Prof. Ing. Lucie Cahlíková, Ph.D.

Research focus

  • secondary metabolites from plant family Amaryllidaceae (analysis, isolation, structural identification)
  • GC/MS analysis of biological active compounds
  • preparation of analoques of Amaryllidaceae alkaloids
  • biological activity of secondary metabolites and their analoques (AChE, BuChE inhibition activity, cytotoxic activity, antioxidative activity)

Education and professional carrier

  • Head of the Department of Pharmaceutical Botany at Faculty of Pharmacy in Hradec Králové, Charles University since 2014 to 2021, since 01/2022 she has become the head the Department of Pharmacognosy and Pharmaceutical Botany at the same Faculty of Pharmacy
  • 2020: Full Professorship, Charles University, Faculty of Pharmacy, Field: Pharmacognosy
  • 2014 Habilitation in Pharmacognosy, Faculty of Pharmacy in Hradec Kralove, Charles University (Docent degree, equiv. Assoc. Prof.). Thesis title: Amaryllidaceae alkaloids as potential drugs
  • 2001-2008 Ph.D in Organic Chemistry, Department of Natural Compound, Academy of Science of the Czech Republic; The Institute of Chemical Technology, Prague
  • 2001-2002 Postgradstelle; Novartis Pharma AG, Basel, Switzerland
  • 1999-2000 Trainee; Novartis Pharma AG, Basel, Switzerland
  • 1994-2001 Ing. In Chemistry of Natural Compounds, Faculty of Food and Biochemical Technology, The Institute of Chemical Technology, Prague

She has studied at the University of Chemistry and Technology in Prague with a specialization in the Chemistry of Natural Products. After graduation in 2001, she continued with doctoral studies at the Institute of Organic Chemistry and Biochemistry in Prague. During her studies she spent two years in Switzerland working for Novartis Pharma AG in the department of Arthritis & Bone Metabolism. In 2004, she entered the Faculty of Pharmacy in Hradec Králové as a member of the Department of Pharmaceutical Botany, and since 2014 she has been head of the Department of Pharmacognosy and Pharmaceutical Botany, and of the Research group „Natural products as potential drugs“. In 2020, she became a full professor in Pharmacognosy. She has published more than 90 scientific papers and supervised eight Ph.D. students. The topics of her research are secondary metabolites from plants, with a focus on alkaloids and their biological activities connected with potential treatment of neurodegenerative, oncological, and microbial diseases. She is also interested in modification of the structure of isoquinoline alkaloids, and total synthesis of minor compounds from the plant family Amaryllidaceae. She is involved in various projects and collaborates with national and international research institutions. 

Currently, she is a Regional representative for Eastern Europe in Phytochemical Society of Europe.

Committee Members – Phytochemical Society of Europe

Teaching activities

  • Phytochemical methods
  • Pharmaceutical botany
  • Toxicity of natural products (lectures)
  • Mentor of 25 Diploma Thesis students so far
  • Mentor of 4 PhD students currently

Professional membership

  • since 1999 – Czech Chemical Society

Grants received

  • CAHLÍKOVÁ, L., OPLETAL, L.: Acquisition of equipment for innovation and improvement of knowledges in the field of chemical structural analysis of low molecular organic compounds and their integration in the pharmaceutical sciences. FRVŠ 190/2012/A (2012).
  • OPLETAL, L., SOLICH, P., JAHODÁŘ, L., VYTLAČILOVÁ, J., MATYSOVÁ, L., MACÁKOVÁ, K., CAHLÍKOVÁ, L., POLÁŠEK, M.: Innovation of laboratories for teaching courses dealing with the isolation of natural products and their analytical evaluation. FRVŠ 664/2011 (2011).
  • CHLEBEK, J., CAHLÍKOVÁ, L., MACÁKOVÁ, K., OPLETAL, L..: Plant secondary metabolites from subclasses Magnoliidae, Ranunculidae, Cornidae a Lamiidae influencing in vitro activity of human cholinesterases as a contribution to study of Alzheimerʼs disease: bio-guided isolation strategy. Grant Agency of Charles University, No. 122309/2009/B-BIO (2009–2011).


Original papers


VRABEC, R., BLUNDEN, G., CAHLÍKOVÁ, L.: Natural alkaloids as multi-target compounds towards factors implicated in Alzheimer's disease. Int. J. Mol. Sci. 24, 4399 (2023).

RITOMSKÁ, A., KOUTOVÁ, D., KŘOUSTKOVÁ, J., KRÁLOVEC, K., MUTHNÁ, D., KUNEŠ, J., NOVÁKOVÁ, L., HAVELEK, R., CAHLÍKOVÁ, L.: Design of semisynthetic derivatives of the Amaryllidaceae alkaloid ambelline and exploration of their in vitro cytotoxic activities. Saudi Pharm. J. 31, 101684 (2023).

PIDANY, F., KROUSTKOVA, J., AL MAMUN, A., SUCHANKOVA, D., BRAZZOLOTTO, X., NACHON, F., CHANTEGREIL, F., DOLEZAL, R., PULKRABKOVÁ, L., MUCKOVA, L., HRABINOVA, M., FINGER, V., KUFA, M., SOUKUP, O., JUN, D., JENCO, J., KUNES, J., NOVAKOVA, L., KORABECNY, J., CAHLIKOVA, L.:  Highly selective butyrylcholinesterase inhibitors related to Amaryllidaceae alkaloids - design, synthesis, and biological evaluation. Eur. J. Med. Chem. 252, 115301 (2023).

KOUTOVÁ, D., MAAFI, N., MUTHNÁ, D., KRÁLOVEC, K., KROUSTKOVA, J., PIDANY, F., TIMBILLA, A., CERMAKOVA, E., CAHLIKOVA, L., REZACOVA, M., HAVELEK, R.: Antiproliferative activity and apoptosis-inducing mechanism of Amaryllidaceae alkaloid montanine on A549 and MOLT-4 human cancer cells. Biomed. Pharmacother. 166, 115295 (2023).


KŘOUSTKOVÁ, J., RITOMSKÁ, A., Al MAMUN, A., HULCOVÁ, D., OPLETAL, L., KUNEŠ, J., CAHLÍKOVÁ, L.,  BUCAR, F.: Structural analysis of unusual alkaloids isolated from Narcissus pseudonarcissus cv. Carlton. Phytochemistry 204, 113439 (2022).  DOI:

WIJAYA, V., JANDOUREK, O., KROUSTKOVA, J., HRADISKA-BREITEROVA, K., KORABECNY, O., SOBOLOVA, K., KOHELOVA, E., HOSTALKOVA, A., KONECNA, K., SAFRATOVA, M., VRABEC, R., KUNES, J., OPLETAL, O., CHLEBEK, J., CAHLIKOVA, L.: Alkaloids of Dicranostigma franchetianum (Papaveraceae) and berberine derivatives as a novel class of antimycobacterial agents. Biomolecules 12, 844 (2022).

UHER, M., HROCH, M., PERINOVA, R., HAVELEK, R., KROUSTKOVA, J., REZACOVA, M., MUTHNA, D., KOUTOVA, D., KUNES, J., CAHLIKOVA, L.: Semisynthetic derivatives of haemanthamine and their in vitro antiproliferative activity evaluation against a panel of human cell lines. Arab. J. Chem. 15,103746 (2022).

VRABEC, R., MAŘÍKOVÁ, J., LOČÁREK, M., KORÁBEČNÝ, J., HULCOVÁ, D., HOŠŤÁLKOVÁ, A., KUNEŠ, J., CHLEBEK, J., KUČERA, T., HRABINOVÁ, M., JUN, D., SOUKUP, O., ANDRISANO, V., JENČO, J., ŠAFRATOVÁ, M., NOVÁKOVÁ, L., OPLETAL, L., CAHLÍKOVÁ, L.: Monoterpene indole alkaloids from Vinca minor L. (Apocynaceae): identification of new structural scaffold for treatment of Alzheimer´s disease. Phytochemistry 194, 113017 (2022).


MAAFI, N., PIDANY, F., MARIKOVA, J., KORABECNY, J., HULCOVA, D., KUCERA, T., SCHMIDT, M., AL SHAMMARI, L., SPULAK, M., CATAPANO, M.C., MECAVA, M., PRCHALD, L., KUNES, J., JANOUSEK, J., KOHELOVA, E., JENCO, J., NOVAKOVA, L., CAHLIKOVA, L.: Derivatives of montanine-type alkaloids and their implication for the treatment of Alzheimer´s disease: Synthesis, biological activity and in silico study. Bioorg. Med. Chem. Let. 51, 128374 (2021).

KOUTOVA, D., HAVELEK, R., PETEROVA, E., MUTHNA, D., KRALOVEC, K., BREITEROVA, K., CAHLIKOVA, L., REZACOVA, M.: Pancracine, a montanine-type Amaryllidaceae alkaloid, inhibits proliferation of A549 lung adenocarcinoma cells and induces apoptotic cell death in MOLT-4 leukemic cells. Int. J. Mol. Sci. 22, 7014 (2021).

AL MAMUN, A., PIDANY, F., HULCOVA, D., MARIKOVA, J., KUCERA, T., SCHMIDT, M., CATAPANO, M.C., HRABINOVA, M., JUN, D., MUCKOVA, L., KUNES, J., JANOUSEK, J., ANDRYS R., NOVAKOVA, L., PERINOVA, R., MAAFI, N., SOUKUP, O., KORABECNY, J., CAHLIKOVA, L.: Amaryllidaceae alkaloids of norbelladine-type as inspiration for development of highly selective butyrylcholinesterase inhibitors: Synthesis, biological activity evaluation, and docking studies. In. J. Mol. Sci. 22, 8308 (2021).
MAAFI, N., AL MAMUN, A., JANĎOUREK, O., MAŘÍKOVA, J., BREITEROVÁ, K., DIEPOLTOVÁ, A., KONEČNÁ, K., HOŠŤÁLKOVÁ, A., HULCOVÁ, D., KUNEŠ, J., KOHELOVÁ, E., KOUTOVÁ, D., ŠAFRATOVÁ, M., NOVÁKOVÁ, L., CAHLÍKOVÁ, L.: Semisynthetic derivatives of selected Amaryllidaceae alkaloids as a new class of antimycobacterial agents. Molecules 26, 6023 (2021).

AL SHAMMARI, L., HULCOVÁ, D., MAŘÍKOVÁ, J., KUČERA, T., ŠAFRATOVÁ, M., NOVÁKOVÁ, L., SCHMIDT, M., PULKRÁBKOVÁ, L., JANOUŠEK, J., SOUKUP, O., KUNEŠ, J., OPLETAL, L., CAHLÍKOVÁ, L.: Amaryllidaceae alkaloids from Hippeastrum x hybridum cv. Ferrari, and preparation of vittatine derivatives as potential ligands for Alzheimer’s disease. S. Afr. J. Bot. 136, 137-146 (2021).

MAŘÍKOVÁ, J., AL MAMUN, A., AL SHAMMARI, L., KORABEČNÝ, J., KUČERA, T., HULCOVÁ, D., KUNEŠ, J., MALANÍK, M., VAŠKOVÁ, M., KOHELOVÁ, E., NOVÁKOVÁ, L., CAHLÍKOVÁ, L., POUR, M.: Structure Elucidation and cholinesterase inhibition activity of two new minor Amaryllidaceae alkaloids; Molecules 26, 1279 (2021).

KOHELOVÁ, E., MAŘÍKOVÁ, J., KORÁBEČNÝ, J., HULCOVÁ, D., KUČERA, T., JUN, D., CHLEBEK, J., JENČO, J., ŠAFRATOVÁ, M., HRABINOVÁ, M., RITOMSKÁ, A., MALANÍK, M., PEŘINOVÁ, R., BREITEROVÁ, K., KUNEŠ, J., NOVÁKOVÁ, L., OPLETAL, L., CAHLÍKOVÁ, L.: Alkaloids of Zephyrantes citrina (Amaryllidaceae) and their implication to Alzheimerʼs disease: isolation, structural elucidation and biological activity. Bioorg. Chem. 107, 104567 (2021).

CAHLÍKOVÁ, L., KAWANO, I., ŘEZÁČOVÁ, M., BLUNDEN, G., HULCOVÁ, D., HAVELEK, R.: The Amaryllidaceae alkaloids haemanthamine, haemanthidine and their semisynthetic derivatives as potential drugs. Phytochem. Rev. 20, 303–323 (2021).


PEŘINOVÁ, R., MAAFI, M., KORÁBEČNÝ, J., KOHELOVÁ, E., DE SIMONE, A., AL MAMUN, A., HULCOVÁ, D.,MARKOVÁ, J., KUČERA, T., JUN, D., ŠAFRATOVÁ, M., MAŘÍKOVÁ, J., ANDRISANO, V., JENČO, J., KUNEŠ, J., MARTINEZ, A., NOVÁKOVÁ, L., CAHLÍKOVÁ, L.: Functionalized aromatic esters of the Amaryllidaceae alkaloid haemanthamine and their in vitro and in silico biological activity connected to Alzheimer´s disease. Bioorg. Chem. 100, 103928 (2020).

KOUTOVA, D., MAAFI, M., HAVELEK, R., OPLETAL, L., BLUNDEN, G., ŘEZÁČOVÁ, M., CAHLÍKOVÁ, L.: Chemical and Biological Aspects of Montanine-Type Alkaloids Isolated from Plants of the Amaryllidaceae Family. Molecules 25, 2337 (2020).

MAŘÍKOVÁ, J., RITOMSKÁ, A., KORÁBEČNÝ, J., PEŘINOVÁ, R., AL MAMUN, A., KUČERA, T., KOHELOVÁ, E., HULCOVÁ, D., KOBRLOVÁ, T., KUNEŠ, J., NOVÁKOVÁ, L., CAHLÍKOVÁ, L.: Aromatic esters of the crinane Amaryllidaceae alkaloid ambelline as selective inhibitors of butyrylcholinesterase. J. Nat. Prod. 83, 1359-1367 (2020).

AL MAMUN, A., MAŘÍKOVÁ, J., HULCOVÁ, D., JANOUŠEK, J., ŠAFRATOVÁ, M., NOVÁKOVÁ, L., KUČERA, T., HRABINOVÁ, M.,  KUNEŠ, J., KORÁBEČNÝ, J., CAHLÍKOVÁ, L: Amaryllidaceae alkaloids of belladine-type from Narcissus pseudonarcissus cv. Carlton as new selective inhibitors of butyrylcholinesterase. Biomolecules 10, 800 (2020).

BREITEROVÁ, K., KOUTOVÁ, D., HAVELEK, R., KUNEŠ, J., MAJOROŠOVÁ, M., OPLETAL, L., HOŠŤÁLKOVÁ, A., JENČO, J., ŘEZÁČOVÁ, M., CAHLÍKOVÁ, L.: Amaryllidaceae alkaloids of different structural types from Narcissus L. cv. Professor Einstein and their cytotoxic activity. Plants 9, 137, (2020).

AL SHAMMARI, L., AL MAMUN, A., KOUTOVÁ, D., MAJOROŠOVÁ, M., HULCOVÁ, D., ŠAFRATOVÁ, M., BREITEROVÁ, K. MAŘÍKOVÁ, J., HAVELEK, R., CAHLÍKOVÁ, L.: Alkaloid profiling of Hippeastrum cultivars by GC-MS, isolation of Amaryllidaceae alkaloids and evaluation of their cytotoxicity. Rec. Nat. Prod. 14, 154-159 (2020).

KOUTOVA, D., KULHAVA, M., HAVELEK, R., MAJOROSOVA, M., KRALOVEC, K., HABARTOVA, K., HOSTALKOVA, A., OPLETAL, L., CAHLIKOVA, L., REZACOVA, M.: Bersavine: a novel bisbenzylisoquinoline alkaloid with cytotoxic, antiproliferative and apoptosis-inducing effect on human leukemic cells. Molecules 25, 964 (2020).


KOHELOVÁ, E., PEŘINOVÁ, R., MAAFI, N., KORABEČNÝ, J., HULCOVÁ, D., MAŘÍKOVÁ, J., KUČERA, T., GONZÁLEZ, L.M., HRABINOVÁ, M., VORČÁKOVÁ, K., NOVÁKOVÁ, L.,  DE SIMONE, A., HAVELEK, R., CAHLÍKOVÁ, L. Derivatives of the β-crinane Amaryllidaceae alkaloid haemanthamine as multi-target directed ligands for Alzheimer’s disease. Molecules 24, 1307 (2019).

CHLEBEK, J., KORÁBEČNÝ, J., DOLEŽAL, R., ŠTĚPÁNKOVÁ, Š., PÉREZ, D.I., HOŠŤÁLKOVÁ, A., OPLETAL, L., CAHLÍKOVÁ, L., MACÁKOVÁ, K., KUČERA, T., HRABINOVÁ, M., JUN, D. In vitro and in silico acetylcholinesterase inhibitory activity of thalictricavine and canadine and their predicted penetration across the blood-brain barrier. Molecules 24, 1340 (2019).

HOSTALKOVA, A., MARIKOVA, J., OPLETAL, L., KORABECNY, J., HULCOVA, D., KUNES, J., NOVAKOVA, L., PEREZ, D.I, JUN, D., KUCERA, T., ANDRISANO, V., CAHLIKOVA, L. Isoquinoline alkaloids from Berberis vulgaris as potential lead compounds for the treatment of Alzheimer’s disease. J. Nat. Prod. 82, 239-248 (2019).

HULCOVÁ, D., MAŘÍKOVÁ, J., KORÁBEČNÝ, J., HOŠŤÁLKOVÁ, A., JUN, D., KUNEŠ, J. CHLEBEK, J., OPLETAL, L., DE SIMONE, A., NOVAKOVA, L., ANDRISANO, V., RŮŽIČKA, A., CAHLÍKOVÁ, L.: Amaryllidaceae alkaloids from Narcissus pseudonarcissus L. cv. Dutch Master as potential drugs in treatment of Alzheimer's disease. Phytochemistry 165, 112055, (2019).


BREITEROVÁ, K., LOČÁREK, M., KOHELOVÁ, E., TALACKOVÁ, M., HULCOVÁ, D., OPLETAL, L., CAHLÍKOVÁ, L.: Daffodils as potential crops of biologically-active compounds: Assesment of 40 ornamental taxa for their alkaloid profile and cholinesterase inhibition activity. Nat. Prod. Commun. 13, 419-422 (2018).

ŠAFRATOVÁ, M., HOŠŤÁLKOVÁ, A., HULCOVÁ, D., BREITEROVÁ, K., HRABCOVÁ, V., MACHADO, M., FONTINHA, D., PRUDENCIO, M., KUNEŠ, J., CHLEBEK, J., JUN, D., HRABINOVÁ, M., NOVÁKOVÁ, L., HAVELEK, R., SEIFERTOVÁ, M., OPLETAL, L., CAHLÍKOVÁ, L: Alkaloids from Narcissus poeticus cv. Pink Parasol of various structural types and their biological activity. Arch. Pharm. Res. 41, 208-218 (2018).

HABARTOVÁ, K., HAVELEK, R., SEIFERTOVÁ, M., KRÁLOVEC, K., CAHLÍKOVÁ, L., CHLEBEK, J., ČERMÁKOVÁ, E., MAZÁNKOVÁ, N., MAŘÍKOVÁ, J., KUNEŠ, J., NOVÁKOVÁ, L., ŘEZÁČOVÁ, M.: Scoulerine affects microtubule structure, inhibits proliferation, arrests cell cycle and thus culminates in the apoptotic death of cancer cells. Sci. Reports 8,  4829 (2018).

HULCOVÁ, D., BREITEROVÁ, K., SIATKA, T., KLÍMOVÁ, K., DAVANI, L., ŠAFRATOVÁ, M., HOŠŤÁLKOVÁ, A., DE SIMONE, A., ANDRISANO, A., CAHLÍKOVÁ, L.: Amaryllidaceae alkaloids as potential glycogen synthase kinase-3 beta inhibitors. Molecules 23, 719 (2018).


SEIFRTOVÁ, M., HAVELEK ,R., CAHLÍKOVÁ, L., HULCOVÁ, D., MAZÁNKOVÁ, N., ŘEZÁČOVÁ, M.: Haemanthamine alters sodium butyrate-induced histone acetylation, p21WAF1/Cip1 expression, Chk1 and Chk2 activation leading to increased growth inhibition and death in A2780 ovarian cancer cells. Phytomedicine 35, 1-10 (2017).

HAVELEK ,R., SEIFRTOVA, M., KRALOVEC, K., HABARTOVA, Klara., CAHLIKOVA, L., REZACOVA, M.: Chelidonine and homochelidonine induce cell death through cell cycle checkpoints and MAP kinase pathways. Nat. Prod. Commun. 12, 1419-1430 (2017).

HAVELEK, R., MUTHNA, D., TOMSIK, P., KRALOVEC, K., SEIFRTOVÁ, M., CAHLÍKOVÁ, L., HOŠŤÁLKOVÁ, A., ŠAFRATOVÁ, M., PERWEIN, M., ČERMÁKOVÁ, E.,  ŘEZÁČOVÁ, M.: Anticancer potential of Amaryllidaceae alkaloids evaluated by a screening with a panel of human cells, real-time cellular analysis and Ehrlich tumor-bearing mice.  Chem. Biol. Interact. 275, 121-132 (2017).

HULCOVÁ, D., BREITEROVÁ, K., ZEMANOVÁ, L., SIATKA, T., ŠAFRATOVÁ, M., VANĚČKOVÁ, N., HOŠŤÁLKOVÁ, A., WSÓL, V., CAHLÍKOVÁ, L.: Screening of AKR1C3 inhibitory potency of naturally occuring Amaryllidaceae alkaloids of different structural types. Nat. Prod. Commun. 12, 245-246 (2017).

ALI, B. H., CAHLÍKOVÁ, L., OPLETAL, L., KARACA, T., MANOJ, P., RAMKUMAR, A., AL SULEIMANI Y. M., AL ZA'ABI, M., NEMMAR, A., CHOCHOLOUŠOVÁ-HAVLÍKOVÁ, L., LOČÁREK, M., SIATKA, T., BLUNDEN, G.: Effect of aqueous extract and anthocyanins of calces of Hibiscus sabdariffa (Malvaceae) in rats with adenine-induced chronic kidney disease. J. Pharm. Pharmacol. 69, 1219-1229 (2017).

OPLETAL, L., CHOCHOLOUŠOVÁ-HAVLÍKOVÁ, L., SIATKA, T., CAHLÍKOVÁ, L., LOČÁREK, M., BADRELDIN, H. A., MANOJ, P., RAMKUMAR, A., Al SULEIMANI, Y. M., AL ZA‘ABI, M., KARACA, T., NEMMAR, A.: Preparation and validated analysis of anthocyanin concentrate from the calyces of Hibiscus sabdariffa. Nat. Prod. Commun. 12, 43-45 (2017).

SIATKA, T., ADAMCOVÁ, M., OPLETAL, L., CAHLÍKOVÁ, L.,  JUN, D., HRABINOVÁ, M., KUNEŠ, J., CHLEBEK, J.: Cholinesterase and prolyl oligopeptidase Inhibitory activities of alkaloids from Argemone platyceras (Papaveraceae). Molecules 22, 1181 (2017).


HABARTOVÁ, K., CAHLÍKOVÁ, L., ŘEZÁČOVÁ M., HAVELEK, R.: The biological activity of alkaloids from the Amaryllidaceae: from cholinesterases inhibition to anticancer activity. Nat. Prod. Commun. 11, 1587-1594 (2016).

VANĚČKOVÁ, N., HOŠŤÁLKOVÁ, A., ŠAFRATOVÁ, M., KUNEŠ, J., HULCOVÁ, D., HRABINOVÁ, H., DOSKOČIL, I., ŠTĚPÁNKOVÁ, Š., OPLETAL, L., NOVÁKOVÁ, L., JUN, D., CHLEBEK, J., CAHLÍKOVÁ, L.: Isolation of Amaryllidaceae alkaloids from Nerine bowdenii W. Watson (Amaryllidaceae) and their biological activity. RSC Advances 6, 80114-80120 (2016).

HAVELEK, R., SEIFERTOVÁ, M., KRÁLOVEC, K., KROCOVÁ, E., TEJKALOVÁ, V., NOVOTNÝ, I., CAHLÍKOVÁ, L., ŠAFRATOVÁ, M., OPLETAL, L., BÍLKOVÁ, Z., VÁVROVÁ, J., ŘEZÁČOVÁ, M.: Comparative cytotoxicity of chelidonine and homochelidonine, the dimethoxy analogues isolated from Chelidonium majus L. (Papaveraceae), against human leukemic and lung carcinoma cells. Phytomedicine  23, 253-266 (2016).

HROCH, M., HAVELEK, R., CAHLÍKOVÁ, L., HOŠŤÁLKOVÁ, A., HULCOVÁ, D., CERMANOVÁ, J., MIČUDA, S.: LC-MS/MS method for determination of haemanthamine in rat plasma, bile and urine: application to a pilot pharmacokinetic study. Biomed. Chrom. 30, 1083-1091 (2016).

CHLEBEK, J., DOSKOČIL, I., HULCOVÁ, D., BREITEROVÁ, K., ŠAFRATOVÁ, M., HAVELEK, R., HABARTOVÁ, K., HOŠŤÁLKOVÁ, A., VOLŠTÁTOVÁ, T., CAHLÍKOVÁ, L.: Cytotoxicity of naturally occurring isoquinoline alkaloids of  different structural types. Nat. Prod. Commun11, 753-756 (2016).

CHLEBEK, J., NOVÁK, Z., KASSEMOVÁ, D., ŠAFRATOVÁ, M., KOSTELNÍK, J., MALÝ, L., LOČÁREK, M., OPLETAL, L., HOŠŤÁLKOVÁ, A., HRABINOVÁ, M., KUNEŠ, J., NOVOTNÁ, P., URBANOVÁ, M., NOVÁKOVÁ, L., MACÁKOVÁ, K., HULCOVÁ, D., SOLICH, P., MARTÍN, C.P., JUN, D., CAHLÍKOVÁ, L..: Isoquinoline alkaloids from Fumaria officinalis L. and their biological activities related to Alzheimer’s disease. Chem. Biodivers. 13, 91-99 (2016).

CHLEBEK, J., DE SIMONE, A., HOŠŤÁLKOVÁ, A., OPLETAL, L., PERÉZ, C., PERÉZ, D.I., HAVLÍKOVÁ, L., CAHLÍKOVÁ, L., ANDRISANO, V.: Application of BACE1 immobilized enzyme reactor for the characterization of multifunctional alkaloids from Corydalis cava (Fumariaceae) as Alzheimer’s disease targets. Fitoterapia 109, 241-247 (2016).


ZEMANOVA, L., HOFMAN, J., NOVOTNA, E., MUSILEK, K., LUNDOVA, T., HAVRANKOVA, J., HOSTALKOVA, A., CHLEBEK, J., CAHLIKOVA, L., WSOL, V.: Flavones inhibit the activity of AKR1B10, a promising therapeutic target for cancer treatment. J. Nat. Prod. 78, 2666-2674 (2015).

NOVÁK, Z., HOŠŤÁLKOVÁ, A., OPLETAL, L., NOVÁKOVÁ, L., HRABINOVÁ, M., KUNEŠ, J., CAHLÍKOVÁ, L.: (+)-Chenabinol (revised NMR data) and two new alkaloids from Berberis vulgaris L. and their biological activity. Nat. Prod. Commun. 10, 1695-1697 (2015).

LOČÁREK, M., NOVÁKOVÁ, J., KLOUČEK, P., HOŠŤÁLKOVÁ, A., KOKOŠKA, L., GÁBRLOVÁ, L., ŠAFRATOVÁ, M., OPLETAL, L., CAHLÍKOVÁ, L.: Antifungal and antibacterial activity of extracts and alkaloids of selected Amaryllidaceae species. Nat. Prod. Commun. 10, 1537-1540 (2015).

DOSKOČIL, I., HOŠŤÁLKOVÁ, A., ŠAFRATOVÁ, M., BENEŠOVÁ, N., HAVLÍK, J., HAVELEK, R., KUNEŠ, J., KRÁLOVEC, K., CHLEBEK, J., CAHLÍKOVÁ, L.: Cytotoxic activities of Amaryllidaceae alkaloids against gastrointestinal cancer cells. Phytochem. Lett. 13, 394-398 (2015).

CAHLÍKOVÁ, L., PÉREZ, D.I., ŠTĚPÁNKOVÁ, Š, CHLEBEK, J., ŠAFRATOVÁ, M., HOŠŤÁLKOVÁ, A., OPLETAL, L.: In vitro inhibitory effects of 8-O-demethylmaritidine and undulatine on acetylcholinesterase, and their predicted penetration across the blood-brain barrier. J. Nat. Prod. 78, 1189-1192 (2015).

HOŠŤÁLKOVÁ, A., OPLETAL, L., KUNEŠ, J., NOVÁK, Z., HRABINOVÁ, M., CHLEBEK, J., CAHLÍKOVÁ, L.: Alkaloids from Peumus boldus Mol. and their acetylcholinesterase, butyrylcholinesterase and prolyl oligopeptidase inhibition activity. Nat.. Prod. Commun. 10, 577-580 (2015).

CAHLÍKOVÁ, L., HULOVÁ, L., HRABINOVÁ, M., CHLEBEK, J., HOŠŤÁLKOVÁ, A., ADAMCOVÁ, M., ŠAFRATOVÁ, M., JUN, D., OPLETAL, L., LOČÁREK, M., MACÁKOVÁ, K.: Isoquinoline alkaloids as potential prolyl oligopeptidase inhibitors. Fitoterapia 103, 192-196 (2015).

CAHLÍKOVÁ, L., ALI B.H., HAVLÍKOVÁ L., LOČÁREK, M., SIATKA, T., OPLETAL, L., BLUNDEN, G.: Anthocyanins of Hibiscus sabdiffera Calyces from Sudan. Nat. Prod. Commun.  10, 77-79 (2015).


OPLETAL, L., LOČÁREK, M., FRAŇKOVÁ, A., CHLEBEK, J., ŠMÍD, J., HOŠŤÁLKOVÁ, A., ŠAFRATOVÁ, M., HULCOVÁ, D., KLOUČEK P., ROZKOT, M., CAHLÍKOVÁ, L.: Antimicrobial activity of extracts and isoquinoline alkaloids of selected Papaveraceae plants. Nat. Prod. Commun. 9, 1709-1712 (2014).

ŠAFRATOVÁ, M., NOVÁK, Z., KULHÁNKOVÁ, A., KUNEŠ, J., HRABINOVÁ,M., JUN, D., MACÁKOVÁ K., OPLETAL, L., CAHLÍKOVÁ, L.: Revised NMR data for 9-O-demethylgalanthine: an alkaloid from Zephyranthes robusta (Amaryllidaceae) and its biological aktivity. Nat. Prod. Commun.  9, 787-788 (2014).

HAVLASOVÁ, J., ŠAFRATOVÁ, M., SIATKA, T., ŠTĚPÁNKOVÁ, Š., LOČÁREK, M., OPLETAL, L., HRABINOVÁ, M., JUN, D., BENEŠOVÁ, N., NOVÁK, Z., KUNEŠ, J., CAHLÍKOVÁ, L.: Chemical composition of bioactive alkaloid extracts from some Narcissus species and varieties and their biological activity. Nat. Prod. Commun. 9, 1151-1155 (2014).

ŠKARYDOVÁ, L., HOFMAN, J., CHLEBEK, J., HAVRÁNKOVÁ, J., KOŠANOVÁ, K., SKARKA, A., HOŠŤÁLKOVÁ, A., PLUCHA, T., CAHLÍKOVÁ, L., WSÓL, V.: Isoquinoline alkaloids as a novel type of AKR1C3 inhibitors. J. Steroid Biochem. Mol. Biol. 143, 250-258 (2014). 

SCHRAMM, A., JÄHNE, E., BABURIN, I., HERING, S., CAHLÍKOVÁ, L., CHLEBEK, J., HAMBURGER, M.: Natural products as potential human ether-a-go-go-related gene channel inhibitors – screening of plant-derived alkaloids . Planta Med. 80, 740-746 (2014).

ŘEHÁKOVÁ, Z., KOLEČKÁŘ, V., JAHODÁŘ, L., OPLETAL, L., MACÁKOVÁ, K., CAHLÍKOVÁ, L., JUN, D., KUČA, K.: Evaluation of the antioxidant activity of several naturally occuring coumarins and their synthesized analouges by „ferric reducing antioxidant power“ assay. J. Enzym. Inhib. Med. Chem. 29, 49-54 (2014).

HAVELEK, R., SEIFERTOVÁ, M., KRÁLOVEC, K., BRŮČKOVÁ, L., CAHLÍKOVÁ, L., DALECKÁ, M., VÁVROVÁ, J., ŘEZÁČOVÁ, M., OPLETAL, L., BÍLKOVÁ, Z.: The effect of Amaryllidaceae alkaloids haemanthamine and haemanthidine on cell cycle progression and apoptosis in p53-negative human leukemic Jurkat cell. Phytomedicine 21, 479-490 (2014).


CAHLÍKOVÁ, L., HRABINOVÁ, M., KULHÁNKOVÁ, A., BENEŠOVÁ, N., CHLEBEK, J., JUN, D., NOVÁK, Z., KUČA, K., MACÁKOVÁ, K., OPLETAL, L. Alkaloids from Chlidanthus fragrans Herb. and their acetylcholinesterase, butyrylcholinesterase and prolyl oligopeptidase inhibition activity. Nat. Prod. Commun. 8, 1541-1544 (2013).

CAHLÍKOVÁ, L., LOČÁREK, M., BENEŠOVÁ, N., KUČERA, R., CHLEBEK, J., NOVÁK, Z., OPLETAL, L.: Isolation and cholinesterase inhibitory activity of Narcissus extracts and Amaryllidaceae alkaloid. Nat. Prod. Commun. 8, 781-785 (2013).

HOŠŤÁLKOVÁ, A., NOVÁK, Z., POUR, M., JIROŠOVÁ, A., OPLETAL, L., KUNEŠ, J., CAHLÍKOVÁ, L.: Berbanine: a new isoquinoline alkaloid from Berberis vulgaris (Berberidaceae). Nat. Prod. Commun. 8, 441-442 (2013).

KULHÁNKOVÁ, A., CAHLÍKOVÁ, L., NOVÁK, Z., MACÁKOVÁ, K., KUNEŠ, J., OPLETAL, L.: Alkaloids from Zephyranthes robusta Baker and their acetylcholinesterase and butyrylcholinesterase inhibition activity. Chem. Biodivers. 10, 1120-1127 (2013).

DALECKÁ, M., HAVELEK, R., KRALOVEC, K., BRUČKOVÁ, L., CAHLÍKOVÁ, L.: Amaryllidaceae family alkaloids as potential drugs for cancer treatment. Chem. listy 107, 701-708 (2013).


CAHLÍKOVÁ, L., KUČERA, R., HOŠŤÁLKOVÁ, A., KLIMEŠ, J., OPLETAL, L.: Identification of pavinane alkaloids in the genera Argemone and Eschscholzia by GC-MS. Nat. Prod. Commun. 7, 1279-1281 (2012).

NOVÁK, Z., CHLEBEK, J., OPLETAL, L., JIROŠ, P., MACÁKOVÁ, K., KUNEŠ, J., CAHLÍKOVÁ, L.: Corylucinine, a new Alkaloid from Corydalis cava (Fumariaceae), and its cholinesterase activity. Nat. Prod. Commun. 7, 859-860 (2012).

CAHLÍKOVÁ, L., BENEŠOVÁ, N., MACÁKOVÁ, K., KUČERA, R., HRSTKA, V., KLIMEŠ, J., JAHODÁŘ, L., OPLETAL, L.: Alkaloids of some Amaryllidaceae species and their cholinesterase activity. Nat. Prod. Commun. 7, 571-574 (2012).


CAHLÍKOVÁ, L., VALTEROVÁ, I., MACÁKOVÁ, K., OPLETAL, L.: Analysis of Amaryllidaceae alkaloids from Zephyranthes grandiflora Lindl. by GC/MS and their cholinesterase activity. Rev. Brasil. Farmacogn. 21, 575-580 (2011).

CAHLÍKOVÁ, L., ZAVADIL, S. MACÁKOVÁ, K., VALTEROVÁ, I., KULHÁNKOVÁ, A., HOŠŤÁLKOVÁ, A., KUNEŠ, J., OPLETAL, L.: Isolation and cholinesterase activity of Amaryllidaceae alkaloids from Nerine bowdenii. Nat. Prod. Commun. 6, 1827-1830 (2011).

CAHLÍKOVÁ, L., BENEŠOVÁ, N., MACÁKOVÁ, K., URBANOVÁ, K., OPLETAL, L.: GC/MS Analysis of three Amaryllidaceae species and their cholinesterase activity. Nat. Prod. Commun. 9, 1255-1258 (2011).

CHLEBEK, J., MACÁKOVÁ, K., CAHLÍKOVÁ, L., KURFÜRST, M., KUNEŠ, J., OPLETAL, L.: Acetylcholinesterase and butyrylcholinesterase inhibitory compounds from Corydalis cava Schweigger. & Korte (Fumariaceae). Nat. Prod. Commun. 6, 607-610 (2011).

CAHLÍKOVÁ, L., MACÁKOVÁ, K., ZAVADIL, S., JIROŠ, P., OPLETAL, L., URBANOVÁ, K., JAHODÁŘ, L.: Analysis of Amaryllidaceae alkaloids from Chlidanthus fragrans and their cholinesterase aktivity. Nat. Prod. Commun. 6, 603-606 (2011).

CAHLÍKOVÁ, L., VALTEROVÁ, I., MACÁKOVÁ, K., OPLETAL, L.: Analysis of Amaryllidaceae alkaloids from Zephyranthes grandiflora Lindl. by GC/MS and their cholinesterase activity. Revista Brasileira de Farmacognosia/Bras. J. Pharmacognosy 21, 575-580 (2011).


CAHLÍKOVÁ, L., OPLETAL, L., KURFÜRST, M., MACÁKOVÁ, K., KULHÁNKOVÁ, A., HOŠŤÁLKOVÁ, A.: Acetylcholinesterase and butyrylcholinesterase inhibitory compounds from Chelidonium majus (Papaveraceae). Nat. Prod. Commun. 5, 1751-1754 (2010).

CAHLÍKOVÁ, L., KULHÁNKOVÁ, A., URBANOVÁ, K., VALTEROVÁ, I., MACÁKOVÁ, K., KUNEŠ, J.: Analysis of Amaryllidaceae alkaloids from Zephyranthes robusta by GC-MS and their cholinesterase activity. Nat. Prod. Commun. 5, 1201-1204 (2010).

CAHLÍKOVÁ, L., MACÁKOVÁ, K., KUNEŠ, J., KURFÜRST, M., OPLETAL, L., CVAČKA, J., CHLEBEK, J., BLUNDEN, G.: Acetylcholinesterase and butyrylcholinesterase inhibitory compounds from Eschscholzia californica (Papaveraceae). Nat. Prod. Commun. 5, 1035-1038 (2010).


URBANOVÁ, K., CAHLÍKOVÁ, L., HOVORKA, O., PTÁČEK, V., VALTEROVÁ, I.: Age-dependent changes in the exocrine glands secretion of Bombus terrestris queens. J. Chem. Ecol. 34, 458-466 (2008).

ŠOBOTNÍK, J., KALINOVÁ, B., CAHLÍKOVÁ, L., WEYDA, F., PTÁČEK, V., VALTEROVÁ, I.: Age-dependent changes in structure and function of the male labial gland in Bombus terrestris. J. Insect Physiol. 54, 204-214 (2008).


RASMONT, P., TENZO, M., AYTEKIN, A. M., HINES, H., URBANOVÁ, K., CAHLÍKOVÁ, L., VALTEROVÁ, I.: Cephalic secretion of the bumblebee subgenus Sibiricobombus Vogt suggest Bombus niveatus kriechbaumer and Bombus vorticosus gerastaecker are conspecific. Apidologie 36, 571-584 (2005).


CAHLÍKOVÁ, L., HOVORKA, O., PTÁČEK, V., VALTEROVÁ, I.: Exocrine gland secretion of virgin queens of five Bumblebee species. Z. Naturforsch. C 59c, 582-589 (2004).



CAHLIKOVA, L., VRABEC, R., PIDANY, F., PERINOVA, R., MAAFI, N., AL MAMUN, A., RITOMSKA, A., WIJAYA, V., BLUNDEN, G.: Recent progress on biological activity of Amaryllidaceae and further isoquinoline alkaloids in connection with Alzheimer´s disease. Molecules 26, 5240 (2021).

CAHLÍKOVÁ, L., BREITEROVÁ, K., OPLETAL, L.: Chemistry and biological activity of alkaloids from the genus Lycoris (Amaryllidaceae). Molecules 25, 4797 (2020).


CAHLIKOVA, L., VANECKOVA, N., SAFRATOVA, M., BREITEROVA, K., BLUNDEN, G., HULCOVA, D., OPLETAL, L.: The genus Nerine Herb. (Amaryllidaceae): ethnobotany, phytochemistry, and biological activity. Molecules 24, 4238 (2019).


HOŠŤÁLKOVÁ, A., SIATKA, T., CHLEBEK, J., OPLETAL, L., DRAŠAR, P., CAHLÍKOVÁ, L.: Boldinové alkaloidy a perspektivity jejich využití. Chem. listy 109, 846-855 (2015).


ČOPÍKOVÁ, J., WIMMER, Z., LAPČÍK, O., CAHLÍKOVÁ, L., OPLETAL, L., MORAVCOVÁ, J., DRAŠAR, P.: Přírodní látky svíravé a trpké chuti. Chem. Listy 108, 1053-1057 (2014).


DALECKÁ, M., HAVELEK, R., KRÁLOVEC, K., BRŮČKOVÁ, L., CAHLÍKOVÁ, L.: Alkaloidy rostlin čeledi Amaryllidaceae jako potenciální léčiva v terapii nádorových onemocnění. Chem. Listy 107, 701-708 (2013).

OPLETAL, L., CHLEBEK, J., MACÁKOVÁ, K., BENEŠOVÁ, N., HOŠŤÁLKOVÁ, A., CAHLÍKOVÁ, L.: Antioxidanty a degenerativní onemocnění. Prakt. Lékáren. 9, 135-138 (2013).


KOLEČKÁŘ, V., ŘEHÁKOVÁ, Z, BROJEROVÁ, E., KUČA, K., JUN, D., MACÁKOVÁ, K., OPLETAL, L., DRAŠAR, P., JAHODÁŘ, L., CHLEBEK, J., CAHLÍKOVÁ, L.: Proanthocyanidiny a jejich antioxidační aktivita. Chem. listy 106, 113-121 (2012).


CAHLÍKOVÁ, L., MACÁKOVÁ, K., CHLEBEK, J., HOŠŤÁLKOVÁ, A., KULHÁNKOVÁ, A., OPLETAL, L.: Ecdysterone and its activity on some degenerative diseases. Nat. Prod. Commun. 6, 707-718 (2011).

OPLETAL, L., WIMMER, Z, ČOPÍKOVÁ, J., LAPČÍK, O., MORAVCOVÁ, J., CAHLÍKOVÁ, L., DRAŠAR, P.: Slaná chuť přírodních látek a jejich derivátů. Chem. listy 105, 761-765 (2011).

Monographs (and chapters)


MACÁKOVÁ, K., KOLEČKÁŘ, V., CAHLÍKOVÁ, L., CHLEBEK, J., HOŠŤÁLKOVÁ, A., KUČA, K., JUN, D., OPLETAL, L.: Tannins and their influence on health. Recent Advances in Medicinal Chemistry. Bentham Science Publishers 1, 159-208 (2014).

CAHLÍKOVÁ, L., MACÁKOVÁ, K., BENEŠOVÁ, N., CHLEBEK, J., HOŠŤÁLKOVÁ, A., OPLETAL, L.: Natural compounds (small molecules) as potential and real drugs of Alzehimer’s disease: A critical review, in: Studies in natural products chemistry (ATTA-ur-RAHMAN, ed.), Chapter 6, Elsevier: Amsterdam 2014, pp. 153-194, ISBN: 978-0-444-63281-4.


OPLETAL, L., MACÁKOVÁ, K., CAHLÍKOVÁ, L.: Antiinvazní látky přírodního původu jako preventivní faktor v ontogenezi zvířat, in: OPLETAL, L., SKŘIVANOVÁ, V. (eds): Přírodní látky a jejich biologická aktivita. Sv. 2: Využití látek pro ovlivnění fyziologických procesů hospodářských zvířat, s. 203–309, Karolinum, Praha 2010, ISBN 978-80-246-1801-2.



CAHLÍKOVÁ, L., ŠAFRATOVÁ, M., HOŠŤÁLKOVÁ, A., CHLEBEK, J., HULCOVÁ, D., BREITEROVÁ, K., OPLETAL, L.: Pharmacognosy and its role in the system of profile disciplines in Pharmacy. Nat. Prod. Commun. 15, 1-7 (2020).

© Charles University, Faculty of Pharmacy in Hradec Králové, Akademika Heyrovského 1203, 500 03 Hradec Králové, Czech Republic
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