Prof. PharmDr. František Štaud, Ph.D.

Contact Information

Charles University, Pharmaceutical Faculty, Heyrovskeho 1203, 500 03 Hradec Kralove, Czech Republic
Tel.: +420-495067407
email: (Placenta in Health and Disease - Charles University Research Team)
Facebook (personal)

Current position

Vice-dean for Research and Postdoctoral Studies

Education and Professional Experience

2012 – present: Head of the Department of Pharmacology and Toxicology, Faculty of Pharmacy, Charles University, Czech Republic
2011 – present: Professor of pharmacology, Department of Pharmacology and Toxicology, Faculty of Pharmacy, Charles University, Czech Republic
2001 - 2011: Associate Professor, Department of Pharmacology and Toxicology, Faculty of Pharmacy, Charles University, Czech Republic
1999 - 2001: Post-doc research fellow, School of Pharmaceutical Sciences, Manchester University, Great Britain.
1997 - 1999: Post-doc research fellow, School of Pharmaceutical Sciences, Kyoto University, Japan.
1994 - 1997: Research fellow, Department of Pharmacology and Toxicology, Faculty of Pharmacy, Charles University, Czech Republic

1994-1999: Masters Study, Charles University in Prague, Faculty of Pharmacy in Hradec Kralove, (M.Sc. in Pharmacy)

Research interests; current and past

  • Developmental/reproductive toxicology
  • Placental homeostasis of serotonin and other monoamines
  • DOHaD - Developmental Origin of Health and Disease, fetal programming 
  • Pharmacotherapy in pregnancy - effect on placenta functions
  • Transplacental pharmacokinetics of drugs – influence of drug transporters and metabolizing enzymes.
  • Drug interactions.
  • Functional expression of efflux drug transporters in tissues - effect on drug resistance and pharmacokinetics.
  • Overcoming biological barriers for cancer gene therapy; application of fluorescence microscopy for tracing plasmids.
  • Targeted delivery of macromolecules.
  • Identification of factors controlling liver uptake and hepato-biliary transfer of macromolecules.
  • Gene-delivery using cationic liposomes and polypeptides.

Teaching activities

Lecturer and examiner of pharmacology for pre(post)gradual students.
Supervisor of numerous Ph.D. and diploma thesis students at the Department of Pharmacology and Toxicology.

Grants received

Principal investigator and co-investigator of several grants.


  • ASPET - American Society for Pharmacology and Experimental Therapeutics.
  • ISSX - International Society for Study of Xenobiotics.
  • Czech Society for Experimental and Clinical Pharmacology and Toxicology
  • Member of the Scientific Council, Charles University in Prague, Faculty of Pharmacy in Hradec Kralove
  • Grant Agency of the Charles University (section C – Medical sciences) 
  • EPTRI - European Paediatric Translational Research Infrastructure

Awards and Prizes

  • Best publication in experimental pharmacology by Czech Society for Experimental and Clinical Pharmacology and toxicology (J Pharmacol Exp Ther, 2006, vol. 319, no. 1, s. 53-62).
  • Best publication in cardiovascular physiology by Blood Pressure (Placenta, 2006, vol. 27, no. 2-3, s. 171-180). 

Awards to PhD students under supervision of F. Staud

  • 2021 Rona Karahoda: Carls Ludwig Award by the Scandinavian Physiological Society
  • 2020 Rona Karahoda, Hana Horackova, Veronika Vachalova: Angelini University Award: Mental Health
  • 2019 Rona Karahoda: selected for a new investigator lecture and travel award at international conference for placentologists in Buenos Aires (IFPA 2019) titled “Sex-dependent differences in placental serotonin handling”
  • 2017 Zuzana Ptackova: Bolzano Award for Medicine by Charles University "Interactions of antiretrovirals with drug efflux transporters and their role in the transplacental pharmacokinetics"
  • 2015 Daniela Cihalova: Finalist of Predoctoral Poster Awards Competition “ABCB1, ABCC1 and ABCG2 modulate transport and pharmacokinetics of dinaciclib in vitro” 13th European ISSX Meeting, 22. – 25. June 2015, Glasgow, Great Britain
  • 2015 Daniela Cihalova: best publication in experimental pharmacology by Czech Society for Experimental and Clinical Pharmacology and toxicology.
  • 2014 Zuzana Neumanova: Best poster in PGS section “Effect of drug efflux transporters ABCB1 and ABCG2 on abacavir transport across the placenta”, 64th Pharmacology days, Martin, Slovakia, 2014
  • 2014 Zuzana Neumanova: Best Publication in Experimental Pharmacology by Czech Society for Experimental and Clinical Pharmacology and Toxicology.
  • 2014 Daniela Cihalova: Young Investigator Award, 5th FEBS Special Meeting 2014, Innsbruck, Austria
  • 2014 Jakub Hofman: trainee award 17th International Workshop on the Enzymology and Molecular Biology of Carbonyl Metabolism, Skytop, PA, USA

Publication activity

Author/co-author of 90+ research articles, 5 review articles, 1 book chapter
2000 + citations (without self-citations)
H-index = 26 (without self-citations, Scopus)

Selected Publications

List of selected important publications since 1998

For full list of Frantisek Staud’s publications, go to: PubMed Search “Staud F”.

If you cannot access any of the papers, do not hesitate to contact me and I will send you a PDF or hardcopy.

Karahoda R, Robles M, Marushka J, Stranik J, Abad C, Horackova H, Tebbens JD, Vaillancourt C, Kacerovsky M, Staud F. Prenatal inflammation as a link between placental expression signature of tryptophan metabolism and preterm birth. 
Hum Mol Genet. 2021 Jun 24:ddab169.

Cerveny L, Murthi P, Staud F. HIV in pregnancy: Mother-to-child transmission, pharmacotherapy, and toxicity. Biochim Biophys Acta Mol Basis Dis. 2021 Oct 1;1867(10):166206.

Karahoda R,  Abad C, Horackova H, Kastner P, Zaugg J, Cerveny L, Kucera R, Albrecht C, Staud F. Dynamics of Tryptophan Metabolic Pathways in Human Placenta and Placental-Derived Cells: Effect of Gestation Age and Trophoblast Differentiation Front. Cell Dev. Biol., 18 September 2020  

Karahoda R, Horackova H, Kastner P, Matthios A, Cerveny L, Kucera R, Kacerovsky M, Duintjer Tebbens J, Bonnin A, Abad C, Staud F.
Serotonin homeostasis in the materno-foetal interface at term: Role of transporters (SERT/SLC6A4 and OCT3/SLC22A3) and monoamine oxidase A (MAO-A) in uptake and degradation of serotonin by human and rat term placenta. Acta Physiol (Oxf). 2020 Apr 20:e13478. doi: 10.1111/apha.13478.

Staud F, Karahoda R. Trophoblast: The central unit of fetal growth, protection and programming. Int J Biochem Cell Biol. 2018 Sep 25;105:35-40. doi: 10.1016/j.biocel.2018.09.016.

Ceckova M, Reznicek J, Deutsch B, Fromm MF, Staud F. Efavirenz reduces renal excretion of lamivudine in rats by inhibiting organic cation transporters (OCT, Oct) and multidrug and toxin extrusion proteins (MATE, Mate). PLoS One. 2018 Aug 16;13(8):e0202706. doi: 10.1371/journal.pone.0202706.

Cerveny L, Ptackova Z, Ceckova M, Karahoda R, Karbanova S, Jiraskova L, Greenwood SL, Glazier JD, Staud F. Equilibrative nucleoside transporter 1 (ENT1, SLC29A1) facilitates transfer of the antiretroviral drug abacavir across the placenta. Drug Metab Dispos. 2018 Aug 10. pii: dmd.118.083329. doi: 10.1124/dmd.118.083329.

Cerveny L, Ptackova Z, Durisova M, Staud F. Interactions of protease inhibitors atazanavir and ritonavir with ABCB1, ABCG2, and ABCC2 transporters: Effect on transplacental disposition in rats. Reprod Toxicol. 2018 Aug;79:57-65. doi: 10.1016/j.reprotox.2018.05.008.

Jiraskova L, Cerveny L, Karbanova S, Ptackova Z, Staud F. Expression of Concentrative Nucleoside Transporters ( SLC28A) in the Human Placenta: Effects of Gestation Age and Prototype Differentiation-Affecting Agents. Mol Pharm. 2018 Jul 2;15(7):2732-2741. doi: 10.1021/acs.molpharmaceut.8b00238.

Karbanova S, Cerveny L, Ceckova M, Ptackova Z, Jiraskova L, Greenwood S, Staud F. Role of nucleoside transporters in transplacental pharmacokinetics of nucleoside reverse transcriptase inhibitors zidovudine and emtricitabine. Placenta. 2017 Dec;60:86-92.

Reznicek J, Ceckova M, Ptackova Z, Martinec O, Tupova L, Cerveny L, Staud F. MDR1 and BCRP Transporter-Mediated Drug-Drug Interaction between Rilpivirine and Abacavir and Effect on Intestinal Absorption. Antimicrob Agents Chemother. 2017 Aug 24;61(9)

Ceckova M, Reznicek J, Ptackova Z, Cerveny L, Müller F, Kacerovsky M, Fromm MF, Glazier JD, Staud F. Interaction of lamivudine with ABC and SLC transporters: role in placental transport. Antimicrob Agents Chemother. 2016 Jul 11. pii: AAC.00648-16. [Epub ahead of print]

Neumanova Z, Cerveny L, Ceckova M, Staud, F. Role of ABCB1, ABCG2, ABCC2 and ABCC5 transporters in placental passage of zidovudine. Biopharm Drug Dispos 2016; 37, 28-38.

Staud F, Ceckova M. Regulation of drug transporter expression and function in the placenta. Expert Opinion on Drug Metabolism and Toxicology 2015; 11(4), 533-555.

Neumanova Z, Cerveny L, Ceckova M, Staud F. Interactions of tenofovir and tenofovir disoproxil fumarate with drug efflux transporters ABCB1, ABCG2, and ABCC2; role in transport across the placenta. AIDS 2014; 28 (1):9-17 (doi: 10.1097/QAD.0000000000000112)

Staud F, Cerveny L, Ahmadimoghaddam D, Ceckova M. 2013 Multidrug and toxin extrusion proteins (MATE/SLC47); role in pharmacokinetics. Int J Biochem Cell Biol. 2013 Sep;45(9):2007-11 (doi: 10.1016/j.biocel.2013.06.022)

Staud F, Cerveny L, Ceckova M. Pharmacotherapy in pregnancy; effect of ABC and SLC transporters on drug transport across the placenta and fetal drug exposure. J Drug Target 2012;20:736-63 (doi: 10.3109/1061186X.2012.716847)

Hofman J, Ahmadimoghaddam D, Hahnova L, Pavek P, Ceckova M, Staud F. Olomoucine II and purvalanol A inhibit ABCG2 transporter in vitro and in situ and synergistically potentiate cytostatic effect of mitoxantrone. Pharmacol Res 2012;65:312-9.

Ahmadimoghaddam D, Hofman J, Zemankova L, Nachtigal P, Dolezelova E, Cerveny L, Staud F. Synchronized Activity of Organic Cation Transporter 3 (Oct3/Slc22a3) and Multidrug and Toxin Extrusion 1 (Mate1/Slc47a1) Transporter in Transplacental Passage of MPP+ in Rat. Toxicol Sci 2012;128:471-81.

Hahnova-Cygalova L, Ceckova M, Staud F. Fetoprotective activity of breast cancer resistance protein (BCRP, ABCG2): expression and function throughout pregnancy. Drug Metab Rev 2011;43:53-68.

Staud F, Ceckova M, Micuda S, Pavek P. Expression and function of p-glycoprotein in normal tissues: effect on pharmacokinetics. Methods Mol Biol 2010;596:199-222.

Vackova Z, Vagnerova K, Libra A, Miksik I, Pacha J, Staud F. Dexamethasone and betamethasone administration during pregnancy affects expression and function of 11 beta-hydroxysteroid dehydrogenase type 2 in the rat placenta. Reprod Toxicol 2009;28:46-51.

Pavek P, Ceckova M, Staud F. Variation of drug kinetics in pregnancy. Curr Drug Metab 2009;10:520-9.

Cygalova LH, Hofman J, Ceckova M, Staud F. Transplacental pharmacokinetics of glyburide, rhodamine 123, and BODIPY FL prazosin: effect of drug efflux transporters and lipid solubility. J Pharmacol Exp Ther 2009;331:1118-25.

Vagnerova K, Vackova Z, Klusonova P, Staud F, Kopecky M, Ergang P, et al. Reciprocal changes in maternal and fetal metabolism of corticosterone in rat during gestation. Reprod Sci 2008;15:921-31.

Cygalova L, Ceckova M, Pavek P, Staud F. Role of breast cancer resistance protein (Bcrp/Abcg2) in fetal protection during gestation in rat. Toxicol Lett 2008;178:176-80.

Ceckova M, Vackova Z, Radilova H, Libra A, Buncek M, Staud F. Effect of ABCG2 on cytotoxicity of platinum drugs: Interference of EGFP. Toxicol In Vitro 2008;22:1846-52.

Vackova Z, Libra A, Ceckova M, Pavek P, Staud F. Effect of dexamethasone and betamethasone on 11beta-hydroxysteroid dehydrogenase type 2 expression in human choriocarcinoma Jeg3 cells. Biomed Pap 2007;151:95-7.

Cerveny L, Svecova L, Anzenbacherova E, Vrzal R, Staud F, Dvorak Z, et al. Valproic acid induces CYP3A4 and MDR1 gene expression by activation of constitutive androstane receptor and pregnane X receptor pathways. Drug Metab Dispos 2007;35:1032-41.

Bremer S, Brittebo E, Dencker L, Knudsen LE, Mathisien L, Olovsson M, Staud F et al. In vitro tests for detecting chemicals affecting the embryo implantation process. The report and recommendations of ECVAM workshop 62 -- a strategic workshop of the EU ReProTect project. Altern Lab Anim 2007;35:421-39.

Staud F, Vackova Z, Pospechova K, Pavek P, Ceckova M, Libra A, et al. Expression and Transport Activity of Breast Cancer Resistance Protein (Bcrp/Abcg2) in Dually Perfused Rat Placenta and HRP-1 Cell Line. J Pharmacol Exp Ther 2006;319:53-62.

Staud F, Mazancova K, Miksik I, Pavek P, Fendrich Z, Pacha J. Corticosterone transfer and metabolism in the dually perfused rat placenta: effect of 11beta-hydroxysteroid dehydrogenase type 2. Placenta 2006;27:171-80.

Libra A, Fernetti C, Lorusso V, Visigalli M, Anelli PL, Staud F, et al. Molecular determinants in the transport of a bile Acid-derived diagnostic agent in tumoral and nontumoral cell lines of human liver. J Pharmacol Exp Ther 2006;319:809-17.

Cerveny L, Pavek P, Malakova J, Staud F, Fendrich Z. Lack of Interactions between Breast Cancer Resistance Protein (BCRP/ABCG2) and Selected Antiepileptic Agents. Epilepsia 2006;47:461-8.

Ceckova-Novotna M, Pavek P, Staud F. P-glycoprotein in the placenta: Expression, localization, regulation and function. Reprod Toxicol 2006;22:400-10.

Ceckova M, Libra A, Pavek P, Nachtigal P, Brabec M, Fuchs R, Staud F. Expression and functional activity of breast cancer resistance protein (bcrp, abcg2) transporter in the human choriocarcinoma cell line bewo. Clin Exp Pharmacol Physiol 2006;33:58-65.

Staud F, Pavek P. Breast cancer resistance protein (BCRP/ABCG2). Int J Biochem Cell Biol 2005;37:720-5.

Novotna M, Libra A, Kopecky M, Pavek P, Fendrich Z, Semecky V, Staud F. P-glycoprotein expression and distribution in the rat placenta during pregnancy. Reprod Toxicol 2004;18:785-92.

Pavek P, Staud F, Fendrich Z, Sklenarova H, Libra A, Novotna M, et al. Examination of the functional activity of P-glycoprotein in the rat placental barrier using rhodamine 123. J Pharmacol Exp Ther 2003;305:1239-50.

Sklenarova H, Pavek P, Satinsky D, Solich P, Karlicek R, Staud F. Determination of rhodamine 123 by sequential injection technique for pharmacokinetic studies in the rat placenta. Talanta 2002;58:1145-149.

Pavek P, Fendrich Z, Staud F, Malakova J, Brozmanova H, Laznicek M, et al. Influence of P-glycoprotein on the transplacental passage of cyclosporine. J Pharm Sci 2001;90:1583-92.

Staud F, Nishikawa M, Takakura Y, Hashida M. Liver uptake and hepato-biliary transfer of galactosylated proteins in rats are determined by the extent of galactosylation. Biochim Biophys Acta 1999;1427:183-92.

Staud F, Nishikawa M, Morimoto K, Takakura Y, Hashida M. Disposition of radioactivity after injection of liver-targeted proteins labeled with 111In or 125I. Effect of labeling on distribution and excretion of radioactivity in rats. J Pharm Sci 1999;88:577-85.

Pavek P, Staud F, Fendrich Z, Malakova J, Palicka V. Transfer of clorazepate and nordiazepam across the umbilically perfused rat term placenta in situ: Comparison with flunitrazepam and diazepam. Trophoblast Res 1999;13:329-42.

Nishikawa M, Staud F, Takemura S, Takakura Y, Hashida M. Pharmacokinetic evaluation of biodistribution data obtained with radiolabeled proteins in mice. Biol Pharm Bull 1999;22:214-8.

Staud F, Morimoto K, Nishikawa M, Takakura Y, Hashida M. Pharmacokinetic analysis of the in vivo disposition of chemically modified proteins in rats: effect of radiolabeling method. J Pharm Sci (Japan) 1998;58:101.

Hobbies and Non-research activities

 When not lecturing, examining or writing up yet another paper, grant application or report, I keep up many activities to distract myself:

I love to travel the world as a photographer for magazines and agencies, see or



I also train my German Shepherd dog, Aaron Dan Klar:

staud-aaron-dan-klar-2.jpg   staud-aaron-dan-klar-3.jpg


And on nights, I tune up my Les Paul six-string, switch on a Marshall amp and wake up all my neighborhoods:





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