PharmDr. Andrej Kováčik, Ph.D.

Born: March 28, 1989

Address: Department of Pharmaceutical technology, Faculty of Pharmacy in Hradec Králové, Charles University, Heyrovského 1203, 500 05 Hradec Králové, Czech Republic

Phone: +420 495 067 340
E-mail: kovacika@faf.cuni.cz

Research Gate

ORCID

Current Job

  • assistant professor at Department of Pharmaceutical Technology

  • member and researcher of Skin Barrier Research Group

  • researcher assistant of Czech Science Foundation projects

Education

  • 2013 - 2017: PhD study in Bioorganic Chemistry (Ph.D.), Department of Organic and Bioorganic Chemistry, Faculty of Pharmacy in Hradec Králové, Charles University; research project: “Study of Effect of Ceramide Hydroxylation on Permeability and Microstructure of Model Lipid Membranes” (supervisor: Prof. Dr. Kateřina Vávrová, PhD.)

  • 2008 – 2013: Master of Pharmacy (Mgr., equiv. MPharm.) at Faculty of Pharmacy in Hradec Králové, Charles University in Prague; diploma thesis: “Synthesis and study of ceramides based on 6-hydroxysphingosine” at the Department of Organic and Bioorganic Chemistry (supervisor: Prof. Dr. Kateřina Vávrová, PhD.)

Research Interests

  • skin, skin barrier, stratum corneum, skin lipids, ceramides

  • sphingolipid chemistry – synthesis, NMR evaluation

  • model lipid membranes – multi-lamellar membrane systems, permeability studies (HPLC), TEWL measuring

  • model membrane biophysics – infrared spectroscopy, X-ray powder diffraction

Teaching Activities

  • Physical Principles of Dosage Forms

  • Pharmaceutical Technology

  • supervisor of MPharm. students

Grants

  • since 2016: Czech Science Foundation and German Science Foundation joint project 16-25687J "Interdependencies between Inflammatory Processes and Barrier Lipids in Diseased Skin" (with Prof. Sarah Hedrich, Freie Universität Berlin) – co-worker

  • since 2014: Grant of Charles University (GAUK 1868214) – principal researcher

  • since 2013: Czech Science Foundation: „Lipid membrane models – a new tool for studying pathophysiology of skin diseases at a molecular level“ (13-23891S) – researcher

  • 2011 - 2013: Czech Science Foundation: Synthesis and structure-activity relationships of skin ceramides and compounds targeting them (207/11/0365) – co-worker

Awards

Publications

  1. Kopečná M, Kováčik A, Kučera O, Macháček M, Sochorová M, Audrlická P, Vávrová K. Mol. Pharm. 2019(IF2016 = 4.6) in press.

  2. Rigon RB, Kaessmeyer S, Wolff Ch, Hausmann Ch, Zhang N, Sochorová M, Kováčik A, Haag R, Vávrová K, Ulrich M, Schäfer-Korting M, Zoschke Ch. Int. J. Mol. Sci. 2018, 19(11), 3521 (IF2016 = 3.7).

  3. Sochorová M, Audrlická P, Červená M, Kováčik A, Kopečná M, Opálka L, Pullmannová P, Vávrová K. J. Colloid Interface Sci. 2018, 535:227-238 (IF2016 = 5.1).

  4. Kováčik A, Vogel A, Adler J, Pullmannová P, Vávrová K, Huster D. Biochim. Biophys. Acta - Biomembranes2018, 1860(5):1162-1170 (IF2016 = 3.5).

  5. Kováčik A, Pullmannová P, Maixner J, Vávrová K. Langmuir. 2018, 34(1):521–529 (IF2016 = 3.8).

  6. Čuříková BA, Procházková K, Filková B, Diblíková P, Svoboda J, Kováčik A, Vávrová K, Zbytovská J. Int. J. Pharm. 2017, 534(1-2):287-296 (IF2016 = 3.6) .

  7. Svoboda M, Hlobilová M, Marešová M, Sochorová M, Kováčik A, Vávrová K, Dolečková I. Arch. Dermatol. Res. 2017, 309(9):757-765 (IF2016 = 2.3).

  8. Stahlberg S, Eichner A, Sonnenberger S, Kováčik A, Lange S, Schmitt T, Demé B, Hauss T, Dobner B, Neubert RHH, Huster D. Langmuir2017, 33(36):9211-9221 (IF2016 = 3.8).

  9. Sochorová M, Staňková K, Pullmannová P, Kováčik A, Zbytovská J, Vávrová K. Sci. Rep. 2017, 7(1):6470 (IF2016 = 4.3).

  10. Vávrová K, Kováčik A, Opálka L. Eur. Pharm. J. 2017, 64 (1):1-8.

  11. Pullmannová P, Pavlíková L, Kováčik A, Sochorová M, Školová B, Slepička P, Maixner J, Zbytovská J, Vávrová K. Biophys. Chem. 2017, 224, 20-31 (IF2016 = 2.4)

  12. Kováčik A, Šilarová M, Pullmannová P, Maixner J, Vávrová K. Langmuir2017, 33, 2890-2899 (IF2016 = 3.8).

  13. Školová B, Kováčik A, Tesař O, Opálka L, Vávrová K. Biochim. Biophys. Acta - Biomembranes2017, 1859(5), 824-834 (IF2016 = 3.5).

  14. Opálka L, Kováčik A, Maixner J, Vávrová K. Langmuir. 2016, 32(48), 12894-12904 (IF2016 = 3.8).

  15. Kováčik A, Opálka L, Šilarová M, Roh J, Vávrová K. RSC Adv. 2016, 6(77), 73343-73350 (IF2016 = 3.1).

  16. Opálka L, Kováčik A, Sochorová M, Roh J, Kuneš J, Lenčo J, Vávrová K. Org. Lett. 2015, 17(21):5456-59 (IF2016 = 6.6).

  17. Wallmeyer L, Lehnen D, Eger N, Sochorová M, Opálka L, Kováčik A, Vávrová K, Hedtrich S. J. Dermatol. Sci. 2015, 80(2):102–10 (IF2016 = 3.7).

  18. Kováčik A, Roh J, Vávrová K. ChemBioChem. 2014, 15(11):1555-62 (IF2016 = 2.8).

  19. Školová B, Hudská K, Pullmannová P, Kováčik A, Palát K, Roh J, Fleddermann J, Estrela-Lopis I, Vávrová K. J. Phys. Chem. B. 2014, 18(35):10460-70 (IF2016 = 3.2).

Professional Memberships

  • since 2018: Czech society for Biochemistry and Molecular Biology (Lipidomic section)

  • since 2015: Czech Chemical Society

  • since 2014: Czech Pharmaceutical Society (sections: Chemical Drugs, Clinical Pharmacy, History of Pharmacy)

Work Experience and Fellowships

  • 2017 (6 months): Institut für Medizinische Physik und Biophysik der Medizinischen Fakultät der Universität Leipzig (Prof. Dr. Daniel Huster, Leipzig, Germany)

  • 2017 (1 week): Training Course “Interpretation of vibrational spectra” (Prague, Czech Republic)

  • 2015: Frank Laboratory of Neutron Physics (JINR, Dubna, Russian Federation)

  • 2012 (3 months): Thomayer Hospital (Pharmacy, Prague, Czech Republic)

  • 2012/2013 (3 months): Homolka Hospital (Pharmacy, Prague, Czech Republic)

Presentations at Conferences

2018:

  • Advances in Pharmaceutical Technology (Brno, Czech Republic; oral presentation)

  • Skin Forum (Skin health and topical formulation - new insights and perspectives), Tallin, Estonia (poster)

  • Czech Lipidomics Conference, Prague, Czech Republic (poster)

  • Sanofi Prize Meeting (Prague, Czech Republic; oral presentation)

  • Perspectives in Percutaneous Penetration, La Grande Motte, France (poster)

2017:

  • European Epidermal Barrier Research Network Meeting (E2BRN), Salzburg, Austria (poster + oral presentation)

  • 12th Sphingolipid Club Meeting, Trabia, Sicily, Italy (poster)

  • XVII. Interdisciplinary Meeting of Young Biologists, Biochemists and Chemists, Milovy, Czech Republic (poster) 

2016:

  • 6th Postgraduate and 4th Postdoc Conference, Hradec Králové, Czech Republic (oral presentation)

  • Perspectives in Percutaneous Penetration, La Grande Motte, France (poster)

  • The 5th Czech Lipidomics Conference, Prague, Czech Republic (poster)

  • The 45th Conference Drug Synthesis and Analysis, Hradec Králové, Czech Republic (oral presentation)

  • 4th European Joint Theoretical/Experimental Meeting on Membranes, Bratislava, Slovakia (poster)

2015:

  • 5th Postgraduate and 3rd Postdoc Conference, Hradec Králové, Czech Republic (oral presentation)

  • Gordon Research Conference: Barrier Function of Mammalian Skin, Waterville, New Hampshire, USA (poster)

  • 50th Advances in Organic, Bioorganic and Pharmaceutical Chemistry, Olomouc, Czech Republic (poster)

2014:

  • 4th Postgraduate and 2nd Postdoc Conference, Hradec Králové, Czech Republic (oral presentation)

  • Perspectives in Percutaneous Penetration, La Grande Motte, France (poster)

  • Skin Forum (Percutaneous Penetration – Measurement, Modulation and Modelling), Prague, Czech Republic (poster)

  • 49th Advances in Organic, Bioorganic and Pharmaceutical Chemistry, Lázně Bělohrad, Czech Republic (poster)

2013:

  • 48th Advances in Organic, Bioorganic and Pharmaceutical Chemistry, Špindlerův Mlýn, Czech Republic (poster)

2012:

  • International Student Research Conference, Prague, Czech Republic (oral presentation; 1st Prize)

Additional Skills

  • languages: English, German, Russian (basics)

  • computer skills: OS Windows, MS Office, MestreNova, ChemDraw, GraphPad, OPUS, X'Pert Data Viewer

  • driving licence “B”

Other Activities

  • 2018: delegate of Faculty of Pharmacy in Hradec Králové on fair GAUDEAMUS (Nitra, Slovakia)

  • 2016: co-author of the exposition of Department of Inorganic and Organic Chemistry at OpenDay of Faculty of Pharmacy

  • 2016: collaboration in “SCIO” tests (chemistry) for grammar students

  • 2015: main author of the exposition of Faculty of Pharmacy in Hradec Králové at “Nábřeží vysokých škol” exhibition (Hradec Králové)

  • 2014: main author and coordinator of the exposition of Faculty of Pharmacy in Hradec Králové at “Nábřeží vysokých škol” exhibition (Hradec Králové)
    Kováčik A. Čas. čes. lék. 2014, 86(10): 29 (article in Czech)

  • 2013: co-author of the exposition of Faculty of Pharmacy in Hradec Králové at “The Day of Science” exhibition (Prague)
    Kováčik A, Pilařová V. Čas. čes. lék. 2013, 85(12): 26 (article in Czech)

  • since 2011: guide and worker in the Czech Pharmaceutical Museum in Kuks

Interests and Hobbies

  • sports: swimming, jogging

  • music: alternative rock and alternative pop

© Charles University, Faculty of Pharmacy in Hradec Králové, Akademika Heyrovského 1203, 500 05 Hradec Králové, Czech Republic
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