /IF₂₀₁₁=3,7/
• Zatloukalová L, Filipský T, Mladěnka P, Semecký V, Macáková K, Holečková M, Vávrová J, Palicka V & Hrdina R. Dexrazoxane provided moderate protection in a catecholamine model of severe cardiotoxicity. Can J Physiol Pharmacol 2012; 90(4):473-84 /IF₂₀₁₀=1,8/
• Filipský T, Zatloukalová L, Mladěnka P & Hrdina R. Acute initial hemodynamic changes in a rat isoprenaline model of cardiotoxicity. Hum Exp Toxicol. 2012; 31(8) 830–43  /IF₂₀₁₀=1,2/
• Filipský T, Mladěnka P, Macáková K, Hrdina R, Saso L, Marchetti F & Pettinari C. In vitro characteristics of 1-phenyl-3-methyl-4-acylpyrazol-5-ones iron chelators. Biochimie. 2012;94(1):125-31. /IF₂₀₁₀=3,8/

2011

• Mladěnka P, Macáková K, Filipský T, Zatloukalová L, Jahodář L, Bovicelli P, Silvestri IP, Hrdina R & Saso L. In vitro analysis of iron chelating activity of flavonoids. J Inorg Biochem. 2011;105(5):693-701. /IF₂₀₁₀=3,3/

2010

• Mladenka P, Zatloukalová L, Filipský T & Hrdina R. Cardiovascular effects of flavonoids are not caused only by direct antioxidant activity. Free Radic Biol Med. 2010;49(6):963-75 /IF₂₀₀₉=6,1/
• Mladenka P, Macáková K, Zatloukalová L, Reháková Z, Singh BK, Prasad AK, Parmar VS, Jahodár L, Hrdina R & Saso L. In vitro interactions of coumarins with iron. Biochimie. 2010;92(9):1108-14. /IF₂₀₀₉=3,9/

• Mladěnka P, Semecký V, Bobrovová Z, Nachtigal P, Vávrová J, Holečková M, Palicka V, Mazurová Y & Hrdina R. The effects of lactoferrin in a rat model of catecholamine cardiotoxicity, Biometals 2009;22:353-61 /IF₂₀₀₉=3,2/
• Mladěnka P, Zatloukalová L, Šimůnek T, Bobrovová Z, Semecký V, Nachtigal P, Hašková P, Macková E, Vávrová J, Holečková M, Palicka V & Hrdina R. Direct administration of rutin does not protect against catecholamine cardiotoxicity. Toxicology 2009;255:25-32 /IF₂₀₀₉=3,2/
• Mladěnka P, Kalinowski D, Hašková P, Bobrovová Z, Hrdina R, Šimůnek T, Nachtigal P, Semecký V, Vávrová J, Holečková M, Palicka V, Mazurová Y, Jansson P & Richardson DR. The Novel Iron Chelator, PCTH, Reduces Catecholamine-Mediated Myocardial Toxicity. Chem Res Toxicol 2009;22:208-17 /IF₂₀₀₉=3,7/
• Mladěnka P, Hrdina R, Bobrovová Z, Semecký V, Vávrová J, Holečková M, Palička V, Mazurová Y & Nachtigal P. Cardiac biomarkers in a model of acute catecholamine cardiotoxicity. Hum Exp Toxicol. 2009; 28(10): 631-40 /IF₂₀₀₉=1,3/

< 2008

• Hrdina R, Mladěnka P, Bobrovová Z & Hübl M. Farmakoterapie ischemické choroby srdeční. Praktické lékárenství, 2007; 3(2): 62-5
• Mladěnka P, Hrdina R, Hübl M & Šimůnek T. The role of reactive oxygen and nitrogen species in cellular iron metabolism. Free Radic Res. 2006;40:263-72 /IF₂₀₀₉=2,2/
• Firuzi O, Mladěnka P, Petrucci R, Marrosu G & Saso L. Hypochloride scavenging activity of flavonoids. J Pharm Pharmacol. 2004;56:801-7 /IF₂₀₁₀=1,9/
• Mladěnka P, Hrdina R, Hübl M & Šimůnek T. The fate of iron in the organism and its regulatory pathways. Acta Medica (Hradec Kralove) 2005; 48:127-35
• Firuzi O, Mladěnka P, Riccieri V, Spadaro A, Petrucci R, Marrosu G & Saso L. Parameters of oxidative stress status in healthy subjects: their correlations and stability after sample collection. J Clin Lab Anal. 2006;20:139-48. /IF₂₀₁₀=1,0/