Laboratory of respiratory pharmacology

The laboratory studies substances acting on the respiratory using both in vitro and in vivo methods.

Current research topics

• In vitro evaluation od quinazoline alkaloids derivatives by the method of isolated trachea
• In vivo study of promising compounds under physiological conditions and in experimentally induced allergic asthma (determination of lung resistance and compliance)
• Determination of acute toxicity potential of antiasthmatics

Current staff  

Faculty employees

• Marie Vopršalová, Pharm.D., Ph.D.
• Jana Pourová, Pharm.D., Ph.D.

Recent publications

• Spulak, M., Pourová, J., Vopršalová, M. et al. Novel bronchodilatory quinazolines and quinoxalines: Synthesis and biological evaluation.  Eur J Med Chem 2014;74: 65-72
• Pourová, J., Kottová,M., Vopršalová, M., Pour., M:. Reactive oxygen and nitrogen species in normal physiological processes. Acta Physiol (Oxf) 2010; 198(1):15-35
• Kottová, M., Vopršalová M., Pourová J: Farmakoterapie asthma bronchiale. Praktické lékárenství 2008; 3: 116-122
• Kottová, M., Pourová, J., Vopršalová, M.: Oxidační stres a jeho role v respiračních onemocněních. Česká Slov Farm 2007;56(5): 215-219
• Suchankova, J., Voprsalova, M., Kottova, M., Semecky, V., Visnovsky, P: Effects of Oral α-Tocopherol on Lung Response in Rat Model of Allergic Asthma. Respirology 2006; 11(4): 414-421

Collaboration

at the faculty

• Department of Inorganic and Organic Chemistry
• Deparment of pharmaceutical botany and ecology

international

• prof. Julio Cortijo and prof. Esteban Morcillo (Facultad de Medicina, Universidad de Valencia, Spain)

Grants

Succesfully finished grants

•  2002 Charles University in Prague: EFFECTS OF ORAL ANTIOXIDANTS  IN RAT MODEL OF ALLERGIC ASTHMA. Principal investigator: Jana Suchánková - Pourová, Pharm.D., Ph.D.
• 2006 Ministry of Education, Youth and Sports: EXTENSION OF PRACTICAL TEACHING IN TOXICOLOGY, MONITORING CHANGES IN AIRWAY REACTIVITY.  Principal investigator: Marie Vopršalová, Pharm.D., Ph.D.
• 2007 Ministry of Education, Youth and Sports: INNOVATION OF PRACTICAL EDUCATION  IN  TOXICOLOGY. Principal investigator: Marie Vopršalová, Pharm.D., Ph.D.
• 2012 - 2014 Charles University in Prague, in collaboration with Department of anorganic and organic chemistry: Novel Types of Chiral Organocatalysts Derived from the Alcaloid Vasicinone

ongoing grants

• 2015 - 2017 Czech grant agency, in collaboration with Department of anorganic and organic chemistry: Natural Lactones and Lactams: Towards Diverse Biological Activities through Purposeful Synthetic Manipulations