PharmDr. Andrej Kováčik, Ph.D.

Born: March 28, 1989

Address: Department of Pharmaceutical technology, Faculty of Pharmacy in Hradec Králové, Charles University, Heyrovského 1203, 500 05 Hradec Králové, Czech Republic

Phone: +420 495 067 340
E-mail: kovacika@faf.cuni.cz

Research Gate

ORCID

Current Job

  • assistant professor at Department of Pharmaceutical Technology

  • member and researcher of Skin Barrier Research Group

  • researcher assistant of Czech Science Foundation projects

Education

  • 2013 - 2017: PhD study in Bioorganic Chemistry (Ph.D.), Department of Organic and Bioorganic Chemistry, Faculty of Pharmacy in Hradec Králové, Charles University; research project: “Study of Effect of Ceramide Hydroxylation on Permeability and Microstructure of Model Lipid Membranes” (supervisor: Prof. Dr. Kateřina Vávrová, PhD.)

  • 2008 – 2013: Master of Pharmacy (Mgr., equiv. MPharm.) at Faculty of Pharmacy in Hradec Králové, Charles University in Prague; diploma thesis: “Synthesis and study of ceramides based on 6-hydroxysphingosine” at the Department of Organic and Bioorganic Chemistry (supervisor: Prof. Dr. Kateřina Vávrová, PhD.)

Research Interests

  • skin, skin barrier, stratum corneum, skin lipids, ceramides

  • sphingolipid chemistry – synthesis, NMR evaluation

  • model lipid membranes – multi-lamellar membrane systems, permeability studies (HPLC), TEWL measuring

  • model membrane biophysics – infrared spectroscopy, X-ray powder diffraction

Teaching Activities

  • Physical Principles of Dosage Forms

  • Pharmaceutical Technology

  • supervisor of MPharm. students

Grants

  • since 2016: Czech Science Foundation and German Science Foundation joint project 16-25687J "Interdependencies between Inflammatory Processes and Barrier Lipids in Diseased Skin" (with Prof. Sarah Hedrich, Freie Universität Berlin) – co-worker

  • since 2014: Grant of Charles University (GAUK 1868214) – principal researcher

  • since 2013: Czech Science Foundation: „Lipid membrane models – a new tool for studying pathophysiology of skin diseases at a molecular level“ (13-23891S) – researcher

  • 2011 - 2013: Czech Science Foundation: Synthesis and structure-activity relationships of skin ceramides and compounds targeting them (207/11/0365) – co-worker

Awards

Publications

  1. Hausmann Ch, Zoschke Ch, Wolff Ch, Darvin M, Sochorová M, Kováčik A, Wanjiku B, Schumacher F, Tigges J, Kleuser B, Lademann J, Fritsche E, Vávrová K, Ma N, Schaefer-Korting M. Sci. Rep. 2019, 9:2913 (IF2016 = 4.3).

  2. Kopečná M, Kováčik A, Kučera O, Macháček M, Sochorová M, Audrlická P, Vávrová K. Mol. Pharm. 2019, 16(2):886-897 (IF2016 = 4.6).

  3. Rigon RB, Kaessmeyer S, Wolff Ch, Hausmann Ch, Zhang N, Sochorová M, Kováčik A, Haag R, Vávrová K, Ulrich M, Schäfer-Korting M, Zoschke Ch. Int. J. Mol. Sci. 2018, 19(11), 3521 (IF2016 = 3.7).

  4. Sochorová M, Audrlická P, Červená M, Kováčik A, Kopečná M, Opálka L, Pullmannová P, Vávrová K. J. Colloid Interface Sci. 2018, 535:227-238 (IF2016 = 5.1).

  5. Kováčik A, Vogel A, Adler J, Pullmannová P, Vávrová K, Huster D. Biochim. Biophys. Acta - Biomembranes2018, 1860(5):1162-1170 (IF2016 = 3.5).

  6. Kováčik A, Pullmannová P, Maixner J, Vávrová K. Langmuir. 2018, 34(1):521–529 (IF2016 = 3.8).

  7. Čuříková BA, Procházková K, Filková B, Diblíková P, Svoboda J, Kováčik A, Vávrová K, Zbytovská J. Int. J. Pharm. 2017, 534(1-2):287-296 (IF2016 = 3.6) .

  8. Svoboda M, Hlobilová M, Marešová M, Sochorová M, Kováčik A, Vávrová K, Dolečková I. Arch. Dermatol. Res. 2017, 309(9):757-765 (IF2016 = 2.3).

  9. Stahlberg S, Eichner A, Sonnenberger S, Kováčik A, Lange S, Schmitt T, Demé B, Hauss T, Dobner B, Neubert RHH, Huster D. Langmuir2017, 33(36):9211-9221 (IF2016 = 3.8).

  10. Sochorová M, Staňková K, Pullmannová P, Kováčik A, Zbytovská J, Vávrová K. Sci. Rep. 2017, 7(1):6470 (IF2016 = 4.3).

  11. Vávrová K, Kováčik A, Opálka L. Eur. Pharm. J. 2017, 64 (1):1-8.

  12. Pullmannová P, Pavlíková L, Kováčik A, Sochorová M, Školová B, Slepička P, Maixner J, Zbytovská J, Vávrová K. Biophys. Chem. 2017, 224, 20-31 (IF2016 = 2.4)

  13. Kováčik A, Šilarová M, Pullmannová P, Maixner J, Vávrová K. Langmuir2017, 33, 2890-2899 (IF2016 = 3.8).

  14. Školová B, Kováčik A, Tesař O, Opálka L, Vávrová K. Biochim. Biophys. Acta - Biomembranes2017, 1859(5), 824-834 (IF2016 = 3.5).

  15. Opálka L, Kováčik A, Maixner J, Vávrová K. Langmuir. 2016, 32(48), 12894-12904 (IF2016 = 3.8).

  16. Kováčik A, Opálka L, Šilarová M, Roh J, Vávrová K. RSC Adv. 2016, 6(77), 73343-73350 (IF2016 = 3.1).

  17. Opálka L, Kováčik A, Sochorová M, Roh J, Kuneš J, Lenčo J, Vávrová K. Org. Lett. 2015, 17(21):5456-59 (IF2016 = 6.6).

  18. Wallmeyer L, Lehnen D, Eger N, Sochorová M, Opálka L, Kováčik A, Vávrová K, Hedtrich S. J. Dermatol. Sci. 2015, 80(2):102–10 (IF2016 = 3.7).

  19. Kováčik A, Roh J, Vávrová K. ChemBioChem. 2014, 15(11):1555-62 (IF2016 = 2.8).

  20. Školová B, Hudská K, Pullmannová P, Kováčik A, Palát K, Roh J, Fleddermann J, Estrela-Lopis I, Vávrová K. J. Phys. Chem. B. 2014, 18(35):10460-70 (IF2016 = 3.2).

Professional Memberships

  • since 2018: Czech society for Biochemistry and Molecular Biology (Lipidomic section)

  • since 2015: Czech Chemical Society

  • since 2014: Czech Pharmaceutical Society (sections: Chemical Drugs, Clinical Pharmacy, History of Pharmacy)

Work Experience and Fellowships

  • 2017 (6 months): Institut für Medizinische Physik und Biophysik der Medizinischen Fakultät der Universität Leipzig (Prof. Dr. Daniel Huster, Leipzig, Germany)

  • 2017 (1 week): Training Course “Interpretation of vibrational spectra” (Prague, Czech Republic)

  • 2015: Frank Laboratory of Neutron Physics (JINR, Dubna, Russian Federation)

  • 2012 (3 months): Thomayer Hospital (Pharmacy, Prague, Czech Republic)

  • 2012/2013 (3 months): Homolka Hospital (Pharmacy, Prague, Czech Republic)

Presentations at Conferences

2018:

  • Advances in Pharmaceutical Technology (Brno, Czech Republic; oral presentation)

  • Skin Forum (Skin health and topical formulation - new insights and perspectives), Tallin, Estonia (poster)

  • Czech Lipidomics Conference, Prague, Czech Republic (poster)

  • Sanofi Prize Meeting (Prague, Czech Republic; oral presentation)

  • Perspectives in Percutaneous Penetration, La Grande Motte, France (poster)

2017:

  • European Epidermal Barrier Research Network Meeting (E2BRN), Salzburg, Austria (poster + oral presentation)

  • 12th Sphingolipid Club Meeting, Trabia, Sicily, Italy (poster)

  • XVII. Interdisciplinary Meeting of Young Biologists, Biochemists and Chemists, Milovy, Czech Republic (poster) 

2016:

  • 6th Postgraduate and 4th Postdoc Conference, Hradec Králové, Czech Republic (oral presentation)

  • Perspectives in Percutaneous Penetration, La Grande Motte, France (poster)

  • The 5th Czech Lipidomics Conference, Prague, Czech Republic (poster)

  • The 45th Conference Drug Synthesis and Analysis, Hradec Králové, Czech Republic (oral presentation)

  • 4th European Joint Theoretical/Experimental Meeting on Membranes, Bratislava, Slovakia (poster)

2015:

  • 5th Postgraduate and 3rd Postdoc Conference, Hradec Králové, Czech Republic (oral presentation)

  • Gordon Research Conference: Barrier Function of Mammalian Skin, Waterville, New Hampshire, USA (poster)

  • 50th Advances in Organic, Bioorganic and Pharmaceutical Chemistry, Olomouc, Czech Republic (poster)

2014:

  • 4th Postgraduate and 2nd Postdoc Conference, Hradec Králové, Czech Republic (oral presentation)

  • Perspectives in Percutaneous Penetration, La Grande Motte, France (poster)

  • Skin Forum (Percutaneous Penetration – Measurement, Modulation and Modelling), Prague, Czech Republic (poster)

  • 49th Advances in Organic, Bioorganic and Pharmaceutical Chemistry, Lázně Bělohrad, Czech Republic (poster)

2013:

  • 48th Advances in Organic, Bioorganic and Pharmaceutical Chemistry, Špindlerův Mlýn, Czech Republic (poster)

2012:

  • International Student Research Conference, Prague, Czech Republic (oral presentation; 1st Prize)

Additional Skills

  • languages: English, German, Russian (basics)

  • computer skills: OS Windows, MS Office, MestreNova, ChemDraw, GraphPad, OPUS, X'Pert Data Viewer

  • driving licence “B”

Other Activities

  • 2018: delegate of Faculty of Pharmacy in Hradec Králové on fair GAUDEAMUS (Nitra, Slovakia)

  • 2016: co-author of the exposition of Department of Inorganic and Organic Chemistry at OpenDay of Faculty of Pharmacy

  • 2016: collaboration in “SCIO” tests (chemistry) for grammar students

  • 2015: main author of the exposition of Faculty of Pharmacy in Hradec Králové at “Nábřeží vysokých škol” exhibition (Hradec Králové)

  • 2014: main author and coordinator of the exposition of Faculty of Pharmacy in Hradec Králové at “Nábřeží vysokých škol” exhibition (Hradec Králové)
    Kováčik A. Čas. čes. lék. 2014, 86(10): 29 (article in Czech)

  • 2013: co-author of the exposition of Faculty of Pharmacy in Hradec Králové at “The Day of Science” exhibition (Prague)
    Kováčik A, Pilařová V. Čas. čes. lék. 2013, 85(12): 26 (article in Czech)

  • since 2011: guide and worker in the Czech Pharmaceutical Museum in Kuks

Interests and Hobbies

  • sports: swimming, jogging

  • music: alternative rock and alternative pop

© Charles University, Faculty of Pharmacy in Hradec Králové, Akademika Heyrovského 1203, 500 05 Hradec Králové, Czech Republic
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