Medicated microdispersion and nanodispersion systems

A group led by Assoc. Prof. RNDr. Milan Dittrich, CSc. focuses on the formulation and testing of medicated polymeric micro-dispersion and nano-dispersion systems, such as fibers, particles and membranes. Newly synthesized model carriers of supramolecular structures with high biocompatibility are formulated and their complex composition with a content of active ingredients such as antitumor agents and antifungal agents are studied.

The research group deals with rheological and thermal characterization of medicated biomaterials and engages with their interaction with a model hydrophilic environment accompanying biodegradation processes. Through AFM evaluates the essential variables of nanofibre formation of polymer membranes as carriers of active substances, particularly polymorphic and nano-mechanical material characteristics, technological possibilities to incorporate nanofiber membrane with active compounds using a unique technology of electrospinning. One-dimensional to three-dimensional dispersion systems are described in terms of granulometric aspects (PCS, Image Analysis), of surface parameters (zetametry, DLVO) and possibilities to increase their adhesivity to biological substrates are sought. The problems of solubility facilitation of biologically active compounds are solved based on increasing values of the surface energy and or on the formulation of solid dispersions. The kinetics of drug release under a variety of in vitro conditions and the influences of impulses from the external environment are studied. The aim is the standardization of the fate of active substances administered by maximizing their bioavailability.

Head of  R&D group

Assoc. Prof. RNDr. Milan Dittrich, CSc.

The selected publications and patents

DITTRICH, M.  ŠNEJDROVÁ, E. Cyclic swelling as a phenomenon inherent to biodegradable polyesters. J. Pharm. Sci., 2014, 103, 3560-3566.

VRBATA, P., BERKA, P.,  STRÁNSKÁ, D., DOLEŽAL, P., LÁZNÍČEK, M. Electrospinning of diosmin from aqueous solutions for improved dissolution and oral absorption. Int. J. Pharm. 2014, 473, 407-413.

ŠNEJDROVÁ, E., DITTRICH, M., DRASTIK, M.  Plasticized branched aliphatic oligoesters as potential mucoadhesive drug carriers. Int. J. Pharm., 2013, 458, 282-286. 

VRBATA, P., BERKA, P.,  STRÁNSKÁ, D., DOLEŽAL, P., MUSILOVÁ, M., ČIŽINSKÁ, L. Electrospun drug loaded membranes for sublingual administration of sumatriptan and naproxen. Int. J. Pharm., 2013, 457, 168-176

ŠNEJDROVÁ, E., DITTRICH, M.  Pharmaceutical applications of plasticized polymers. In: Recent Advances in Plasticizers. M. LUQMAN (ed.), Intech 2012, pp. 69-90. ISBN 978-953-51-0363-9. 

ŠNEJDROVÁ, E., DITTRICH, M.  Pharmaceutically used plasticizers. In: Recent Advances in Plasticizers.  LUQMAN,  M. (ed.), Intech 2012, pp.45-68. ISBN 978-953-51-0363-9. 

KOŠÍK, D., DITTRICH, M.  Composition for buccal absorption of nicotine for the purpose of smoking cessation US Pat Appl Publ., US 2011/0293535 A1, Heglund, A.S., Dec. 1, 2011.

PANÁČEK, A., PRUCEK, R., ŠAFÁŘOVÁ, D. DITTRICH, M, RICHTROVÁ, J., BENÍČKOVÁ, K., ZBOŘIL, R., KVÍTEK, L.  Acute and chronic toxicity effects of silver nanoparticles (NPs) on Drosophila melanogaster, Environ. Sci. Technol., 2011, 45, 4974-4979.

STRÁNSKÁ, D., KLABANOVÁ, A., DOLEŽAL, P., VRBATA, P., BERKA, P., MUSILOVÁ, M.  A carrier for oromucosal, especially sublingual administration of physiologically active substances, especially drugs. PCT/WO CZ 2011/000116 (2011)

KVÍTEK, L., VANÍČKOVÁ, M., PANÁČEK, A., SOUKUPOVÁ, J., DITTRICH, M., VALENTOVÁ, E., PRUCEK, R., BANČÍŘOVÁ, M., MILDE, D., ZBOŘIL, R. Initial study of the toxicity of silver nanoparticles against Paramecium caudatum. J. Phys. Chem C, 2009,  113, 4296-4300

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