Assoc. Prof. PharmDr. Jaroslav Roh, Ph.D.

Date and Place of Birth: 1983 in Jihlava, Czech Republic

Present Positions

Contact Information

  • Work Address: Akademika Heyrovského 1203, 500 05 Hradec Králové, Czech Republic
  • E-mail: jaroslav.roh@faf.cuni.cz
  • Tel.: +420 495 067 339

ORCID ID: 0000-0003-4698-8379
ResearcherID: S-7863-2017
Scopus Author ID: 16647003200

Education, positions, international experiences

  • since 2018 - Associate Professor at the Department of Organic and Bioorganic Chemistry, Faculty of Pharmacy in Hradec Králové, Charles University
  • 2013 - three months research stay at the University of Bath (UK) in the group of Dr. Ian M. Eggleston
  • 2008 - 2017 assistant professor at the Department of Organic and Bioorganic Chemistry, Faculty of Pharmacy in Hradec Králové, Charles University
  • 2007 - three month traineeship at State Technological Institute in St.Petersburg, (Russian federation) - supervisor Prof. G. I. Koldobskii
  • 2006-2010 - Doctoral study of Bioorganic chemistry at the Department of Inorganic and Organic Chemistry, Faculty of Pharmacy in Hradec Králové, Charles University in Prague
  • 2001-2006 - Master’s study of pharmacy at Faculty of Pharmacy in Hradec Králové, Charles University in Prague

Research interests

  • Structure-activity relationships of potential antitubercular agents
  • Structure-activity relationships of dexrazoxane analogues
  • (chemistry of nitrogen heterocycles)
  • (synthesis of hydrazone and thiosemicabazone-based iron chelators)

Teaching and popularization of science:

  • 2019/2020 Guarantor of subjects
    M.Sc. study program Pharmacy: General and Inorganic Chemistry; Diploma Thesis Elaboration I; Exercises in General Chemistry; Constitution of Organic Compounds; Research Project I; Research Project II
    B.Sc. study program Medical Bioanalytics: General and Inorganic Chemistry, Exercises in General Chemistry; Research Project
  • since 2008:
    • supervisor of >20 M.Sc. students (diploma theses);
    • co-supervisor of one Ph.D. students (graduated), supervisor of four Ph.D. students (one graduated)
    • lecturer of General and Inorganic Chemistry study courses for B.Sc. and M.Sc. students (Pharmacy and Medical Bioanalytics), Chemical Laboratory Technique for M.Sc. students (Pharmacy), Charles University, Faculty of Pharmacy in Hradec Králové
  • 2014 - 2019 - organizer of “Postgraduate and Postdoc conference” at the Faculty of Pharmacy
  • Presentations “Science at the Faculty of Pharmacy” for Secondary schools

Scientific Grants

Ongoing

Finished projects

  • 2018-2020 - co-worker of Czech science foundation project 18-08169S - Study of individual topoisomerase II isoforms in anticancer and cardiotoxic effects of anthracyclines and their modulations by bisdioxopiperazines

  • 2014-2016 - co-worker of finished Czech science foundation project 14-08423S - Structure-activity-toxicity relationships studies in the group of small-molecule compounds with antimycobacterial activity - corresponding author of all resulting publications

  • 2014-2016 - Co-Principal and later Principal Investigator of finished Czech science foundation project 14-02165P

  • Co-worker of other 5 finished Czech science foundation projects:
    2013-2017 - 13-15008S - New potential cardioprotective agents: Study of structure-activity relationships in various types of myocardial injury
    2013-2017 - 13-23891S - Lipid membrane models – a new tool for studying pathophysiology of skin diseases at a molecular level
    GACR 203/07/1302; GACR 207/10/2048; GACR 207/11/0365

  • 2012-2017 - co-worker of Charles University Research Centre (UNCE 204019/304019/2012): Centre for the Study of Toxic and Protective Effects of Drugs on Cardiovascular System

  • 2012 - 2015 - co-worker in two EU-funded projects “Pre-seed activities of CU out of Prague“, reg. no. CZ.1.05/3.1.00/13.0284 and "Pre-seed activities of CU out of Prague II", reg. no. CZ.1.05/3.1.00/14.0299.

Awards

Professional Memberships

Czech Chemical Society

Publications

author and co-author of 46 papers in international peer-reviewed journals, Σ IF > 180, >840 citations (WoS; excluding self-citations); H-index: 18 (WoS).

Complete list

Patents and patent applications

PCT patent applications

  1. WO2021/144746 A1 (PCT/IB2021/050285). Roh J., Štěrba M., Šimůnek T., Štěrbová P., Karabanovich G., Jirkovská A., Jirkovský E., Bavlovič Piskáčková H., Kubeš J., Jansová H., Kollárová P. Use of ICRF-193 derivatives and pharmaceutical preparations containing thereof for the prevention of chronic cumulative cardiotoxicity caused by therapy with anthracycline anticancer drugs. 

  2. WO2016/091228 A1 (PCT/CZ2015/000126). Roh J., Němeček J., Hrabálek A., Klimesova V., Karabanovich G., Pavek P., Sychra P. Substituted phenyltetrazole, its use and pharmaceutical preparation containing the same.

  3. WO2014/161516 (PCT/CZ2013/000131). Hrabálek A., Roh J., Karabanovich G., Klimešová V., Němeček J., Pávek P.: Oxa- and thia-diazoles useful in the treatment of Tuberculosis.

Czech patents

  1. CZ 305622 B6. Hrabálek A., Roh J., Karabanovich G., Klimešová V., Němeček J., Pávek P.: Substituovaný tetrazol, jeho použití a farmaceutický přípravek ho obsahující.

  2. CZ 305680 B6. Hrabálek A., Roh J., Karabanovich G., Klimešová V., Němeček J., Pávek P.: Substituovaný diazol, jeho použití a farmaceutický přípravek ho obsahující.

  3. CZ 306408 B6. Karabanovich G., Roh J., Hrabálek A., Klimešová V., Pávek P.: Dinitrofenyl oxadiazol a triazol, jeho použití a farmaceutický přípravek ho obsahující.

  4. CZ 306245 B6. Roh J., Němeček J., Hrabálek A., Klimešová V., Karabanovich G., Pávek P., Sychra P.: Substituovaný fenyltetrazol, jeho použití a farmaceutický přípravek ho obsahující.

  5. CZ 306321 B6. Němeček J., Roh J., Hrabálek A., Klimešová V., Karabanovich G., Pávek P.: Substituovaný dinitrofenyltetrazol, jeho použití a farmaceutický přípravek ho obsahující.

  6. CZ 307936 B6. Substituovaný nitrobenzyltetrazol, jeho použití a farmaceutický přípravek ho obsahující. Čonka P., Hrabálek A., Karabanovich G., Němeček J., Klimešová V., Valášková L., Roh. J.

  7. CZ 308557​ B6. Substituovaný 1,2,4-oxadiazol, jeho použití a farmaceutický přípravek ho obsahující (Substituted 1,2,4-oxadiazole, its use and pharmaceutical preparation containing the same). Roh. J., Karabanovich G., Pavek P., Hrabálek A. - bought by Svenox Pharmaceuticals LLC

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