WORKING EXPERIENCE:
- Charles University in Prague, Faculty of Pharmacy in Hradec Králové, Department of Pharmaceutical Technology, Hradec Králové, Czech Republic
Assistant Professor, January 2016-December 2024
- Charles University in Prague, Faculty of Pharmacy in Hradec Králové, Department of Inorganic and Organic Chemistry, Hradec Králové, Czech Republic
Postdoctoral Researcher, September 2013-December 2015
- University of Birmingham, School of Biosciences, Institute of Microbiology and Infection, Birmingham, United Kingdom
Visiting Postdoctoral Researcher, October 2014-March 2015
- University of Ioannina, School of Sciences, Department of Chemistry, Ioannina, Greece
Researcher, September 2012-August 2013
- University of Pennsylvania, Perelman School of Medicine, Department of Pathology and Laboratory Medicine, Philadelphia, PA, USA
Postdoctoral Researcher, November 2011-June 2012
STUDIES:
- University of Ioannina, School of Sciences, Department of Chemistry, Ioannina, Greece
PhD in Organic Chemistry, October 2011 (Distinction)
MSc in Chemistry, 2007 (Chemical and Biochemical Technologies- Distinction)
BSc in Chemistry, 2004 (Bachelor thesis: Synthesis of isoflavonoids)
PUBLICATIONS:
Paraskevopoulos, G. #; Opálka, L. #; Kováčik, A.; Paraskevopoulou, A.; Panoutsopoulou, E.; Sagrafena, I.; Pullmannová, P.; Čáp, R.; Vávrová, K. Lysosphingolipids in ceramide-deficient skin lipid models, Journal of Lipid Research 2025, 66, 1, 100722 (#: equal contribution)
Sagrafena, I.;∙Morin, M.; Paraskevopoulos, G.; Nilsson, EJ.; Hrdinová, I.; Kováčik, A.; Björklund, S.; Vávrová, K. Structure and function of skin barrier lipids: Effects of hydration and natural moisturizers in vitro, Biophysical Journal 2024, 123, 3951
Paraskevopoulos, G.#; Fandrei, F.#; Pratihast, A. K.; Paraskevopoulou, A.; Panoutsopoulou, E.; Opálka, L.; Mithu, V. S.; Huster, D.; Vávrová, K. Effects of imidazolium ionic liquids on skin barrier lipids – Perspectives for drug delivery, Journal of Colloid and Interface Science 2024, 659, 449 (#: equal contribution)
Sun, B.#; Paraskevopoulos, G.#; Min, J.#; Rossdeutcher, R.; Ghosh, S.; Quinn, B.; Lin, M.‐H.; Sarkar, D.; Sukumaran, D.; Wang, Y.; Vávrová, K.; Lovell, J. F.; Zhang,Y. Topical Drug Delivery of Concentrated Cabazitaxel in an α‐Tocopherol and DMSO Solution, Advanced Science 2023, 2302658 (#: equal contribution)
Panoutsopoulou, E.; Zbytovská, J.; Vávrová, K.; Paraskevopoulos, G.*, Phospholipid-Based Microemulsions for Cutaneous Imiquimod Delivery, Pharmaceuticals 2022, 15, 515 (*: corresponding author)
Sagrafena, I.; Paraskevopoulos, G.; Pullmannová, P.; Opálka, L.; Nováčková, A.; Lourantou, O.; Vávrová, K. Assembly of Human Stratum Corneum Lipids In Vitro: Fluidity Matters, Journal of Investigative Dermatology, 2022, 142(7), 2036
Nováčková, A.; Sagrafena, I.; Pullmannová, P.; Paraskevopoulos, G.; Dwivedi, A,; Mazumder, A.; Růžičková, K.; Slepička, P.; Zbytovská, Z.; Vávrová, K., Acidic pH Is Required for the Multilamellar Assembly of Skin Barrier Lipids In Vitro, Journal of Investigative Dermatology. 2021, 141(8) 1915
Šnejdrová, E.; Martiška, J.; Loskot, J.; Paraskevopoulos, G.; Kováčik, A.; Regdon Jr. G.; Budai-Szűcse, M.; Palát, K.; Konečná, K., PLGA based film forming systems for superficial fungal infections treatment, European Journal of Pharmaceutical Sciences, 2021, 163, 105855
Kopečná, M.; Macháček, M.; Nováčková, A.; Paraskevopoulos, G.; Roh, J.; Vávrová, K., Esters of terpene alcohols as highly potent, reversible, and low toxic skin penetration enhancers, Scientific Reports, 2019, 9, 14617
Monteiro, S.; Paraskevopoulos, G.; Imramovský, A., Synthesis of 13,14-Dehydro-prostaglandins Synthetic Analogues: A Review, ChemistrySelect, 2019, 4, 11247
Paraskevopoulos, G.; Monteiro, S.; Vosátká, R.; Krátký, M.; Navrátilová, L.; Trejtnar, F.; Stolařiková, J.; Vinšová, J., Novel salicylanilides from 4,5-dihalogenated salicylic acids: Synthesis, antimicrobial activity and cytotoxicity, Bioorganic & Medicinal Chemistry, 2017, 25, 1524
Paraskevopoulos, G.; Krátký, M.; Mandíková,J.; Trejtnar, F.; Stolařiková, J.; Pávek, P.; Besra, G. S.; Vinšová, J., Novel derivatives of nitro-substituted salicylic acids: Synthesis, antimicrobial activity and cytotoxicity, Bioorganic & Medicinal Chemistry, 2015, 23, 7292
Theodorou, V.; Paraskevopoulos, G.; Skobridis, K., A mild alkaline hydrolysis of N, N-substituted amides and nitriles, ARKIVOC, 2015,(vii) 101
Paraskevopoulos, G.; Alivertis, D.; Theodorou, V.; Skobridis, K., New Calix[4]arene-cored Peripherally Fuctionalized Dendrimers: Synthesis and Conformational Characteristics, Helvetica Chimica Acta, 2015, 98, 593
Krátký, M.; Bősze, S.; Baranyai, Z.; Szabó, I.; Stolařiková, J.; Paraskevopoulos, G.; Vinšová, J., Synthesis and in vitro biological evaluation of 2-(phenylcarbamoyl)phenyl 4-substituted benzoates, Bioorganic & Medicinal Chemistry, 2015, 23, 868.
Skobridis, K.; Theodorou, V.; Paraskevopoulos, G.; Seichter, W.; Weber, E., 3,3’’-Bis(9-hydroxyfluoren-9-yl)-1,1’:3’,1’’-terphenyl, Acta Crystallographica E, 2013, 69, 10, o1514
Ricklin, D.; Qu, H.K.; Huang, Y.J.; Bai, H.J.; Reis, E.S.; Chen, H.; DeAngelis, R.A.; Tzekou, A.; Paraskevopoulos, G.; Li, Y.X.; Maciejewsi, M.; Resuello, R.R.G.; Lupu, F.; Barlow, P.N.; Lambris, J.D., Bringing Compstatin to the next level: novel analogs with improved potency, pharmacokinetic profiles and administration options suitable for systemic application, (Conference Abstract) Immunobiology, 2012, 217, 11, 1141
Skobridis, K.; Theodorou, V.; Paraskevopoulos, G.; Seichter, W.; Weber, E., Crystalline host-guest complexes of constitutionally isomeric diol hosts. A structural case study, Crystal Growth & Design, 2011, 11 (12), 5275
Theodorou, V.; Gogou, M.; Philippidou, M.; Ragoussis, V.; Paraskevopoulos, G.; Skobridis, K., Synthesis of β,γ-unsaturated primary amides from α,β-unsaturated acids and investigation of the mechanism, Tetrahedron, 2011, 67, 5630
Alivertis, D.; Paraskevopoulos, G.; Theodorou, V.; Skobridis, K., Dendritic effects of crown ether-fuctionalized dendrimers on the solvent extraction of metal ions, Tetrahedron Letters, 2009, 50, 6019
Alivertis, D.; Theodorou, V.; Paraskevopoulos, G.; Skobridis, K., Searching for new host compounds: synthesis and characterization of novel crown ether-functionalized Dendrimers, Tetrahedron Letters, 2007, 48, 4091
PATENTS:
- CZ patent 305738, Vinšová, J.; Krátký, M.; Paraskevopoulos, G., Substituovaný derivát kyslíkatých kyselin fosforu, jeho použití a farmaceutický přípravek ho obsahující, PCT/CZ2015/000129
CONFERENCES AND SYMPOSIUMS:
Day of Pharmaceutical Technology, Brno, Czech Republic, 10 October 2024, (Invited talk)
Skin Forum, London, UK, 25-26 June 2024
Improving Drug Solubility: Recent Advances in Pharmaceutical Technology, Hradec Králové, Czech Republic, 6-7 February 2023 (Invited talk)
Skin Forum, Malmö, Sweden, 21-22 June 2022, Best Presentation and Best Poster Award
7. Česká lipidomická konference, Hrádec Králové, Czech Republic, 19-20 May 2022
Skin Forum, Reims, France, 23-24 September 2019
International Dendrimer Symposium 11 IDS:11 Funchal, Madeira, Portugal, 14-18 July 2019
Skin Forum, Tallinn, Estonia, 20-21 June 2017
7th Postgraduate & 5rd Postdoctoral Conference, Hradec Králové, Czech Republic, 7-8 February 2017
“Liblice 2016”, 51st Advances in Organic, Bioorganic and Pharmaceutical Chemistry, Lázně Bělohrad, Czech Republic, 11-13 November 2016
The 2015 TB Summit, London, United Kingdom, 24-26 March 2015
5th Postgraduate & 3rd Postdoctoral Conference, Hradec Králové, Czech Republic, 3-4 February 2015
1st International Congress: From Drug Discovery to Drug Delivery, Athens, Greece, 13-15 November 2014, Best Poster Award
4th Meeting of the Paul Ehrlich MedChem Euro-PhD Network, Hradec Králové, Czech Republic, 20-22 June 2014
Towards New Therapeutics for Diseases of the Developing World, Madrid, Spain, 11-13 May 2014
4th Postgraduate & 2nd Postdoctoral Conference, Hradec Králové, Czech Republic, 28-29 January 2014
ΧΧΙV International Complement Workshop, Chania-Crete, Greece, 10-15 October 2012
International Dendrimer Symposium 5 IDS:5 Toulouse, France, 28 August – 1 September 2007
20th Greek Conference of Chemistry, Ioannina, 20-25 September 2005
4th International Conference of the Chemical Societies of the South-East European Countries, ICOSECS 4, Belgrade, Serbia and Montenegro, 18-21 July 2004
TEACHING EXPERIENCE:
- Pharmaceutical Technology I and II (Lectures and Practical Exercises)
2016-today: Faculty of Pharmacy in Hradec Králové, Charles University in Prague, Hradec Králové, Czech Republic
- Physical Principles of Dosage Forms
2016-today: Faculty of Pharmacy in Hradec Králové, Charles University in Prague, Hradec Králové, Czech Republic
- Cosmetology for Pharmacists
2019-today: Faculty of Pharmacy in Hradec Králové, Charles University in Prague, Hradec Králové, Czech Republic
- Assistantship in the Laboratory of Organic Chemistry
2005-2011: Department of Chemistry, University of Ioannina, Ioannina, Greece
2013-2015: Faculty of Pharmacy in Hradec Králové, Charles University in Prague, Hradec Králové, Czech Republic
- Teaching Organic Chemistry to Chemistry and Pharmacy Students
2005-2011: Department of Chemistry, University of Ioannina, Ioannina, Greece
2013-2015: Faculty of Pharmacy in Hradec Králové, Charles University in Prague, Hradec Králové, Czech Republic