PharmDr. Jana Křoustková, Ph.D.

Research interest

• Isolation and structure elucidation of biologically active plant constituents – mostly alkaloids
• NMR spectroscopy in comprehensive structure identification of isolated compounds
• Modern techniques of plant analysis

Education

2016–2021 Ph.D.
Charles University, Faculty of Pharmacy in Hradec Králové (FaF UK), Study program: Bioorganic chemistry
NMR Spectroscopy in Structure Elucidation of Isolated Alkaloids, supervisor: Assoc. Prof. Jiří Kuneš

2021 PharmDr.
Charles University, FaF UK, Study program: Bioorganic chemistry

2011–2016 Mgr.
Charles University, FaF UK, Study program: Pharmacy
Use of the NMR Spectroscopy for Structural Analysis of the Plant Metabolites, supervisor: Assoc. Prof. Jiří Kuneš

2003–2011
High school Vítězslava Nováka, Jindřichův Hradec

Professional Carrier

4/2021–ongoing
Assistant professor at the Department of Pharmacognosy and Pharmaceutical Botany of FaF UK

2020–2021
Technical staff at NMR laboratory at the Department of Organic and Bioorganic chemistry FaF UK – EFSA-CDN project

2018–2019
Research assistant at the project of prof. Milan Pour supported by Czech Science Foundation

Research fellowship

Starting 3/2022
University of Graz, Institute of Pharmaceutical Sciences, Department of Pharmacognosy (prof. Franz Bucar) – supported by Aktion Austria-Czech Republic programme

9–12/2015
University of Las Palmas de Gran Canaria, Facultad de Ciencias del Mar, AQMA laboratory (prof. José Juan Santana Rodríguez)
UHPLC-MS/MS analysis of steroids in sewage sludge samples (ERASMUS+)

Teaching Activities

Pharmaceutical Botany, Phytochemical methods (CZ&ENG)

Hobbies

Hiking, cross-country skiing and travelling

Publications

Summary bibliographical data according to Web of Science (7.1.2022)

• Number of publications    17
• Number of citations    128
• without self-citations    97
• h-index    7

1. Habartová, K.; Havelek, R.; Seifrtová, M.; Královec, K.; Cahlíková, L.; Chlebek, J.; Čermáková, E.; Mazánková, N.; Maříková, J.; Kuneš, J.; Nováková, L.; Řezačová, M. Scoulerine Affects Microtubule Structure, Inhibits Proliferation, Arrests Cell Cycle and Thus Culminates in the Apoptotic Death of Cancer Cells, Sci. Rep. 2018, 8, 4829. DOI: 10.1038/s41598-018-22862-0; IF²⁰¹⁷ 4.122 (Q1), AIS²⁰¹⁷ 1.356 (Q1)
2. Hošťálková, A.; Maříková, J.; Opletal, L.; Korábečný, J.; Hulcová, D.; Kuneš, J.; Nováková, L.; Peréz, D.I.; Jun, D.; Kučera, T.; Andrisano, V.; Siatka, T.; Cahlíková, L. Isoquinoline Alkaloids from Berberis vulgaris as Potential Lead Compounds for the Treatment of Alzheimer's Disease, J. Nat. Prod. 2019, 82, 239–248. DOI: 10.1021/acs.jnatprod.8b00592; IF²⁰¹⁸ 4.257 (Q1/Q1/Q1), AIS²⁰¹⁸ 0.827 (Q1/Q1/Q2)
3. Kohelová, E.; Perinová, R.; Maafi, N.; Korábečný, J.; Hulcová, D.; Maříková, J.; Kučera, T.; Gonzalez, L. M.; Hrabinová, M.; Vorčáková, K.; Nováková, L.; De Simone, A.; Havelek, R.; Cahlíková, L. Derivatives of the β-Crinane Amaryllidaceae Alkaloid Haemanthamine as Multi-Target Directed Ligands for Alzheimer’s Disease, Molecules 2019, 24, 1307. DOI: 10.3390/molecules24071307; IF²⁰¹⁸ 3.060 (Q2), AIS²⁰¹⁸ 0.620 (Q2)
4. Brůža, Z.; Kratochvíl, J.; Harvey, J. N.; Rulíšek, L.; Nováková, L.; Maříková, J.; Kuneš, J.; Kočovský, P.; Pour, M. A New Insight into the Stereoelectronic Control of the Pd 0‐Catalyzed Allylic Substitution: Application for the Synthesis of Multisubstituted Pyran‐2‐ones via an Unusual 1,3‐Transposition, Chem. Eur. J. 2019, 25, 8053. DOI: 10.1002/chem.201900323; IF²⁰¹⁸ 5.160 (Q1), AIS²⁰¹⁸ 1.152 (Q1)
5. Hulcová, D.; Maříková, J.; Korábečný, J.; Hošťálková, A.; Jun, D.; Kuneš, J.; Chlebek, J.; Opletal, L.; De Simone, A.; Nováková, L.; Andrisano, V.; Růžička, A.; Cahlíková, L. Amaryllidaceae Alkaloids from Narcissus pseudonarcissus L. cv. Dutch Master as Potential Drugs in Treatment of Alzheimer's Disease, Phytochemistry 2019, 165, 112055. DOI: 10.1016/j.phytochem.2019.112055; IF²⁰¹⁸ 2.905 (Q1/Q2), AIS²⁰¹⁸ 0.761 (Q1/Q1)
6. Al Shammari, L.; Al Mamun, A.; Koutová, A.; Majorošová, M.; Hulcová, D.; Šafratová, M.; Breiterová, K.; Maříková, J.; Havelek, R.; Cahlíková, L. Alkaloid Profiling of Hippeastrum cultivars by GC-MS, Isolation of Amaryllidaceae Alkaloids, and Evaluation of their Cytotoxicity, Rec. Nat. Prod. 2020, 14, 154–159. DOI: 10.25135/rnp.147.19.06.1302; IF²⁰¹⁹ 1.268 (Q3/Q3/Q3), AIS²⁰¹⁹ 0.195 (Q3/Q3/Q4)
7. Breiterová, K.; Koutová, D.; Maříková, J.; Havelek, R.; Kuneš, J.; Majorošová, M.; Opletal, L.; Hošťálková, A.; Jenčo, J.; Řezáčová, M.; Cahlíková, L. Amaryllidaceae Alkaloids of Different Structural Types from Narcissus L. cv. Professor Einstein and their Cytotoxic Activity, Plants 2020, 9, 137. DOI: 10.3390/plants9020137; IF²⁰¹⁹ 4.082 (Q1)
8. Al Mamun, A.; Maříková, J.; Hulcová, D.; Janoušek, J.; Šafratová, M.; Nováková, L.; Kučera, T.; Hrabinová, M.; Kuneš, J.; Korábečný, J.; Cahlíková, L. Amaryllidaceae Alkaloids of Belladine-Type from Narcissus pseudonarcissus cv. Carlton as New Selective Inhibitors of Butyrylcholinesterase. Biomolecules 2020, 10, 800. DOI: 10.3390/biom10050800; IF²⁰¹⁹ 4.082 (Q2)
9. Peřinová, R.; Maafi, N.; Korábečný, J.; Kohelová, E.; De Simone, A.; Al Mamun, A.; Hulcová, D.; Marková, J.; Kučera, T.; Jun, D.; Šafratová, M.; Maříková, J.; Andrisano, V.; Jenčo, J.; Kuneš, J.; Martinez, A.; Nováková, L.; Cahlíková, L. Functionalized Aromatic Esters of the Amaryllidaceae Alkaloid Haemanthamine and their in vitro and in silico Biological Activity Connected to Alzheimer’s Disease, Bioorg. Chem. 2020, 100. DOI: 10.1016/j.bioorg.2020.103928; IF²⁰¹⁹ 4.831 (Q1/Q1), AIS²⁰¹⁹ 0.643 (Q2/Q2)
10. Maříková, J.; Ritomská, A.; Korábečný, J.; Peřinová, R.; Al Mamun, A.; Kučera, T.; Kohelová, E; Hulcová, D.; Kobrlová, T.; Kuneš, J.; Nováková, L.; Cahlíková, L. Aromatic Esters of the Crinane Amaryllidaceae Alkaloid Ambelline as Selective Inhibitors of Butyrylcholinesterase. J. Nat. Prod. 2020, 83, 1359–1367. DOI: 10.1021/acs.jnatprod.9b00561; IF²⁰¹⁹ 3.779 (Q1/Q2/Q2), AIS²⁰¹⁹ 0.778 (Q1/Q1/Q2)
11. Matouš, P.; Kadaník, M.; Timoracký, M.; Kuneš, J.; Maříková, J.; Růžička, A.; Kočovský, P.; Pour, M. Nucleophile-assisted Cyclization of β-Propargylamino Acrylic Compounds Catalyzed by Gold(I): a Rapid Construction of Multisubstituted Tetrahydropyridines and their Fused Derivatives. Org. Chem. Front. 2020, 7, 3356–3367. DOI: 10.1039/D0QO00653J; IF²⁰¹⁹ 5.155 (Q1), AIS²⁰¹⁹ 1.062 (Q1)
12. Al Shammari, L.; Hulcová, D.; Maříková, J.; Kučera, T.; Šafratová, M.; Nováková, L.; Schmidt, M.; Pulkrábková, L.; Janoušek, J.; Soukup, O.; Kuneš, J.; Opletal, L.; Cahlíková, L. Amaryllidaceae Alkaloids from Hippeastrum X hybridum cv. Ferrari, and Preparation of Vittatine Derivatives as Potential Ligands for Alzheimer´s Disease. S. Afr. J. Bot. 2021, 136, 137–146. DOI: 10.1016/j.sajb.2020.06.024; IF²⁰¹⁹ 1.792 (Q2), AIS²⁰¹⁹ 0.348 (Q3)
13. Kohelová, E.; Maříková, J.; Korábečný, J.; Hulcová, D.; Kučera, T.; Jun, D.; Chlebek, J.; Jenčo, J.; Šafratová, M.; Hrabinová, M.; Ritomská, A.; Malaník, M.; Peřinová, R.; Breiterová, K.; Kuneš, J.; Nováková, L.; Opletal, L.; Cahlíková, L. Alkaloids of Zephyranthes citrina (Amaryllidaceae) and their Implication to Alzheimer's Disease: Isolation, Structural Elucidation and Biological Activity. Bioorg. Chem. 2021, 107, 104567. DOI: 10.1016/j.bioorg.2020.104567; IF²⁰¹⁹ 4.831 (Q1/Q1), AIS²⁰¹⁹ 0.643 (Q2/Q2)
14. Maříková, J.; Mamun, A.A.; Shammari, L.A.; Korábečný, J.; Kučera, T.; Hulcová, D.; Kuneš, J.; Malaník, M.; Vašková, M.; Kohelová, E.; Nováková, L.; Cahlíková, L.; Pour, M. Structure Elucidation and Cholinesterase Inhibition Activity of Two New Minor Amaryllidaceae Alkaloids. Molecules 2021, 26, 1279. DOI:10.3390/molecules26051279; IF²⁰¹⁹ 3.267 (Q2/Q2), AIS²⁰¹⁹ 0.599(Q2/Q3)
15. Matouš, P.; Májek, M.; Kysilka, O.; Kuneš, J.; Maříková, J.; Růžička, A.; Pour, M.; Kočovský, P. Reaction Outcome Critically Dependent on the Way of Workup: An Example from the Synthesis of 1‑Isoquinolones. J. Org. Chem. 2021, 86, 8078–8088. DOI: 10.1021/acs.joc.1c00561; IF²⁰²⁰ 4.354 (Q1); AIS²⁰²⁰ 0.793 (Q1)
16. Maafi, N.; Pidaný, F.; Maříková, J.; Korábečný, J.; Hulcová, D.; Kučera, T.; Schmidt, M.; Al Shammari, L.; Špulák, M.; Catapano, M. C.; Mecava, M.; Prchal, L.; Kuneš, J.; Janoušek, J.; Kohelová, E.; Jenčo, J.; Nováková, L.; Cahlíková, L. Derivatives of Montanine-Type Alkaloids and their Implication for the Treatment of Alzheimer‘s Disease: Synthesis, Biological Activity and in silico Study, Bioorg. Med. Chem. Lett. 2021, 51, 128374. DOI: 10.1016/j.bmcl.2021.128374; IF²⁰²⁰ 2.823 (Q2/Q3), AIS²⁰²⁰ 0.471(Q2/Q3)
17. Mamun, A. A.; Pidaný, F.; Hulcová, D.; Maříková, J.; Kučera, T.; Schmidt, M.; Catapano, M. C.; Hrabinová, M.; Jun, D.; Múčková, L.; Kuneš, J.; Janoušek, J.; Andrýs, R.; Nováková, L.; Peřinová, R.; Maafi, N.; Soukup, O.; Korábečný, J.; Cahlíková, L. Amaryllidaceae Alkaloids of Norbelladine-Type as Inspiration for Development of Highly Selective Butyrylcholinesterase Inhibitors: Synthesis, Biological Activity Evaluation, and Docking Studies. Int. J. Mol. Sci. 2021, 22, 8308. DOI: 10.3390/ijms22158308; IF²⁰²⁰ 5.923 (Q1/Q2), AIS²⁰²⁰ 1.123 (Q2/Q1)
18. Maafi, N.; Al Mamun, A.; Janďourek, O.; Maříková, J.; Breiterová, K.; Diepoltová, A.; Konečná, K.; Hošťálková, A.; Hulcová, D.; Kuneš, J.; Kohelová, E.; Koutová, D.; Šafratová, M.; Nováková, L.; Cahlíková, L. Semisynthetic Derivatives of Selected Amaryllidaceae Alkaloids as a New Class of Antimycobacterial Agents. Molecules 2021, 26, 6023. DOI: 10.3390/molecules26196023; IF²⁰²⁰ 4.411 (Q2/Q3), AIS²⁰²⁰ 0.694 (Q3/Q2)
19. Vrabec, R.; Maříková, J.; Ločárek, M.; Korábečný, J.; Hulcová, D.; Hošťálková, A.; Kuneš, J.; Chlebek, J.; Kučera, T.; Hrabinová, M.; Jun, D.; Soukup, O.; Andrisano, V.; Jenčo, J.; Šafratová, M.; Nováková, L.; Opletal, L.; Cahlíková, L. Monoterpene Indole Alkaloids from Vinca minor L. (Apocynaceae): Identification of New Structural Scaffold for Treatment of Alzheimer‘s Disease. Phytochemistry 2022, 113017. DOI: 10.1016/j.phytochem.2021.113017; IF²⁰²⁰ 4.072 (Q1/Q3), AIS²⁰²⁰ 0.755 (Q1/Q3)
20. Křoustková, J.; Ritomská, A.; Al Mamun, A.; Hulcová, D.; Opletal, L.; Kuneš, J.; Cahlíková, L.; Bucar, F. Structural analysis of unusual alkaloids isolated from Narcissus pseudonarcissus cv. Carlton. Phytochemistry 2022, 204, 113439.  DOI: 10.1016/j.phytochem.2022.113439; IF²⁰²⁰ 4.072 (Q1/Q3), AIS²⁰²⁰ 0.755 (Q1/Q3)