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PharmDr. Jaroslav Roh, Ph.D.

Personal Profiles

Last updated: 30-September-2017

Date and Place of Birth: 5. 5. 1983 in Jihlava, Czech Republic

Present Position

Contact Information

  • Work Address: Heyrovského 1203, 500 05 Hradec Králové, Czech Republic
  • E-mail: jaroslav.roh@faf.cuni.cz
  • Tel.: +420 495 067 339; Fax: +420 495 067 166

Education, positions, international experiences

  • 2013 - three months research stay at the University of Bath (UK) in the group of Dr. Ian M. Eggleston
  • since 2008 assistant professor at the Department of Inorganic and Organic Chemistry, Faculty of Pharmacy in Hradec Králové, Charles University in Prague
  • 2007 - three month traineeship at State Technological Institute in St.Petersburg, (Russian federation) - supervisor Prof. G. I. Koldobskii
  • 2006-2010 - Doctoral study of Bioorganic chemistry at the Department of Inorganic and Organic Chemistry, Faculty of Pharmacy in Hradec Králové, Charles University in Prague
  • 2001-2006 - Master’s study of pharmacy at Faculty of Pharmacy in Hradec Králové, Charles University in Prague

Research interests

  • chemistry of nitrogen heterocycles
  • synthesis of potential antitubercular agents
  • synthesis of dexrazoxane analogues
  • synthesis of hydrazone and thiosemicabazone-based iron chelators

Teaching and popularization of science:

  • since 2008: supervisor of >10 M.Sc. (Pharmacy) diploma theses, co-supervisor of three Ph.D. students
  • since 2008: lecturer of General and Inorganic Chemistry study courses for B.Sc. and M.Sc. students (Pharmacy and Medical Bioanalytics), Chemical Laboratory Technique for M.Sc. students (Pharmacy), Charles University in Prague, Faculty of Pharmacy in Hradec Králové
  • 2014 - 2016 - organizer of “Postgraduate and Postdoc conference” at the Faculty of Pharmacy
  • Presentations “Science on the Faculty of Pharmacy” for Secondary schools

Scientific Grants

  • Co-worker of finished Czech science foundation project 14-08423S - Structure-activity-toxicity relationships studies in the group of small-molecule compounds with antimycobacterial activity - corresponding author of all resulting publications

  • Co-Principal and later principal Investigator of finished Czech science foundation project 14-02165P

  • Co-worker of 2 ongoing Czech science foundation projects:
    13-15008S - New potential cardioprotective agents: Study of structure-activity relationships in various types of myocardial injury
    13-23891S - Lipid membrane models – a new tool for studying pathophysiology of skin diseases at a molecular level

  • Co-worker of other 3 finished Czech science foundation projects: 203/07/1302; 207/10/2048; 207/11/0365

  • Co-worker of Charles University Research Centre (UNCE 204019/304019/2012): Centre for the Study of Toxic and Protective Effects of Drugs on Cardiovascular System

  • Co-worker in two EU-funded projects “Pre-seed activities of CU out of Prague“, reg. no. CZ.1.05/3.1.00/13.0284 and "Pre-seed activities of CU out of Prague II", reg. no. CZ.1.05/3.1.00/14.0299.

Awards obtained

  • 2009 - Medal of the Faculty of Pharmacy
  • 2006 - Award of the Dean of the Faculty of Pharmacy in Hradec Králové, Charles University

Professional Memberships

Czech Chemical Society

Publications

author and co-author of 34 papers in international peer-reviewed journals, Σ IF > 120, >330 citations (WoS; excluding self-citations); H-index: 10 (WoS)

  1. L. V. Myznikov, J. Roh, T. V. Artamonova, A. Hrabálek, G. I. Koldobskii, Synthesis of 5-Substituted Tetrazoles under Microwave Activation. Russ. J. Org. Chem. 2007, 43 (5), 765-768. (IF2007 = 0.511)

  2. J. Roh,* T. V. Artamonova, K. Vávrová, G. I. Koldobskii, A. Hrabálek, Practical Synthesis of 5-Substituted Tetrazoles under Microwave Irradiation. Synthesis 2009, (13), 2175-2178. (IF2009 = 2.572)

  3. J. Roh,* K. Vávrová, A. Hrabálek. One-pot regioselective vinylation of tetrazoles: preparation of 5-substituted 2-vinyl-2H-tetrazoles. Tetrahedron Lett. 2010, 51 (10), 1411–1414. (IF2010 = 2.618)

  4. K. Vávrová, P. Kovaříková, B. Školová, M. Líbalová, J. Roh, R. Čáp, A. Holý, A. Hrabálek, Enhanced topical and transdermal delivery of antineoplastic and antiviral acyclic nucleoside phosphonate cPr‑PMEDAP. Pharm. Res. 2011; 28 (12), 3105-3115. (IF2011 = 4.093) (Q1)

  5. V. Novakova, J. Roh, P. Gela, J. Kuneš, P. Zimcik, Azaphthalocyanines with fused triazolo rings: formation of sterically stressed constitutional isomers. Chem. Commun. 2012, 48, 4326-4328. (IF2012 = 6.378) (Q1)

  6. J. Roh,* K. Vavrova, A. Hrabalek, Synthesis and Functionalization of 5-Substituted Tetrazoles, Eur. J. Org. Chem., 2012, 6101–6118. (IF2012 = 3.344) (Q1)

  7. B. Janůšová, B. Školová, K. Tükörová, L. Wojnarová, T. Šimůnek, P. Mladěnka, T. Filipský, M. Říha, J. Roh, K. Palát, A. Hrabálek, K. Vávrová, Amino acid derivatives as transdermal permeation enhancers. J. Control. Release 2013, 165 (2), 91-100. (IF2013 = 7.261) (Q1)

  8. L. Myznikov, U. Dmitrieva, T. Artamonova, J. Roh, A. Hrabálek, Y. Zevatskii, An Efficient Synthesis of 1-Substituted 5-Bromo-1H-tetrazoles. Synthesis 2013, 45, 2029-2033. (IF2013 =2.443)

  9. G. Karabanovich, J. Roh,* Z. Padělková, Z. Novák, K. Vávrová, A. Hrabálek, One-pot synthesis of 1-substituted-5-alkylselanyl-1H-tetrazoles from isoselenocyanates: Unexpected formation of N-alkyl-N-arylcyanamides and (Z)-Se-alkyl-N-cyano-N,N’-diarylisoselenoureas. Tetrahedron 2013, 69, 8798-8808. (IF2013 = 2.817)

  10. B. Školová, B. Janůšová, J. Zbytovská, G. Gooris, J. A. Bouwstra, P. Slepička, P. Berka, J. Roh, K. Palát, A. Hrabálek, K. Vávrová. Ceramides in the Skin Lipid Membranes: Length Matters. Langmuir 2013, 29, 15624-15633. (IF2013 = 4.384) (Q1)

  11. D. Diblikova, M. Kopecna, B. Skolova, M. Krecmerova, J. Roh, A. Hrabalek, K. Vavrova. Transdermal Delivery and Cutaneous Targeting of Antivirals using a Penetration Enhancer and Lysolipid Prodrugs. Pharm. Res. 2014, 31 (4), 1071-1081. (IF2014 = 3.420) (Q1)

  12. J. Stariat, V. Suprunova, J. Roh, V. Sestak, T. Eisner, T. Filipsky, P. Mladenka, M. Nobilis, T. Simunek, J. Klimes, D. S. Kalinowski, D. R. Richardson, P. Kovarikova. Simultaneous determination of the novel thiosemicarbazone anti-cancer agent, Bp4eT, and its main phase I metabolites in plasma: Application to a pilot pharmacokinetic study in rats. Biomed. Chromatogr. 2014, 28 (5), 621-629. (IF2014 = 1.723)

  13. B. Skolova, K. Jandovska, P. Pullmannova, O. Tesar, J. Roh, A. Hrabalek, K. Vavrova. The Role of the Trans Double Bond in Skin Barrier Sphingolipids: Permeability and Infrared Spectroscopic Study of Model Ceramide and Dihydroceramide Membranes. Langmuir 2014, 30 (19), 5527-5535. (IF2014 = 4.457) (Q1)

  14. A. Kovacik, J. Roh, K. Vavrova. The Chemistry and Biology of 6-Hydroxyceramide, the Youngest Member of the Human Sphingolipid Family. ChemBioChem 2014, 15 (11), 1555-1562. (IF2014 = 3.088)

  15. G. Karabanovich, J. Roh,* T. Smutný, J. Něměcek, P. Vicherek, J. Stolaříková, M. Vejsová, I. Dufková, K. Vávrová, P. Pávek, V. Klimešová, A. Hrabálek. 1-Substituted-5-[(3,5-dinitrobenzyl)sulfanyl]-1H-tetrazoles and their isosteric analogs: A new class of selective antitubercular agents active against drug-susceptible and multidrug-resistant mycobacteria. Eur. J. Med. Chem. 2014, 82, 324-340. (IF2014 = 3.447) (Q1)

  16. B. Skolova, K. Hudska, P. Pullmannova, A. Kovacik, K. Palat, J. Roh, J. Fleddermann, I. Estrela-Lopis, K. Vavrova. Different Phase Behavior and Packing of Ceramides with Long (C16) and Very Long (C24) Acyls in Model Membranes: Infrared Spectroscopy Using Deuterated Lipids. J. Phys. Chem. B 2014, 118 (35), 10460-10470. (IF2014 = 3.302)

  17. G. Karabanovich, J. Roh,* O. Soukup, I. Pávková, M. Pasdiorová, V. Tambor, J. Stolaříková, M. Vejsová, K. Vávrová, V. Klimešová, A. Hrabálek. Tetrazole Regioisomers in the Development of Nitro Group-Containing Antitubercular Agents. Med. Chem. Commun. 2015, 6, 174-181. (IF2015 = 2.319)

  18. L. Lochman, J. Svec, J. Roh, V. Novakova. The role of the size of aza-crown recognition moiety in azaphthalocyanine fluorescence sensors for alkali and alkaline earth metal cations. Dyes Pigment. 2015, 121, 178-187. (IF2015 = 4.055) (Q1)

  19. A. Jirkovska, J. Roh, O. Lenčová-Popelová, E. Jirkovsky, K. Hruskova, E. Potuckova, H. Jansova, P. Haskova, P. Martinkova, T. Eisner, M. Kratochvil, J. Sus, M. Machacek, L. Tichotova, V. Gersl, D. S. Kalinowski, M. Muller, D. Richardson, K. Vavrova, M. Sterba, T. Simunek. Synthesis and analysis of novel analogues of dexrazoxane and its open-ring hydrolysis product for protection against anthracycline cardiotoxicity in vitro and in vivo. Toxicol. Res. 2015, 4, 1098–1114. (IF2015 = 2.161)

  20. E. Potůčková, J. Roh, M. Macháček, S. Sahni, J. Stariat, V. Šesták, H. Jansová, P. Hašková, A. Jirkovská, K. Vávrová, P. Kovaříková, D. S. Kalinowski, D. R. Richardson, T. Šimůnek. In Vitro Characterization of the Pharmacological Properties of the Anti-Cancer Chelator, Bp4eT, and Its Phase I Metabolites. PLoS ONE 2015, 10 (10). e0139929. (IF2015 = 3.057) (Q1)

  21. L. Opálka, A. Kováčik, M. Sochorová, J. Roh, J. Kuneš, J. Lenčo, K. Vávrová. Scalable Synthesis of Human Ultralong Chain Ceramides. Org. Lett., 2015, 17 (21), 5456–5459. (IF2015 = 6.732) (Q1)

  22. V. Sestak, J. Stariat, J. Cermanova, E. Potuckova, J. Chladek, J. Roh, J. Bures, H. Jansova, P. Prusa, M. Sterba, S. Micuda, T. Simunek, D. S. Kalinowski, D. R. Richardson, P. Kovarikova. Novel and potent anti-tumor and anti-metastatic di-2-pyridylketone thiosemicarbazones demonstrate marked differences in pharmacology between the first and second generation lead agents. Oncotarget, 2016, 6 (40), 42411-42428. (IF2016 = 5.168) (Q1)

  23. L. Lochman, J. Svec, J. Roh, K. Kirakci, K. Lang, P. Zimcik, V. Novakova. Metal-Cation Recognition in Water by a Tetrapyrazinoporphyrazine-Based Tweezer Receptor. Chem. Eur. J., 2016, 22(7), 2417-2426. (IF2016 = 5.317) (Q1)

  24. G. Karabanovich, J. Zemanová, T. Smutný, R. Székely, M. Šarkan, I. Centárová, A. Vocat, I. Pávková, P. Čonka, J. Němeček, J. Stolaříková, M. Vejsová, K. Vávrová, V. Klimešová, A. Hrabálek, P. Pávek, S. T. Cole, K. Mikušová, J. Roh.* Development of 3,5-Dinitrobenzylsulfanyl-1,3,4-Oxadiazoles and Thiadiazoles as Selective Antitubercular Agents Active Against Replicating and Nonreplicating Mycobacterium tuberculosis. J. Med. Chem. 2016, 59, 2362−2380. (IF2016 = 6.259) (Q1)

  25. V. Sestak , J. Roh, L. Klepalova, P. Kovarikova. A UHPLC-UV-QTOF Study on the Stability of Carfilzomib, A Novel Proteasome Inhibitor. Journal of Pharmaceutical and Biomedical Analysis, 2016, 124, 365–373. (IF2016 = 3.255) (Q1)

  26. H. Jansová, J. Bureš, M. Macháček, P. Hašková, A. Jirkovská, J. Roh, Q. Wang, K. J. Franz, P. Kovaříková, T. Šimůnek. Characterization of cytoprotective and toxic properties of iron chelator SIH, prochelator BSIH and their degradation products. Toxicology, 2016, 350, 15–24. (IF2016 = 3.582) (Q1)

  27. A. Kováčik, L. Opálka, M. Šilarová, J. Roh, K. Vávrová. Synthesis of 6-hydroxyceramide using rutheniumcatalyzed hydrosilylation–protodesilylation. Unexpected formation of a long periodicity lamellar phase in skin lipid membranes. RSC Advances, 2016, 6, 73343–73350. (IF2016 = 3.108)

  28. J. Roh,* G. Karabanovich, V. Novakova, T. Šimůnek, K. Vávrová. Large-scale synthesis of piperazine-2,6-dione and its use in the synthesis of dexrazoxane analogues. Synthesis. 2016, 48, 4580-4588. (IF2016 = 2.650)

  29. G. Karabanovich, J. Němeček, L. Valášková, A. Carazo, K. Konečná, J. Stolaříková, A. Hrabálek, O. Pavliš, P. Pávek, K. Vávrová, J. Roh,* V. Klimešová. S-Substituted 3,5-Dinitrophenyl 1,3,4-Oxadiazole-2-thiols and Tetrazole-5-thiols as Highly Efficient Antitubercular Agents. Eur. J. Med. Chem. 2017, 126, 369-383. (IF2016 = 4.519) (Q1)

  30. J. Němeček, P. Sychra, M. Macháček, M. Benková, G. Karabanovich, K. Konečná, V. Kavková, J. Stolaříková, A. Hrabálek, K. Vávrová, O. Soukup, J. Roh,* V. Klimešová. Structure-activity relationship studies on 3,5-dinitrophenyl tetrazoles as antitubercular agents. Eur. J. Med. Chem. 2017, 130, 419–432. (IF2016 = 4.519) (Q1)

  31. E. Mezeiova, J. Korabecny, V. Sepsova, M. Hrabinova, P. Jost, L. Muckova, T. Kucera, R. Dolezal, J. Misik, K. Spilovska, N. L. Pham, L. Pokrievkova, J. Roh, D. Jun, O. Soukup, D. Kaping, K. Kuca. Development of 2-Methoxyhuprine as Novel Lead for Alzheimer’s Disease Therapy. Molecules 2017, 22, 1265.

  32. J. Roh *, G. Karabanovich, H. Vlčková, A. Carazo, J. Němeček, P. Sychra, L. Valášková, O. Pavliš, J. Stolaříková, V. Klimešová, K. Vávrová, P. Pávek, A. Hrabálek. Development of Water-Soluble 3,5-Dinitrophenyl Tetrazole and Oxadiazole Antitubercular Agents. Bioorg. Med. Chem. DOI: 10.1016/j.bmc.2017.08.010

  33. I. Melnikova, J. Roh, J. Kuneš, T. Artamonova, Y. Zevatskii, L. Myznikov. Non-catalyzed addition of heterocyclic thiols and 5-substituted-1H-tetrazoles to vinyl ethers. Tetrahedron Lett. 2017, 58, 3842–3845.

  34. J. Bureš, A. Jirkovská, V. Šesták, H. Jansová, G. Karabanovich, J. Roh, M. Štěrba, T. Šimůnek, P. Kovaříková. Investigation of novel dexrazoxane analogue JR-311 shows significant cardioprotective effects through topoisomerase IIbeta but not its iron chelating metabolite. Toxicology. DOI: 10.1016/j.tox.2017.09.012.

Patents and patent applications

  1. CZ 305622 B6. Hrabálek A., Roh J., Karabanovich G., Klimešová V., Němeček J., Pávek P.: Substituovaný tetrazol, jeho použití a farmaceutický přípravek ho obsahující.

  2. CZ 305680 B6. Hrabálek A., Roh J., Karabanovich G., Klimešová V., Němeček J., Pávek P.: Substituovaný diazol, jeho použití a farmaceutický přípravek ho obsahující.

  3. WO 2014/161516 (PCT/CZ2013/000131). Hrabálek A., Roh J., Karabanovich G., Klimešová V., Němeček J., Pávek P.: Oxa- and thia-diazoles useful in the treatment of Tuberculosis.

  4. CZ 306408 B6. Karabanovich G., Roh J., Hrabálek A., Klimešová V., Pávek P.: Dinitrofenyl oxadiazol a triazol, jeho použití a farmaceutický přípravek ho obsahující.

  5. CZ 306245 B6. Roh J., Němeček J., Hrabálek A., Klimešová V., Karabanovich G., Pávek P., Sychra P.: Substituovaný fenyltetrazol, jeho použití a farmaceutický přípravek ho obsahující.

  6. CZ 306321 B6. Němeček J., Roh J., Hrabálek A., Klimešová V., Karabanovich G., Pávek P.: Substituovaný dinitrofenyltetrazol, jeho použití a farmaceutický přípravek ho obsahující.

  7. WO2016/091228 A1 (PCT/CZ2015/000126) Roh J., Němeček J., Hrabálek A., Klimesova V., Karabanovich G., Pavek P., Sychra P. Substituted phenyltetrazole, its use and pharmaceutical preparation containing the same.

  8. PV 2015-444. Substituovaný nitrobenzyltetrazol, jeho použití a farmaceutický přípravek ho obsahující. Čonka P., Hrabálek A., Karabanovich G., Němeček J., Klimešová V., Valášková L., Roh. J.

 

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