Current research on compliance is facing several problems: variations in terminology, diverse non-standard methodology (difficult to compare), the absence of studies of psychological determinants, distorted interpretation of the results of studies funded by the pharmaceutical industry, difficult implementation of evidence into clinical practice and limited possibilities to apply the results  to other health care systems.

Compared to other European countries, poor compliance has been shown in the Czech Republic, especially in the elderly. In the AdHOC study (Aged in Home Care) the non-compliance of persons over 65 years in the Czech Republic and Germany was found to be the highest out of 11 European countries. Since there is no universal (cost) effective intervention to increase compliance, comprehensive strategies based on high-quality studies for a defined group of patients that would be applicable in routine clinical practice are required. Health care professionals, pharmaceutical companies, public authorities and media should participate in promotion of compliance. 

The objectives of the group:

  1. to examine the level and nature of non-compliance and to analyze the factors that affect non-compliance;
  2. specifically to design and develop strategies to promote compliance and to test their effectiveness;
  3. to integrate knowledge of compliance to the broader context of pharmacoepidemiology;
  4. to contribute to the development of the methodology of the research in this area;
  5. to integrate the findings into clinical practice and to provide a basis for subsequent pharmacoeconomic analyses.

Priorities of our group represent serious chronic diseases.


Key words:  patient compliance; health care professionals-compliance; low trauma fractures; adherence; clinical guidelines; prescription-based database; risk management; pharmacoeconomics; costs; drug consumption; general practitioner; self-report; compliance-related outcomes; knowledge; medical records.

Methods: Osteoporosis Specific Morisky Medication Adherence Scale© (OS-MMAS), medication event monitoring system (MEMS), administrative data − prescription database, medical records.

Diabetes mellitus

Key words: patient compliance; type 1 diabetes; type 2 diabetes; self-care; self-management; self-monitoring; self-report; treatment satisfaction; hypoglycaemia; adverse effects; metabolic control; insulin dose; therapy-related problems; diet; dietary recommendations; fat and  fibre intake; medical records.

Methods: Self Care Inventory-Revised©; Diabetes Treatment Satisfaction Questionnaire©, medical records.

Rheumatic diseases

Key words: systemic scleroderma; patient compliance; rheumatoid arthritis; self-report; structured interviews; quality of life; medical records.

Methods: Health Assessment Questionnaire (HAQ); Compliance Questionnaire Rheumatology© (CQR), medical records.

Chronic Obstructive Pulmonary Disease

Key words: adherence; inhalators; inhalation technique; essential steps; self-report; Morisky Medication Adherence Scale; multicentre observational prospective study; Czech Multicentre Research Database of COPD

Methods: direct observation; Morisky Medication Adherence Scale; medical records.

Methodological issues

Key words: bias; healthy adherer effect.

Methods: reviews, systematic reviews.

© Charles University, Faculty of Pharmacy in Hradec Králové, Akademika Heyrovského 1203, 500 05 Hradec Králové, Czech Republic
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