Research focus
- Interactions of natural compounds with biogenic metals
- In vitro screening of novel iron/copper/zinc/cobalt chelators (comparison of chelating activity at different pHs, assessment of the abilities of these compounds to inhibit Fenton chemistry leading to highly reactive oxygen species and tissue derangement)
- Effect of nature compounds on copper-induced red blood cell lysis
- Anti-diabetic potential of dietary polyphenols (inhibition of α-glucosidase)
Education
- 2019: Master degree: Charles University, Faculty of Pharmacy, Diploma Thesis: Interactions of tamarixetin and isorhamnetin with copper.
- 2023: Ph.D. and PharmDr. degree: Charles University, Faculty of Pharmacy, Department of Pharmacognosy and Pharmaceutical Botany in the study programme: Pharmacognosy and Nutraceuticals. Doctoral Thesis: Interactions of natural phenolic compounds with biogenic metals.
Employment
- from 2022: Charles University, Faculty of Pharmacy in Hradec Králové, Department of Pharmacognosy and Pharmaceutical Botany
Teaching activities
- Pharmacognosy I and II, Experimental Pharmacodynamics (Czech and English)
Research fellowships
- 2021 research fellowship at the Department of Pharmacology, Faculty of Pharmacy, University of Pécs (3 months)
- 2023 research fellowship at the Department of Pharmacognosy, Institute of Pharmaceutical Sciences, University of Graz (3 months)
Publications
2026
HRUBŠA M, SOLOVIOVA A, HARČÁROVÁ P, GUNASEELAN C, LOMOZOVÁ Z, JIRKOVSKÝ E, CARAZO A, SOLLNER DOLENC M, PETERLIN MAŠIČ L, MLADĚNKA P: The effect of bisphenol PH and seven other bisphenol A alternatives on human haemostasis in vitro. Environ Toxicol Phar. 2026, 121: 104897, DOI:10.1016/j.etap.2025.104897 /IF2024 4.2/
2025
JANOUCHOVÁ V, HURTOVÁ M, KOČOVÁ VLČKOVÁ H, LOMOZOVÁ Z, POUROVÁ J, NOVÁKOVÁ L, PETRÁSKOVÁ L, PELANTOVÁ H, CVAČKA J, VALENTOVÁ K: Glucuronidated Hydroxyphenylacetic and Hydroxyphenylpropanoic Acids as Standards for Bioavailability Studies with Flavonoids. ACS Omega. 2025, DOI: 10.1021/acsomega.5c09380 /IF2024 4.3/
LOMOZOVÁ Z, HARČÁROVÁ P, ADLER B, KARLÍČKOVÁ J, KUČERA R, MLADĚNKA P: Interactions of di- and trihydroxybenzenes with transition metals and their biological consequences. Free Rad Res. 2025, 59: 824–839, DOI: 10.1080/10715762.2025.2598763 /IF2024 2.9/
GUNASEELAN C, LOMOZOVÁ Z, HRUBŠA M, PACLIKOVÁ M, SKOŘEPA P, MATOUŠOVÁ K, TURONOVÁ D, KRCMOVÁ LK, BLÁHA M, BLAHA V, MLADĚNKA P, CARAZO A: Occurrence of Platelet-Monocyte Aggregates in Patients with Metabolic Disorders and Effect of Direct Anticoagulants. Thromb Haemost. 2025, DOI: 10.1055/a-2747-8963 /IF2024 4.3/
MLADĚNKA P, FADRAERSADA J, DIAS P, TVRDÝ V, POUROVÁ J, JIRKOVSKÝ E, CARAZO A, GUNASEELAN C, HARČÁROVÁ P, LOMOZOVÁ Z, SOLLNER DOLENC M, TRONTELJ J, PETERLIN MAŠIČ L: The first subacute study with oral administration of bisphenol AP in male rats: Cardiovascular data and metabolite detection. Ecotox Environ Safe. 2025, 304: 19143, DOI: 10.1016/j.ecoenv.2025.119143 /IF2024 6.1/
HRUBŠA M, SOLOVIOVA A, GUNASEELAN C, HARČÁROVÁ P, LOMOZOVÁ Z, JIRKOVSKÝ E, CARAZO A, SOLLNER DOLENC M, PETERLIN MAŠIČ L, MLADĚNKA P: A novel bisphenol A alternative, DD-70, may negatively affect haemostasis through cyclooxygenase 1 inhibition. Environment International 2025, 203: 109738, DOI: 10.1016/j.envint.2025.109738 /IF2024 9.7/
SIATKA T, MÁT’UŠ M, MORAVCOVÁ M, HARČÁROVÁ P, LOMOZOVÁ Z, MATOUŠOVÁ K, SUWANVECHO C, KRČMOVÁ LK, MLADĚNKA P: Biological, dietetic and pharmacological properties of vitamin B9. NPJ Sci. Food 2025, 9:30, DOI: 10.1038/s41538-025-00396-w /IF2023 6.3/
HARČÁROVÁ P, LOMOZOVÁ Z, KALLIVRETAKI M, KARLÍČKOVÁ J, KUČERA R, MLADĚNKA P: Different behavior of food-related benzoic acids toward iron and copper, Food Chem. 2025, 462: 141014, DOI: 10.1016/j.foodchem.2024.141014 /IF2023 8.5/
2024
KONECNY L, LOMOZOVÁ Z, KARABANOVICH G, ROH J, VAVROVÁ K, MLADĚNKA P: Rapid method for screening of both calcium and magnesium chelation with comparison of 21 known metal chelators. J. Biol. Inorg. Chem. 2024, 29:785–800, DOI: 10.1007/s00775-024-02078-6 /IF2023 2,7/
RASSU G, VLČKOVÁ HK, GIUNCHEDI P, DIAS P, COSSU M, POUROVÁ J, HARČÁROVÁ P, LOMOZOVÁ Z, NOVÁKOVÁ L, GAVINI E, MLADĚNKA P: A water-soluble preparation for intravenous administration of isorhamnetin and its pharmacokinetics in rats. Chem. Biol. Interact. 2024, 396:111064, DOI: 10.1016/j.cbi.2024.111064 /IF2023 5.1/
2023
MORAVCOVÁ M, LOMOZOVÁ Z, KUČERA R, MLADĚNKA P: 3-hydroxyflavone is a mildly active and safe cobalt chelator while cobalt markedly enhances baicalein toxicity toward erythrocytes. RSC Adv. 2023, 13: 29242-29251, DOI: 10.1039/d3ra02735j /IF2022 3.9/
MORAVCOVÁ M, HRUBŠA M, LOMOZOVÁ Z, CATAPANO MC, ARGENTO R, JIRKOVSKÝ E, KUČERA R, MERCOLINI L, MLADĚNKA P: A complex methodological approach for the screening of efficient and safe cobalt chelators. Med. Chem. 2023, 19(5): 495-507, DOI: 10.2174/1871530322666221006144449 /IF2021 2.3/
2022
LOMOZOVÁ Z, HRUBŠA M, CONTE PF, PAPASTEFANAKI E, MORAVCOVÁ M, CATAPANO MC, PROIETTI SILVESTRI I, KARLÍČKOVÁ J, KUČERA R, MACÁKOVÁ K, MLADĚNKA P: The effect of flavonoids on the reduction of cupric ions, the copper-driven Fenton reaction and copper-triggered haemolysis. Food Chem. 2022, 394, 133461, DOI: 10.1016/j.foodchem.2022. /IF2020 7.5/
PARVIN M S, CHLEBEK J, HOŠŤÁLKOVÁ A, CATAPANO M C, LOMOZOVÁ Z, MACÁKOVÁ K, MLADĚNKA P: Interactions of Isoquinoline Alkaloids with Transition Metals Iron and Copper. Molecules. 2022, 27(19), 6429, DOI: 10.3390/molecules27196429. /IF2021 4.9/
LEMLI B, LOMOZOVÁ Z, HUBER T, LUKÁCS A, POÓR M: Effects of Heme Site (FA1) Ligands Bilirubin, Biliverdin, Hemin, and Methyl Orange on the Albumin Binding of Site I Marker Warfarin: Complex Allosteric Interactions. Int. J. Mol. Sci. 2022, 23(22), 14007, DOI: 10.3390/ijms232214007. /IF2021 6.2/
2021
LOMOZOVÁ Z, CATAPANO M C, HRUBŠA M, KARLÍČKOVÁ J, MACÁKOVÁ K, KUČERA R, MLADĚNKA P: Chelation of Iron and Copper by Quercetin B-Ring Methyl Metabolites, Isorhamnetin and Tamarixetin, and Their Effect on Metal-Based Fenton Chemistry. J. Agric. Food Chem. 2021, 69(21), 5926–5937, DOI: 10.1021/acs.jafc.1c01729. /IF2019 4.2/
LOMOZOVÁ Z, TVRDÝ V, HRUBŠA M, CATAPANO M C, MACÁKOVÁ K, BIEDERMANN D, KUČERA R, KŘEN V, MLADĚNKA P, VALENTOVÁ K: Dehydroflavonolignans from Silymarin Potentiate Transition Metal Toxicity In Vitro but Are Protective for Isolated Erythrocytes Ex Vivo. Antioxidants 2021, 10(5), 679, DOI: 10.3390/antiox10050679. /IF2019=5.0/