PharmDr. Nela Váňová, Ph.D.

Research focus:

• Separation techniques (HPLC/LC-MS/MS)
• Development of analytical and bioanalytical methods for the determination of toxic and pharmaceutically active compounds
• Oxidative stress biomarkers

Education:

• 2013 – 2019
  Ph.D. in Toxicology - Faculty of Military Health Sciences in Hradec Kralove, University of Defence (Thesis: Determination of oxidative stress biomarkers by HPLC; supervisor: Assoc. Prof. PharmDr. Daniel Jun, Ph.D.)
• 2008 – 2013
  Mgr. (equiv. MS.c.) in Pharmacy - Faculty of Pharmacy in Hradec Kralove, Charles University (Diploma Thesis: Analysis of oxidative and free radical induced DNA damage; supervisor: Assoc. Prof. PharmDr. Radim Kucera, Ph.D.)

Professional carrier:

• Since 2018
  Assistant professor at Department of Pharmaceutical Chemistry and Pharmaceutical Analysis, Faculty of Pharmacy in Hradec Kralove, Charles University
• 2017 – 2018
  Assistant at Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences in Hradec Kralove, University of Defence
• Since 2013
  Researcher at Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences in Hradec Kralove, University of Defence

Educational activities:

• Since 2018 Tutor of practical training from Pharmaceutical Analysis
• Since 2018 Consultant of Diploma Theses at Faculty of Pharmacy in Hradec Kralove
• Since 2017 Supervisor of Student research projects at Faculty of Military Health Sciences in Hradec Kralove, University of Defence  

Grant projects:

• Since 2018     
  SV/FVZ201807 – Determination of toxicological parameters and markers of exposure to potential chemical warfare agents (co-investigator)
• 2015 – 2017   
  SV/FVZ201505 – Determination of selected chemical warfare agents and toxins in complex biological matrices using chromatography methods (co-investigator)
• 2014-2016     
  SV/FVZ2018 – Development of LC-MS methods for determination of oxidative stress biomarkers for evaluation of toxicity of new potential drugs (principal investigator)

International projects:

• Since 2015     
  Organization for the prohibition of chemical weapons (OPCW, Haag, Netherlands) – Official OPCW Biomedical Proficiency Tests on the determination of markers of exposure to chemical warfare agents

Research fellowship:

• 2012 – 2013   
  National Research Council, Institute of Organic Synthesis and Photoreactivity  (Bologna, Italy) - Analysis of oxidative and free radical induced DNA damage – Dr. Carla Ferreri (5 months)

Publications:

Journals with impact factor (∑IF = 13.026; ØIF = 2.605)

VANOVA, Nela, Jaroslav PEJCHAL, David HERMAN, Alzbeta DLABKOVA and Daniel JUN. Oxidative stress in organophosphate poisoning: role of standard antidotal therapy. Journal of Applied Toxicology. 2018, 38(8), 1058-1070. (IF₂₀₁₈=2.909)

MUCKOVA, Lubica, Jaroslav PEJCHAL, Petr JOST, Nela VANOVA, David HERMAN and Daniel JUN. Cytotoxicity of acetylcholinesterase reactivators evaluated in vitro and its relation to their structure. Drug and Chemical Toxicology. 2018, 1-5.  (IF₂₀₁₇=1.531)

VANOVA, Nela, Lubica MUCKOVA, Monika SCHMIDT, David HERMAN, Alzbeta DLABKOVA, Jaroslav PEJCHAL and Daniel JUN. Simultaneous determination of malondialdehyde and 3-nitrotyrosine in cultured human hepatoma cells by liquid chromatography-mass spectrometry. Biomedical Chromatography. 2018, 32(12), e4349. (IF₂₀₁₈=1.688)

MUCKOVA, Lubica, Nela VANOVA, Jakub MISIK, David HERMAN, Jaroslav PEJCHAL and Daniel JUN. Oxidative stress induced by oxime reactivators of acetylcholinesterase in vitro. Toxicology in Vitro [online]. 2019, 56, 110-117. (IF₂₀₁₈=3.067)

VALIS, Martin, David HERMAN, Nela VANOVA, et al. The Concentration of Memantine in the Cerebrospinal Fluid of Alzheimer’s Disease Patients and Its Consequence to Oxidative Stress Biomarkers. Frontiers in Pharmacology [online]. 2019, 10. (IF₂₀₁₈=3.831)