Assoc. Prof. PharmDr. Lukáš Červený, Ph.D.

ONGOING RESEARCH

• the role of nucleoside transporters, nucleosides, and adenosine receptors for the growth of the trophoblast layer
• adenosine in immune response of the trophoblast layer to pathogenic stimulus
• antiviral drugs and caffeine interference with adenosine homeostasis in the placenta
• expression and regulation of glucagon-like petide-1 receptor in the placenta
• drug-drug interactions on intestinal drug transporters and biotransformation enzymes and their effects on intestinal drug absorption with special focus on antiviral drugs

RECENT/PAST RESEARCH AREAS

• role of ABC and SLC transporters in placental kinetics of antiviral drugs
• identification of prognostic markers of disease progress in patients with resected pancreatic cancer treated with gemcitabine
• identification of virulence factors in Francisella tularensis 
• nuclear receptor-mediated transcriptional regulation of ABCB1 and CYP3A4 
• interactions of antiepileptic drugs with breast cancer resistance protein
• tryptophan and serotonin handling in the placenta; role in the fetal programming

EMPLOYMENT HISTORY

• since 7/2019 – Assoc. Prof. at the Department of Pharmacology and Toxicology (Faculty of Pharmacy in Hradec Králové, Charles University)
• 11/2011 – 6/2019 – Assist. Prof. at the Department of Pharmacology and Toxicology (Faculty of Pharmacy in Hradec Králové, Charles University in Prague)
• 7/2006 - 10/2011 – Head of the group B focused on biology, Centre of Advanced Studies (Faculty of Military Health Sciences, University of Defence)
• 2003 - 2004 - Centre for Research of Structure and Mechanism of Action of Potential New Drugs

EDUCATION

• 2019 – Assoc. Prof. in human and veterinary pharmacology (Faculty of Pharmacy in Hradec Králové, Charles University)
• 2008 – PharmDr. and Ph.D. degree (program: Pharmacology and Toxicology; Faculty of Pharmacy in Hradec Králové, Charles University in Prague)
• 2003 – Master’s degree in pharmacy (program: Pharmacy; Faculty of Pharmacy in Hradec Králové, Charles University in Prague)

FOREIGN WORK EXPERIENCE

• 2007 - Department of Medical Countermeasures, Division of NBC-Defence, Swedish Defence Research Agency (FOI), Umea (Sweden) (1 month)
• 2006 - Department of Medical Countermeasures, Division of NBC-Defence, Swedish Defence Research Agency (FOI), Umea (Sweden) (3 months)
• 2004 - Department of Pathophysiology, University in Vienna (Austria) (2 months)

SCIENTIFIC EXPERIENCE (2021-2026)

• published full-text papers with IF: 10 (2x first author, 5x corresponding author
• currently, 1x full-text paper (corresponding author) is under review in journal with IF (Frontiers in Pharmacology) addressing the effect of antiviral entecavir on the placental molecular processes
• supervising consultant of Ph.D. students: 1x, doctoral thesis was defended
• supervisor of Ph.D. students: 3x
• member of evaluation medicinal sciences panel in the Charles University Grant Agency (GAUK)
• reviewer of grant applications: GAUK (> 10x, in total >90x]), Czech Health Research Council (5x)
• reviewer of full-text papers in journals with/without IF: e.g. Frontiers in Pharmacology, Pharmaceutical Research, Infection and Immunity, DNA and Cell Biology, Xenobiotica, Cancers, Antimicrobial Agents and Chemotherapeutics, Phytomedicine, European Journal of Obstetrics and Gynecology, PeerJ, Scientific Reports, Reproductive Toxicology, Biochemical Pharmacology, Journal of Antimicromial Chemotherapy, Toxicology and Applied Pharmacology etc.

FUNDING (2021-2026)

• a guarantor of projects provided by the Charles University Grant Agency (2x): „Adenosine receptors the unknown player in placental growth, differentiation, and maintaining immunotolerance“ (2023-2025) and “Expression and Signaling of the GLP-1 Receptor Across Placental Models and Ontogeny” (2026-2028)
• principle investigator of a grant provided by the Czech Science Foundation “Effects of antivirals and methylxanthines on placental growth; interference with nucleoside uptake and purinergic signaling in trophoblasts” (22-17643S) -2022-2024
• a professional colleague in Czech Health Research Council project “Placental NLRP3 inflammasome signaling in gestational diabetes and the therapeutic potential of metformin” (NU22J-01-00066) - 2022-2025
• a professional colleague in an ongoing Johannes Amos Comenius project “New technologies for translational research in pharmaceutical Sciences /NETPHARM” – 2024 -2028 (CZ.02.01.01/00/22_008/0004607)
• a professional colleague in a grant provided by the Czech Science Foundation “Antidepressants in pregnancy; effect on placental transport and metabolism of serotonin” (20-13017S) -2020-2022
• principle investigator of the 4EU+ project “From fetal to lifelong health: dynamic maternal environments and impact of the placenta” (4EU+2024F106)

CUMULATIVE IMPACT FACTOR:

• > 185 (in total 47 full-text papers in SCOPUS database), average IF = 3.91

CITATIONS (2 July 2026 in Scopus database)

• 1660 (with self-citations), H-index = 24

TEACHING

• Pharmacology seminars (96 hours/academic year)
• Pharmacology lectures (14 hours/academic year)
• Pharmacokinetics lectures (4 hours/academic year; a guarantor of this subject)
• Pharmacokinetics lab exercises (10 hours/academic year)
• Modern Strategy in Pharmacotherapy lectures (6 hours/academic year; aguarantor of this subject)
• Pharmacology lectures at the MBS College of Crete (14 hours/academic year)
• supervision of diploma theses (> 40x)
• an author of a chapter on drug receptors in a textbook for students of Molecular pathology (University of Defence)
• oral/written exams in Pharmacology, Pharmacokinetics, Modern Strategy in Pharmacology
• a member of the committee for state exams of undergraduate and postgraduate students
• a member of the committee for diploma theses defense
• a member of the committee for dissertation thesis defense

PROFESSIONAL MEMBERSHIP (2021 - 2026)

• Czech Society for Experimental and Clinical Pharmacology and Toxicology
• International Society for the Study of Xenobiotics
• International Federation of Placenta Associations