Prof. PharmDr. Kateřina Vávrová, Ph.D.

Head of Skin Barrier Research Group

Born: December 10, 1975
Address: Department of Organic and Bioorganic Chemistry, Charles University, Faculty of Pharmacy Hradec Kralove, Akademika Heyrovskeho 1203, CZ-50005 Hradec Kralove, Czech Republic

Tel: +420-495-067 497, Fax: +420-495-067 166

Room No. 2126

Research interests

Education, professional experience

  • since 2017: professor in Medicinal chemistry (Charles University, Faculty of Pharmacy)
  • since 2009: associate professor in Medicinal chemistry (Charles University, Faculty of Pharmacy)
  • 2005 - 2011: researcher at the Centre “New antivirals and antineoplastics“ and “Research of new drugs“
  • 2004 - 2005: visiting researcher at the University of Franche-Comte, Faculty of Medicine and Pharmacy, Laboratory of Cutaneous Biology, Besancon, France
  • 2003 - 2009: researcher at the Department of Inorganic and Organic Chemistry, Charles University, Faculty of Pharmacy
  • 1999 - 2003: PhD in Bioorganic chemistry, Charles University
  • 1994 - 1999: MSc in Pharmacy, Charles University

Teaching activities

  • teaching of Organic chemistry I, Organic chemistry II and Solved problems in organic chemistry for Pharmacy and Organic chemistry and Solved problems in organic chemistry for Healthcare bioanalytics at the Faculty of Pharmacy, Charles University
  • supervisor of PhD (10; 5 defended), PharmD (5; 4 defended) and MSc students (31; 26 defended)
  • e-learning course “Solved problems in organic chemistry” (in Czech)
  • presentations at Schola ludus and Summer School (2013), Day of Science (2012), Czech TV series “About Science and Scientists” (2014)

Scientific grants

Principal researcher:

  • since 2016: Czech Science Foundation-German Science Foundation joint project 16-25687J (with Freie Universitaet Berlin): Interdependencies between Inflammatory Processes and Barrier Lipids in Diseased Skin
  • 2016: Graпt of the Representative of the Czech Republic in the Committee of Рlепiроtепtiаries of JINR "Role of the structural variability of ceramides in the arrangement of the stratum corneum model membranes" (with Frank Laboratory of Neutron Physics, Joint Institute of Nuclear Research, Dubna, Russia - Dr. Norbert Kučerka)
  • 2013-2017: Czech Science Foundation: Lipid membrane models – a new tool for studying pathophysiology of skin diseases at a molecular level (13-23891S)
  • 2011 - 2013: Czech Science Foundation: Synthesis and structure-activity relationships of skin ceramides and compounds targeting them (207/11/0365)
  • 2004 - 2006: Czech Science Foundation post-doc project: Ceramide analogues as transdermal permeation enhancers (203/04/P042)
  • 2004 - 2006: Charles University: Modification of skin barrier properties by biodegradable amino acid derivatives (407/2004/B-CH/FaF)
  • 2001 - 2003: Charles University: Transdermal permeation enhancers: effects of their similarity to ceramides on their enhancing activity
  • 2002: Ministry of education, „Modification of skin barrier properties by synthetic ceramide analogs”

Mentor: operational programme ECOP (CZ.1.07/2.3.00/30.0061) (Increasing of the R&D capacity at Charles University through new positions for graduates of doctoral studies); Ph.D. student projects of the Charles University (8)

Co-worker: project EFSA-CDN CZ.02.1.01/0.0/0.0/16_019/0000841; Centre for new antivirals and antineoplastics 1M6138896301 (2005-2011), Research of new drugs MSM 0021620822 (2005-2011), University centre for research of toxic and protective effects of drugs on cardiovascular system UNCE 204019/304019/2012 (since 2012), projects of the Czech Science Foundation (3), Charles University, Ministry of industry and trade and Ministry of education


  • Editorial Board Member for Scientific Reports, a Nature Research journal.
  • Scientific council of the Faculty of Pharmacy, Charles University (since 2014)
  • Scientific council of the Faculty of Military Health, University of Defense (2015-16)
  • PhD board in Bioorganic Chemistry, PhD board in Pharmaceutical Technology, PharmD, MSc and Bc boards at the Faculty of Pharmacy, Charles University in Prague
  • Agency for Healthcare Research of the Czech republic (Agentura pro Zdravotnický Výzkum ČR) - panel 08 (biomedical technologies - 2015-2017)
  • Scientific jury of the Sanofi Pharmacy Prize (2012-2014)
  • American Chemical Society, European Epidermal Barrier Research Network, Czech Chemical Society

Invited lectures

Perspectives in Percutanous Penetration, La Grande Motte, France (2018), 4th EJTEMM conference Bratislava (2016), Freie Universitat Berlin (2015), 11th European Epidermal Barrier Research Network (E2BRN) meeting, Edinburgh, UK (2013), 10th European Epidermal Barrier Research Network (E2BRN) meeting, Venice, Italy (2012), Joint Meeting in Medicinal Chemistry, Catania, Italy (2011), Skin Research Group, Leiden University, The Netherlands (2011), Congres of practical pharmacy, Olomouc, Czech Republic (2010)


  • 2009: Medal of the Faculty of Pharmacy, Charles University
  • 2003: winner of the Prix de Pharmacie organized by the French Institute in Prague and Jean-Marie Lehn, a Nobel Prize laureate in Chemistry; and Award of the Minister of education, youth and sports
  • 2002: Josef Hlávka Award
  • 1999: Award of the Dean of the Faculty of Pharmacy, Charles University


100 publications (ΣIF > 300), 2 Czech patents, 3 book chapters, over 1200 citations, H-index 23 (WoS);

ORCID, ResearchGate, Google Scholar


Sochorová M, Audrlická P, Červená M, Kováčik A, Kopečná M, Opálka L, Pullmannová P, Vávrová K. Permeability and microstructure of cholesterol-depleted skin lipid membranes and human stratum corneumJ. Colloid Interface Sci. 2019, 535:227-238, DOI: 10.1016/j.jcis.2018.09.104

Kopečná M, Kováčik A, Kučera O, Macháček M, Sochorová M, Audrlická P, Vávrová K. Fluorescent Penetration Enhancers Reveal Complex Interactions among the Enhancer, Drug, Solvent, and Skin. Mol Pharm. 2019;16(2):886-897.

Hausmann C, Zoschke C, Wolff C, Darvin ME, Sochorová M, Kováčik A, Wanjiku B, Schumacher F, Tigges J, Kleuser B, Lademann J, Fritsche E, Vávrová K, Ma N, Schäfer-Korting M. Fibroblast origin shapes tissue homeostasis, epidermal differentiation, and drug uptake. Sci Rep. 2019; 9(1):2913.


Mauldin EA, Crumrine D, Casal LM, Jeong S, Opálka L, Vavrova K, Uchida Y, Park K, Craiglow B, Choate KA, Shin‖ K, Lee‖ Y, Grove GL, Wakefield JS, Khnykin D, Elias PM. Cellular and Metabolic Basis for the Ichthyotic Phenotype in NIPAL4 (Ichthyin) Deficient Canines. Am. J. Pathol. 2018;188(6):1419-1429. DOI: 10.1016/j.ajpath.2018.02.008

Balansin Rigon R, Kaessmeyer S, Wolff C, Hausmann C, Zhang N, Sochorová M, Kováčik A, Haag R, Vávrová K, Ulrich M, Schäfer-Korting M, Zoschke, C. Ultrastructural and molecular analysis of ribose-induced glycated reconstructed human skin. Int J Mol Sci. 2018;19, 3521.

Kováčik A, Vogel A, Adler J, Pullmannová P, Vávrová K, Huster D. Probing the role of ceramide hydroxylation in skin barrier lipid models by 2H solid-state NMR spectroscopy and X-ray powder diffraction. Biochim Biophys Acta. 2018;1860(5):1162-1170

Kováčik A, Pullmannová P, Maixner J, Vávrová K. Effects of Ceramide and Dihydroceramide Stereochemistry at C-3 on the Phase Behavior and Permeability of Skin Lipid Membranes. Langmuir. 2018, 34 (1), 521–529

Hájek R, Lísa M, Khalikova M, Jirásko R, Cífková E, Študent V Jr, Vrána D, Opálka L, Vávrová K, Matzenauer M, Melichar B, Holčapek M. HILIC/ESI-MS determination of gangliosides and other polar lipid classes in renal cell carcinoma and surrounding normal tissues. Anal Bioanal Chem. 2018;410(25):6585-6594.

Hrušková K, Potůčková E, Opálka L, Hergeselová T, Hašková P, Kovaříková P, Šimůnek T, Vávrová K. Structure-Activity Relationships of Nitro-Substituted Aroylhydrazone Iron Chelators with Antioxidant and Antiproliferative Activities. Chem Res Toxicol. 2018;31(6):435-446. doi: 10.1021/acs.chemrestox.7b00324.


Čuříková BA, Procházková K, Filková B, Diblíková P, Svoboda J, Kováčik A, Vávrová K, Zbytovská J. Simplified stratum corneum model membranes for studying the effects of permeation enhancers. Int. J. Pharm. 2017, 534(1-2):287-296.

Svoboda M, Hlobilová M, Marešová M, Sochorová M, Kováčik A, Vávrová K, Dolečková I. Comparison of suction blistering and tape stripping for analysis of epidermal genes, proteins and lipids. Arch. Dermatol. Res. 2017, 309(9):757-765.

Sochorová M, Staňková K, Pullmannová P, Kováčik A, Zbytovská J, Vávrová K. Permeability Barrier and Microstructure of Skin Lipid Membrane Models of Impaired Glucosylceramide Processing. Sci. Rep. 2017, 7:6470.

Kopečná M, Macháček M, Prchalová E, Štěpánek P, Drašar P, Kotora M, Vávrová K. Galactosyl Pentadecene Reversibly Enhances Transdermal and Topical Drug Delivery. Pharm. Res. 2017; 34(10), 2097-2108.

Pullmannová P, Pavlíková L, Kováčik A, Sochorová M, Školová B, Slepička P, Maixner J, Zbytovská J, Vávrová K. Permeability and microstructure of model stratum corneum lipid membranes containing ceramides with long (C16) and very long (C24) acyl chains. Biophys. Chem. 2017, 224:20-31

Wallmeyer L, Dietert K, Sochorová M, Gruber AD, Kleuser B, Vávrová K, Hedtrich S. TSLP is a direct trigger for T cell migration in filaggrin-deficient skin equivalents. Sci. Rep. 2017, 7:774.

Kováčik A, Šilarová M, Pullmannová P, Maixner J, Vávrová K. Effects of 6-hydroxyceramides on the thermotropic phase behavior and permeability of model skin lipid membranes. Langmuir 2017, 33(11):2890-2899

Schroeter A, Stahlberg S, Školová B, Sonnenberger S, Eichner A, Huster D, Vavrova K, Hauß T, Dobner B, Neubert R, Vogel A, Phase separation in Ceramide [NP] containing lipid model membranes: Neutron diffraction and solid-state NMR. Soft Matter, 2017, 13, 2107-2119.

Kopečná M, Macháček M, Prchalová E, Štěpánek P, Drašar P, Kotora M, Vávrová K. Dodecyl amino glucoside enhances transdermal and topical drug delivery via reversible interaction with skin barrier lipids. Pharm. Res. 2017; 34:640-653. Springer sharing link

Školová B, Kováčik A, Tesař O, Opálka L, Vávrová K. Phytosphingosine, sphingosine and dihydrosphingosine ceramides in model skin lipid membranes: permeability and biophysics. Biochim. Biophys. Acta - Biomembranes. 2017; 1859(5):824-834.

Vávrová K, Kováčik A, Opálka L. Ceramides in the skin barrier. Eur. Pharm. J. 2017, 64(2): 28–35.

Bezrouk A, Fiala Z, Kotingová L, Selke Krulichová I, Kopečná M, Vávrová K. SAMPA: A free software tool for skin and membrane permeation data analysis. Toxicol. in Vitro 2017, 44:361-371.

Roh J, Karabanovich G, Vlčková H, Carazo A, Němeček J, Sychra P, Valášková L, Pavliš O, Stolaříková J, Klimešová V, Vávrová K, Pávek P, Hrabálek A. Development of Water-Soluble 3,5-Dinitrophenyl Tetrazole and Oxadiazole Antitubercular Agents. Bioorg. Med. Chem. 2017,25(20):5468-5476.

Němeček J, Sychra P, Macháček M, Benková M, Karabanovich G, Konečná K, Kavková V, Stolaříková J, Hrabálek A, Vávrová K, Soukup O, Roh J, Klimešová V. Structure-activity relationship studies on 3,5-dinitrophenyl tetrazoles as antitubercular agents. Eur. J. Med. Chem. 2017; 130: 419-432.

Karabanovich G, Němeček J, Valášková L, Carazo A, Konečná K, Stolaříková J, Hrabálek A, Pavliš O, Pávek P, Vávrová K, Roh J, Klimešová V.  S-substituted 3,5-dinitrophenyl 1,3,4-oxadiazole-2-thiols and tetrazole-5-thiols as highly efficient antitubercular agents. Eur. J. Med. Chem. 2017; 126: 369-383


Opálka L, Kováčik A, Maixner J, Vávrová K. Omega-O-acylceramides in Skin Lipid Membranes: Effects of Concentration, Sphingoid Base and Model Complexity on Microstructure and Permeability. Langmuir 2016; 32(48):12894–12904. DOI: 10.1021/acs.langmuir.6b03082 - Open Access

Zoschke C, Ulrich M, Sochorová M, Wolff C, Vávrová K, Ma N, Ulrich C, Brandner J, Schäfer-Korting M. The barrier function of organotypic non-melanoma skin cancer models. J. Control. Release. 2016; 233:10-18.

Kováčik A, Opálka L, Šilarová M, Roh J, Vávrová K. Synthesis of 6-Hydroxyceramide Using Ruthenium-Catalyzed Hydrosilylation-Protodesilylation. Unexpected Formation of a Long Periodicity Lamellar Phase in Skin Lipid Membranes. RSC Adv. 2016, 6(77), 73343-73350.

Školová B; Janůšová B; Vávrová K. Ceramides with a pentadecasphingosine chain and short acyls have strong permeabilization effects on skin and model lipid membranes. Biochim Biophys Acta. Biomembranes 2016; 1858(2):220–232.

Vávrová K. Emerging small-molecule compounds for treatment of atopic dermatitis: a review. Exp. Opin. Ther. Patents 2016; 26(1):21-34. 50 free reprints

Hrušková K, Potůčková E, Hergeselová T, Liptáková L, Hašková P, Mingas P, Kovaříková P, Šimůnek T, Vávrová K. Aroylhydrazone Iron Chelators: Tuning Antioxidant and Antiproliferative Properties by Hydrazide Modifications. Eur. J. Med. Chem. 2016; in press. doi: 10.1016/j.ejmech.2016.05.015

Karabanovich G, Zemanová J, Smutný T, Székely R, Šarkan M, Centárová I, Vocat A, Pávková I, Čonka P, Němeček J, Stolaříková J, Vejsová M, Vavrova K, Klimešová K, Hrabalek A, Pavek P, Cole ST, Mikušová K, Roh J. Development of 3,5-Dinitrobenzylsulfanyl-1,3,4-Oxadiazoles and Thiadiazoles as Selective Antitubercular Agents Active Against Replicating and Nonreplicating Mycobacterium tuberculosis. J. Med. Chem. 2016, 59 (6), pp 2362–2380.

Roh J, Karabanovich G, Novakova V, Šimůnek T, Vávrová K. Large-Scale Synthesis of Piperazine-2,6-dione and Its Use in the Synthesis of Dexrazoxane Analogues. Synthesis 2016; DOI: 10.1055/s-0035-1562618

Vávrová K, Hrabálek A. Amino Acid-Based Transdermal Penetration Enhancers. In: Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement. Modification of the Stratum Corneum, 2016, Editors. Nina Dragicevic, Howard I. Maibach, Edition: 1, Springer-Verlag Berlin Heidelberg, pp.325-336. DOI: 10.1007/978-3-662-47039-8, ISBN 978-3-662-47038-1

Hrabálek A, Vávrová K. Transkarbams: Transdermal Penetration-Enhancing Carbamates. In: Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement. Modification of the Stratum Corneum, 2016, Editors. Nina Dragicevic, Howard I. Maibach, Edition: 1, Springer-Verlag Berlin Heidelberg, pp.309-323. DOI: 10.1007/978-3-662-47039-8, ISBN 978-3-662-47038-1


Opálka L, Kováčik A, Sochorová M, Roh J, Kuneš J, Lenčo J, Vávrová K. Scalable Synthesis of Human Ultralong Chain Ceramides. Org. Lett. 2015; 17(21):5456-5459. DOI: 10.1021/acs.orglett.5b02816 - Open Access

Wallmeyer L; Lehnen D; Eger N; Sochorová M; Opálka L; Kováčik A; Vávrová K, Hedtrich S. Stimulation of PPARalpha Normalizes the Skin Lipid Ratio and Improves the Skin Barrier of Normal and Filaggrin Deficient Reconstructed Skin. J. Dermatol. Sci. 2015; 80(2):102–110. doi:10.1016/j.jdermsci.2015.09.012.

Paloncýová M, Vávrová K, Sovová Ž, DeVane R, Otyepka M, Berka K. Structural Changes in Ceramide Bilayers Rationalize Increased Permeation through Stratum Corneum Models with Shorter Acyl Tails. J Phys Chem B. 2015;119(30):9811-9

Stahlberg S, Školová B, Madhu PK, Vogel A, Vávrová K, Huster D. Probing the Role of the Ceramide Acyl Chain Length and Sphingosine Unsaturation in Model Skin Barrier Lipid Mixtures by 2H Solid-State NMR Spectroscopy. Langmuir 2015;31(17):4906-15

Witting M, Boreham A, Brodwolf R, Vávrová K, Alexiev U, Friess W, Hedtrich S. Interactions of Hyaluronic Acid with the Skin and Implications for the Dermal Delivery of Biomacromolecules. Mol Pharm. 2015;12(5):1391-401

Karabanovich G, Roh J, Soukup O, Pasdiorová M, Tambor V, Stolaříková J, Vejsová M, Vávrová K, Klimešová V, Hrabálek A. Tetrazole Regioisomers in the Development of Nitro Group-Containing Antitubercular Agents. MedChemComm. 2015;6:174-181

Potůčková E; Roh J; Macháček M; Sahni S; Stariat J; Šesták V; Jansová H; Hašková P; Jirkovská A; Vávrová K; Kovaříková P; Kalinowski DS; Richardson DR; Simunek T. In Vitro Characterization of the Pharmacological Properties of the Anti-Cancer Chelator, Bp4eT, and its Phase I Metabolites. PLOS One. 2015; 10(10):e0139929. DOI: 10.1371/journal.pone.0139929.

Jirkovská-Vávrová A., Roh J., Lenčová-Popelová O., Jirkovský E., Hrušková K., Potůčková-Macková E., Jansová H., Hašková P., Martinková P., Eisner T., Kratochvíl M., Šůs J., Macháček M., Vostatková-Tichotová L., Geršl V., Kalinowski D.S., Muller M., Richardson D.R., Vávrová K., Štěrba M., Šimůnek T. Synthesis and analysis of novel analogues of dexrazoxane and its open-ring hydrolysis product for protection against anthracycline cardiotoxicity in vitro and in vivo. Toxicology Res. 2015;4:1098-1114


Vávrová K, Henkes D, Strüver K, Sochorová M, Školová B, Witting M, Friess W, Schreml S, Meier RJ, Schäfer-Korting M, Fluhr JW, Küchler S. Filaggrin Deficiency Leads to Impaired Lipid Profile and Altered Acidification Pathways in a 3 D Skin Construct. J. Invest. Dermatol. 2014, 134(3): 746-753.

Kováčik A, Roh J, Vávrová K. The chemistry and biology of 6 hydroxyceramide, the youngest member of the human sphingolipid family. ChemBioChem 2014, 15:1555-1562.

Pullmannová P, Staňková K, Pospíšilová M, Skolová B, Zbytovská J, Vávrová K. Effects of sphingomyelin/ceramide ratio on the permeability and microstructure of model stratum corneum lipid membranes. Biochim Biophys Acta. 2014, 1838(8):2115-2126.

Školová B, Jandovská K, Pullmannová P, Tesař O, Roh J, Hrabálek A, Vávrová K. The role of the trans double bond in skin barrier sphingolipids: permeability and infrared spectroscopic study of model ceramide and dihydroceramide membranes. Langmuir. 2014; 30(19):5527-5535.

Školová B, Hudská K, Pullmannová P, Kováčik A, Palát K, Roh J, Fleddermann J, Estrela-Lopis I, Vávrová K. Different Phase Behavior and Packing of Ceramides with Long (C16) and Very Long (C24) Acyls in Model Membranes: Infrared Spectroscopy Using Deuterated Lipids. J Phys Chem B. 2014, 118 (35), 10460–10470.

Diblíková D, Kopečná M, Školová B, Krečmerová M, Roh J, Hrabálek A, Vávrová K. Transdermal Delivery and Cutaneous Targeting of Antivirals using a Penetration Enhancer and Lysolipid Prodrugs. Pharm. Res. 2014, 31(4):1071-1081.

Karabanovich G, Roh J, Smutný T, Němeček J, Vicherek P, Stolaříková J, Vejsová M, Dufková I, Vávrová K, Pávek P, Klimešová V, Hrabálek A. 1-Substituted-5-[(3,5-dinitrobenzyl)sulfanyl]-1H-tetrazoles and their isosteric analogs: A new class of selective antitubercular agents active against drug-susceptible and multidrug-resistant mycobacteria. Eur. J. Med. Chem. 2014; 82:324-340.

Potůčková E, Hrušková K, Bureš J, Kovaříková P, Špirková IA, Pravdíková K, Kolbabová L, Hergeselová T, Hašková P, Jansová H, Macháček M, Jirkovská A, Richardson V, Lane DJR, Kalinowski DS, Richardson DR, Vávrová K, Šimůnek T. Structure-activity relationships of novel salicylaldehyde isonicotinoyl hydrazone (SIH) analogs: iron chelation, anti-oxidant and cytotoxic properties. PLOS One. 2014; 9(11):e112059


Školová B, Janůšová B, Zbytovská J, Gooris G, Bouwstra JA, Slepička P, Berka P, Roh J, Palát K, Hrabálek A, Vávrová K. Ceramides in the Skin Lipid Membranes: Length Matters. Langmuir 2013, 29(50):15624-15633.

Janůšová B, Školová B, Tükörová K, Wojnarová L, Šimůnek T, Mladěnka P, Filipský T, Říha M, Roh J, Palát K, Hrabálek A, Vávrová K. Amino acid derivatives as transdermal permeation enhancers. J. Control. Release 2013, 165(2):91-100.

Karabanovich G, Roh J, Padělková Z, Novák Z, Vávrová K, Hrabálek A. One-pot synthesis of 1-substituted-5-alkylselanyl-1H-tetrazoles from isoselenocyanates: unexpected formation of N-alkyl-N-arylcyanamides and (Z)-Se-alkyl-N-cyano-N,N′-diarylisoselenoureas. Tetrahedron 2013, 69(41):8798-8808.

Filipský T, Říha M, Hrdina R, Vávrová K, Mladěnka P, Mathematical calculations of iron complex stoichiometry by direct UV-Vis spectrophotometry. Bioorg. Chem. 2013, 49:1-8.


Roh J, Vávrová K, Hrabálek A. Synthesis and Functionalization of 5-Substituted Tetrazoles. Eur. J. Org. Chem. 2012, 31:6101-6118.

Macková E, Hrušková K, Bendová P, Vávrová A, Jansová H, Hašková P, Kovaříková P, Vávrová K, Šimůnek T. Methyl and ethyl ketone analogs of salicylaldehyde isonicotinoyl hydrazone: Novel iron chelators with selective antiproliferative action. Chem.-Biol. Interact. 2012; 197(2–3):69-79.

Stariat J, Šesták V, Vávrová K, Nobilis M, Kollárová Z, Klimeš J, Kalinowski DS, Richardson DR, Kovaříková P. LC-MS/MS identification of the principal in vitro and in vivo phase I metabolites of the novel thiosemicarbazone anti-cancer drug, Bp4eT. Anal. Bioanal. Chem. 2012, 403(1):309-321.


Vávrová K, Kovaříková P, Školová B, Líbalová M, Roh J, Čáp R, Holý A, Hrabálek A. Enhanced topical and transdermal delivery of antineoplastic and antiviral acyclic nucleoside phosphonate cPr‑PMEDAP. Pharm. Res. 2011; 28(12):3105-3115.

Janůšová B, Zbytovská J, Lorenc P, Vavrysová H, Palát K, Hrabálek A, Vávrová K. Effect of ceramide acyl chain length on skin permeability and thermotropic phase behavior of model stratum corneum lipid membranes. Biochim. Biophys. Acta Mol. Cell Biol. Lipids 2011; 1811(3):129-137.

Novotný M, Klimentová J, Janůšová B, Palát K. Hrabálek A, Vávrová K. Ammonium carbamates as highly active transdermal permeation enhancers with a dual mechanism of action. J. Control. Release 2011; 150(2):164-70.

Žebrakovská I, Máša M, Srp J, Horn M, Vávrová K, Mareš M. Complex modulation of peptidolytic activity of cathepsin D by sphingolipids. Biochim. Biophys. Acta Mol. Cell Biol. Lipids 2011; 1811(12):1097-1104.

Vavříková E, Polanc S, Kočevar M, Horváti K, Bősze S, Stolaříková J, Vávrová K, Vinšová J. New fluorine-containing hydrazones active against MDR-tuberculosis. Eur. J. Med. Chem. 2011, 46(10):4937-45.

Hašková P, Koubková L, Vávrová A, Macková E, Hrušková K, Kovaříková P, Vávrová K, Šimůnek T. Comparison of various iron chelators used in clinical practice as protecting agents against catecholamine-induced oxidative injury and cardiotoxicity. Toxicology 2011, 289(2-3):122-131.

Hrušková K, Kovaříková P, Bendová P, Hašková P, Macková E, Stariat J, Vávrová A, Vávrová K, Šimůnek T. Synthesis and initial in vitro evaluations of novel antioxidant aroylhydrazone iron chelators with increased stability against plasma hydrolysis. Chem. Res. Toxicol. 2011; 24(3):290-302.

Kovaříková P, Stariat J, Klimeš J, Hrušková K, Vávrová K. Hydrophilic interaction liquid chromatography in the separation of a moderately lipophilic drug from its highly polar metabolites - the cardioprotectant dexrazoxane as a model case. J. Chrom. A 2011; 1218(3):416-426.


Novotný M, Hrabálek A, Janůšová B, Novotný J, Vávrová K. Transkarbams as transdermal permeation enhancers; Effects of ester position and ammonium carbamate formation. Bioorg. Med. Chem. Lett. 2010; 20(9): 2726-8.

Novotný J, Hrabálek A, Vávrová K. Synthesis and Structure-Activity Relationships of Skin Ceramides. Curr. Med. Chem. 2010; 17(21):2301-24.

Bendova P, Mackova E, Haskova P, Vavrova A, Jirkovsky E, Sterba M, Popelova O, Kalinowski DS, Kovarikova P, Vavrova K, Richardson DR, Simunek T. Comparison of clinically used and experimental iron chelators for protection against oxidative stress-induced cellular injury. Chem. Res. Toxicol. 2010; 23(6):1105-14.

Roh J, Vávrová K, Hrabálek A. One-pot regioselective vinylation of tetrazoles: preparation of 5-substituted 2-vinyl-2H-tetrazoles. Tetrahedron Lett. 2010; 51(10):1411-4.

Ferriz JM, Vávrová K, Kunc F, Imramovský A, Stolaříková J, Vavříková E, Vinšová J. Salicylanilide carbamates: Antitubercular agents active against multidrug-resistant Mycobacterium tuberculosis strains. Bioorg. Med. Chem. 2010; 18(3):1054-61.


Novotný J, Pospěchová K, Hrabálek A, Čáp R, Vávrová K. Synthesis of Fluorescent C24-Ceramide: Evidence for Acyl Chain Length Dependent Differences in Penetration of Exogenous NBD-Ceramides into Human Skin. Bioorg. Med. Chem. Lett. 2009; 19(24): 6975-6977.

Zbytovská J, Vávrová K, Kiselev MA, Lessieur P, Wartewig S, Neubert RHH. The effects of transdermal permeation enhancers on thermotropic phase behaviour of a stratum corneum lipid model. Col. Surf. A 2009; 351:30-37.

Novotný M, Hrabálek A, Janůšová B, Novotný J, Vávrová K. Dicarboxylic acid esters as transdermal permeation enhancers: effects of chain number and geometric isomers. Bioorg. Med. Chem. Lett. 2009; 19(2):344-347.

Novotný J, Kovaříková P, Novotný M, Janůšová B, Hrabálek A, Vávrová K. Dimethylamino acid esters as biodegradable and reversible transdermal permeation enhancers: effects of linking chain length, chirality and polyfluorination. Pharm. Res. 2009;26(4):811-21.

Novotný J, Janůšová B, Novotný M, Hrabálek A, Vávrová K. Short-Chain Ceramides Decrease Skin Barrier Properties. Skin Pharmacol. Physiol. 2009; 22(1):22-30.

Roh J, Artamonova TV, Vávrová K, Koldobskii GI, Hrabálek A. Practical Synthesis of 5-Substituted Tetrazoles under Microwave Irradiation. Synthesis 2009; 13: 2175-2178.


Vávrová K, Lorencová K, Novotný J, Holý A, Hrabálek A. Permeation enhancer dodecyl 6-(dimethylamino)hexanoate increases transdermal and topical delivery of adefovir; influence of pH, ion-pairing and skin species. Eur. J. Pharm. Biopharm. 2008; 70(3):901-7.

Klimentová J, Kosák P, Vávrová K, Holas T, Novotný J, Hrabálek A. Transkarbams with Terminal Branching as Transdermal Permeation Enhancers. Bioorg. Med. Chem. Lett. 2008; 18(5):1712-1715.

Vávrová K, Lorencová K, Klimentová J, Novotný J, Holý A, Hrabálek A. Transdermal and dermal delivery of adefovir; effects of pH and permeation enhancers. Eur. J. Pharm. Biopharm. 2008; 69(2):597-604.

Kovaříková P, Vávrová K, Tomalová K, Schöngut M, Hrušková K, Hašková P, Klimeš J. HPLC-DAD and MS/MS analysis of novel drug candidates from the group of aromatic hydrazones revealing the presence of geometric isomers. J. Pharm. Biomed. Anal. 2008; 48(2):295-302.


Vávrová K, Hrabálek A, Mac-Mary S, Humbert P, Muret P. Ceramide analogue 14S24 selectively recovers perturbed human skin barrier. Brit. J. Dermatol. 2007; 157 (4):704-712.

Vávrová K, Lorencová K, Klimentová J, Novotný J, Hrabálek A. HPLC method for determination of in vitro delivery through and into porcine skin of adefovir (PMEA). J. Chromatogr. B. 2007; 853(1-2):198-203.

Hrabálek A, Vávrová K. Historie a současný stav ve vývoji akcelerantů transdermální permeace na Farmaceutické fakultě UK v Hradci Králové – od esterů 6-aminohexanové kyseliny k transkarbamům (II. část). Praktické lékárenství 2007; 3(6):299-300.

Hrabálek A, Doležal P, Vávrová K. Historie a současný stav ve vývoji akcelerantů transdermální permeace na Farmaceutické fakultě UK v Hradci Králové – od esterů 6-aminohexanové kyseliny k transkarbamům (I. část). Praktické lékárenství 2007; 3(2):90-2.


Klimentová J, Kosák P, Vávrová K, Holas T, Hrabálek A. Influence of terminal branching on the transdermal permeation-enhancing activity in fatty alcohols and acids. Bioorg. Med. Chem. 2006; 14(23):7681-7.

Holas T, Vávrová K, Šíma M, Klimentová J, Hrabálek A. Synthesis and transdermal permeation-enhancing activity of carbonate and carbamate analogs of Transkarbam 12. Bioorg. Med. Chem. 2006; 14(23):7671-80.

Hrabálek A, Doležal P, Vávrová K, Zbytovská J, Holas T, Klimentová J, Novotný J. Synthesis and Enhancing Effect of Transkarbam 12 on the Transdermal Delivery of Theophylline, Clotrimazole, Flobufen, and Griseofulvin. Pharm. Res. 2006; 23(5):912-8.

Klimentová J, Hrabálek A, Vávrová K, Holas T, Kroutil A. Synthesis and transdermal penetration-enhancing activity of carbonic and carbamic acid esters-comparison with transkarbam 12. Bioorg. Med. Chem. Lett. 2006; 16(7):1981-4.

Holas T, Vávrová K, Klimentová J, Hrabálek A. Synthesis and transdermal permeation-enhancing activity of ketone, amide, and alkane analogs of Transkarbam 12. Bioorg. Med. Chem. 2006; 14(9):2896-2903.

Kovaříková P, Mokrý M, Klimeš J, Vávrová K. HPLC study on stability of pyridoxal isonicotinoyl hydrazone. J. Pharm. Biomed. Anal. 2006; 40(1):105-12.

Holas T, Zbytovská J, Vávrová K, Berka P, Mádlová M, Klimentová J, Hrabálek A. Thermotropic phase behavior of long-chain alkylammonium-alkylcarbamates. Thermochim. Acta 2006; 441(2):116-123

Vávrová K, Hrabálek A. Role ceramidů v kůži. Praktické lékárenství 2006; 2:55-58.


Vávrová K, Zbytovská J, Hrabálek A. Amphiphilic transdermal permeation enhancers: structure-activity relationships. Curr. Med. Chem. 2005; 12(19):2273-91.

Hrabálek A, Vávrová K, Doležal P, Macháček M. Esters of 6-aminohexanoic acid as skin permeation enhancers: The effect of branching in the alkanol moiety. J. Pharm. Sci. 2005; 94(7):1494-9.

Vávrová K, Hrabálek A, Doležal P, Holas T, Klimentová J. Biodegradable derivatives of tranexamic acid as transdermal permeation enhancers. J. Control. Release. 2005; 104(1):41-9.

Hrabálek A, Vávrová K. Lze překonat kožní bariéru? Praktické lékárenství 2005; 1:8-11.


Kovaříková P, Mokrý M, Klimeš J, Vávrová K. Chromatographic methods for the separation of biocompatible iron chelators from their synthetic precursors and iron chelates. J. Sep. Sci. 2004; 27(17-18):1503-10.

Vávrová K, Zbytovská J, Palát K, Holas T, Klimentová J, Hrabálek A, Doležal P. Ceramide analogue 14S24 ((S)-2-tetracosanoylamino-3-hydroxypropionic acid tetradecyl ester) is effective in skin barrier repair in vitro. Eur. J. Pharm. Sci. 2004; 21(5):581-7.

Hrabálek A, Myznikov L, Kuneš J, Vávrová K, Koldobskii G. A simple method for the preparation of 5-alkylsulfinyl-1-aryltetrazoles. Tetrahedron Lett. 2004; 45(42):7955-7.


Vávrová K, Hrabálek A, Doležal P, Šámalová L, Palát K, Zbytovská J, Holas T, Klimentová J. Synthetic ceramide analogues as skin permeation enhancers: structure-activity relationships. Bioorg. Med. Chem. 2003; 11(24):5381-90.

Vávrová K, Hrabálek A, Doležal P, Holas T, Zbytovská J. L-Serine and glycine based ceramide analogues as transdermal permeation enhancers: polar head size and hydrogen bonding. Bioorg. Med. Chem. Lett. 2003; 13(14):2351-3.

Doležal P, Hrabálek A, Svozil M, Vávrová K, Zbytovská J. In vitro studies on transkarbam 12 and laurocapram effect on transdermal permeation of butorphanol. Farmacevtski Vestnik 2003; 54 (Spec. Iss.):527-8


Vávrová K, Hrabálek A, Doležal P. Enhancement effects of (R) and (S) enantiomers and the racemate of a model enhancer on permeation of theophylline through human skin. Arch. Dermatol. Res. 2002; 294(8):383-5.

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