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Publications

Group of Clinical and Molecular Pharmacotherapy

Selected publication over last 3 years:

  1. Pavek P, Dusek J, Smutny T, Lochman L, Kucera R, Skoda J, Smutna L, Kamaraj R, Soucek P, Vrzal R, Dvorak Z. Gene Expression Profiling of 1α,25(OH)2 D3 Treatment in 2D/3D Human Hepatocyte Models Reveals CYP3A4 Induction but Minor Changes in Other Xenobiotic-Metabolizing Genes. Mol Nutr Food Res. 2022 ;66(9):e2200070.
     
  2. Kamaraj R, Drastik M, Maixnerova J, Pavek P. Allosteric Antagonism of the Pregnane X Receptor (PXR): Current-State-of-the-Art and Prediction of Novel Allosteric Sites. Cells. 2022 Sep 24;11(19):2974.
     
  3. Barta P, Kamaraj R, Kucharova M, Novy Z, Petrik M, Bendova K, Hajduch M, Pavek P, Trejtnar F. Preparation, In Vitro Affinity, and In Vivo Biodistribution of Receptor-Specific 68Ga-Labeled Peptides Targeting Vascular Endothelial Growth Factor Receptors. Bioconjug Chem. 2022 Oct 19;33(10):1825-1836.
     
  4. Aguinaga Martínez MV, Jozičová N, Dušek J, Horstkotte B, Pávek P, Miró M, Sklenářová H. Real-time monitoring of Metridia luciferase release from cells upon interaction with model toxic substances by a fully automatic flow setup - A proof of concept. Talanta. 2022;245:123465.
     
  5. Alaei Faradonbeh F, Lastuvkova H, Cermanova J, Hroch M, Nova Z, Uher M, Hirsova P, Pavek P, Micuda S. Multidrug Resistance-Associated Protein 2 Deficiency Aggravates Estrogen-Induced Impairment of Bile Acid Metabolomics in Rats. Front Physiol. 2022; 13:859294.
     
  6. Zhang J, Pavek P, Kamaraj R, Ren L, Zhang T. Dietary phytochemicals as modulators of human pregnane X receptor. Crit Rev Food Sci Nutr. 2021,:1-23.
     
  7. Smutny T, Dusek J, Hyrsova L, Nekvindova J, Horvatova A, Micuda S, Gerbal-Chaloin S, Pavek P.The 3'-untranslated region contributes to the pregnane X receptor (PXR) expression down-regulation by PXR ligands and up-regulation by glucocorticoids. Acta Pharm Sin B. 2020;10(1):136-152.
     
  8. Skoda J, Dohnalova K, Chalupsky K, Stahl A, Templin M, Maixnerova J, Micuda S, Grøntved L, Braeuning A, Pavek P. Off-target lipid metabolism disruption by the mouse constitutive androstane receptor ligand TCPOBOP in humanized mice. Biochem Pharmacol. 2022;197:114905.
     
  9. Smutny T, Bernhauerova V, Smutna L, Tebbens JD, Pavek P. Expression dynamics of pregnane X receptor-controlled genes in 3D primary human hepatocyte spheroids. Arch Toxicol. 2022;96(1):195-210.
     
  10. Boltnarova B, Kubackova J, Skoda J, Stefela A, Smekalova M, Svacinova P, Pavkova I, Dittrich M, Scherman D, Zbytovska J, Pavek P, Holas O. PLGA Based Nanospheres as a Potent Macrophage-Specific Drug Delivery System. Nanomaterials (Basel). 2021;11(3):749.
     
  11. Kubackova J, Holas O, Zbytovska J, Vranikova B, Zeng G, Pavek P, Mullertz A. Oligonucleotide Delivery across the Caco-2 Monolayer: The Design and Evaluation of Self-Emulsifying Drug Delivery Systems (SEDDS). Pharmaceutics. 2021;13(4):459.
     
  12. Vinarov, Z, Abrahamsson, B, Artursson, P, Batchelor, H, Berben, P, Bernkop-Schnürch, A,  Butler, J, Ceulemans, J, Pavek, P et al., Current challenges and future perspectives in oral absorption research: An opinion of the UNGAP network. Adv Drug Deliv Rev. 2021; 171:289-331.
     
  13. Sklenářová H, Rosecká M, Horstkotte B, Pavek P, Miró M, Solich P. 3D printed permeation module to monitor interaction of cell membrane transporters with exogenic compounds in real-time. Anal Chim Acta. 2021 Apr 8;1153:338296.
     
  14. Pavek P. 3D Spheroids of Primary Human Hepatocytes: An In Vitro Model That Will Make Pharmacotherapy Safer?  Clin Pharmacol Ther. 2020 Sep 19. doi: 10.1002/cpt.2019 (IF6,889 2020)
     
  15. Stefela A, Kaspar M, Drastik M, Holas O, Hroch M, Smutny T, Skoda J, Hutníková M, Pandey AV, Micuda S, Kudova E, Pavek P. 3β-Isoobeticholic acid efficiently activates the farnesoid X receptor (FXR) due to its epimerization to 3α-epimer by hepatic metabolism. J Steroid Biochem Mol Biol. 2020; 202:105702.  (IF4,294 2020)
     
  16. Karabanovich G, Dušek J, Savková K, Pavliš O, Pávková I, Korábečný J, Kučera T, Kočová Vlčková H, Huszár S, Konyariková Z, Konečná K, Jand'ourek O, Stolaříková J, Korduláková J, Vávrová K, Pávek P, Klimešová V, Hrabálek A, Mikušová K, Roh J. Development of 3,5-Dinitrophenyl-Containing 1,2,4-Triazoles and Their Trifluoromethyl Analogues as Highly Efficient Antitubercular Agents Inhibiting Decaprenylphosphoryl-β-d-ribofuranose 2'-Oxidase. J Med Chem. 2019 Sep 12;62(17):8115-8139.
     
  17. Dusek J, Skoda J, Holas O, Horvatova A, Smutny T, Linhartova L, Hirsova P, Kucera O, Micuda S, Braeuning A, Pavek P. Stilbene compound trans-3,4,5,4´-tetramethoxystilbene, a potential anticancer drug, regulates constitutive androstane receptor (Car) target genes, but does not possess proliferative activity in mouse liver. Toxicol Lett. 2019 Jun 3. pii: S0378-4274(19)30160-2.
     
  18. Smutny T, Barvik I, Veleta T, Pavek P, Soukup T. Genetic Predispositions of Glucocorticoid Resistance and Therapeutic Outcomes in Polymyalgia Rheumatica and Giant Cell Arteritis. J Clin Med. 2019 Apr 27;8(5).
     
  19. Hyrsova L, Vanduchova A, Dusek J, Smutny T, Carazo A, Maresova V, Trejtnar F, Barta P, Anzenbacher P, Dvorak Z, Pavek P. Trans-resveratrol, but not other natural stilbenes occurring in food, carries the risk of drug-food interaction via inhibition of cytochrome P450 enzymes or interaction with xenosensor receptors. Toxicol Lett. 2019 Jan;300:81-91.
     
  20. Carazo A, Dusek J, Holas O, Skoda J, Hyrsova L, Smutny T, Soukup T, Dosedel M, Pávek P. Teriflunomide Is an Indirect Human Constitutive Androstane Receptor (CAR) Activator Interacting With Epidermal Growth Factor (EGF) Signaling. Front Pharmacol. 2018 Oct 11;9:993.
     
  21. Koziolek M, Alcaro S, Augustijns P, Basit AW, Grimm M, Hens B, Hoad CL, Jedamzik P, Madla CM, Maliepaard M, Marciani L, Maruca A, Parrott N, Pávek P, Porter CJH, Reppas C, van Riet-Nales D, Rubbens J, Statelova M, Trevaskis NL, Valentová K, Vertzoni M, Čepo DV, Corsetti M. The mechanisms of pharmacokinetic food-drug interactions - A perspective from the UNGAP group. Eur J Pharm Sci. 2019 Jun 15;134:31-59.
     
  22. Dovrtelova G, Zendulka O, Noskova K, Jurica J, Pes O, Dusek J, Carazo A, Zapletalova I, Hlavacova N, Pavek P.Effect of Endocannabinoid Oleamide on Rat and Human Liver Cytochrome P450 Enzymes in In Vitro and In Vivo Models. Drug Metab Dispos. 2018 Jun;46(6):913-923.
     
  23. Tebbens JD, Azar M, Friedmann E, Lanzendörfer M, Pávek P. Mathematical Models in the Description of Pregnane X Receptor (PXR)-Regulated Cytochrome P450 Enzyme Induction.Int J Mol Sci. 2018 Jun 15;19(6).
     
  24. Soukup T, Barvik I, Nekvindova J, Veleta T, Kubena AA, Duintjer Tebbens J, Pavek P, Dosedel M. Are haplotypes in a single methotrexate pathway more predictive for response in rheumatoid arthritis than in different pathways? Pharmacogenomics. 2018 Mar 26. doi: 10.2217/pgs-2016-0182.
     
  25. Smutný T, Harjumäki R, Kanninen L, Yliperttula M, Pávek P, Lou YR.A feasibility study of the toxic responses of human induced pluripotent stem cell-derived hepatocytes to phytochemicals.Toxicol In Vitro. 2018 Jun 11;52:94-105.
     
  26. Horvatova A, Utaipan T, Otto AC, Zhang Y, Gan-Schreier H, Pavek P, Pathil A, Stremmel W, Chamulitrat W.Ursodeoxycholyl lysophosphatidylethanolamide negatively regulates TLR-mediated lipopolysaccharide response in human THP-1-derived macrophages. Eur J Pharmacol. 2018 Apr 15;825:63-74
     
  27. Knebel C, Neeb J, Zahn E, Schmidt F, Carazo A, Holas O, Pavek P, Püschel GP, Zanger UM, Süssmuth R, Lampen A, Marx-Stoelting P, Braeuning A.Unexpected effects of propiconazole, tebuconazole and their mixture on the receptors CAR and PXR in human liver cells. Toxicol Sci. 2018 Feb 6. doi: 10.1093/toxsci/kfy026.
     
  28. Roh J, Karabanovich G, Vlčková H, Carazo A, Němeček J, Sychra P, Valášková L, Pavliš O, Stolaříková J, Klimešová V, Vávrová K, Pávek P, Hrabálek A. Development of water-soluble 3,5-dinitrophenyl tetrazole and oxadiazole antitubercular agents. Bioorg Med Chem. 2017 Oct 15;25(20):5468-5476.  IF 2,930 (2016)
     
  29. Dolezelova E, Prasnicka A, Cermanova J, Carazo A, Hyrsova L, Hroch M, Mokry J, Adamcova M, Mrkvicova A, Pavek P, Micuda S. Resveratrol modifies biliary secretion of cholephilic compounds in sham-operated and cholestatic rats. World J Gastroenterol. 2017 Nov 21;23(43):7678-7692. IF 3,365 (2016)
     
  30. Prasnicka A, Cermanova J, Hroch M, Dolezelova E, Rozkydalova L, Smutny T, Carazo A, Chladek J, Lenicek M, Nachtigal P, Vitek L, Pavek P, Micuda S.Iron depletion induces hepatic secretion of biliary lipids and glutathione in rats. Biochim Biophys Acta. 2017;1862(12):1469-1480. IF 5,547 (2016)
     
  31. Dusek J, Carazo A, Trejtnar F, Hyrsova L, Holas O, Smutny T, Micuda S, Pavek P*. Steviol, an aglycone of steviol glycoside sweeteners, interacts with the pregnane X (PXR) and aryl hydrocarbon (AHR) receptors in detoxification regulation. Food Chem Toxicol. 2017 Sep 5;109(Pt 1):130-142. doi: 10.1016/j.fct.2017.09.007
     
  32. Pavek P. Pregnane X Receptor (PXR)-Mediated Gene Repression and Cross-Talk of PXR with Other Nuclear Receptors via Coactivator Interactions, Front Pharmacol. 2016 Nov 25;7:456 (IF 2016 4,418)
     
  33. Soukup T, Dosedel M, Nekvindova J, Kubena A, Tacheci I, Duintjer Tebbens J, Vlcek J, Bradna P, Barvik I, Pavek P. The plausible association of MTHFR and adenosine A2a receptor polymorphisms with nodules in rheumatoid arthritis patients treated with methotrexate. Pharmacogenetics and Genomics  2017 Feb;27(2):43-50. (IF2,1842016)
     
  34. Karabanovich G, Zemanová J, Smutný T, Székely R, Šarkan M, Centárová I, Vocat A, Pávková I, Čonka P, Němeček J, Stolaříková J, Vejsová M, Vávrová K, Klimešová V, Hrabálek A, Pávek P, Cole ST, Mikušová K, Roh J. Development of 3,5-Dinitrobenzylsulfanyl-1,3,4-oxadiazoles and Thiadiazoles as Selective Antitubercular Agents Active Against Replicating and Nonreplicating Mycobacterium tuberculosis. J Med Chem. 2016 Mar 24;59(6):2362-80.
     
  35. Carazo A, Hyrsova L, Dusek J, Chodounska H, Horvatova A, Berka K, Bazgier V, Gan-Schreier H, Chamulitrat W, Kudova E, Pavek P. Acetylated deoxycholic (DCA) and cholic (CA) acids are potent ligands of pregnane X (PXR) receptor. Toxicol Lett. 2017 Jan 4;265:86-96. (IF2016 3,522)

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