Research focus
- Interactions of natural compounds with biogenic metals
- In vitro screening of novel iron/copper/zinc/cobalt chelators (comparison of chelating activity at different pHs, assessment of the abilities of these compounds to inhibit Fenton chemistry leading to highly reactive oxygen species and tissue derangement)
- Effect of nature compounds on copper-induced red blood cell lysis
- Anti-diabetic potential of dietary polyphenols (inhibition of α-glucosidase)
Education
- 2019: Master degree: Charles University, Faculty of Pharmacy, Diploma Thesis: Interactions of tamarixetin and isorhamnetin with copper.
- 2023: Ph.D. and PharmDr. degree: Charles University, Faculty of Pharmacy, Department of Pharmacognosy and Pharmaceutical Botany in the study programme: Pharmacognosy and Nutraceuticals. Doctoral Thesis: Interactions of natural phenolic compounds with biogenic metals.
Employment
- from 2022: Charles University, Faculty of Pharmacy in Hradec Králové, Department of Pharmacognosy and Pharmaceutical Botany
Teaching activities
- Pharmacognosy I and II, Experimental Pharmacodynamics (Czech and English)
Research fellowships
- 2021 research fellowship at the Department of Pharmacology, Faculty of Pharmacy, University of Pécs (3 months)
- 2023 research fellowship at the Department of Pharmacognosy, Institute of Pharmaceutical Sciences, University of Graz (3 months)
Publications
2023
MORAVCOVÁ M, HRUBŠA M, LOMOZOVÁ Z, CATAPANO MC, ARGENTO R, JIRKOVSKÝ E, KUČERA R, MERCOLINI L, MLADĚNKA P: A complex methodological approach for the screening of efficient and safe cobalt chelators. Med. Chem. 2023;19(5): 495-507, DOI: 10.2174/1871530322666221006144449. /IF2021 2.3/
2022
LOMOZOVÁ Z, HRUBŠA M, CONTE PF, PAPASTEFANAKI E, MORAVCOVÁ M, CATAPANO MC, PROIETTI SILVESTRI I, KARLÍČKOVÁ J, KUČERA R, MACÁKOVÁ K, MLADĚNKA P: The effect of flavonoids on the reduction of cupric ions, the copper-driven Fenton reaction and copper-triggered haemolysis. Food Chem. 2022, 394, 133461, DOI: 10.1016/j.foodchem.2022. /IF2020 7.5/
PARVIN M S, CHLEBEK J, HOŠŤÁLKOVÁ A, CATAPANO M C, LOMOZOVÁ Z, MACÁKOVÁ K, MLADĚNKA P: Interactions of Isoquinoline Alkaloids with Transition Metals Iron and Copper. Molecules. 2022, 27(19), 6429, DOI: 10.3390/molecules27196429. /IF2021 4.9/
LEMLI B, LOMOZOVÁ Z, HUBER T, LUKÁCS A, POÓR M: Effects of Heme Site (FA1) Ligands Bilirubin, Biliverdin, Hemin, and Methyl Orange on the Albumin Binding of Site I Marker Warfarin: Complex Allosteric Interactions. Int. J. Mol. Sci. 2022, 23(22), 14007, DOI: 10.3390/ijms232214007. /IF2021 6.2/
2021
LOMOZOVÁ Z, CATAPANO M C, HRUBŠA M, KARLÍČKOVÁ J, MACÁKOVÁ K, KUČERA R, MLADĚNKA P: Chelation of Iron and Copper by Quercetin B-Ring Methyl Metabolites, Isorhamnetin and Tamarixetin, and Their Effect on Metal-Based Fenton Chemistry. J. Agric. Food Chem. 2021, 69(21), 5926–5937, DOI: 10.1021/acs.jafc.1c01729. /IF2019 4.2/
LOMOZOVÁ Z, TVRDÝ V, HRUBŠA M, CATAPANO M C, MACÁKOVÁ K, BIEDERMANN D, KUČERA R, KŘEN V, MLADĚNKA P, VALENTOVÁ K: Dehydroflavonolignans from Silymarin Potentiate Transition Metal Toxicity In Vitro but Are Protective for Isolated Erythrocytes Ex Vivo. Antioxidants 2021, 10(5), 679, DOI: 10.3390/antiox10050679. /IF2019=5.0/