Prof. Ing. Lucie Cahlíková, Ph.D.

Research focus

  • secondary metabolites from plant family Amaryllidaceae (analysis, isolation, structural identification)
  • GC/MS analysis of biological active compounds
  • preparation of analoques of Amaryllidaceae alkaloids
  • biological activity of secondary metabolites and their analoques (AChE, BuChE inhibition activity, cytotoxic activity, antioxidative activity)

Education and professional carrier

  • Head of the Department of Pharmaceutical Botany at Faculty of Pharmacy in Hradec Králové, Charles University since 2014
  • 2014 Habilitation in Pharmacognosy, Faculty of Pharmacy in Hradec Kralove, Charles University (Docent degree, equiv. Assoc. Prof.). Thesis title: Amaryllidaceae alkaloids as potential drugs

  • 2001-2008 Ph.D in Organic Chemistry, Department of Natural Compound, Academy of Science of the Czech Republic; The Institute of Chemical Technology, Prague
  • 2001-2002 Postgradstelle; Novartis Pharma AG, Basel, Switzerland
  • 1999-2000 Trainee; Novartis Pharma AG, Basel, Switzerland
  • 1994-2001 Ing. In Chemistry of Natural Compounds, Faculty of Food and Biochemical Technology, The Institute of Chemical Technology, Prague
  • 2020: Full Professorship, Charles University, Faculty of Pharmacy, Field: Pharmacognosy

Teaching activities

  • Phytochemical methods
  • Pharmaceutical botany
  • Toxicity of natural products (lectures)
  • Mentor of 25 Diploma Thesis students so far
  • Mentor of 4 PhD students currently

Professional membership

  • since 1999 – Czech Chemical Society

Grants received

  • CAHLÍKOVÁ, L., OPLETAL, L.: Acquisition of equipment for innovation and improvement of knowledges in the field of chemical structural analysis of low molecular organic compounds and their integration in the pharmaceutical sciences. FRVŠ 190/2012/A (2012).
  • OPLETAL, L., SOLICH, P., JAHODÁŘ, L., VYTLAČILOVÁ, J., MATYSOVÁ, L., MACÁKOVÁ, K., CAHLÍKOVÁ, L., POLÁŠEK, M.: Innovation of laboratories for teaching courses dealing with the isolation of natural products and their analytical evaluation. FRVŠ 664/2011 (2011).
  • CHLEBEK, J., CAHLÍKOVÁ, L., MACÁKOVÁ, K., OPLETAL, L..: Plant secondary metabolites from subclasses Magnoliidae, Ranunculidae, Cornidae a Lamiidae influencing in vitro activity of human cholinesterases as a contribution to study of Alzheimerʼs disease: bio-guided isolation strategy. Grant Agency of Charles University, No. 122309/2009/B-BIO (2009–2011).

Publications

Monographs (and chapters)

2014

MACÁKOVÁ, K., KOLEČKÁŘ, V., CAHLÍKOVÁ, L., CHLEBEK, J., HOŠŤÁLKOVÁ, A., KUČA, K., JUN, D., OPLETAL, L.: Tannins and their influence on health. Recent Advances in Medicinal Chemistry. Bentham Science Publishers 1, 159-208 (2014).

CAHLÍKOVÁ, L., MACÁKOVÁ, K., BENEŠOVÁ, N., CHLEBEK, J., HOŠŤÁLKOVÁ, A., OPLETAL, L.: Natural compounds (small molecules) as potential and real drugs of Alzehimers disease: A critical review, in: Studies in natural products chemistry (ATTA-ur-RAHMAN, ed.), Chapter 6, Elsevier: Amsterdam 2014, pp. 153-194, ISBN: 978-0-444-63281-4.

2010

OPLETAL, L., MACÁKOVÁ, K., CAHLÍKOVÁ, L.: Antiinvazní látky přírodního původu jako preventivní faktor v ontogenezi zvířat, in: OPLETAL, L., SKŘIVANOVÁ, V. (eds): Přírodní látky a jejich biologická aktivita. Sv. 2: Využití látek pro ovlivnění fyziologických procesů hospodářských zvířat, s. 203–309, Karolinum, Praha 2010, ISBN 978-80-246-1801-2.

Original papers

2021

AL SHAMMARI, L., HULCOVÁ, D., MAŘÍKOVÁ, J., KUČERA, T., ŠAFRATOVÁ, M., NOVÁKOVÁ, L., SCHMIDT, M., PULKRÁBKOVÁ, L., JANOUŠEK, J., SOUKUP, O., KUNEŠ, J., OPLETAL, L., CAHLÍKOVÁ, L.: Amaryllidaceae alkaloids from Hippeastrum x hybridum cv. Ferrari, and preparation of vittatine derivatives as potential ligands for Alzheimer’s disease. S. Afr. J. Bot. 136, 137-146 (2021). https://doi.org/10.1016/j.sajb.2020.06.024

MAŘÍKOVÁ, J., AL MAMUN, A., AL SHAMMARI, L., KORABEČNÝ, J., KUČERA, T., HULCOVÁ, D., KUNEŠ, J., MALANÍK, M., VAŠKOVÁ, M., KOHELOVÁ, E., NOVÁKOVÁ, L., CAHLÍKOVÁ, L., POUR, M.: Structure Elucidation and cholinesterase inhibition activity of two new minor Amaryllidaceae alkaloids; Molecules 26, 1279 (2021). https://doi.org/10.3390/molecules26051279

KOHELOVÁ, E., MAŘÍKOVÁ, J., KORÁBEČNÝ, J., HULCOVÁ, D., KUČERA, T., JUN, D., CHLEBEK, J., JENČO, J., ŠAFRATOVÁ, M., HRABINOVÁ, M., RITOMSKÁ, A., MALANÍK, M., PEŘINOVÁ, R., BREITEROVÁ, K., KUNEŠ, J., NOVÁKOVÁ, L., OPLETAL, L., CAHLÍKOVÁ, L.: Alkaloids of Zephyrantes citrina (Amaryllidaceae) and their implication to Alzheimerʼs disease: isolation, structural elucidation and biological activity. Bioorg. Chem. 107, 104567 (2021). https://doi.org/10.1016/j.bioorg.2020.104567

2020

CAHLÍKOVÁ, L., KAWANO, I., ŘEZÁČOVÁ, M., BLUNDEN, G., HULCOVÁ, D., HAVELEK, R.: The Amaryllidaceae alkaloids haemanthamine, haemanthidine and their semisynthetic derivatives as potential drugs. Phytochem. Rev. 20, 303–323 (2020). https://doi.org/10.1007/s11101-020-09675-8

PEŘINOVÁ, R., MAAFI, M., KORÁBEČNÝ, J., KOHELOVÁ, E., DE SIMONE, A., AL MAMUN, A., HULCOVÁ, D.,MARKOVÁ, J., KUČERA, T., JUN, D., ŠAFRATOVÁ, M., MAŘÍKOVÁ, J., ANDRISANO, V., JENČO, J., KUNEŠ, J., MARTINEZ, A., NOVÁKOVÁ, L., CAHLÍKOVÁ, L.: Functionalized aromatic esters of the Amaryllidaceae alkaloid haemanthamine and their in vitro and in silico biological activity connected to Alzheimer´s disease. Bioorg. Chem. 100, 103928 (2020). https://doi.org/10.1016/j.bioorg.2020.103928

KOUTOVA, D., MAAFI, M., HAVELEK, R., OPLETAL, L., BLUNDEN, G., ŘEZÁČOVÁ, M., CAHLÍKOVÁ, L.: Chemical and Biological Aspects of Montanine-Type Alkaloids Isolated from Plants of the Amaryllidaceae Family. Molecules 25, 2337 (2020). https://doi.org/10.3390/molecules25102337

MAŘÍKOVÁ, J., RITOMSKÁ, A., KORÁBEČNÝ, J., PEŘINOVÁ, R., AL MAMUN, A., KUČERA, T., KOHELOVÁ, E., HULCOVÁ, D., KOBRLOVÁ, T., KUNEŠ, J., NOVÁKOVÁ, L., CAHLÍKOVÁ, L.: Aromatic esters of the crinane Amaryllidaceae alkaloid ambelline as selective inhibitors of butyrylcholinesterase. J. Nat. Prod. 83, 1359-1367 (2020). https://doi.org/10.1021/acs.jnatprod.9b00561

AL MAMUN, A., MAŘÍKOVÁ, J., HULCOVÁ, D., JANOUŠEK, J., ŠAFRATOVÁ, M., NOVÁKOVÁ, L., KUČERA, T., HRABINOVÁ, M.,  KUNEŠ, J., KORÁBEČNÝ, J., CAHLÍKOVÁ, L: Amaryllidaceae alkaloids of belladine-type from Narcissus pseudonarcissus cv. Carlton as new selective inhibitors of butyrylcholinesterase. Biomolecules 10, 800 (2020). https://doi.org/10.3390/biom10050800

BREITEROVÁ, K., KOUTOVÁ, D., HAVELEK, R., KUNEŠ, J., MAJOROŠOVÁ, M., OPLETAL, L., HOŠŤÁLKOVÁ, A., JENČO, J., ŘEZÁČOVÁ, M., CAHLÍKOVÁ, L.: Amaryllidaceae alkaloids of different structural types from Narcissus L. cv. Professor Einstein and their cytotoxic activity. Plants 9, 137, (2020). https://doi.org/10.3390/plants9020137

AL SHAMMARI, L., AL MAMUN, A., KOUTOVÁ, D., MAJOROŠOVÁ, M., HULCOVÁ, D., ŠAFRATOVÁ, M., BREITEROVÁ, K. MAŘÍKOVÁ, J., HAVELEK, R., CAHLÍKOVÁ, L.: Alkaloid profiling of Hippeastrum cultivars by GC-MS, isolation of Amaryllidaceae alkaloids and evaluation of their cytotoxicity. Rec. Nat. Prod. 14, 154-159 (2020). http://doi.org/10.25135/rnp.147.19.06.1302

KOUTOVA, D., KULHAVA, M., HAVELEK, R., MAJOROSOVA, M., KRALOVEC, K., HABARTOVA, K., HOSTALKOVA, A., OPLETAL, L., CAHLIKOVA, L., REZACOVA, M.: Bersavine: a novel bisbenzylisoquinoline alkaloid with cytotoxic, antiproliferative and apoptosis-inducing effect on human leukemic cells. Molecules 25, 964 (2020). https://doi.org/10.3390/molecules25040964

2019

KOHELOVÁ, E., PEŘINOVÁ, R., MAAFI, N., KORABEČNÝ, J., HULCOVÁ, D., MAŘÍKOVÁ, J., KUČERA, T., GONZÁLEZ, L.M., HRABINOVÁ, M., VORČÁKOVÁ, K., NOVÁKOVÁ, L.,  DE SIMONE, A., HAVELEK, R., CAHLÍKOVÁ, L. Derivatives of the β-crinane Amaryllidaceae alkaloid haemanthamine as multi-target directed ligands for Alzheimer’s disease. Molecules 24, 1307 (2019). https://doi.org/10.3390/molecules24071307

CHLEBEK, J., KORÁBEČNÝ, J., DOLEŽAL, R., ŠTĚPÁNKOVÁ, Š., PÉREZ, D.I., HOŠŤÁLKOVÁ, A., OPLETAL, L., CAHLÍKOVÁ, L., MACÁKOVÁ, K., KUČERA, T., HRABINOVÁ, M., JUN, D. In vitro and in silico acetylcholinesterase inhibitory activity of thalictricavine and canadine and their predicted penetration across the blood-brain barrier. Molecules 24, 1340 (2019). https://doi.org/10.3390/molecules24071340

HOSTALKOVA, A., MARIKOVA, J., OPLETAL, L., KORABECNY, J., HULCOVA, D., KUNES, J., NOVAKOVA, L., PEREZ, D.I, JUN, D., KUCERA, T., ANDRISANO, V., CAHLIKOVA, L. Isoquinoline alkaloids from Berberis vulgaris as potential lead compounds for the treatment of Alzheimer’s disease. J. Nat. Prod. 82, 239-248 (2019). https://doi.org/10.1021/acs.jnatprod.8b00592

HULCOVÁ, D., MAŘÍKOVÁ, J., KORÁBEČNÝ, J., HOŠŤÁLKOVÁ, A., JUN, D., KUNEŠ, J. CHLEBEK, J., OPLETAL, L., DE SIMONE, A., NOVAKOVA, L., ANDRISANO, V., RŮŽIČKA, A., CAHLÍKOVÁ, L.: Amaryllidaceae alkaloids from Narcissus pseudonarcissus L. cv. Dutch Master as potential drugs in treatment of Alzheimer's disease. Phytochemistry 165, 112055, (2019). https://doi.org/10.1016/j.phytochem.2019.112055

2018

BREITEROVÁ, K., LOČÁREK, M., KOHELOVÁ, E., TALACKOVÁ, M., HULCOVÁ, D., OPLETAL, L., CAHLÍKOVÁ, L.: Daffodils as potential crops of biologically-active compounds: Assesment of 40 ornamental taxa for their alkaloid profile and cholinesterase inhibition activity. Nat. Prod. Commun. 13, 419-422 (2018). https://doi.org/10.1177/1934578X1801300410

ŠAFRATOVÁ, M., HOŠŤÁLKOVÁ, A., HULCOVÁ, D., BREITEROVÁ, K., HRABCOVÁ, V., MACHADO, M., FONTINHA, D., PRUDENCIO, M., KUNEŠ, J., CHLEBEK, J., JUN, D., HRABINOVÁ, M., NOVÁKOVÁ, L., HAVELEK, R., SEIFERTOVÁ, M., OPLETAL, L., CAHLÍKOVÁ, L: Alkaloids from Narcissus poeticus cv. Pink Parasol of various structural types and their biological activity. Arch. Pharm. Res. 41, 208-218 (2018).  https://doi.org/10.1007/s12272-017-1000-4

HABARTOVÁ, K., HAVELEK, R., SEIFERTOVÁ, M., KRÁLOVEC, K., CAHLÍKOVÁ, L., CHLEBEK, J., ČERMÁKOVÁ, E., MAZÁNKOVÁ, N., MAŘÍKOVÁ, J., KUNEŠ, J., NOVÁKOVÁ, L., ŘEZÁČOVÁ, M.: Scoulerine affects microtubule structure, inhibits proliferation, arrests cell cycle and thus culminates in the apoptotic death of cancer cells. Sci. Reports 8,  4829 (2018). https://doi.org/10.1038/s41598-018-22862-0

HULCOVÁ, D., BREITEROVÁ, K., SIATKA, T., KLÍMOVÁ, K., DAVANI, L., ŠAFRATOVÁ, M., HOŠŤÁLKOVÁ, A., DE SIMONE, A., ANDRISANO, A., CAHLÍKOVÁ, L.: Amaryllidaceae alkaloids as potential glycogen synthase kinase-3 beta inhibitors. Molecules 23, 719 (2018). https://doi.org/10.3390/molecules23040719

2017

SEIFRTOVÁ, M., HAVELEK ,R., CAHLÍKOVÁ, L., HULCOVÁ, D., MAZÁNKOVÁ, N., ŘEZÁČOVÁ, M.: Haemanthamine alters sodium butyrate-induced histone acetylation, p21WAF1/Cip1 expression, Chk1 and Chk2 activation leading to increased growth inhibition and death in A2780 ovarian cancer cells. Phytomedicine 35, 1-10 (2017). https://doi.org/10.1016/j.phymed.2017.08.019

HAVELEK ,R., SEIFRTOVA, M., KRALOVEC, K., HABARTOVA, Klara., CAHLIKOVA, L., REZACOVA, M.: Chelidonine and homochelidonine induce cell death through cell cycle checkpoints and MAP kinase pathways. Nat. Prod. Commun. 12, 1419-1430 (2017). https://doi.org/10.1177/1934578X1701200910

HAVELEK, R., MUTHNA, D., TOMSIK, P., KRALOVEC, K., SEIFRTOVÁ, M., CAHLÍKOVÁ, L., HOŠŤÁLKOVÁ, A., ŠAFRATOVÁ, M., PERWEIN, M., ČERMÁKOVÁ, E.,  ŘEZÁČOVÁ, M.: Anticancer potential of Amaryllidaceae alkaloids evaluated by a screening with a panel of human cells, real-time cellular analysis and Ehrlich tumor-bearing mice.  Chem. Biol. Interact. 275, 121-132 (2017). https://doi.org/10.1016/j.cbi.2017.07.018

HULCOVÁ, D., BREITEROVÁ, K., ZEMANOVÁ, L., SIATKA, T., ŠAFRATOVÁ, M., VANĚČKOVÁ, N., HOŠŤÁLKOVÁ, A., WSÓL, V., CAHLÍKOVÁ, L.: Screening of AKR1C3 inhibitory potency of naturally occuring Amaryllidaceae alkaloids of different structural types. Nat. Prod. Commun. 12, 245-246 (2017). https://doi.org/10.1177/1934578X1701200226

ALI, B. H., CAHLÍKOVÁ, L., OPLETAL, L., KARACA, T., MANOJ, P., RAMKUMAR, A., AL SULEIMANI Y. M., AL ZA'ABI, M., NEMMAR, A., CHOCHOLOUŠOVÁ-HAVLÍKOVÁ, L., LOČÁREK, M., SIATKA, T., BLUNDEN, G.: Effect of aqueous extract and anthocyanins of calces of Hibiscus sabdariffa (Malvaceae) in rats with adenine-induced chronic kidney disease. J. Pharm. Pharmacol. 69, 1219-1229 (2017). https://doi.org/10.1111/jphp.12748

OPLETAL, L., CHOCHOLOUŠOVÁ-HAVLÍKOVÁ, L., SIATKA, T., CAHLÍKOVÁ, L., LOČÁREK, M., BADRELDIN, H. A., MANOJ, P., RAMKUMAR, A., Al SULEIMANI, Y. M., AL ZA‘ABI, M., KARACA, T., NEMMAR, A.: Preparation and validated analysis of anthocyanin concentrate from the calyces of Hibiscus sabdariffa. Nat. Prod. Commun. 12, 43-45 (2017). https://doi.org/10.1177/1934578X1701200112

SIATKA, T., ADAMCOVÁ, M., OPLETAL, L., CAHLÍKOVÁ, L.,  JUN, D., HRABINOVÁ, M., KUNEŠ, J., CHLEBEK, J.: Cholinesterase and prolyl oligopeptidase Inhibitory activities of alkaloids from Argemone platyceras (Papaveraceae). Molecules 22, 1181 (2017). https://doi.org/10.3390/molecules22071181

2016

HABARTOVÁ, K., CAHLÍKOVÁ, L., ŘEZÁČOVÁ M., HAVELEK, R.: The biological activity of alkaloids from the Amaryllidaceae: from cholinesterases inhibition to anticancer activity. Nat. Prod. Commun. 11, 1587-1594 (2016). https://doi.org/10.1177/1934578X1601101038

VANĚČKOVÁ, N., HOŠŤÁLKOVÁ, A., ŠAFRATOVÁ, M., KUNEŠ, J., HULCOVÁ, D., HRABINOVÁ, H., DOSKOČIL, I., ŠTĚPÁNKOVÁ, Š., OPLETAL, L., NOVÁKOVÁ, L., JUN, D., CHLEBEK, J., CAHLÍKOVÁ, L.: Isolation of Amaryllidaceae alkaloids from Nerine bowdenii W. Watson (Amaryllidaceae) and their biological activity. RSC Advances 6, 80114-80120 (2016). https://doi.org/10.1039/C6RA20205E

HAVELEK, R., SEIFERTOVÁ, M., KRÁLOVEC, K., KROCOVÁ, E., TEJKALOVÁ, V., NOVOTNÝ, I., CAHLÍKOVÁ, L., ŠAFRATOVÁ, M., OPLETAL, L., BÍLKOVÁ, Z., VÁVROVÁ, J., ŘEZÁČOVÁ, M.: Comparative cytotoxicity of chelidonine and homochelidonine, the dimethoxy analogues isolated from Chelidonium majus L. (Papaveraceae), against human leukemic and lung carcinoma cells. Phytomedicine  23, 253-266 (2016). https://doi.org/10.1016/j.phymed.2016.01.001

HROCH, M., HAVELEK, R., CAHLÍKOVÁ, L., HOŠŤÁLKOVÁ, A., HULCOVÁ, D., CERMANOVÁ, J., MIČUDA, S.: LC-MS/MS method for determination of haemanthamine in rat plasma, bile and urine: application to a pilot pharmacokinetic study. Biomed. Chrom. 30, 1083-1091 (2016). https://doi.org/10.1002/bmc.3653

CHLEBEK, J., DOSKOČIL, I., HULCOVÁ, D., BREITEROVÁ, K., ŠAFRATOVÁ, M., HAVELEK, R., HABARTOVÁ, K., HOŠŤÁLKOVÁ, A., VOLŠTÁTOVÁ, T., CAHLÍKOVÁ, L.: Cytotoxicity of naturally occurring isoquinoline alkaloids of  different structural types. Nat. Prod. Commun11, 753-756 (2016). https://doi.org/10.1177/1934578X1601100614

CHLEBEK, J., NOVÁK, Z., KASSEMOVÁ, D., ŠAFRATOVÁ, M., KOSTELNÍK, J., MALÝ, L., LOČÁREK, M., OPLETAL, L., HOŠŤÁLKOVÁ, A., HRABINOVÁ, M., KUNEŠ, J., NOVOTNÁ, P., URBANOVÁ, M., NOVÁKOVÁ, L., MACÁKOVÁ, K., HULCOVÁ, D., SOLICH, P., MARTÍN, C.P., JUN, D., CAHLÍKOVÁ, L..: Isoquinoline alkaloids from Fumaria officinalis L. and their biological activities related to Alzheimer’s disease. Chem. Biodivers. 13, 91-99 (2016). https://doi.org/10.1002/cbdv.201500033

CHLEBEK, J., DE SIMONE, A., HOŠŤÁLKOVÁ, A., OPLETAL, L., PERÉZ, C., PERÉZ, D.I., HAVLÍKOVÁ, L., CAHLÍKOVÁ, L., ANDRISANO, V.: Application of BACE1 immobilized enzyme reactor for the characterization of multifunctional alkaloids from Corydalis cava (Fumariaceae) as Alzheimer’s disease targets. Fitoterapia 109, 241-247 (2016). https://doi.org/10.1016/j.fitote.2016.01.008

2015

ZEMANOVA, L., HOFMAN, J., NOVOTNA, E., MUSILEK, K., LUNDOVA, T., HAVRANKOVA, J., HOSTALKOVA, A., CHLEBEK, J., CAHLIKOVA, L., WSOL, V.: Flavones inhibit the activity of AKR1B10, a promising therapeutic target for cancer treatment. J. Nat. Prod. 78, 2666-2674 (2015). https://doi.org/10.1021/acs.jnatprod.5b00616

NOVÁK, Z., HOŠŤÁLKOVÁ, A., OPLETAL, L., NOVÁKOVÁ, L., HRABINOVÁ, M., KUNEŠ, J., CAHLÍKOVÁ, L.: (+)-Chenabinol (revised NMR data) and two new alkaloids from Berberis vulgaris L. and their biological activity. Nat. Prod. Commun. 10, 1695-1697 (2015). https://doi.org/10.1177/1934578X1501001015

LOČÁREK, M., NOVÁKOVÁ, J., KLOUČEK, P., HOŠŤÁLKOVÁ, A., KOKOŠKA, L., GÁBRLOVÁ, L., ŠAFRATOVÁ, M., OPLETAL, L., CAHLÍKOVÁ, L.: Antifungal and antibacterial activity of extracts and alkaloids of selected Amaryllidaceae species. Nat. Prod. Commun. 10, 1537-1540 (2015). https://doi.org/10.1177/1934578X1501000912

DOSKOČIL, I., HOŠŤÁLKOVÁ, A., ŠAFRATOVÁ, M., BENEŠOVÁ, N., HAVLÍK, J., HAVELEK, R., KUNEŠ, J., KRÁLOVEC, K., CHLEBEK, J., CAHLÍKOVÁ, L.: Cytotoxic activities of Amaryllidaceae alkaloids against gastrointestinal cancer cells. Phytochem. Lett. 13, 394-398 (2015). https://doi.org/10.1016/j.phytol.2015.08.004

CAHLÍKOVÁ, L., PÉREZ, D.I., ŠTĚPÁNKOVÁ, Š, CHLEBEK, J., ŠAFRATOVÁ, M., HOŠŤÁLKOVÁ, A., OPLETAL, L.: In vitro inhibitory effects of 8-O-demethylmaritidine and undulatine on acetylcholinesterase, and their predicted penetration across the blood-brain barrier. J. Nat. Prod. 78, 1189-1192 (2015). https://doi.org/10.1021/acs.jnatprod.5b00191

HOŠŤÁLKOVÁ, A., OPLETAL, L., KUNEŠ, J., NOVÁK, Z., HRABINOVÁ, M., CHLEBEK, J., CAHLÍKOVÁ, L.: Alkaloids from Peumus boldus Mol. and their acetylcholinesterase, butyrylcholinesterase and prolyl oligopeptidase inhibition activity. Nat.. Prod. Commun. 10, 577-580 (2015). https://doi.org/10.1177/1934578X1501000410

CAHLÍKOVÁ, L., HULOVÁ, L., HRABINOVÁ, M., CHLEBEK, J., HOŠŤÁLKOVÁ, A., ADAMCOVÁ, M., ŠAFRATOVÁ, M., JUN, D., OPLETAL, L., LOČÁREK, M., MACÁKOVÁ, K.: Isoquinoline alkaloids as potential prolyl oligopeptidase inhibitors. Fitoterapia 103, 192-196 (2015). https://doi.org/10.1016/j.fitote.2015.04.004

CAHLÍKOVÁ, L., ALI B.H., HAVLÍKOVÁ L., LOČÁREK, M., SIATKA, T., OPLETAL, L., BLUNDEN, G.: Anthocyanins of Hibiscus sabdiffera Calyces from Sudan. Nat. Prod. Commun.  10, 77-79 (2015). https://doi.org/10.1177/1934578X1501000120

2014

OPLETAL, L., LOČÁREK, M., FRAŇKOVÁ, A., CHLEBEK, J., ŠMÍD, J., HOŠŤÁLKOVÁ, A., ŠAFRATOVÁ, M., HULCOVÁ, D., KLOUČEK P., ROZKOT, M., CAHLÍKOVÁ, L.: Antimicrobial activity of extracts and isoquinoline alkaloids of selected Papaveraceae plants. Nat. Prod. Commun. 9, 1709-1712 (2014). https://doi.org/10.1177/1934578X1400901211

ŠAFRATOVÁ, M., NOVÁK, Z., KULHÁNKOVÁ, A., KUNEŠ, J., HRABINOVÁ,M., JUN, D., MACÁKOVÁ K., OPLETAL, L., CAHLÍKOVÁ, L.: Revised NMR data for 9-O-demethylgalanthine: an alkaloid from Zephyranthes robusta (Amaryllidaceae) and its biological aktivity. Nat. Prod. Commun.  9, 787-788 (2014). https://doi.org/10.1177/1934578X1400900614

HAVLASOVÁ, J., ŠAFRATOVÁ, M., SIATKA, T., ŠTĚPÁNKOVÁ, Š., LOČÁREK, M., OPLETAL, L., HRABINOVÁ, M., JUN, D., BENEŠOVÁ, N., NOVÁK, Z., KUNEŠ, J., CAHLÍKOVÁ, L.: Chemical composition of bioactive alkaloid extracts from some Narcissus species and varieties and their biological activity. Nat. Prod. Commun. 9, 1151-1155 (2014). https://doi.org/10.1177/1934578X1400900823

ŠKARYDOVÁ, L., HOFMAN, J., CHLEBEK, J., HAVRÁNKOVÁ, J., KOŠANOVÁ, K., SKARKA, A., HOŠŤÁLKOVÁ, A., PLUCHA, T., CAHLÍKOVÁ, L., WSÓL, V.: Isoquinoline alkaloids as a novel type of AKR1C3 inhibitors. J. Steroid Biochem. Mol. Biol. 143, 250-258 (2014). https://doi.org/10.1016/j.jsbmb.2014.04.005 

SCHRAMM, A., JÄHNE, E., BABURIN, I., HERING, S., CAHLÍKOVÁ, L., CHLEBEK, J., HAMBURGER, M.: Natural products as potential human ether-a-go-go-related gene channel inhibitors – screening of plant-derived alkaloids . Planta Med. 80, 740-746 (2014). https://doi.org/10.1055/s-0034-1368590

ŘEHÁKOVÁ, Z., KOLEČKÁŘ, V., JAHODÁŘ, L., OPLETAL, L., MACÁKOVÁ, K., CAHLÍKOVÁ, L., JUN, D., KUČA, K.: Evaluation of the antioxidant activity of several naturally occuring coumarins and their synthesized analouges by „ferric reducing antioxidant power“ assay. J. Enzym. Inhib. Med. Chem. 29, 49-54 (2014). https://doi.org/10.3109/14756366.2012.753589

HAVELEK, R., SEIFERTOVÁ, M., KRÁLOVEC, K., BRŮČKOVÁ, L., CAHLÍKOVÁ, L., DALECKÁ, M., VÁVROVÁ, J., ŘEZÁČOVÁ, M., OPLETAL, L., BÍLKOVÁ, Z.: The effect of Amaryllidaceae alkaloids haemanthamine and haemanthidine on cell cycle progression and apoptosis in p53-negative human leukemic Jurkat cell. Phytomedicine 21, 479-490 (2014). https://doi.org/10.1016/j.phymed.2013.09.005

2013

CAHLÍKOVÁ, L., HRABINOVÁ, M., KULHÁNKOVÁ, A., BENEŠOVÁ, N., CHLEBEK, J., JUN, D., NOVÁK, Z., KUČA, K., MACÁKOVÁ, K., OPLETAL, L. Alkaloids from Chlidanthus fragrans Herb. and their acetylcholinesterase, butyrylcholinesterase and prolyl oligopeptidase inhibition activity. Nat. Prod. Commun. 8, 1541-1544 (2013). https://doi.org/10.1177/1934578X1300801110

CAHLÍKOVÁ, L., LOČÁREK, M., BENEŠOVÁ, N., KUČERA, R., CHLEBEK, J., NOVÁK, Z., OPLETAL, L.: Isolation and cholinesterase inhibitory activity of Narcissus extracts and Amaryllidaceae alkaloid. Nat. Prod. Commun. 8, 781-785 (2013). https://doi.org/10.1177/1934578X1300800625

HOŠŤÁLKOVÁ, A., NOVÁK, Z., POUR, M., JIROŠOVÁ, A., OPLETAL, L., KUNEŠ, J., CAHLÍKOVÁ, L.: Berbanine: a new isoquinoline alkaloid from Berberis vulgaris (Berberidaceae). Nat. Prod. Commun. 8, 441-442 (2013). https://doi.org/10.1177/1934578X1300800407

KULHÁNKOVÁ, A., CAHLÍKOVÁ, L., NOVÁK, Z., MACÁKOVÁ, K., KUNEŠ, J., OPLETAL, L.: Alkaloids from Zephyranthes robusta Baker and their acetylcholinesterase and butyrylcholinesterase inhibition activity. Chem. Biodivers. 10, 1120-1127 (2013). https://doi.org/10.1002/cbdv.201200144

DALECKÁ, M., HAVELEK, R., KRALOVEC, K., BRUČKOVÁ, L., CAHLÍKOVÁ, L.: Amaryllidaceae family alkaloids as potential drugs for cancer treatment. Chem. listy 107, 701-708 (2013). http://chemicke-listy.cz/docs/full/2013_09_701-708.pdf

2012

CAHLÍKOVÁ, L., KUČERA, R., HOŠŤÁLKOVÁ, A., KLIMEŠ, J., OPLETAL, L.: Identification of pavinane alkaloids in the genera Argemone and Eschscholzia by GC-MS. Nat. Prod. Commun. 7, 1279-1281 (2012). https://doi.org/10.1177/1934578X1200701008

NOVÁK, Z., CHLEBEK, J., OPLETAL, L., JIROŠ, P., MACÁKOVÁ, K., KUNEŠ, J., CAHLÍKOVÁ, L.: Corylucinine, a new Alkaloid from Corydalis cava (Fumariaceae), and its cholinesterase activity. Nat. Prod. Commun. 7, 859-860 (2012). https://doi.org/10.1177/1934578X1200700712

CAHLÍKOVÁ, L., BENEŠOVÁ, N., MACÁKOVÁ, K., KUČERA, R., HRSTKA, V., KLIMEŠ, J., JAHODÁŘ, L., OPLETAL, L.: Alkaloids of some Amaryllidaceae species and their cholinesterase activity. Nat. Prod. Commun. 7, 571-574 (2012). https://doi.org/10.1177/1934578X1200700506

2011

CAHLÍKOVÁ, L., VALTEROVÁ, I., MACÁKOVÁ, K., OPLETAL, L.: Analysis of Amaryllidaceae alkaloids from Zephyranthes grandiflora Lindl. by GC/MS and their cholinesterase activity. Rev. Brasil. Farmacogn. 21, 575-580 (2011).  https://doi.org/10.1590/S0102-695X2011005000089.

CAHLÍKOVÁ, L., ZAVADIL, S. MACÁKOVÁ, K., VALTEROVÁ, I., KULHÁNKOVÁ, A., HOŠŤÁLKOVÁ, A., KUNEŠ, J., OPLETAL, L.: Isolation and cholinesterase activity of Amaryllidaceae alkaloids from Nerine bowdenii. Nat. Prod. Commun. 6, 1827-1830 (2011). https://doi.org/10.1177/1934578X1100601210

CAHLÍKOVÁ, L., BENEŠOVÁ, N., MACÁKOVÁ, K., URBANOVÁ, K., OPLETAL, L.: GC/MS Analysis of three Amaryllidaceae species and their cholinesterase activity. Nat. Prod. Commun. 9, 1255-1258 (2011). https://doi.org/10.1177/1934578X1100600912

CHLEBEK, J., MACÁKOVÁ, K., CAHLÍKOVÁ, L., KURFÜRST, M., KUNEŠ, J., OPLETAL, L.: Acetylcholinesterase and butyrylcholinesterase inhibitory compounds from Corydalis cava Schweigger. & Korte (Fumariaceae). Nat. Prod. Commun. 6, 607-610 (2011).  https://doi.org/10.1177/1934578X1100600507

CAHLÍKOVÁ, L., MACÁKOVÁ, K., ZAVADIL, S., JIROŠ, P., OPLETAL, L., URBANOVÁ, K., JAHODÁŘ, L.: Analysis of Amaryllidaceae alkaloids from Chlidanthus fragrans and their cholinesterase aktivity. Nat. Prod. Commun. 6, 603-606 (2011). https://doi.org/10.1177/1934578X1100600506

CAHLÍKOVÁ, L., VALTEROVÁ, I., MACÁKOVÁ, K., OPLETAL, L.: Analysis of Amaryllidaceae alkaloids from Zephyranthes grandiflora Lindl. by GC/MS and their cholinesterase activity. Revista Brasileira de Farmacognosia/Bras. J. Pharmacognosy 21, 575-580 (2011). https://doi.org/10.1590/S0102-695X2011005000089

2010

CAHLÍKOVÁ, L., OPLETAL, L., KURFÜRST, M., MACÁKOVÁ, K., KULHÁNKOVÁ, A., HOŠŤÁLKOVÁ, A.: Acetylcholinesterase and butyrylcholinesterase inhibitory compounds from Chelidonium majus (Papaveraceae). Nat. Prod. Commun. 5, 1751-1754 (2010). https://doi.org/10.1177/1934578X1000501110

CAHLÍKOVÁ, L., KULHÁNKOVÁ, A., URBANOVÁ, K., VALTEROVÁ, I., MACÁKOVÁ, K., KUNEŠ, J.: Analysis of Amaryllidaceae alkaloids from Zephyranthes robusta by GC-MS and their cholinesterase activity. Nat. Prod. Commun. 5, 1201-1204 (2010). https://doi.org/10.1177/1934578X1000500810

CAHLÍKOVÁ, L., MACÁKOVÁ, K., KUNEŠ, J., KURFÜRST, M., OPLETAL, L., CVAČKA, J., CHLEBEK, J., BLUNDEN, G.: Acetylcholinesterase and butyrylcholinesterase inhibitory compounds from Eschscholzia californica (Papaveraceae). Nat. Prod. Commun. 5, 1035-1038 (2010). https://doi.org/10.1177/1934578X1000500710

2008

URBANOVÁ, K., CAHLÍKOVÁ, L., HOVORKA, O., PTÁČEK, V., VALTEROVÁ, I.: Age-dependent changes in the exocrine glands secretion of Bombus terrestris queens. J. Chem. Ecol. 34, 458-466 (2008). https://doi.org/10.1007/s10886-008-9456-9

ŠOBOTNÍK, J., KALINOVÁ, B., CAHLÍKOVÁ, L., WEYDA, F., PTÁČEK, V., VALTEROVÁ, I.: Age-dependent changes in structure and function of the male labial gland in Bombus terrestris. J. Insect Physiol. 54, 204-214 (2008). https://doi.org/10.1016/j.jinsphys.2007.09.003

2005

RASMONT, P., TENZO, M., AYTEKIN, A. M., HINES, H., URBANOVÁ, K., CAHLÍKOVÁ, L., VALTEROVÁ, I.: Cephalic secretion of the bumblebee subgenus Sibiricobombus Vogt suggest Bombus niveatus kriechbaumer and Bombus vorticosus gerastaecker are conspecific. Apidologie 36, 571-584 (2005). https://doi.org/10.1051/apido:2005047

2004

CAHLÍKOVÁ, L., HOVORKA, O., PTÁČEK, V., VALTEROVÁ, I.: Exocrine gland secretion of virgin queens of five Bumblebee species. Z. Naturforsch. C 59c, 582-589 (2004). https://doi.org/10.1515/znc-2004-7-824

Reviews

2020

CAHLÍKOVÁ, L., BREITEROVÁ, K., OPLETAL, L.: Chemistry and biological activity of alkaloids from the genus Lycoris (Amaryllidaceae). Molecules 25, 4797 (2020). https://doi.org/10.3390/molecules25204797

2019

CAHLIKOVA, L., VANECKOVA, N., SAFRATOVA, M., BREITEROVA, K., BLUNDEN, G., HULCOVA, D., OPLETAL, L.: The genus Nerine Herb. (Amaryllidaceae): ethnobotany, phytochemistry, and biological activity. Molecules 24, 4238 (2019).  https://doi.org/10.3390/molecules24234238

2015

HOŠŤÁLKOVÁ, A., SIATKA, T., CHLEBEK, J., OPLETAL, L., DRAŠAR, P., CAHLÍKOVÁ, L.: Boldinové alkaloidy a perspektivity jejich využití. Chem. listy 109, 846-855 (2015). http://chemicke-listy.cz/docs/full/2015_11_846-855.pdf

2014

ČOPÍKOVÁ, J., WIMMER, Z., LAPČÍK, O., CAHLÍKOVÁ, L., OPLETAL, L., MORAVCOVÁ, J., DRAŠAR, P.: Přírodní látky svíravé a trpké chuti. Chem. Listy 108, 1053-1057 (2014). http://www.chemicke-listy.cz/ojs3/index.php/chemicke-listy/article/view/437/437

2013

DALECKÁ, M., HAVELEK, R., KRÁLOVEC, K., BRŮČKOVÁ, L., CAHLÍKOVÁ, L.: Alkaloidy rostlin čeledi Amaryllidaceae jako potenciální léčiva v terapii nádorových onemocnění. Chem. Listy 107, 701-708 (2013). http://chemicke-listy.cz/docs/full/2013_09_701-708.pdf

OPLETAL, L., CHLEBEK, J., MACÁKOVÁ, K., BENEŠOVÁ, N., HOŠŤÁLKOVÁ, A., CAHLÍKOVÁ, L.: Antioxidanty a degenerativní onemocnění. Prakt. Lékáren. 9, 135-138 (2013). https://www.praktickelekarenstvi.cz/pdfs/lek/2013/03/11.pdf

2012

KOLEČKÁŘ, V., ŘEHÁKOVÁ, Z, BROJEROVÁ, E., KUČA, K., JUN, D., MACÁKOVÁ, K., OPLETAL, L., DRAŠAR, P., JAHODÁŘ, L., CHLEBEK, J., CAHLÍKOVÁ, L.: Proanthocyanidiny a jejich antioxidační aktivita. Chem. listy 106, 113-121 (2012). http://www.chemicke-listy.cz/ojs3/index.php/chemicke-listy/article/view/997/997

2011

CAHLÍKOVÁ, L., MACÁKOVÁ, K., CHLEBEK, J., HOŠŤÁLKOVÁ, A., KULHÁNKOVÁ, A., OPLETAL, L.: Ecdysterone and its activity on some degenerative diseases. Nat. Prod. Commun. 6, 707-718 (2011). https://doi.org/10.1177/1934578X1100600527

OPLETAL, L., WIMMER, Z, ČOPÍKOVÁ, J., LAPČÍK, O., MORAVCOVÁ, J., CAHLÍKOVÁ, L., DRAŠAR, P.: Slaná chuť přírodních látek a jejich derivátů. Chem. listy 105, 761-765 (2011). http://w.chemicke-listy.cz/docs/full/2011_10_761-765.pdf

Others

2020

CAHLÍKOVÁ, L., ŠAFRATOVÁ, M., HOŠŤÁLKOVÁ, A., CHLEBEK, J., HULCOVÁ, D., BREITEROVÁ, K., OPLETAL, L.: Pharmacognosy and its role in the system of profile disciplines in Pharmacy. Nat. Prod. Commun. 15, 1-7 (2020). https://doi.org/10.1177/1934578X20945450

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