Alejandro Carazo Fernández, Ph.D.

Born in Madrid in 1987

Contact
Department of Pharmacology and Toxicology
Research group: Pharmacology of the cardiovascular system and respiratory system
Akademika Heyrovského 1203, 500 05, Hradec Králové
Tel.: +420 495 067 307
E-mail: carazofa@faf.cuni.cz

Research focus

Research group of the experimental cardiovascular pharmacology

Role of platelets in the development of cardiovascular conditions and its physiological processes

Molecular pharmacology

Education

2019
PharmDr. in Pharmacology Department of Pharmacology and Toxicology, Faculty of Pharmacy in Hradec Králové, Charles University (Czech Republic).

2017
Ph.D. study in Pharmacology, Department of Pharmacology and Toxicology, Faculty of Pharmacy in Hradec Králové, Charles University (Czech Republic). Thesis: „Nuclear receptors – new ligands study and importance of gene variability“. Supervisor: prof. Petr Pávek, Ph.D.

2013
Degree in Pharmacy, Faculty of Pharmacy, University of Alcalá (Alcalá de Henares, Madrid, Spain)

Employment

09.2019 - present
Assistant professor, Department of Pharmacology and Toxicology, Faculty of Pharmacy in Hradec Králové, Charles University (Czech Republic)

09.2017 - 08.2019
Junior researcher, Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacký University (Czech Republic)

10.2013 – 08.2017
Junior researcher, Department of Pharmacology and Toxicology, Faculty of Pharmacy in Hradec Králové, Charles University (Czech Republic)

Teaching activities

From 2020
Guarantor of new optional subject „Experimental Pharmacodynamics“ – 4th year of Pharmacy Master Degree

2019/20 - present
Lecturer and examiner of Toxicology for M.Sc. students, Czech and English languages

2019 – present
Consultant of post-gradual students – Ph.D. program (2 ongoing)
Supervisor of diploma students (3 ongoing)

2019 – present
Erasmus + students mentor (1 ongoing)

Research stages

04-06.2016  
Laboratory of prof. S. Mani, Albert Einstein School of Medicine, Yeshiva University, Bronx, New York City, New York, USA

Grants

2020 - 2023
OEMONOM – Erasmus+ project: Strategic partnership for higher education

2017 - 2020
Grant Agency Charles University: GAUK1206517 – Využití smíšených parciálních/obyčejních diferenciálních rovnic k modelování průběhu koncentrace léků pro efektivní farmakoterapii

2017 - 2020
Grant Agency Charles University: GAUK1574417 – Genetický manipulované model pro studium funkce a terapeutického využití ligandů CAR (NR1I3) receptoru

Publication activity

17 papers in IF journals
Orcid No.: https://orcid.org/0000-0002-3604-7981
Scopus author ID: 56506910600
WoS author ID: AAC-9590-2019
H-index (Scopus/WoS): 10/9

2019

Marine Ligands of the Pregnane X Receptor (PXR): An Overview. Carazo A, Přemysl MladěnkaPetr Pávek. Mar Drugs. 2019;17(10):554. Published 2019 Sep 28. doi:10.3390/md17100554
Mar Drugs 2019 - Review. PMID 31569349; IF2018=3,772; Q1

Trans-resveratrol, but not other natural stilbenes occurring in food, carries the risk of drug-food interaction via inhibition of cytochrome P450 enzymes or interaction with xenosensor receptors. Hyrsova L, Vanduchova A, Dusek J, Smutny T, Carazo A, Maresova V, Trejtnar F, Barta P, Anzenbacher P, Dvorak Z, Pavek P. Toxicol Lett. 2019 Jan;300:81-91. doi: 10.1016/j.toxlet.2018.10.028. Epub 2018 Oct 27. PMID:30394306; IF2018=3,499; Q2

2018

Teriflunomide Is an Indirect Human Constitutive Androstane Receptor (CAR) Activator Interacting With Epidermal Growth Factor (EGF) Signaling. Carazo A, Dusek J, Holas O, Skoda J, Hyrsova L, Smutny T, Soukup T, Dosedel M, Pávek P. Front Pharmacol. 2018 Oct 11;9:993. doi: 10.3389/fphar.2018.00993. eCollection 2018. PMID:30364229; IF2017=3,831; Q1

Effect of Endocannabinoid Oleamide on Rat and Human Liver Cytochrome P450 Enzymes in In Vitro and In Vivo Models. Dovrtelova G, Zendulka O, Noskova K, Jurica J, Pes O, Dusek J, Carazo A, Zapletalova I, Hlavacova N, Pavek P. Drug Metab Dispos. 2018 Jun;46(6):913-923. doi: 10.1124/dmd.117.079582. Epub 2018 Apr 12. PMID:29650790; IF2017=3,640; Q1

Unexpected Effects of Propiconazole, Tebuconazole, and Their Mixture on the Receptors CAR and PXR in Human Liver Cells. Knebel C, Neeb J, Zahn E, Schmidt F, Carazo A, Holas O, Pavek P, Püschel GP, Zanger UM, Süssmuth R, Lampen A, Marx-Stoelting P, Braeuning A. Toxicol Sci. 2018 May 1;163(1):170-181. doi: 10.1093/toxsci/kfy026. PMID:29420809; IF2017=4,181; Q1

2017

Resveratrol modifies biliary secretion of cholephilic compounds in sham-operated and cholestatic rats. Dolezelova E, Prasnicka A, Cermanova J, Carazo A, Hyrsova L, Hroch M, Mokry J, Adamcova M, Mrkvicova A, Pavek P, Micuda S. World J Gastroenterol. 2017 Nov 21;23(43):7678-7692. doi: 10.3748/wjg.v23.i43.7678. PMID:29209109; IF2016=3,365; Q2

Iron depletion induces hepatic secretion of biliary lipids and glutathione in rats. Prasnicka A, Cermanova J, Hroch M, Dolezelova E, Rozkydalova L, Smutny T, Carazo A, Chladek J, Lenicek M, Nachtigal P, Vitek L, Pavek P, Micuda S. Biochim Biophys Acta Mol Cell Biol Lipids. 2017 Dec;1862(12):1469-1480. doi: 10.1016/j.bbalip.2017.09.003. Epub 2017 Sep 6. PMID:28888833; IF2016=5,547; Q1

Steviol, an aglycone of steviol glycoside sweeteners, interacts with the pregnane X (PXR) and aryl hydrocarbon (AHR) receptors in detoxification regulation. Dusek J, Carazo A, Trejtnar F, Hyrsova L, Holas O, Smutny T, Micuda S, Pavek P. Food Chem Toxicol. 2017 Nov;109(Pt 1):130-142. doi: 10.1016/j.fct.2017.09.007. Epub 2017 Sep 5. PMID:28887089; IF2016=3,778; Q1

Development of water-soluble 3,5-dinitrophenyl tetrazole and oxadiazole antitubercular agents. Roh J, Karabanovich G, Vlčková H, Carazo A, Němeček J, Sychra P, Valášková L, Pavliš O, Stolaříková J, Klimešová V, Vávrová K, Pávek P, Hrabálek A. Bioorg Med Chem. 2017 Oct 15;25(20):5468-5476. doi: 10.1016/j.bmc.2017.08.010. Epub 2017 Aug 8. PMID:28835350; IF2016=2,930; Q2

S-substituted 3,5-dinitrophenyl 1,3,4-oxadiazole-2-thiols and tetrazole-5-thiols as highly efficient antitubercular agents. Karabanovich G, Němeček J, Valášková L, Carazo A, Konečná K, Stolaříková J, Hrabálek A, Pavliš O, Pávek P, Vávrová K, Roh J, Klimešová V. Eur J Med Chem. 2017 Jan 27;126:369-383. doi: 10.1016/j.ejmech.2016.11.041. Epub 2016 Nov 21. PMID:27907875; IF2016=4,519; Q1

Acetylated deoxycholic (DCA) and cholic (CA) acids are potent ligands of pregnane X (PXR) receptor. Carazo A, Hyrsova L, Dusek J, Chodounska H, Horvatova A, Berka K, Bazgier V, Gan-Schreier H, Chamulitrat W, Kudova E, Pavek P. Toxicol Lett. 2017 Jan 4;265:86-96. doi: 10.1016/j.toxlet.2016.11.013. Epub 2016 Nov 18. PMID:27871908; IF2016=3,858; Q1

2016

2-(3-Methoxyphenyl)quinazoline Derivatives: A New Class of Direct Constitutive Androstane Receptor (CAR) Agonists. Smutny T, Nova A, Drechslerová M, Carazo A, Hyrsova L, Hrušková ZR, Kuneš J, Pour M, Špulák M, Pavek P. J Med Chem. 2016 May 26;59(10):4601-10. doi: 10.1021/acs.jmedchem.5b01891. Epub 2016 May 12. Erratum in: J Med Chem. 2016 Dec 22;59(24):11195. PMID:27145071; IF2015=5,589; Q1

The pregnane X receptor down-regulates organic cation transporter 1 (SLC22A1) in human hepatocytes by competing for ("squelching") SRC-1 coactivator. Hyrsova L, Smutny T, Carazo A, Moravcik S, Mandikova J, Trejtnar F, Gerbal-Chaloin S, Pavek P. Br J Pharmacol. 2016 May;173(10):1703-15. doi: 10.1111/bph.13472. Epub 2016 Apr 8. PMID:26920453; IF2015=5,259; Q1

2015

The Use of the LanthaScreen TR-FRET CAR Coactivator Assay in the Characterization of Constitutive Androstane Receptor (CAR) Inverse Agonists. Carazo A, Pávek P. Sensors (Basel). 2015 Apr 21;15(4):9265-76. doi: 10.3390/s150409265. PMID:25905697; IF2014=2,245; Q1

The impact of C677T and A1298C MTHFR polymorphisms on methotrexate therapeutic response in East Bohemian region rheumatoid arthritis patients. Soukup T, Dosedel M, Pavek P, Nekvindova J, Barvik I, Bubancova I, Bradna P, Kubena AA, Carazo AF, Veleta T, Vlcek J. Rheumatol Int. 2015 Jul;35(7):1149-61. doi: 10.1007/s00296-015-3219-z. Epub 2015 Jan 25. PMID:25618758; IF2014=1,516; Q3

Chrysin, baicalein and galangin are indirect activators of the human constitutive androstane receptor (CAR). Carazo Fernández A, Smutny T, Hyrsová L, Berka K, Pavek P. Toxicol Lett. 2015 Mar 4;233(2):68-77. doi: 10.1016/j.toxlet.2015.01.013. Epub 2015 Jan 24. PMID:25625231; IF2014=3,262; Q1

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