1. Application of catalytic reactions of Pd on the synthesis of natural products and their analogs
Cyclization of enynes, couplings, carbonylative lactonization
Screening of the compounds (Xcelligence tests – Institute of Molecular Genetics, Czech Academy of Science, Prague; cytostatic activity and cytotoxicity - School of Medicine, Palacký University, Olomouc; antifungal and antimicrobial activity – Department of Biological and Medical Sciences, Faculty of Pharmacy)
2. Specifically substituted heterocycles via enyne cyclization and direct activation of C-H bond
3. Analogues of quinazoline alkaloids as bronchodilatory compounds and/or organocatalysts
Bronchodilatory effect (isolated trachea model) – Laboratory of Respiratory Pharmacology, Faculty of Pharmacy