Abdullah Al Mamun, Ph.D.

Education

• 2006-2010 Bachelor of Pharmacy, Bangladesh University, Department of Pharmacy
• 2011-2012 Master degree, University of Asia Pacific, Department of Pharmacy, Bangladesh
• 2022 Ph.D., Charles University, Faculty of Pharmacy in Hradec Kralove, Department of Pharmacognosy and Pharmaceutical Botany

Current Position

• a postdoc at Charles University, Faculty of Pharmacy in Hradec Kralove, Department of Pharmaceutical Botany

Research focus

• isolation of secondary metabolites from the family Amaryllidaceae (isolation, characterization and structural identification of pure compounds)
• screening biological activity of isolated compounds (AChE, BuChE, POP, GSK-3β, anticancer and antimalarial activity)
• preparation of semisynthetic derivatives of isolated compounds.

Professional career

• 2016-2017 research assistant; Quest International University Perak, Malaysia
• 2012-2016 industrial pharmacist; Pharmasia Pharmaceutical Ltd. Bangladesh

Professional membership

• since 2015 Bangladesh Pharmaceutical Society
• professional (grade-A) registered pharmacist in Bangladesh (Reg. No - A4349)

Publication

Original Papers

2023

PIDANY, F., KROUSTKOVA, J., AL MAMUN, A., SUCHANKOVA, D., BRAZZOLOTTO, X., NACHON, F., CHANTEGREIL, F., DOLEZAL, R., PULKRABKOVÁ, L., MUCKOVA, L., HRABINOVA, M., FINGER, V., KUFA, M., SOUKUP, O., JUN, D., JENCO, J., KUNES, J., NOVAKOVA, L., KORABECNY, J., CAHLIKOVA, L.:  Highly selective butyrylcholinesterase inhibitors related to Amaryllidaceae alkaloids - design, synthesis, and biological evaluation. Eur. J. Med. Chem. 252, 115301 (2023).  https://doi.org/10.1016/j.ejmech.2023.115301

2022

KŘOUSTKOVÁ, J., RITOMSKÁ, A., Al MAMUN, A., HULCOVÁ, D., OPLETAL, L., KUNEŠ, J., CAHLÍKOVÁ, L.,  BUCAR, F.: Structural analysis of unusual alkaloids isolated from Narcissus pseudonarcissus cv. Carlton. Phytochemistry 204, 113439 (2022).  DOI: https://doi.org/10.1016/j.phytochem.2022.113439.

2021

AL MAMUN, A., PIDANY, F., HULCOVA, D., MARIKOVA, J., KUCERA, T., SCHMIDT, M., CATAPANO, M.C., HRABINOVA, M., JUN, D., MUCKOVA, L., KUNES, J., JANOUSEK, J., ANDRYS R., NOVAKOVA, L., PERINOVA, R., MAAFI, N., SOUKUP, O., KORABECNY, J., CAHLIKOVA, L.: Amaryllidaceae alkaloids of norbelladine-type as inspiration for development of highly selective butyrylcholinesterase inhibitors: Synthesis, biological activity evaluation, and docking studies. In. J. Mol. Sci. 22, 8308 (2021).  https://doi.org/10.3390/ijms22158308

MAŘÍKOVÁ, J., AL MAMUN, A., AL SHAMMARI, L., KORABEČNÝ, J., KUČERA, T., HULCOVÁ, D., KUNEŠ, J., MALANÍK, M., VAŠKOVÁ, M., KOHELOVÁ, E., NOVÁKOVÁ, L., CAHLÍKOVÁ, L., POUR, M.: Structure Elucidation and cholinesterase inhibition activity of two new minor Amaryllidaceae alkaloids; Molecules 26, 1279 (2021). https://doi.org/10.3390/molecules26051279

MAAFI, N., AL MAMUN, A., JANĎOUREK, O., MAŘÍKOVA, J., BREITEROVÁ, K., DIEPOLTOVÁ, A., KONEČNÁ, K., HOŠŤÁLKOVÁ, A., HULCOVÁ, D., KUNEŠ, J., KOHELOVÁ, E., KOUTOVÁ, D., ŠAFRATOVÁ, M., NOVÁKOVÁ, L., CAHLÍKOVÁ, L.: Semisynthetic derivatives of selected Amaryllidaceae alkaloids as a new class of antimycobacterial agents. Molecules 26, 6023 (2021). https://doi.org/10.3390/molecules26196023

2020

AL MAMUN, A., MAŘÍKOVÁ, J., HULCOVÁ, D., JANOUŠEK, J., ŠAFRATOVÁ, M., NOVÁKOVÁ, L., KUČERA, T., HRABINOVÁ, M.,  KUNEŠ, J., KORÁBEČNÝ, J., CAHLÍKOVÁ, L: Amaryllidaceae alkaloids of belladine-type from Narcissus pseudonarcissus cv. Carlton as new selective inhibitors of butyrylcholinesterase. Biomolecules 10, 800 (2020). https://doi.org/10.3390/biom10050800

PEŘINOVÁ, R., MAAFI, M., KORÁBEČNÝ, J., KOHELOVÁ, E., DE SIMONE, A., AL MAMUN, A., HULCOVÁ, D.,MARKOVÁ, J., KUČERA, T., JUN, D., ŠAFRATOVÁ, M., MAŘÍKOVÁ, J., ANDRISANO, V., JENČO, J., KUNEŠ, J., MARTINEZ, A., NOVÁKOVÁ, L., CAHLÍKOVÁ, L.: Functionalized aromatic esters of the Amaryllidaceae alkaloid haemanthamine and their in vitro and in silico biological activity connected to Alzheimer´s disease. Bioorg. Chem. 100, 103928 (2020). https://doi.org/10.1016/j.bioorg.2020.103928

MAŘÍKOVÁ, J., RITOMSKÁ, A., KORÁBEČNÝ, J., PEŘINOVÁ, R., AL MAMUN, A., KUČERA, T., KOHELOVÁ, E., HULCOVÁ, D., KOBRLOVÁ, T., KUNEŠ, J., NOVÁKOVÁ, L., CAHLÍKOVÁ, L.: Aromatic esters of the crinane Amaryllidaceae alkaloid ambelline as selective inhibitors of butyrylcholinesterase. J. Nat. Prod. 83, 1359-1367 (2020). https://doi.org/10.1021/acs.jnatprod.9b00561

AL SHAMMARI, L., AL MAMUN, A., KOUTOVÁ, D., MAJOROŠOVÁ, M., HULCOVÁ, D., ŠAFRATOVÁ, M., BREITEROVÁ, K. MAŘÍKOVÁ, J., HAVELEK, R., CAHLÍKOVÁ, L.: Alkaloid profiling of Hippeastrum cultivars by GC-MS, isolation of Amaryllidaceae alkaloids and evaluation of their cytotoxicity. Rec. Nat. Prod. 14, 154-159 (2020). http://doi.org/10.25135/rnp.147.19.06.1302

2015

ZAMAN, A., KHAN, M. S., AKTER, L., SYEED, S. H., AKTER, J., MAMUN, A. A., ALAM, M. E., HABIB, M. A., JALIL, M. A.: Exploring new pharmacology and toxicological screening and safety evaluation of one widely used formulation of Nidrakar Bati from South Asia region. BMC Complement. Altern. Med. 15, 121 (2015). http://doi.org/10.1186/s12906-015-0635-2

2014

KHAN, M. S.,  MAMUN, A. A., PARVIN, S., ALAM, M. E., HABIB, M. A.: Screening of BADH Activity of Borreria articularies (Linn.) for the Inhibition of P. aeruginosa. Inter. J. Phytopharmacy 4, 99-104 (2014). http://doi.org/10.7439/IJPP.V4I4.98

MAMUN, A. A., HABIB, M. A.,  ALAM, M. E., RAHMAN, M. M., PARVIN, M. S.: Effect on CNS activity and analgesic activity of Perthenium histerophorous L. by methanolic extract at aerial part in swiss albino mice. Inter. J. Innov. Pharm. Sci. Res. 2, 1625-1637 (2014).

Reviews

2021

CAHLIKOVA, L., VRABEC, R., PIDANY, F., PERINOVA, R., MAAFI, N., AL MAMUN, A., RITOMSKA, A., WIJAYA, V., BLUNDEN, G.: Recent progress on biological activity of Amaryllidaceae and further isoquinoline alkaloids in connection with Alzheimer´s disease. Molecules 26, 5240 (2021). https://doi.org/10.3390/molecules26175240