Prof. Ing. Barbora Szotáková, Ph.D.

Doc. Ing. Barbora Szotáková, Ph.D.

Present position:

Contact information:

 

Previous Education and Training

  • Since 2016: Professor at the Department of Biochemical Sciences, Faculty of Pharmacy in Hradec Králové, Charles University 
  • 2007-2016: Associate Professor at the Department of Biochemical Sciences, Faculty of Pharmacy in Hradec Králové, Charles University
  • 2006: Habilitation in Biochemistry
  • 2001: Ph.D. degree in Patobiochemistry and Xenobiochemistry
  • 2000 - 2003: Short internships in Institute of Pharmacology and Toxicology, Philipps-University of Marburg,  Germany
  • 1988 - 2006: Assistant professor at the Department of Biochemical Sciences, Faculty of Pharmacy in Hradec Králové, Charles University in Prague
  • 1982 - 1988: Institute of Chemical Technology, Prague, Faculty of Food and Biochemical Technology

Research Interest

  • Study of drug metabolizing enzymes (cytochromes P450 - CYP1A, 2B, 2C, 2D6, 2E1, 3A; flavine monooxygenases; carbonyl reducing enzymes; glutathione S-transferases; UDP-glucuronosyl transferases…)
  • Study of enzymes of oxidative stress (peroxidase, glutathione peroxidase, catalase, superoxide dismutase, thioredoxin reductase…)
  • In
    • human
    • farm animals and free living animals
    • laboratory animals
    • tumor cell lines
    • parasiting helminths
    • plants
  • Activities and properties of these enzymes
  • Their modulation (induction, inhibition) by drugs, dietary supplements and environmental contaminants
  • Identification of metabolites of xenobiotics
  • Pharmacokinetics of drugs in target animal species

Teaching

Professional Memberships

  • International Society for the Study of Xenobiotics (ISSX)
  • Czech Society for Biochemistry and Molecular Biology (CSBMB)
  • Czech Science Foundation (GAČR), P503 – Food technology, ecotoxicology and environmental chemistry
  • Head of the Ethical Committee of the Charles University, Faculty of Pharmacy in Hradec Králové for ensuring of the laboratory animals welfare

Grants Received

  • 2018-2020: GAČR 18-08452S, Anthelmintics in plants – interactions with polyphenols biosynthesis and antioxidant defence
  • 2015-2017: GAČR P503/15-05325S, Anthelmintics in plants – uptake, biotransformation and transcriptional response
  • 2007-2009: GAČR 524/07/0611, Dicrocoeliosis in farm animals - defence mechanisms of lancet fluke against anthelmintics

   Member of further grants GAČR, GAUK, FRVŠ, MŠMT

Publications

Author and co-author of >100 papers in international peer-reviewed journals; >900 citations (WoS); H-index: 16 (WoS)

Most of the papers with full-text links can be found with the PubMed Search “Szotakova B”

 

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