prof. RNDr. Lenka Skálová, Ph.D.

Current position


  • 1983-1988    Master study of Biochemistry at Faculty of Nature Sciences, Charles University 
  • 1994-1999    Postgraduate study of Pathobiochemistry and Xenobiochemistry, Faculty of Pharmacy, Charles University

Work experience

  • 1988-1989    Research stay at Institute of Organic Chemistry and Biochemistry, Prague
  • 1989-1994    Maternity leave
  • 1995-2004    assistant lecturer at the Department of Biochemical Sciences, Faculty of Pharmacy, Charles University
  • 1999    two-month internship in Faculty of Pharmacy, University of Ljubljana, Slovenia
  • 2000    one-month internship in Department of Hepatocytes detoxication and pathophysiology, INSERM U128, Montpelliere, France
  • 2004-2012    Assoc. Professor of Biochemistry, Department of Biochemical Sciences, Faculty of Pharmacy, Charles University
  • Since 2012    Professor of Biochemistry, Department of Biochemical Sciences, Faculty of Pharmacy, Charles University

Research interest

  • Metabolism of xenobiotics in various species and models
  • Xenobiotic-metabolizing enzymes and their regulation 
  • Role of xenobiotic-metabolizing enzymes in drug-resistance
  • Drugs in the environment


  • Basis of biochemistry
  • Xenobiochemistry
  • Practical classes in Xenobiochemistry
  • Enzymology

Grants Received

  • 1998-2000    GAUK 247/1998/C    
  • 2000-2002    GAČR 524/00/0514    
  • 2003-2005    GAČR 524/03/1361    
  • 2006-2008    GAČR 524/06/1345    
  • 2010-2014    GAČR P502/10/0217    
  • 2018-2020    GAČR 18-07724S

Summary of publication activity

> 175 papers in international peer-reviewed journals 
> 2150 times cited (without self-citation)
h-index 27

Selected publications over the last three years

  • Dimunová D., Matoušková P., Navrátilová M., ...Szotáková B., Skálová L. Environmental circulation of the anthelmintic drug albendazole affects expression and activity of resistance-related genes in the parasitic nematode Haemonchus contortus. (2022) Science of the Total Environment 822, 153527 
  • Zajíčková, M., Prchal, L., Vokřál, I., Nguyen, L.T., Kurz, T., Gasser, R., Bednářová, K., Mičundová, M., Lungerich, B., Michel, O., Skálová, L. (2022) Assessing the Anthelmintic Candidates BLK127 and HBK4 for Their Efficacy on Haemonchus contortus Adults and Eggs, and Their Hepatotoxicity and Biotransformation. Pharmaceutics 14(4),754
  • Zajíčková M., Prchal L., Navrátilová M., Matoušková P., ...Nguyen L.T., Skálová L. Sertraline as a new potential anthelmintic against Haemonchus contortus: toxicity, efficacy, and biotransformation. (2021) Veterinary Research 52(1), pp. 143
  • Hanousková B., Vávrová G., Ambrož M., ...Skálová L., Matoušková P. MicroRNAs mediated regulation of glutathione peroxidase 7 expression and its changes during adipogenesis. (2021) Biochimica et Biophysica Acta - Gene Regulatory Mechanisms 1864(10), 194734.  
  • Navrátilová M., Raisová Stuchlíková L., Matoušková P., ...Szotáková B., Skálová L. Proof of the environmental circulation of veterinary drug albendazole in real farm conditions. (2021) Environmental Pollution 286, 117590.  
  • Nguyen L.T., Zajíčková M., Mašátová E., Matoušková P., Skálová L. The ATP bioluminescence assay: a new application and optimization for viability testing in the parasitic nematode Haemonchus contortus. (2021) Veterinary Research 52(1), 124. 
  • Kellerová P., Navrátilová M., Nguyen L.T., ...Skálová L., Matoušková P. UDP-Glycosyltransferases and Albendazole Metabolism in the Juvenile Stages of Haemonchus contortus. (2020) Frontiers in Physiology 11, 594116. 
  • Kellerová P., Raisová Stuchlíková L., Matoušková P., ...Szotáková B., Skálová L. Sub-lethal doses of albendazole induce drug metabolizing enzymes and increase albendazole deactivation in Haemonchus contortus adults.  (2020) Veterinary Research 51(1), 94. 
  • Zárybnický, T., Matoušková, P., Skálová, L., Boušová, I. The Hepatotoxicity of Alantolactone and Germacrone: Their Influence on Cholesterol and Lipid Metabolism in Differentiated HepaRG Cells (2020) Nutrients, 12 (6)
  • Raisová Stuchlíková, L., Navrátilová, M., Langhansová, L., Moťková, K., Podlipná, R., Szotáková, B.,  Skálová, L. The identification of metabolites and effects of albendazole in alfalfa (Medicago sativa). (2020) International Journal of Molecular Sciences, 21(16), 1-12.
  • Zajíčková M., Nguyen L.T., Skálová L., Raisová Stuchlíková L., Matoušková P. Anthelmintics in the future: current trends in the discovery and development of new drugs against gastrointestinal nematodes. (2020) Drug Discovery Today 25(2), pp. 430–437.  

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