Research Funding

Ongoing Projects


Czech Science Foundation (GA ČR):

18-08169S - Study of individual topoisomerase ii isoforms in anticancer and cardiotoxic effects of anthracyclines and their modulations by bisdioxopiperazines (2018 - 2020)


Past Projects


Charles University in Prague:

UNCE 204019/304019/2012 - Research Center for the Study of Toxic and Protective Effects of Drugs on Cardiovascular System (2012 – 2017)


Czech Science Foundation (GA ČR):

13-15008S - New potential cardioprotective agents: study of structure-activity relationships in various types of myocardial injury (2013 - 2017)

13-27761S - Development of new photosensitizers for photodynamic therapy and investigation of their mechanism of action on cellular
level (2013 - 2016)

GA305/09/0416 - Myocardial damage induced by anticancer drugs and ischemia-reperfusion: new possibilities of pharmacological cardioprotection (2009-2012)

GP305/05/P156 - Study of protective effects of novel iron chelators in the heart injury induced by oxidative stress and anthracycline cytostatics (2005-2007)

GA305/03/1511 – Cardiovascular, potentially cardioprotective and biotransformation effects of novel iron-chelating agents (2003-2005)


Grant Agency, Ministry of Health of the Czech Republic (IGA MZ ČR):

NT12403 – Pharmaceutical analysis, study of pharmacokinetics and biotransformation of novel thiosemicarbazone anticancer drugs (2011- 2013)

NT13457 – Anthracycline cardiotoxicity – new possibilities of pharmacological cardioprotection and risks of combination with biologically-targeted anticancer therapy (2012-2015)


Grant Agency of the Charles University in Prague (GA UK):

1916214 - Study of the novel phthalocyanine and azaphthalocyanine photosensitizers for photodynamic therapy of tumors on cellular and molecular level (2014-2016)

299511 - Synthesis and study of antiproliferative effects of novel aroylhydrazone iron chelators (2011-2013)

367911 - Study of cardioprotective effects of novel aroylhydrazone prochelators of iron that are activated by oxidative stress (2011 – 2013)

112409 - Cardiotoxicity of anthracycline drugs: Study of molecular mechanisms of dexrazoxane-afforded cardioprotection; synthesis and initial pharmacological evaluation of its novel analogues (2009-2011)

51308 - Study of the role of free intracellular iron in the pathophysiology of catecholamine cardiotoxicity and possibilities of pharmacological cardioprotection (2008-2010)

124307 - Development of new cardioprotective iron chelators – Synthesis, pharmacological and bioanalytical evaluation (2007-2009)


Czech Society of Cardiology:

Study of the role of apoptosis in the anthracycline-induced myocardial damage (2006-2008)

© Charles University, Faculty of Pharmacy in Hradec Králové, Akademika Heyrovského 1203, 500 05 Hradec Králové, Czech Republic
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