Ing. Rozálie Peřinová

Research focus

• isolation of alkaloid haemanthamine from the crude extract
• preparation of semi-synthetic derivatives from haemanthamine
• working with HPLC/MS and GC/MS
• in vitro biological activities of prepared compounds (AChE, BuChE, POP and cytotoxicity)

Education

• 2014-2018 University of Pardubice, Faculty of Chemical Technology, Evaluation and analysis of foodstuffs
• Bachelor thesis: Determination of biologically active substances in coffee by spectrophotometric methods.
• Master thesis: Monitoring of microorganisms in nutritionally balanced snacks and the effect of natural extracts on the occurrence of microorganisms

Current Position

• a doctoral student at Charles University, Faculty of Pharmacy in Hradec Králové, Department of Pharmaceutical Botany

Publications

Original papers

2022

UHER, M., HROCH, M., PERINOVA, R., HAVELEK, R., KROUSTKOVA, J., REZACOVA, M., MUTHNA, D., KOUTOVA, D., KUNES, J., CAHLIKOVA, L.: Semisynthetic derivatives of haemanthamine and their in vitro antiproliferative activity evaluation against a panel of human cell lines. Arab. J. Chem. 15,103746 (2022). https://doi.org/10.1016/j.arabjc.2022.103746

2021

AL MAMUN, A., PIDANY, F., HULCOVA, D., MARIKOVA, J., KUCERA, T., SCHMIDT, M., CATAPANO, M.C., HRABINOVA, M., JUN, D., MUCKOVA, L., KUNES, J., JANOUSEK, J., ANDRYS R., NOVAKOVA, L., PERINOVA, R., MAAFI, N., SOUKUP, O., KORABECNY, J., CAHLIKOVA, L.: Amaryllidaceae alkaloids of norbelladine-type as inspiration for development of highly selective butyrylcholinesterase inhibitors: Synthesis, biological activity evaluation, and docking studies. In. J. Mol. Sci. 22, 8308 (2021).  https://doi.org/10.3390/ijms22158308

KOHELOVÁ, E., MAŘÍKOVÁ, J., KORÁBEČNÝ, J., HULCOVÁ, D., KUČERA, T., JUN, D., CHLEBEK, J., JENČO, J., ŠAFRATOVÁ, M., HRABINOVÁ, M., RITOMSKÁ, A., MALANÍK, M., PEŘINOVÁ, R., BREITEROVÁ, K., KUNEŠ, J., NOVÁKOVÁ, L., OPLETAL, L., CAHLÍKOVÁ, L.: Alkaloids of Zephyrantes citrina (Amaryllidaceae) and their implication to Alzheimerʼs disease: isolation, structural elucidation and biological activity. Bioorg. Chem. 107, 104567 (2021). https://doi.org/10.1016/j.bioorg.2020.104567

2020

PEŘINOVÁ, R., MAAFI, M., KORÁBEČNÝ, J., KOHELOVÁ, E., DE SIMONE, A., AL MAMUN, A., HULCOVÁ, D.,MARKOVÁ, J., KUČERA, T., JUN, D., ŠAFRATOVÁ, M., MAŘÍKOVÁ, J., ANDRISANO, V., JENČO, J., KUNEŠ, J., MARTINEZ, A., NOVÁKOVÁ, L., CAHLÍKOVÁ, L.: Functionalized aromatic esters of the Amaryllidaceae alkaloid haemanthamine and their in vitro and in silico biological activity connected to Alzheimer´s disease. Bioorg. Chem. 100, 103928 (2020). https://doi.org/10.1016/j.bioorg.2020.103928

MAŘÍKOVÁ, J., RITOMSKÁ, A., KORÁBEČNÝ, J., PEŘINOVÁ, R., AL MAMUN, A., KUČERA, T., KOHELOVÁ, E., HULCOVÁ, D., KOBRLOVÁ, T., KUNEŠ, J., NOVÁKOVÁ, L., CAHLÍKOVÁ, L.: Aromatic esters of the crinane Amaryllidaceae alkaloid ambelline as selective inhibitors of butyrylcholinesterase. J. Nat. Prod. 83, 1359-1367 (2020). https://doi.org/10.1021/acs.jnatprod.9b00561

2019

KOHELOVÁ, E., PEŘINOVÁ, R., MAAFI, N., KORABEČNÝ, J., HULCOVÁ, D., MAŘÍKOVÁ, J., KUČERA, T., GONZÁLEZ, L.M., HRABINOVÁ, M., VORČÁKOVÁ, K., NOVÁKOVÁ, L.,  DE SIMONE, A., HAVELEK, R., CAHLÍKOVÁ, L. Derivatives of the β-crinane Amaryllidaceae alkaloid haemanthamine as multi-target directed ligands for Alzheimer’s disease. Molecules 24, 1307 (2019). https://doi.org/10.3390/molecules24071307

Reviews

2021

CAHLIKOVA, L., VRABEC, R., PIDANY, F., PERINOVA, R., MAAFI, N., AL MAMUN, A., RITOMSKA, A., WIJAYA, V., BLUNDEN, G.: Recent progress on biological activity of Amaryllidaceae and further isoquinoline alkaloids in connection with Alzheimer´s disease. Molecules 26, 5240 (2021). https://doi.org/10.3390/molecules26175240