PharmDr. Jana Křoustková, Ph.D.

Research interest

  • Isolation and structure elucidation of biologically active plant constituents – mostly alkaloids
  • NMR spectroscopy in comprehensive structure identification of isolated compounds
  • Modern techniques of plant analysis


2016–2021 Ph.D.
Charles University, Faculty of Pharmacy in Hradec Králové (FaF UK), Study program: Bioorganic chemistry
NMR Spectroscopy in Structure Elucidation of Isolated Alkaloids, supervisor: Assoc. Prof. Jiří Kuneš

2021 PharmDr.
Charles University, FaF UK, Study program: Bioorganic chemistry

2011–2016 Mgr.
Charles University, FaF UK, Study program: Pharmacy
Use of the NMR Spectroscopy for Structural Analysis of the Plant Metabolites, supervisor: Assoc. Prof. Jiří Kuneš

High school Vítězslava Nováka, Jindřichův Hradec

Professional Carrier

Assistant professor at the Department of Pharmacognosy and Pharmaceutical Botany of FaF UK

Technical staff at NMR laboratory at the Department of Organic and Bioorganic chemistry FaF UK – EFSA-CDN project

Research assistant at the project of prof. Milan Pour supported by Czech Science Foundation

Research fellowship

Starting 3/2022
University of Graz, Institute of Pharmaceutical Sciences, Department of Pharmacognosy (prof. Franz Bucar) – supported by Aktion Austria-Czech Republic programme

University of Las Palmas de Gran Canaria, Facultad de Ciencias del Mar, AQMA laboratory (prof. José Juan Santana Rodríguez)
UHPLC-MS/MS analysis of steroids in sewage sludge samples (ERASMUS+)

Teaching Activities

Pharmaceutical Botany, Phytochemical methods (CZ&ENG)


Hiking, cross-country skiing and travelling


Summary bibliographical data according to Web of Science (7.1.2022)

  • Number of publications    17
  • Number of citations    128
  • without self-citations    97
  • h-index    7


  1. Habartová, K.; Havelek, R.; Seifrtová, M.; Královec, K.; Cahlíková, L.; Chlebek, J.; Čermáková, E.; Mazánková, N.; Maříková, J.; Kuneš, J.; Nováková, L.; Řezačová, M. Scoulerine Affects Microtubule Structure, Inhibits Proliferation, Arrests Cell Cycle and Thus Culminates in the Apoptotic Death of Cancer Cells, Sci. Rep. 2018, 8, 4829. DOI: 10.1038/s41598-018-22862-0; IF2017 4.122 (Q1), AIS2017 1.356 (Q1)
  2. Hošťálková, A.; Maříková, J.; Opletal, L.; Korábečný, J.; Hulcová, D.; Kuneš, J.; Nováková, L.; Peréz, D.I.; Jun, D.; Kučera, T.; Andrisano, V.; Siatka, T.; Cahlíková, L. Isoquinoline Alkaloids from Berberis vulgaris as Potential Lead Compounds for the Treatment of Alzheimer's Disease, J. Nat. Prod. 2019, 82, 239–248. DOI: 10.1021/acs.jnatprod.8b00592; IF2018 4.257 (Q1/Q1/Q1), AIS2018 0.827 (Q1/Q1/Q2)
  3. Kohelová, E.; Perinová, R.; Maafi, N.; Korábečný, J.; Hulcová, D.; Maříková, J.; Kučera, T.; Gonzalez, L. M.; Hrabinová, M.; Vorčáková, K.; Nováková, L.; De Simone, A.; Havelek, R.; Cahlíková, L. Derivatives of the β-Crinane Amaryllidaceae Alkaloid Haemanthamine as Multi-Target Directed Ligands for Alzheimer’s Disease, Molecules 2019, 24, 1307. DOI: 10.3390/molecules24071307; IF2018 3.060 (Q2), AIS2018 0.620 (Q2)
  4. Brůža, Z.; Kratochvíl, J.; Harvey, J. N.; Rulíšek, L.; Nováková, L.; Maříková, J.; Kuneš, J.; Kočovský, P.; Pour, M. A New Insight into the Stereoelectronic Control of the Pd 0‐Catalyzed Allylic Substitution: Application for the Synthesis of Multisubstituted Pyran‐2‐ones via an Unusual 1,3‐Transposition, Chem. Eur. J. 2019, 25, 8053. DOI: 10.1002/chem.201900323; IF2018 5.160 (Q1), AIS2018 1.152 (Q1)
  5. Hulcová, D.; Maříková, J.; Korábečný, J.; Hošťálková, A.; Jun, D.; Kuneš, J.; Chlebek, J.; Opletal, L.; De Simone, A.; Nováková, L.; Andrisano, V.; Růžička, A.; Cahlíková, L. Amaryllidaceae Alkaloids from Narcissus pseudonarcissus L. cv. Dutch Master as Potential Drugs in Treatment of Alzheimer's Disease, Phytochemistry 2019, 165, 112055. DOI: 10.1016/j.phytochem.2019.112055; IF2018 2.905 (Q1/Q2), AIS2018 0.761 (Q1/Q1)
  6. Al Shammari, L.; Al Mamun, A.; Koutová, A.; Majorošová, M.; Hulcová, D.; Šafratová, M.; Breiterová, K.; Maříková, J.; Havelek, R.; Cahlíková, L. Alkaloid Profiling of Hippeastrum cultivars by GC-MS, Isolation of Amaryllidaceae Alkaloids, and Evaluation of their Cytotoxicity, Rec. Nat. Prod. 2020, 14, 154–159. DOI: 10.25135/rnp.; IF2019 1.268 (Q3/Q3/Q3), AIS2019 0.195 (Q3/Q3/Q4)
  7. Breiterová, K.; Koutová, D.; Maříková, J.; Havelek, R.; Kuneš, J.; Majorošová, M.; Opletal, L.; Hošťálková, A.; Jenčo, J.; Řezáčová, M.; Cahlíková, L. Amaryllidaceae Alkaloids of Different Structural Types from Narcissus L. cv. Professor Einstein and their Cytotoxic Activity, Plants 2020, 9, 137. DOI: 10.3390/plants9020137; IF2019 4.082 (Q1)
  8. Al Mamun, A.; Maříková, J.; Hulcová, D.; Janoušek, J.; Šafratová, M.; Nováková, L.; Kučera, T.; Hrabinová, M.; Kuneš, J.; Korábečný, J.; Cahlíková, L. Amaryllidaceae Alkaloids of Belladine-Type from Narcissus pseudonarcissus cv. Carlton as New Selective Inhibitors of Butyrylcholinesterase. Biomolecules 202010, 800. DOI: 10.3390/biom10050800; IF2019 4.082 (Q2)
  9. Peřinová, R.; Maafi, N.; Korábečný, J.; Kohelová, E.; De Simone, A.; Al Mamun, A.; Hulcová, D.; Marková, J.; Kučera, T.; Jun, D.; Šafratová, M.; Maříková, J.; Andrisano, V.; Jenčo, J.; Kuneš, J.; Martinez, A.; Nováková, L.; Cahlíková, L. Functionalized Aromatic Esters of the Amaryllidaceae Alkaloid Haemanthamine and their in vitro and in silico Biological Activity Connected to Alzheimer’s Disease, Bioorg. Chem. 2020, 100. DOI: 10.1016/j.bioorg.2020.103928; IF2019 4.831 (Q1/Q1), AIS2019 0.643 (Q2/Q2)
  10. Maříková, J.; Ritomská, A.; Korábečný, J.; Peřinová, R.; Al Mamun, A.; Kučera, T.; Kohelová, E; Hulcová, D.; Kobrlová, T.; Kuneš, J.; Nováková, L.; Cahlíková, L. Aromatic Esters of the Crinane Amaryllidaceae Alkaloid Ambelline as Selective Inhibitors of Butyrylcholinesterase. J. Nat. Prod. 2020, 83, 1359–1367. DOI: 10.1021/acs.jnatprod.9b00561; IF2019 3.779 (Q1/Q2/Q2), AIS2019 0.778 (Q1/Q1/Q2)
  11. Matouš, P.; Kadaník, M.; Timoracký, M.; Kuneš, J.; Maříková, J.; Růžička, A.; Kočovský, P.; Pour, M. Nucleophile-assisted Cyclization of β-Propargylamino Acrylic Compounds Catalyzed by Gold(I): a Rapid Construction of Multisubstituted Tetrahydropyridines and their Fused Derivatives. Org. Chem. Front. 2020, 7, 3356–3367. DOI: 10.1039/D0QO00653J; IF2019 5.155 (Q1), AIS2019 1.062 (Q1)
  12. Al Shammari, L.; Hulcová, D.; Maříková, J.; Kučera, T.; Šafratová, M.; Nováková, L.; Schmidt, M.; Pulkrábková, L.; Janoušek, J.; Soukup, O.; Kuneš, J.; Opletal, L.; Cahlíková, L. Amaryllidaceae Alkaloids from Hippeastrum X hybridum cv. Ferrari, and Preparation of Vittatine Derivatives as Potential Ligands for Alzheimer´s Disease. S. Afr. J. Bot. 2021, 136, 137–146. DOI: 10.1016/j.sajb.2020.06.024; IF2019 1.792 (Q2), AIS2019 0.348 (Q3)
  13. Kohelová, E.; Maříková, J.; Korábečný, J.; Hulcová, D.; Kučera, T.; Jun, D.; Chlebek, J.; Jenčo, J.; Šafratová, M.; Hrabinová, M.; Ritomská, A.; Malaník, M.; Peřinová, R.; Breiterová, K.; Kuneš, J.; Nováková, L.; Opletal, L.; Cahlíková, L. Alkaloids of Zephyranthes citrina (Amaryllidaceae) and their Implication to Alzheimer's Disease: Isolation, Structural Elucidation and Biological Activity. Bioorg. Chem. 2021, 107, 104567. DOI: 10.1016/j.bioorg.2020.104567; IF2019 4.831 (Q1/Q1), AIS2019 0.643 (Q2/Q2)
  14. Maříková, J.; Mamun, A.A.; Shammari, L.A.; Korábečný, J.; Kučera, T.; Hulcová, D.; Kuneš, J.; Malaník, M.; Vašková, M.; Kohelová, E.; Nováková, L.; Cahlíková, L.; Pour, M. Structure Elucidation and Cholinesterase Inhibition Activity of Two New Minor Amaryllidaceae Alkaloids. Molecules 202126, 1279. DOI:10.3390/molecules26051279; IF2019 3.267 (Q2/Q2), AIS2019 0.599(Q2/Q3)
  15. Matouš, P.; Májek, M.; Kysilka, O.; Kuneš, J.; Maříková, J.; Růžička, A.; Pour, M.; Kočovský, P. Reaction Outcome Critically Dependent on the Way of Workup: An Example from the Synthesis of 1‑Isoquinolones. J. Org. Chem. 202186, 8078–8088. DOI: 10.1021/acs.joc.1c00561; IF2020 4.354 (Q1); AIS2020 0.793 (Q1)
  16. Maafi, N.; Pidaný, F.; Maříková, J.; Korábečný, J.; Hulcová, D.; Kučera, T.; Schmidt, M.; Al Shammari, L.; Špulák, M.; Catapano, M. C.; Mecava, M.; Prchal, L.; Kuneš, J.; Janoušek, J.; Kohelová, E.; Jenčo, J.; Nováková, L.; Cahlíková, L. Derivatives of Montanine-Type Alkaloids and their Implication for the Treatment of Alzheimer‘s Disease: Synthesis, Biological Activity and in silico Study, Bioorg. Med. Chem. Lett. 2021, 51, 128374. DOI: 10.1016/j.bmcl.2021.128374; IF2020 2.823 (Q2/Q3), AIS2020 0.471(Q2/Q3)
  17. Mamun, A. A.; Pidaný, F.; Hulcová, D.; Maříková, J.; Kučera, T.; Schmidt, M.; Catapano, M. C.; Hrabinová, M.; Jun, D.; Múčková, L.; Kuneš, J.; Janoušek, J.; Andrýs, R.; Nováková, L.; Peřinová, R.; Maafi, N.; Soukup, O.; Korábečný, J.; Cahlíková, L. Amaryllidaceae Alkaloids of Norbelladine-Type as Inspiration for Development of Highly Selective Butyrylcholinesterase Inhibitors: Synthesis, Biological Activity Evaluation, and Docking Studies. Int. J. Mol. Sci. 202122, 8308. DOI: 10.3390/ijms22158308; IF2020 5.923 (Q1/Q2), AIS2020 1.123 (Q2/Q1)
  18. Maafi, N.; Al Mamun, A.; Janďourek, O.; Maříková, J.; Breiterová, K.; Diepoltová, A.; Konečná, K.; Hošťálková, A.; Hulcová, D.; Kuneš, J.; Kohelová, E.; Koutová, D.; Šafratová, M.; Nováková, L.; Cahlíková, L. Semisynthetic Derivatives of Selected Amaryllidaceae Alkaloids as a New Class of Antimycobacterial Agents. Molecules 2021, 26, 6023. DOI: 10.3390/molecules26196023; IF2020 4.411 (Q2/Q3), AIS2020 0.694 (Q3/Q2)
  19. Vrabec, R.; Maříková, J.; Ločárek, M.; Korábečný, J.; Hulcová, D.; Hošťálková, A.; Kuneš, J.; Chlebek, J.; Kučera, T.; Hrabinová, M.; Jun, D.; Soukup, O.; Andrisano, V.; Jenčo, J.; Šafratová, M.; Nováková, L.; Opletal, L.; Cahlíková, L. Monoterpene Indole Alkaloids from Vinca minor L. (Apocynaceae): Identification of New Structural Scaffold for Treatment of Alzheimer‘s Disease. Phytochemistry 2022, 113017. DOI: 10.1016/j.phytochem.2021.113017; IF2020 4.072 (Q1/Q3), AIS2020 0.755 (Q1/Q3)
  20. Křoustková, J.; Ritomská, A.; Al Mamun, A.; Hulcová, D.; Opletal, L.; Kuneš, J.; Cahlíková, L.; Bucar, F. Structural analysis of unusual alkaloids isolated from Narcissus pseudonarcissus cv. Carlton. Phytochemistry 2022, 204, 113439.  DOI: 10.1016/j.phytochem.2022.113439; IF2020 4.072 (Q1/Q3), AIS2020 0.755 (Q1/Q3)

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