Employment
05/2022 – present
Associate professor; Charles University, Faculty of Pharmacy in Hradec Králové, Akademika Heyrovského 1203, 500 05 Hradec Králové
02/2016 – 04/2022
Assistant professor; Charles University, Faculty of Pharmacy in Hradec Králové, Akademika Heyrovského 1203, 500 05 Hradec Králové
07/2019 – 09/2019
Researcher; University of Applied Sciences Northwestern Switzerland, Institute for Pharma Technology, Hofackerstrasse 30, CH-4132 Muttenz, Switzerland
09/2018 – 02/2019
International internship; University of Applied Sciences Northwestern Switzerland, Institute for Pharma Technology, Hofackerstrasse 30, CH-4132 Muttenz, Switzerland
09/2015 – 01/2016
Instructor; Charles University, Faculty of Pharmacy in Hradec Králové, Akademika Heyrovského 1203, 500 05 Hradec Králové
01/2012 – 06/2015
Instructor; University of Veterinary and Pharmaceutical Sciences Brno, Faculty of Pharmacy, Palackého tř. 1946/1, 612 42 Brno
Education
2022
Habilitation in Pharmaceutical Technology (assoc. prof.)
Charles University, Faculty of Pharmacy in Hradec Králové, Depratment of Pharmaceutical Technology
2011 – 2016
Postgradual study program in Pharmaceutical Technology (Ph.D.)
University of Veterinary and Pharmaceutical Sciences Brno, Faculty of Pharmacy, Department of Pharmaceutics
2014
Advanced master study in Pharmaceutical Technology (PharmDr.)
University of Veterinary and Pharmaceutical Sciences Brno, Faculty of Pharmacy, Department of Pharmaceutics
2006 – 2011
Master study program in Pharmacy (Mgr.)
University of Veterinary and Pharmaceutical Sciences Brno, Faculty of Pharmacy
Research activities
Current interest: preparation and evaluation of liquisolid systems; controlled release; colon targeting; dissolution testing; determination of critical micelle concentration; measurement of surface tension
Grants:
TAČR SIGMA DC2 project No. TQ03000522 (Rational formulation of extruded solid dispersions and liquisolid systems into dosage forms with the desired pharmacokinetic profile)
Johannes Amos Comenius project CZ.02.01.01/00/22_008/0004607 (Nové technologie pro translační výzkum ve farmaceutických vědách /NETPHARM)
GAUK No. 126324/2024 ( Unravelling the mechanisms of drug-silica interactions during drug release in simulated media)
GAUK No. 337622/2022 (Towards a better understanding of drug-silica interactions in mesoporous bioenabeling formulations)
GAUK No. 70119/2019 (Development of colon-targeted liquisolid systems for the local therapy of inflammatory bowel diseases)
IGA VFU Brno No. 82/2013/FaF (Effect of fillers and disintegrants on properties and dissolution profiles of liquisolid systems)
IGA VFU No. 76/2012/FaF (Formulation and evaluation of liquisolid systems with hypolipidemic drug)
Memberships
Czech Pharmaceutical Society (vice-chairwoman of the Pharmaceutical technology section since 2023)
Editorial board of the journal Česká a Slovenská farmacie
Scientific Committee of the III. Symposium of young researchers on pharmaceutical technology, biotechnology and regulatory science“. Szeged. 2021.
Academic Senate of the Faculty of Pharmacy in Hradec Králové (vice-chairwoman since 2022)
Study Committee of the Academic Senate of the Faculty of Pharmacy in Hradec Králové (chairwoman since 2022)
Top 10 publications
OGADAH, C. U., K. MRŠTNÁ, L. MATYSOVÁ, A. MULLERTZ, T. RADES, A. NIEDERQUELL, Z. ŠKLUBALOVÁ a B. VRANÍKOVÁ. Comparison of the liquisolid technique and co-milling for loading of a poorly soluble drug in inorganic porous excipients. International Journal of Pharmaceutics. 2024, 650. 123702. https://doi.org/10.1016/j.ijpharm.2023.123702. (IF2022= 5,8 ; AIS2022= 0,718; QAIS2; QIF1)
NIEDERQUELL, A., B. VRANÍKOVÁ, M. KUENTZ. Study of Disoedered Mesoporous Silica Regarding Intrinsic Compound Affinity to the Carrier and Drug-Accessible Surface Area. Molecular Pharmaceutics. 2023, 20(12): 6301-6310. https://doi.org/10.1021/acs.molpharmaceut.3c00690. (IF2022= 4,9 ; AIS2022= 0,808; QAIS2; QIF1)
BROKEŠOVÁ, J., M. SLÁMOVÁ, P. ZÁMOSTNÝ, M. KUENTZ, J. KOKTAN, L. KREJČÍK, B. VRANÍKOVÁ, P. SVAČINOVÁ a Z. ŠKLUBALOVÁ. Mechanistic study dissolution enhancement by interactive mixtures of chitosan with meloxicam as model. European Journal of Pharmaceutical Sciences. 2022, 169. 106087. https://doi.org/10.1016/j.ejps.2021.106087. ( IF2022 = 4.600; AIS2022 = 0.615; QAIS 2; QIF 3)
BROKEŠOVÁ, J., A. NIEDERQUELL, M. KUENTZ, P. ZÁMOSTNÝ, B. VRANÍKOVÁ a Z. ŠKLUBALOVÁ. Powder cohesion and energy to break an avalanche: Can we address surface heterogeneity? International Journal of Pharmaceutics. 2022, 626. 122198. https://doi.org/10.1016/
j.ijpharm.2022.122198 (IF2022 = 5.800 ; AIS2022 = 0.715; QAIS 2; QIF 1)
DOMINIK, M.*, B. VRANÍKOVÁ*, P. SVAČINOVÁ*, J. ELBL, S. PAVLOKOVÁ, B. BLÁHOVÁ PRUDILOVÁ, Z. ŠKLUBALOVÁ a A. FRANC. Comparison of flow and compression properties of four lactose-based co-processed excipients: Cellactose® 80, CombiLac®, MicroceLac® 100, and StarLac®. Pharmaceutics. 2021, 13. 1486. https://doi.org/10.3390/pharmaceutics13091486. ( IF2021 = 6.525; AIS2021 = 0.879; QAIS 2; QIF1)
VRANÍKOVÁ, B., P. SVAČINOVÁ, J. MARUSHKA, J. BROKEŠOVÁ, O. HOLAS, J. D. TEBBENS a Z. ŠKLUBALOVÁ. The importance of the coating material type and amount in the preparation of liquisolid systems based on magnesium aluminometasilicate carrier. European Journal of Pharmaceutical Sciences. 2021, 165. 105952. https://doi.org/10.1016/j.ejps.2021.105952 (IF2020 = 4.384; AIS2020 = 0.698; QAIS 2; QIF 2)
KUBAČKOVÁ, J., O. HOLAS, J. ZBYTOVSKÁ, B. VRANÍKOVÁ, G. ZENG, P. PÁVEK, A. MULLERTZ. Oligonucleotide delivery across the Caco-2 monolayer: The design and evaluation of self-emulsifying drug delivery systems (SEEDS). Pharmaceutics. 2021, 4. 459. https://doi.org/10.3390/pharmaceutics13040459. ( IF2021 = 5.112; AIS2021 = 0.654; QAIS 3; QIF 2)
VRANÍKOVÁ, B., A. NEIDERQUELL, Z. ŠKLUBALOVÁ a M. KUENTZ. Relevance of the theoretical critical pore radius in mesoporous silica for fast crystallizing drugs. International Journal of Pharmaceutics. 2020, 591. 120019. https://doi.org/10.1016/j.ijpharm.2020.120019 (IF2020 = 5.875; AIS2020 = 0.713; QAIS2; QIF1)
VRANÍKOVÁ, B., A. NEIDERQUELL, F. DITZINGER, Z. ŠKLUBALOVÁ and M. KUENTZ. Mechanistics aspects of drug loading in liquisolid systems with hydrophilicc lipid-based mixtures. International Journal of Pharmaceutics. 2020, 578. https://doi.org/10.1016/j.ijpharm.2020.119099. (IF2020 = 5.875; AIS2020 = 0.713; QAIS2; QIF1)
SVAČINOVÁ, P., B. VRANÍKOVÁ, M. DOMINIK, J. ELBL, S. PAVLOKOVÁ, R. KUBALÁK, P. KOPECKÁ and A. FRANC. Comprehensive study of co-processed excipients F-Melts(r): flow, viscoelastic and compacts properties. Powder Technology. 2019, 355: 675-687. https://doi.org/10.1016/j.powtec.2019.07.048. (IF2019 = 4.142; ; AIS2019 = 0.613; QAIS2; QIF1)
VRANÍKOVÁ, B., S. PAVLOKOVÁ and J. GAJDZIOK. Experimental Design for Determination of Effects of Superdisintegrant Combinations on Liquisolid Systém Properties. Journal of Pharmaceutical Sciences. 2017, 106(3): 817-825. ISSN 1520-6017. (IF2017 =3.075; AIS2017 = 0.628; QAIS2; QIF2)
* contributed equally