Mgr. Daniela Hulcová

Research focus

  • isolation of secondary metabolites from the family Amaryllidaceae (isolation, analysis, structural identification)
  • in vitro biological activities of isolated compounds (AChE, BuChE, POP and cytotoxicity)

Education

  • 2009-2014 Charles University in Prague, Faculty of Pharmacy, (Master degree), Thesis: Biological aktivity of plant metabolites. XXVII. Alkaloids of Fumaria officinalis L. and their effect on acetylcholinesterase and butyrylcholinesterase.

Current position

  • a postgraduate student at Charles University in Prague, Faculty of Pharmacy in Hradec Králové, Department of Pharmaceutical Botany and Ecology

Publications

Original papers

2017

SEIFRTOVÁ, M., HAVELEK ,R., CAHLÍKOVÁ, L., HULCOVÁ, D., MAZÁNKOVÁ, N., ŘEZÁČOVÁ, M.: Haemanthamine alters sodium butyrate-induced histone acetylation, p21WAF1/Cip1 expression, Chk1 and Chk2 activation leading to increased growth inhibition and death in A2780 ovarian cancer cells. Phytomedicine 35, 1-10 (2017).

HULCOVÁ, D., BREITEROVÁ, K., ZEMANOVÁ, L., SIATKA, T., ŠAFRATOVÁ, M., VANĚČKOVÁ, N., HOŠŤÁLKOVÁ, A., WSÓL, V., CAHLÍKOVÁ, L.: Screening of AKR1C3 inhibitory potency of naturally occuring Amaryllidaceae alkaloids of different structural types. Nat. Prod. Commun. 12, 245-246 (2017).

2016

VANĚČKOVÁ, N., HOŠŤÁLKOVÁ, A., ŠAFRATOVÁ, M., KUNEŠ, J., HULCOVÁ, D., HRABINOVÁ, H., DOSKOČIL, I., ŠTĚPÁNKOVÁ, Š., OPLETAL, L., NOVÁKOVÁ, L., JUN, D., CHLEBEK, J., CAHLÍKOVÁ, L.: Alkaloids from Nerine bowdenii W. Watson (Amaryllidaceae) and their biological activity. RSC Advances 6, 80114-80120 (2016).

HROCH, M., HAVELEK, R., CAHLÍKOVÁ, L., HOŠŤÁLKOVÁ, A., HULCOVÁ, D., CERMANOVÁ, J., MIČUDA, S.: LC-MS/MS method for determination of haemanthamine in rat plasma, bile and urine: application to a pilot pharmacokinetic study. Biomed. Chrom. 30, 1083-1091 (2016).

CHLEBEK, J., DOSKOČIL, I., HULCOVÁ, D., BREITEROVÁ, K., ŠAFRATOVÁ, M., HAVELEK, R., HABARTOVÁ, K., HOŠŤÁLKOVÁ, A., VOLŠTÁTOVÁ, T., CAHLÍKOVÁ, L.: Cytotoxicity of Naturally Occurring Isoquinoline Alkaloids of  Different Structural Types. Nat. Prod. Commun11, 753-756 (2016).

CHLEBEK, J., NOVÁK, Z., KASSEMOVÁ, D., ŠAFRATOVÁ, M., KOSTELNÍK, J., MALÝ, L., LOČÁREK, M., OPLETAL, L., HOŠŤÁLKOVÁ, A., HRABINOVÁ, M., KUNEŠ, J., NOVOTNÁ, P., URBANOVÁ, M., NOVÁKOVÁ, L., MACÁKOVÁ, K., HULCOVÁ, D., SOLICH, P., MARTÍN, C.P., JUN, D., CAHLÍKOVÁ, L..: Isoquinoline alkaloids from Fumaria officinalis L. and their biological activities related to Alzheimer’s disease. Chem. Biodivers. 13, 91-99 (2016).

2014

OPLETAL, L., LOČÁREK, M., FRAŇKOVÁ, A., CHLEBEK, J., ŠMÍD, J., HOŠŤÁLKOVÁ, A., ŠAFRATOVÁ, M., HULCOVÁ, D., KLOUČEK P., ROZKOT, M., CAHLÍKOVÁ, L.: Antimicrobial activity of extracts and isoquinoline alkaloids of selected Papaveraceae plants. Nat. Prod. Commun. 9, 1709-1712, (2014).

© 2017 Charles University, Faculty of Pharmacy in Hradec Králové, Akademika Heyrovského 1203, 500 05 Hradec Králové, Czech Republic
Website information | Powered by Kentico