Petr Pavek, PhD, Professor

Department of Pharmacology and Toxicology and Centre for Drug Development, Professor

Laboratory of Clinical and Molecular Pharmacotherapy
e-mail: Pavek@faf.cuni.cz
address: Heyrovského 1203, Hradec Kralove 500 05
phone: +420 495 067 334

Chair of Local Scientific Committee
The 23rd International Symposium on Microsomes and Drug Oxidations
„Microsomes and Drug Oxidations: From Structures to Regulations and Modeling“
August 30 – September 3, 2020, Prague, Czech Republic

MDO Prague

Previous Education and Emplyoment

M.Sc. 1996 – Faculty of Pharmacy, Charles University in Prague

Ph.D. 2000 – Pharmacology and Toxicology - Department of Pharmacology and Toxicology, Faculty of Pharmacy, Charles University in Prague

Assistant, 2000-2008, Associate Professor 2008

Professor 2014 - present, Department of Pharmacology and Toxicology

Research Interests

Aspects of gene regulation of proteins involved in pharmacokinetics, nuclear receptors, cytochrome P450 gene regulation, pharmacokinetics (DMPK), ADME-Tox, Drug-drug and drug-food interactions, pharmacogenetics and drug development

Teaching

Pharmacology and toxicology, Personalized pharmacotherapy and pharmacogenetics, Gene therapy, Biologics

Professional Memberships

  • Scientific Secretary of the Czech Society for Experimental and Clinical Pharmacology and Toxicology
  • Chair of the Section of Cellular and Molecular Pharmacology CSECPT
  • Advisory Board of Czech Scientific Foundation

Current grants

GA ČR Dynamics of nuclear receptor-mediated gene regulation:implement for the understanding of
detoxification functions and optimization of therapy GAČR 17-06841S, 2017-2019  

GA ČR Novel interventions for the treatment of triglycerides, cholesterol and bile acids diseases with
human CAR ligands 19-14497S 2019-2021       

edcmet Horizon 2020 - Metabolic effects of Endocrine Disrupting Chemicals: novel testing methods and adverse outcome Pathways (EDCMET) 2018-2023

UNGAP Horizon 2020 COST action - The European Network on Understanding Gastrointestinal Absorption-related Processes (UNGAP)

Awards/Prizes/Fellowships

2002, 2003, 2006, 2009, 2011 – Award of the Czech Society for Experimental and Clinical Pharmacology and Toxicology - as a first author

2004 – Stasek´s Award in Oncology by Janssen Foundation

2003 – The International Pharmaceutical Federation Fellowship

2001-2003- the Czech Science Foundation POST-DOC Fellowship

2017 – Award of the Czech Medical Society of J.E. Perkynje

Publications

more than 120 papers in international journals

H-index 30 (WoS), 2300+ citation

Selected publication over last 3 years:

  1. Dusek J, Skoda J, Holas O, Horvatova A, Smutny T, Linhartova L, Hirsova P, Kucera O, Micuda S, Braeuning A, Pavek P. Stilbene compound trans-3,4,5,4´-tetramethoxystilbene, a potential anticancer drug, regulates constitutive androstane receptor (Car) target genes, but does not possess proliferative activity in mouse liver. Toxicol Lett. 2019 Jun 3. pii: S0378-4274(19)30160-2.
     
  2. Smutny T, Barvik I, Veleta T, Pavek P, Soukup T. Genetic Predispositions of Glucocorticoid Resistance and Therapeutic Outcomes in Polymyalgia Rheumatica and Giant Cell Arteritis. J Clin Med. 2019 Apr 27;8(5).
     
  3. Hyrsova L, Vanduchova A, Dusek J, Smutny T, Carazo A, Maresova V, Trejtnar F, Barta P, Anzenbacher P, Dvorak Z, Pavek P. Trans-resveratrol, but not other natural stilbenes occurring in food, carries the risk of drug-food interaction via inhibition of cytochrome P450 enzymes or interaction with xenosensor receptors. Toxicol Lett. 2019 Jan;300:81-91.
     
  4. Carazo A, Dusek J, Holas O, Skoda J, Hyrsova L, Smutny T, Soukup T, Dosedel M, Pávek P. Teriflunomide Is an Indirect Human Constitutive Androstane Receptor (CAR) Activator Interacting With Epidermal Growth Factor (EGF) Signaling. Front Pharmacol. 2018 Oct 11;9:993.
     
  5. Koziolek M, Alcaro S, Augustijns P, Basit AW, Grimm M, Hens B, Hoad CL, Jedamzik P, Madla CM, Maliepaard M, Marciani L, Maruca A, Parrott N, Pávek P, Porter CJH, Reppas C, van Riet-Nales D, Rubbens J, Statelova M, Trevaskis NL, Valentová K, Vertzoni M, Čepo DV, Corsetti M. The mechanisms of pharmacokinetic food-drug interactions - A perspective from the UNGAP group. Eur J Pharm Sci. 2019 Jun 15;134:31-59.
     
  6. Dovrtelova G, Zendulka O, Noskova K, Jurica J, Pes O, Dusek J, Carazo A, Zapletalova I, Hlavacova N, Pavek P.Effect of Endocannabinoid Oleamide on Rat and Human Liver Cytochrome P450 Enzymes in In Vitro and In Vivo Models. Drug Metab Dispos. 2018 Jun;46(6):913-923.
     
  7. Tebbens JD, Azar M, Friedmann E, Lanzendörfer M, Pávek P. Mathematical Models in the Description of Pregnane X Receptor (PXR)-Regulated Cytochrome P450 Enzyme Induction.Int J Mol Sci. 2018 Jun 15;19(6).
     
  8. Soukup T, Barvik I, Nekvindova J, Veleta T, Kubena AA, Duintjer Tebbens J, Pavek P, Dosedel M. Are haplotypes in a single methotrexate pathway more predictive for response in rheumatoid arthritis than in different pathways? Pharmacogenomics. 2018 Mar 26. doi: 10.2217/pgs-2016-0182.
     
  9. Smutný T, Harjumäki R, Kanninen L, Yliperttula M, Pávek P, Lou YR.A feasibility study of the toxic responses of human induced pluripotent stem cell-derived hepatocytes to phytochemicals.Toxicol In Vitro. 2018 Jun 11;52:94-105.
     
  10. Horvatova A, Utaipan T, Otto AC, Zhang Y, Gan-Schreier H, Pavek P, Pathil A, Stremmel W, Chamulitrat W.Ursodeoxycholyl lysophosphatidylethanolamide negatively regulates TLR-mediated lipopolysaccharide response in human THP-1-derived macrophages. Eur J Pharmacol. 2018 Apr 15;825:63-74
     
  11. Knebel C, Neeb J, Zahn E, Schmidt F, Carazo A, Holas O, Pavek P, Püschel GP, Zanger UM, Süssmuth R, Lampen A, Marx-Stoelting P, Braeuning A.Unexpected effects of propiconazole, tebuconazole and their mixture on the receptors CAR and PXR in human liver cells. Toxicol Sci. 2018 Feb 6. doi: 10.1093/toxsci/kfy026.
     
  12. Roh J, Karabanovich G, Vlčková H, Carazo A, Němeček J, Sychra P, Valášková L, Pavliš O, Stolaříková J, Klimešová V, Vávrová K, Pávek P, Hrabálek A. Development of water-soluble 3,5-dinitrophenyl tetrazole and oxadiazole antitubercular agents. Bioorg Med Chem. 2017 Oct 15;25(20):5468-5476.  IF 2,930 (2016)
     
  13. Dolezelova E, Prasnicka A, Cermanova J, Carazo A, Hyrsova L, Hroch M, Mokry J, Adamcova M, Mrkvicova A, Pavek P, Micuda S. Resveratrol modifies biliary secretion of cholephilic compounds in sham-operated and cholestatic rats. World J Gastroenterol. 2017 Nov 21;23(43):7678-7692. IF 3,365 (2016)
     
  14. Prasnicka A, Cermanova J, Hroch M, Dolezelova E, Rozkydalova L, Smutny T, Carazo A, Chladek J, Lenicek M, Nachtigal P, Vitek L, Pavek P, Micuda S.Iron depletion induces hepatic secretion of biliary lipids and glutathione in rats. Biochim Biophys Acta. 2017;1862(12):1469-1480. IF 5,547 (2016)
     
  15. Dusek J, Carazo A, Trejtnar F, Hyrsova L, Holas O, Smutny T, Micuda S, Pavek P*. Steviol, an aglycone of steviol glycoside sweeteners, interacts with the pregnane X (PXR) and aryl hydrocarbon (AHR) receptors in detoxification regulation. Food Chem Toxicol. 2017 Sep 5;109(Pt 1):130-142. doi: 10.1016/j.fct.2017.09.007
     
  16. Pavek P. Pregnane X Receptor (PXR)-Mediated Gene Repression and Cross-Talk of PXR with Other Nuclear Receptors via Coactivator Interactions, Front Pharmacol. 2016 Nov 25;7:456 (IF 2016 4,418)
     
  17. Soukup T, Dosedel M, Nekvindova J, Kubena A, Tacheci I, Duintjer Tebbens J, Vlcek J, Bradna P, Barvik I, Pavek P. The plausible association of MTHFR and adenosine A2a receptor polymorphisms with nodules in rheumatoid arthritis patients treated with methotrexate. Pharmacogenetics and Genomics  2017 Feb;27(2):43-50. (IF2,1842016)
     
  18. Karabanovich G, Zemanová J, Smutný T, Székely R, Šarkan M, Centárová I, Vocat A, Pávková I, Čonka P, Němeček J, Stolaříková J, Vejsová M, Vávrová K, Klimešová V, Hrabálek A, Pávek P, Cole ST, Mikušová K, Roh J. Development of 3,5-Dinitrobenzylsulfanyl-1,3,4-oxadiazoles and Thiadiazoles as Selective Antitubercular Agents Active Against Replicating and Nonreplicating Mycobacterium tuberculosis. J Med Chem. 2016 Mar 24;59(6):2362-80.
     
  19. Carazo A, Hyrsova L, Dusek J, Chodounska H, Horvatova A, Berka K, Bazgier V, Gan-Schreier H, Chamulitrat W, Kudova E, Pavek P. Acetylated deoxycholic (DCA) and cholic (CA) acids are potent ligands of pregnane X (PXR) receptor. Toxicol Lett. 2017 Jan 4;265:86-96. (IF2016 3,522)

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