Assoc. Prof. PharmDr. Jaroslav Roh, Ph.D.

Date and Place of Birth: 5. 5. 1983 in Jihlava, Czech Republic

Present Positions

Contact Information

  • Work Address: Akademika Heyrovského 1203, 500 05 Hradec Králové, Czech Republic
  • E-mail: jaroslav.roh@faf.cuni.cz
  • Tel.: +420 495 067 339; Fax: +420 495 067 166

ORCID ID: 0000-0003-4698-8379
ResearcherID: S-7863-2017
Scopus Author ID: 16647003200

Education, positions, international experiences

  • since 2018 - Associate Professor at the Department of Organic and Bioorganic Chemistry, Faculty of Pharmacy in Hradec Králové, Charles University
  • 2013 - three months research stay at the University of Bath (UK) in the group of Dr. Ian M. Eggleston
  • 2008 - 2017 assistant professor at the Department of Organic and Bioorganic Chemistry, Faculty of Pharmacy in Hradec Králové, Charles University
  • 2007 - three month traineeship at State Technological Institute in St.Petersburg, (Russian federation) - supervisor Prof. G. I. Koldobskii
  • 2006-2010 - Doctoral study of Bioorganic chemistry at the Department of Inorganic and Organic Chemistry, Faculty of Pharmacy in Hradec Králové, Charles University in Prague
  • 2001-2006 - Master’s study of pharmacy at Faculty of Pharmacy in Hradec Králové, Charles University in Prague

Research interests

  • synthesis of potential antitubercular agents
  • synthesis of dexrazoxane analogues
  • (chemistry of nitrogen heterocycles)
  • (synthesis of hydrazone and thiosemicabazone-based iron chelators)

Teaching and popularization of science:

  • since 2008: supervisor of >15 M.Sc. (Pharmacy) diploma theses, co-supervisor of three Ph.D. students
  • since 2008: lecturer of General and Inorganic Chemistry study courses for B.Sc. and M.Sc. students (Pharmacy and Medical Bioanalytics), Chemical Laboratory Technique for M.Sc. students (Pharmacy), Charles University, Faculty of Pharmacy in Hradec Králové
  • 2014 - 2018 - organizer of “Postgraduate and Postdoc conference” at the Faculty of Pharmacy
  • Presentations “Science on the Faculty of Pharmacy” for Secondary schools
  • 2014 - 2017 - organizing of “Postgraduate and Postdoc conference” on the Faculty of Pharmacy

Scientific Grants

  • since 2019 – senior researcher in EU-funded project Pre-application research into innovative medicines and medical technologies (InoMed), reg. no. CZ.02.1.01/0.0/0.0/18_069/0010046

  • since 2018 - co-worker of ongoing Czech science foundation project 18-08169S - Study of individual topoisomerase II isoforms in anticancer and cardiotoxic effects of anthracyclines and their modulations by bisdioxopiperazines

  • 2014-2016 - co-worker of finished Czech science foundation project 14-08423S - Structure-activity-toxicity relationships studies in the group of small-molecule compounds with antimycobacterial activity - corresponding author of all resulting publications

  • 2014-2016 - Co-Principal and later Principal Investigator of finished Czech science foundation project 14-02165P

  • Co-worker of other 5 finished Czech science foundation projects:
    2013-2017 - 13-15008S - New potential cardioprotective agents: Study of structure-activity relationships in various types of myocardial injury
    2013-2017 - 13-23891S - Lipid membrane models – a new tool for studying pathophysiology of skin diseases at a molecular level
    GACR 203/07/1302; GACR 207/10/2048; GACR 207/11/0365

  • 2012-2017 - co-worker of Charles University Research Centre (UNCE 204019/304019/2012): Centre for the Study of Toxic and Protective Effects of Drugs on Cardiovascular System

  • 2012 - 2015 - co-worker in two EU-funded projects “Pre-seed activities of CU out of Prague“, reg. no. CZ.1.05/3.1.00/13.0284 and "Pre-seed activities of CU out of Prague II", reg. no. CZ.1.05/3.1.00/14.0299.

Awards obtained

Professional Memberships

Czech Chemical Society

Publications

author and co-author of 39 papers in international peer-reviewed journals, Σ IF > 140, >580 citations (WoS; excluding self-citations); H-index: 14 (WoS).

Complete list

Patents and patent applications

  1. CZ 305622 B6. Hrabálek A., Roh J., Karabanovich G., Klimešová V., Němeček J., Pávek P.: Substituovaný tetrazol, jeho použití a farmaceutický přípravek ho obsahující.

  2. CZ 305680 B6. Hrabálek A., Roh J., Karabanovich G., Klimešová V., Němeček J., Pávek P.: Substituovaný diazol, jeho použití a farmaceutický přípravek ho obsahující.

  3. WO 2014/161516 (PCT/CZ2013/000131). Hrabálek A., Roh J., Karabanovich G., Klimešová V., Němeček J., Pávek P.: Oxa- and thia-diazoles useful in the treatment of Tuberculosis.

  4. CZ 306408 B6. Karabanovich G., Roh J., Hrabálek A., Klimešová V., Pávek P.: Dinitrofenyl oxadiazol a triazol, jeho použití a farmaceutický přípravek ho obsahující.

  5. CZ 306245 B6. Roh J., Němeček J., Hrabálek A., Klimešová V., Karabanovich G., Pávek P., Sychra P.: Substituovaný fenyltetrazol, jeho použití a farmaceutický přípravek ho obsahující.

  6. CZ 306321 B6. Němeček J., Roh J., Hrabálek A., Klimešová V., Karabanovich G., Pávek P.: Substituovaný dinitrofenyltetrazol, jeho použití a farmaceutický přípravek ho obsahující.

  7. WO2016/091228 A1 (PCT/CZ2015/000126) Roh J., Němeček J., Hrabálek A., Klimesova V., Karabanovich G., Pavek P., Sychra P. Substituted phenyltetrazole, its use and pharmaceutical preparation containing the same.

  8. PV 2015-444. Substituovaný nitrobenzyltetrazol, jeho použití a farmaceutický přípravek ho obsahující. Čonka P., Hrabálek A., Karabanovich G., Němeček J., Klimešová V., Valášková L., Roh. J.

  9. PV 2018-664. Substituovaný 1,2,4-oxadiazol, jeho použití a farmaceutický přípravek ho obsahující (Substituted 1,2,4-oxadiazole, its use and pharmaceutical preparation containing the same). Roh. J., Karabanovich G., Pavek P., Hrabálek A. - bought by Svenox Pharmaceuticals LLC

© Univerzita Karlova, Farmaceutická fakulta v Hradci Králové, Akademika Heyrovského 1203, 500 05 Hradec Králové, Česká republika
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