Research conducted by our team is focused on bringing more light into understanding the process of drug resistance with the focus on hematological malignancies, mainly acute myeloid leukemia (AML).
Using cellular and patient-derived models alongside techniques such as flow cytometry, cell sorting, transcriptomics, qRT-PCR and digital PCR, we aim to identify the mechanisms responsible for the development of resistant subsets of AML cells and persistence of minimal residual disease. We further aim to explore the transport of essential molecules (e.g. L-carnitine, cytokines) in pathological, inflammatory and pre-malignant tissue models. Moreover, we employ cell viability and apoptosis assays and cell function-related approaches to address our scientific questions.
Latest news
- Simona Suchá succesfully defended her PhD thesis (read more)
- Two our research projects funded by the Czech Health Research Council (read more)
- NCCR TransCure Final Conference (read more)
- ITTS Conference (read more)
- 3rd place at the supranational round of Student Scientific Conference (read more)
- Paper published in Biomedicine & Pharmacotherapy (IF 7.419) (read more)
- First place in XXIX. Student Scientific Conference (read more)
- Paper published in Toxicology and Applied Pharmacology (IF 4.219) (read more)