List of publications

List of selected publications by the Group of Placenta in Health and Disease; for a full list of group publications, go to: PubMed Search. If you cannot access any of the papers, do not hesitate to contact us and we will send you a PDF or hardcopy.


Portillo R, Abad C, Synova T, Kastner P, Heblik D, Kucera R, Karahoda R, Staud F. Cannabidiol disrupts tryptophan metabolism in the human term placenta. Toxicology. 2024 Apr 23;505:153813. doi: 10.1016/j.tox.2024.153813

Karahoda R, Vachalova V, Portillo R, Mahrla F, Viñas-Noguera M, Abad C, Staud F. Developmental expression of catecholamine system in the human placenta and rat fetoplacental unit. Sci Rep. 2024 Mar 23;14(1):6948. doi: 10.1038/s41598-024-57481-5

Cifkova E, Karahoda R, Stranik J, Abad C, Kacerovsky M, Lisa M, Staud F. Metabolomic analysis of the human placenta reveals perturbations in amino acids, purine metabolites, and small organic acids in spontaneous preterm birth. EXCLI J. 2024 Feb 13;23:264-282. doi: 10.17179/excli2023-6785

Abad C, Karahoda R, Orbisova A, Kastner P, Heblik D, Kucera R, Portillo R, Staud F. Pathological shifts in tryptophan metabolism in human term placenta exposed to LPS or poly I:C. Biol Reprod. 2024 Apr 11;110(4):722-738. doi: 10.1093/biolre/ioad181


Staud F, Pan X, Karahoda R, Dong X, Kastner P, Horackova H, Vachalova V, Markert UR, Abad C. Characterization of a human placental clearance system to regulate serotonin levels in the fetoplacental unit. Reprod Biol Endocrinol. 2023 Aug 23;21(1):74. doi: 10.1186/s12958-023-01128-z

Cerveny L, Karbanova S, Karahoda R, Horackova H, Jiraskova L, Ali MNH, Staud F. Assessment of the role of nucleoside transporters, P-glycoprotein, breast cancer resistance protein, and multidrug resistance-associated protein 2 in the placental transport of entecavir using in vitro, ex vivo, and in situ methods. Toxicol Appl Pharmacol. 2023 Feb 16;463:116427. doi: 10.1016/j.taap.2023.116427.

Horackova H, Vachalova V, Abad C, Karahoda R, Staud F. Perfused rat term placenta as a preclinical model to investigate placental dopamine and norepinephrine transport. Clin Sci (Lond). 2023 Jan 31;137(2):149-161. doi: 10.1042/CS20220726.

Anandam KY, Abad C, Synova T, Vinar-Noguera M, Bolboli B, Vokral I, Karahoda R,  Staud F. Precision-cut rat placental slices as a model to study sex-dependent inflammatory response to LPS and Poly I:C. Front. Immunol., Sec. Immunological Tolerance and Regulation 


Vachalova V, Karahoda R, Ottaviani M, Anandam KY, Abad C, Albrecht C, Staud F. Functional reorganization of monoamine transport systems during villous trophoblast differentiation: evidence of distinct differences between primary human trophoblasts and BeWo cells. Reprod Biol Endocrinol. 2022 Aug 4;20(1):112.

Horackova H, Karahoda R, Vachalova V, Turkova H, Abad C, Staud F. Functional characterization of dopamine and norepinephrine transport across the apical and basal plasma membranes of the human placental syncytiotrophoblast. Sci Rep. 2022 Jul 8;12(1):11603.

Lederer CW, Koniali L, Buerki-Thurnherr T, Papasavva PL, La Grutta S, Licari A, Staud F, Bonifazi D, Kleanthous M. Catching Them Early: Framework Parameters and Progress for Prenatal and Childhood Application of Advanced Therapies. Pharmaceutics. 2022 Apr 5;14(4):793.

Stranik J, Kacerovsky M, Sterba M, Andrys C, Abad C, Staud F, Micuda S, Soucek O, Jacobsson B, Musilova I. Development of a Rat Model of Intra-Amniotic Inflammation via Ultrasound-Guided Administration of a Triggering Agent in the Gestational Sac to Enable Analysis of Individual Amniotic Fluid Samples. Front Pharmacol. 2022 Apr 12;13:871193.

Karahoda R, Zaugg J, Fuenzalida B, Kallol S, Moser-Haessig R, Staud F, Albrecht C. Trophoblast Differentiation Affects Crucial Nutritive Functions of Placental Membrane Transporters. Front Cell Dev Biol. 2022 Feb 22;10:820286.

Huličiak M, Vokřál I, Holas O, Martinec O, Štaud F, Červený L. Evaluation of the Potency of Anti-HIV and Anti-HCV Drugs to Inhibit P-Glycoprotein Mediated Efflux of Digoxin in Caco-2 Cell Line and Human Precision-Cut Intestinal Slices. Pharmaceuticals (Basel). 2022 Feb 18;15(2):242.


Horackova H, Karahoda R, Cerveny L, Vachalova V, Ebner R, Abad C, Staud F. Effect of Selected Antidepressants on Placental Homeostasis of Serotonin: Maternal and Fetal Perspectives. Pharmaceutics. 2021 Aug 20;13(8):1306. 

Karahoda R, Robles M, Marushka J, Stranik J, Abad C, Horackova H, Tebbens JD, Vaillancourt C, Kacerovsky M, Staud F. Prenatal inflammation as a link between placental expression signature of tryptophan metabolism and preterm birth. 
Hum Mol Genet. 2021 Jun 24:ddab169.

Cerveny L, Murthi P, Staud F. HIV in pregnancy: Mother-to-child transmission, pharmacotherapy, and toxicity. Biochim Biophys Acta Mol Basis Dis. 2021 Oct 1;1867(10):166206.

Yong HEJ, Chan SY, Chakraborty A, Rajaraman G, Ricardo S, Benharouga M, Alfaidy N, Staud F, Murthi P. Significance of the placental barrier in antenatal viral infections. Biochim Biophys Acta Mol Basis Dis. 2021 Dec 1;1867(12):166244. 

Karahoda R, Kallol S, Groessl M, Ontsouka E, Anderle P, Fluck C, Staud F, Albrecht C. Revisiting Steroidogenic Pathways in the Human Placenta and Primary Human Trophoblast Cells. Int. J. Mol. Sci. 2021, 22, 1704. 


Abad C, Karahoda R,  Kastner P, Portillo R, Horackova H, Kucera R, Nachtigal P, Staud F. Profiling of Tryptophan Metabolic Pathways in the Rat Fetoplacental Unit during Gestation Int. J. Mol. Sci. 2020, 21(20), 7578; 

Karahoda R,  Abad C, Horackova H, Kastner P, Zaugg J, Cerveny L, Kucera R, Albrecht C, Staud F. Dynamics of Tryptophan Metabolic Pathways in Human Placenta and Placental-Derived Cells: Effect of Gestation Age and Trophoblast Differentiation Front. Cell Dev. Biol., 18 September 2020  

Karahoda R, Horackova H, Kastner P, Matthios A, Cerveny L, Kucera R, Kacerovsky M, Duintjer Tebbens J, Bonnin A, Abad C, Staud F.
Serotonin homeostasis in the materno-foetal interface at term: Role of transporters (SERT/SLC6A4 and OCT3/SLC22A3) and monoamine oxidase A (MAO-A) in uptake and degradation of serotonin by human and rat term placenta. Acta Physiol (Oxf). 2020 Apr 20:e13478. doi: 10.1111/apha.13478.

Karbanova S, Cerveny L, Jiraskova L, Karahoda R, Ceckova M, Ptackova Z, Staud F. Transport of ribavirin across the rat and human placental barrier: roles of nucleoside and ATP-binding cassette drug efflux transporters. Biochem Pharmacol. 2019 Feb 1. pii: S0006-2952(19)30030-9. doi: 10.1016/j.bcp.2019.01.024.

S-(4-Nitrobenzyl)-6-thioinosine (NBMPR) is Not a Selective Inhibitor of Equilibrative Nucleoside Transporters but Also Blocks Efflux Activity of Breast Cancer Resistance Protein. Karbanova S, Sorf A, Jiraskova L, Lalinska A, Ptackova Z, Staud F, Cerveny L. Pharm Res. 2020 Feb 21;37(3):58. doi: 10.1007/s11095-020-2782-5.


Karbanova S, Cerveny L, Jiraskova L, Karahoda R, Ceckova M, Ptackova Z, Staud F. Transport of ribavirin across the rat and human placental barrier: roles of nucleoside and ATP-binding cassette drug efflux transporters. Biochem Pharmacol. 2019 Feb 1. pii: S0006-2952(19)30030-9. doi: 10.1016/j.bcp.2019.01.024. [Epub ahead of print]

Tupova L, Ceckova M, Ambrus C, Sorf A, Ptackova Z, Gaborik Z, Staud F. Interactions between Maraviroc and the ABCB1, ABCG2, and ABCC2 Transporters: An Important Role in Transplacental Pharmacokinetics. Drug Metab Dispos. 2019 Sep;47(9):954-960. doi:10.1124/dmd.119.087684. Epub 2019 Jul 2.

Martinec O, Huliciak M, Staud F, Cecka F, Vokral I, Cerveny L. Anti-HIV and Anti-Hepatitis C Virus Drugs Inhibit P-Glycoprotein Efflux Activity in Caco-2 Cells and Precision-Cut Rat and Human Intestinal Slices. Antimicrob Agents Chemother. 2019 Oct 22;63(11):e00910-19. doi: 10.1128/AAC.00910-19. Print 2019 Nov.

Karahoda R, Ceckova M, Staud F. The inhibitory effect of antiretroviral drugs on the L-carnitine uptake in human placenta. Toxicology and Applied Pharmacology 2019


Staud F, Karahoda R. Trophoblast: The central unit of fetal growth, protection and programming. Int J Biochem Cell Biol. 2018 Sep 25;105:35-40. doi: 10.1016/j.biocel.2018.09.016.

Ceckova M, Reznicek J, Deutsch B, Fromm MF, Staud F. Efavirenz reduces renal excretion of lamivudine in rats by inhibiting organic cation transporters (OCT, Oct) and multidrug and toxin extrusion proteins (MATE, Mate). PLoS One. 2018 Aug 16;13(8):e0202706. doi: 10.1371/journal.pone.0202706.

Cerveny L, Ptackova Z, Ceckova M, Karahoda R, Karbanova S, Jiraskova L, Greenwood SL, Glazier JD, Staud F. Equilibrative nucleoside transporter 1 (ENT1, SLC29A1) facilitates transfer of the antiretroviral drug abacavir across the placenta. Drug Metab Dispos. 2018 Aug 10. pii: dmd.118.083329. doi: 10.1124/dmd.118.083329.

Cerveny L, Ptackova Z, Durisova M, Staud F. Interactions of protease inhibitors atazanavir and ritonavir with ABCB1, ABCG2, and ABCC2 transporters: Effect on transplacental disposition in rats. Reprod Toxicol. 2018 Aug;79:57-65. doi: 10.1016/j.reprotox.2018.05.008.

Jiraskova L, Cerveny L, Karbanova S, Ptackova Z, Staud F. Expression of Concentrative Nucleoside Transporters ( SLC28A) in the Human Placenta: Effects of Gestation Age and Prototype Differentiation-Affecting Agents. Mol Pharm. 2018 Jul 2;15(7):2732-2741. doi: 10.1021/acs.molpharmaceut.8b00238.

Sorf A, Hofman J, Kučera R, Staud F, Ceckova M. Ribociclib shows potential for pharmacokinetic drug-drug interactions being a substrate of ABCB1 and potent inhibitor of ABCB1, ABCG2 and CYP450 isoforms in vitro. Biochem Pharmacol. 2018 Aug;154:10-17. doi: 10.1016/j.bcp.2018.04.013.

Hepnarova V, Korabecny J, Matouskova L, Jost P, Muckova L, Hrabinova M, Vykoukalova N, Kerhartova M, Kucera T, Dolezal R, Nepovimova E, Spilovska K, Mezeiova E, Pham NL, Jun D, Staud F, Kaping D, Kuca K, Soukup O. The concept of hybrid molecules of tacrine and benzyl quinolone carboxylic acid (BQCA) as multifunctional agents for Alzheimer's disease. Eur J Med Chem. 2018 Apr 25;150:292-306. doi: 10.1016/j.ejmech.2018.02.083.

Siroka J, Ceckova M, Urbánek L, Kryštof V, Gucký T, Hofman J, Strnad M, Staud F. LC-MS/MS method for determination of cyclin-dependent kinase inhibitors, BP-14 and BP-20, and its application in pharmacokinetic study in rat. J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Jul 1;1089:24-32. doi: 10.1016/j.jchromb.2018.04.049


Karbanova S, Cerveny L, Ceckova M, Ptackova Z, Jiraskova L, Greenwood S, Staud F. Role of nucleoside transporters in transplacental pharmacokinetics of nucleoside reverse transcriptase inhibitors zidovudine and emtricitabine. Placenta. 2017 Dec;60:86-92.

Reznicek J, Ceckova M, Cerveny L, Müller F, Staud F. Emtricitabine is a substrate of MATE1 but not of OCT1, OCT2, P-gp, BCRP or MRP2 transporters. Xenobiotica. 2017 Jan;47(1):77-85

Reznicek J, Ceckova M, Ptackova Z, Martinec O, Tupova L, Cerveny L, Staud F. MDR1 and BCRP Transporter-Mediated Drug-Drug Interaction between Rilpivirine and Abacavir and Effect on Intestinal Absorption. Antimicrob Agents Chemother. 2017 Aug 24;61(9)


Ceckova M, Reznicek J, Ptackova Z, Cerveny L, Müller F, Kacerovsky M, Fromm MF, Glazier JD, Staud F. Interaction of lamivudine with ABC and SLC transporters: role in placental transport. Antimicrob Agents Chemother. 2016 Jul 11. pii: AAC.00648-16. [Epub ahead of print]

Neumanova Z, Cerveny L, Ceckova M, Staud, F. Role of ABCB1, ABCG2, ABCC2 and ABCC5 transporters in placental passage of zidovudine. Biopharm Drug Dispos 2016; 37, 28-38.

Cerveny L, Neumanova Z, Karbanova S, Havlova I, Staud, F. Long-term administration of tenofovir or emtricitabine to pregnant rats; Effect on Abcb1a, Abcb1b and Abcg2 expression in the placenta and in maternal and fetal organs. J Pharm Pharmacol 2015; 68, 84-92.

Hofman J, Kucera R, Klimes J, Ceckova M, Staud F. Placental passage of olomoucine II, but not purvalanol A, is affected by p-glycoprotein (ABCB1), breast cancer resistance protein (ABCG2) and multidrug resistance-associated proteins (ABCCs). Xenobiotica 2016; 46, 416-423.


Cihalova D, Ceckova M, Kucera R, Klimes J, Staud F. Dinaciclib, a cyclin-dependent kinase inhibitor, is a substrate of human ABCB1 and ABCG2 and an inhibitor of human ABCC1 in vitro. Biochemical Pharmacology 2015

Neumanova Z, Cerveny L, Greenwood SL, Ceckova M, Staud F. Effect of drug efflux transporters on placental transport of antiretroviral agent abacavir. Reproductive Toxicology 2015; 57, 176-182.

Cihalova D, Staud F, Ceckova M. Interactions of cyclin-dependent kinase inhibitors AT-7519, flavopiridol and SNS-032 with ABCB1, ABCG2 and ABCC1 transporters and their potential to overcome multidrug resistance in vitro. Cancer Chemotherapy and Pharmacology 2015; 19 May 2015; (76(1), 105-116.

Staud F, Ceckova M. Regulation of drug transporter expression and function in the placenta. Expert Opinion on Drug Metabolism and Toxicology 2015; 11(4), 533-555.


Neumanova Z, Cerveny L, Ceckova M, Staud F. Interactions of tenofovir and tenofovir disoproxil fumarate with drug efflux transporters ABCB1, ABCG2, and ABCC2; role in transport across the placenta. AIDS 2014; 28 (1):9-17 (doi: 10.1097/QAD.0000000000000112)


Cihalova D, Hofman J, Ceckova M, Staud F. Purvalanol A, Olomoucine II and Roscovitine Inhibit ABCB1 Transporter and Synergistically Potentiate Cytotoxic Effects of Daunorubicin In Vitro. PLoS One. 2013;23;8(12):e83467

Hofman J, Kučera R, Cihalova D, Klimes J, Ceckova M, Staud F. Olomoucine II, but not purvalanol A, is transported by breast cancer resistance protein (ABCG2) and P-glycoprotein (ABCB1). PLoS One. 2013 8;8(10):e75520

Staud F, Cerveny L, Ahmadimoghaddam D, Ceckova M. 2013 Multidrug and toxin extrusion proteins (MATE/SLC47); role in pharmacokinetics. Int J Biochem Cell Biol. 2013 Sep;45(9):2007-11 (doi: 10.1016/j.biocel.2013.06.022)

Ahmadimoghaddam D, Staud F. Transfer of Metformin across the Rat Placenta is Mediated by Organic Cation Transporter 3 (OCT3/SLC22A3) and Multidrug and Toxin Extrusion 1 (MATE1/SLC47A1) Protein. Reprod Toxicol 2013;39:17-22 (doi: 10.1016/j.reprotox.2013.03.001)

Ahmadimoghaddam D, Zemankova L, Nachtigal P, Dolezelova E, Cerveny L, Ceckova M, Kacerovský M, Neumanová Z, Micuda S, Staud F. Organic Cation Transporter 3 (OCT3/SLC22A3) and Multidrug and Toxin Extrusion 1 (MATE1/SLC47A1) Transporter in the Placenta and Fetal Tissues; Expression Profile and Fetus Protective Role at Different Stages of Gestation. Biol Reprod 2013;88 (doi: 10.1095/biolreprod.112.105064)

Cerveny L, Straskova A, Dankova V, Hartlova A, Ceckova M, Staud F, Stulik J. Tetratricopeptide Repeat Motifs in the World of Bacterial Pathogens; Role in Virulence Mechanisms. Infect Immun 2013;81:629-35 (doi: 10.1128/IAI.01035-12)


Staud F, Cerveny L, Ceckova M. Pharmacotherapy in pregnancy; effect of ABC and SLC transporters on drug transport across the placenta and fetal drug exposure. J Drug Target 2012;20:736-63 (doi: 10.3109/1061186X.2012.716847)

Hofman J, Ahmadimoghaddam D, Hahnova L, Pavek P, Ceckova M, Staud F. Olomoucine II and purvalanol A inhibit ABCG2 transporter in vitro and in situ and synergistically potentiate cytostatic effect of mitoxantrone. Pharmacol Res 2012;65:312-9 (doi: 10.1016/j.phrs.2011.11.017)

Ahmadimoghaddam D, Hofman J, Zemankova L, Nachtigal P, Dolezelova E, Cerveny L, Staud F. Synchronized Activity of Organic Cation Transporter 3 (Oct3/Slc22a3) and Multidrug and Toxin Extrusion 1 (Mate1/Slc47a1) Transporter in Transplacental Passage of MPP+ in Rat. Toxicol Sci 2012;128:471-81 (doi: 10.1093/toxsci/kfs160)

2011 and older

Hahnova-Cygalova L, Ceckova M, Staud F. Fetoprotective activity of breast cancer resistance protein (BCRP, ABCG2): expression and function throughout pregnancy. Drug Metab Rev 2011;43:53-68.

Staud F, Ceckova M, Micuda S, Pavek P. Expression and function of p-glycoprotein in normal tissues: effect on pharmacokinetics. Methods Mol Biol 2010;596:199-222.

Vackova Z, Vagnerova K, Libra A, Miksik I, Pacha J, Staud F. Dexamethasone and betamethasone administration during pregnancy affects expression and function of 11 beta-hydroxysteroid dehydrogenase type 2 in the rat placenta. Reprod Toxicol 2009;28:46-51.

Pavek P, Ceckova M, Staud F. Variation of drug kinetics in pregnancy. Curr Drug Metab 2009;10:520-9.

Cygalova LH, Hofman J, Ceckova M, Staud F. Transplacental pharmacokinetics of glyburide, rhodamine 123, and BODIPY FL prazosin: effect of drug efflux transporters and lipid solubility. J Pharmacol Exp Ther 2009;331:1118-25.

Vagnerova K, Vackova Z, Klusonova P, Staud F, Kopecky M, Ergang P, et al. Reciprocal changes in maternal and fetal metabolism of corticosterone in rat during gestation. Reprod Sci 2008;15:921-31.

Cygalova L, Ceckova M, Pavek P, Staud F. Role of breast cancer resistance protein (Bcrp/Abcg2) in fetal protection during gestation in rat. Toxicol Lett 2008;178:176-80.

Ceckova M, Vackova Z, Radilova H, Libra A, Buncek M, Staud F. Effect of ABCG2 on cytotoxicity of platinum drugs: Interference of EGFP. Toxicol In Vitro 2008;22:1846-52.

Vackova Z, Libra A, Ceckova M, Pavek P, Staud F. Effect of dexamethasone and betamethasone on 11beta-hydroxysteroid dehydrogenase type 2 expression in human choriocarcinoma Jeg3 cells. Biomed Pap 2007;151:95-7.

Cerveny L, Svecova L, Anzenbacherova E, Vrzal R, Staud F, Dvorak Z, et al. Valproic acid induces CYP3A4 and MDR1 gene expression by activation of constitutive androstane receptor and pregnane X receptor pathways. Drug Metab Dispos 2007;35:1032-41.

Bremer S, Brittebo E, Dencker L, Knudsen LE, Mathisien L, Olovsson M, Staud F et al. In vitro tests for detecting chemicals affecting the embryo implantation process. The report and recommendations of ECVAM workshop 62 -- a strategic workshop of the EU ReProTect project. Altern Lab Anim 2007;35:421-39.

Staud F, Vackova Z, Pospechova K, Pavek P, Ceckova M, Libra A, et al. Expression and Transport Activity of Breast Cancer Resistance Protein (Bcrp/Abcg2) in Dually Perfused Rat Placenta and HRP-1 Cell Line. J Pharmacol Exp Ther 2006;319:53-62.

Staud F, Mazancova K, Miksik I, Pavek P, Fendrich Z, Pacha J. Corticosterone transfer and metabolism in the dually perfused rat placenta: effect of 11beta-hydroxysteroid dehydrogenase type 2. Placenta 2006;27:171-80.

Libra A, Fernetti C, Lorusso V, Visigalli M, Anelli PL, Staud F, et al. Molecular determinants in the transport of a bile Acid-derived diagnostic agent in tumoral and nontumoral cell lines of human liver. J Pharmacol Exp Ther 2006;319:809-17.

Cerveny L, Pavek P, Malakova J, Staud F, Fendrich Z. Lack of Interactions between Breast Cancer Resistance Protein (BCRP/ABCG2) and Selected Antiepileptic Agents. Epilepsia 2006;47:461-8.

Ceckova-Novotna M, Pavek P, Staud F. P-glycoprotein in the placenta: Expression, localization, regulation and function. Reprod Toxicol 2006;22:400-10.

Ceckova M, Libra A, Pavek P, Nachtigal P, Brabec M, Fuchs R, Staud F. Expression and functional activity of breast cancer resistance protein (bcrp, abcg2) transporter in the human choriocarcinoma cell line bewo. Clin Exp Pharmacol Physiol 2006;33:58-65.

Staud F, Pavek P. Breast cancer resistance protein (BCRP/ABCG2). Int J Biochem Cell Biol 2005;37:720-5.

Novotna M, Libra A, Kopecky M, Pavek P, Fendrich Z, Semecky V, Staud F. P-glycoprotein expression and distribution in the rat placenta during pregnancy. Reprod Toxicol 2004;18:785-92.

Pavek P, Staud F, Fendrich Z, Sklenarova H, Libra A, Novotna M, et al. Examination of the functional activity of P-glycoprotein in the rat placental barrier using rhodamine 123. J Pharmacol Exp Ther 2003;305:1239-50.

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