Publications

For reprints, contact katerina.vavrova@faf.cuni.cz

2017

Svoboda M, Hlobilová M, Marešová M, Sochorová M, Kováčik A, Vávrová K, Dolečková I. Comparison of suction blistering and tape stripping for analysis of epidermal genes, proteins and lipids. Arch. Dermatol. Res. 2017, DOI 10.1007/s00403-017-1776-6, in press

Stahlberg S, Eichner A, Sonnenberger S, Kováčik A, Lange S, Schmitt T, Demé B, Hauss T, Dobner B, Neubert RHH, Huster D. The Influence of a Novel Dimeric Ceramide Molecule on the Nanostructure and the Thermotropic Phase Behavior of a Stratum Corneum Model Mixture Langmuir2017, 33(36):9211-9221. DOI: 10.1021/acs.langmuir.7b01227.

Sochorová M, Staňková K, Pullmannová P, Kováčik A, Zbytovská J, Vávrová K. Permeability Barrier and Microstructure of Skin Lipid Membrane Models of Impaired Glucosylceramide Processing​Sci. Rep. 2017, 7(1):6470. DOI:10.1038/s41598-017-06990-7.

Bezrouk A, Fiala Z, Kotingová L, Krulichová IS, Kopečná M, Vávrová K. SAMPA: A free software tool for skin and membrane permeation data analysis. Toxicol. in Vitro. 2017, 44:361-371. DOI: 10.1016/j.tiv.2017.07.017.

Vávrová K, Kováčik A, Opálka L. Ceramides in the Skin Barrier.  Eur. Pharm. J. 2017, 64 (1):1-8. DOI: 10.1515/afpuc-2017-0004.

Kopečná M, Macháček M, Prchalová E, Štěpánek P, Drašar P, Kotora M, Vávrová K. Galactosyl Pentadecene Reversibly Enhances Transdermal and Topical Drug DeliveryPharm. Res2017. DOI: 10.1007/s11095-017-2214-3. 

Pichery M, Huchenq A, Sandhoff R, Severino-Freire M, Zaafouri S, Opálka L, Levade T, Soldan V, Bertrand-Michel J, Lhuillier E, Serre G, Maruani A, Mazereeuw-Hautier J, Jonca N. PNPLA1 defects in patients with autosomal recessive congenital ichthyosis and KO mice sustain PNPLA1 irreplaceable function in epidermal omega-O-acylceramide synthesis and skin permeability barrierHum. Mol. Genet2017; 26(10):1787-1800. DOI: 10.1093/hmg/ddx079

Wallmeyer L, Dietert K, Sochorová M, Gruber AD, Kleuser B, Vávrová K, Hedtrich S. TSLP is a direct trigger for T cell migration in filaggrin-deficient skin equivalentsSci. Rep. 2017; 7(1):774. DOI: 10.1038/s41598-017-00670-2

Pullmannová P, Pavlíková L, Kováčik A, Sochorová M, Školová B, Slepička P, Maixner J, Zbytovská J, Vávrová K. Permeability and Microstructure of Model Stratum Corneum Lipid Membranes Containing Ceramides With Long (C16) and Very Long (C24) Acyl Chains. Biophys. Chem. 2017; 224:20-31. DOI: 10.1016/j.bpc.2017.03.004

Kováčik A, Šilarová M, Pullmannová P, Maixner J, Vávrová K. Effects of 6-hydroxyceramides on the thermotropic phase behavior and permeability of model skin lipid membranes. Langmuir. 2017; 33:2890-2899. DOI: 10.1021/acs.langmuir.7b00184

Schroeter A, Stahlberg S, Školová B, Sonnenberger S, Eichner A, Huster D, Vavrova K, Hauß T, Dobner B, Neubert R, Vogel A, Phase separation in Ceramide [NP] containing lipid model membranes: Neutron diffraction and solid-state NMR. Soft Matter. 2017; 13:2107-2119. DOI: 10.1039/C6SM02356H

Kopečná M, Macháček M, Prchalová E, Štěpánek P, Drašar P, Kotora M, Vávrová K. Dodecyl amino glucoside enhances transdermal and topical drug delivery via reversible interaction with skin barrier lipids. Pharm. Res. 2017; 34(3):640-653. DOI: 10.1007/s11095-016-2093-z. Springer sharing link

Školová B, Kováčik A, Tesař O, Opálka L, Vávrová K. Phytosphingosine, sphingosine and dihydrosphingosine ceramides in model skin lipid membranes: permeability and biophysics. Biochim. Biophys. Acta - Biomembranes. 2017; 1859(5):824-834. DOI: 10.1016/j.bbamem.2017.01.019

2016

Opálka L, Kováčik A, Maixner J, Vávrová K. Omega-O-acylceramides in Skin Lipid Membranes: Effects of Concentration, Sphingoid Base and Model Complexity on Microstructure and Permeability. Langmuir 2016; 32(48):12894–12904. DOI: 10.1021/acs.langmuir.6b03082 - Open Access

Kováčik A, Opálka L, Šilarová M, Roh J, Vávrová K. Synthesis of 6-Hydroxyceramide Using Ruthenium-Catalyzed Hydrosilylation-Protodesilylation. Unexpected Formation of a Long Periodicity Lamellar Phase in Skin Lipid MembranesRSC Adv. 2016; 6(77), 73343-73350.

Zoschke C, Ulrich M, Sochorová M, Wolff C, Vávrová K, Ma N, Ulrich C, Brandner J, Schäfer-Korting M. The barrier function of organotypic non-melanoma skin cancer models. J. Control. Release. 2016; 233:10-18.

Školová B; Janůšová B; Vávrová K. Ceramides with a pentadecasphingosine chain and short acyls have strong permeabilization effects on skin and model lipid membranes. Biochim Biophys Acta. Biomembranes 2016; 1858(2):220–232. DOI:10.1016/j.bbamem.2015.11.019

Vávrová K. Emerging small-molecule compounds for treatment of atopic dermatitis: a review. Exp. Opin. Ther. Patents 2016; 26(1):21-34. DOI: 10.1517/13543776.2016.1101451 - 50 free reprints

2015

Opálka L, Kováčik A, Sochorová M, Roh J, Kuneš J, Lenčo J, Vávrová K. Scalable Synthesis of Human Ultralong Chain Ceramides. Org. Lett. 2015; 17(21):5456-5459. DOI: 10.1021/acs.orglett.5b02816 - Open Access

Wallmeyer L; Lehnen D; Eger N; Sochorová M; Opálka L; Kováčik A; Vávrová K, Hedtrich S. Stimulation of PPARalpha Normalizes the Skin Lipid Ratio and Improves the Skin Barrier of Normal and Filaggrin Deficient Reconstructed Skin. J. Dermatol. Sci. 2015; 80(2):102–110. doi:10.1016/j.jdermsci.2015.09.012.

Paloncýová M, Vávrová K, Sovová Ž, DeVane R, Otyepka M, Berka K. Structural Changes in Ceramide Bilayers Rationalize Increased Permeation through Stratum Corneum Models with Shorter Acyl Tails. J Phys Chem B. 2015;119(30):9811-9

Stahlberg S, Školová B, Madhu PK, Vogel A, Vávrová K, Huster D. Probing the Role of the Ceramide Acyl Chain Length and Sphingosine Unsaturation in Model Skin Barrier Lipid Mixtures by 2H Solid-State NMR Spectroscopy. Langmuir 2015;31(17):4906-15

Witting M, Boreham A, Brodwolf R, Vávrová K, Alexiev U, Friess W, Hedtrich S. Interactions of Hyaluronic Acid with the Skin and Implications for the Dermal Delivery of Biomacromolecules. Mol Pharm. 2015;12(5):1391-401

2014

Vávrová K, Henkes D, Strüver K, Sochorová M, Školová B, Witting M, Friess W, Schreml S, Meier RJ, Schäfer-Korting M, Fluhr JW, Küchler S. Filaggrin Deficiency Leads to Impaired Lipid Profile and Altered Acidification Pathways in a 3 D Skin Construct. J. Invest. Dermatol. 2014, 134(3): 746-753.

Kováčik A, Roh J, Vávrová K. The chemistry and biology of 6 hydroxyceramide, the youngest member of the human sphingolipid family. ChemBioChem 2014, 15:1555-1562.

Pullmannová P, Staňková K, Pospíšilová M, Skolová B, Zbytovská J, Vávrová K. Effects of sphingomyelin/ceramide ratio on the permeability and microstructure of model stratum corneum lipid membranes. Biochim Biophys Acta. 2014, 1838(8):2115-2126.

Školová B, Jandovská K, Pullmannová P, Tesař O, Roh J, Hrabálek A, Vávrová K. The role of the trans double bond in skin barrier sphingolipids: permeability and infrared spectroscopic study of model ceramide and dihydroceramide membranes. Langmuir. 2014; 30(19):5527-5535.

Školová B, Hudská K, Pullmannová P, Kováčik A, Palát K, Roh J, Fleddermann J, Estrela-Lopis I, Vávrová K. Different Phase Behavior and Packing of Ceramides with Long (C16) and Very Long (C24) Acyls in Model Membranes: Infrared Spectroscopy Using Deuterated Lipids. J Phys Chem B. 2014, 118 (35), 10460–10470.

Diblíková D, Kopečná M, Školová B, Krečmerová M, Roh J, Hrabálek A, Vávrová K. Transdermal Delivery and Cutaneous Targeting of Antivirals using a Penetration Enhancer and Lysolipid Prodrugs. Pharm. Res. 2014, 31(4):1071-1081.

2013

Školová B, Janůšová B, Zbytovská J, Gooris G, Bouwstra JA, Slepička P, Berka P, Roh J, Palát K, Hrabálek A, Vávrová K. Ceramides in the Skin Lipid Membranes: Length Matters. Langmuir 2013, 29(50):15624-15633.

Janůšová B, Školová B, Tükörová K, Wojnarová L, Šimůnek T, Mladěnka P, Filipský T, Říha M, Roh J, Palát K, Hrabálek A, Vávrová K. Amino acid derivatives as transdermal permeation enhancers. J. Control. Release 2013, 165(2):91-100.

2011

Vávrová K, Kovaříková P, Školová B, Líbalová M, Roh J, Čáp R, Holý A, Hrabálek A. Enhanced topical and transdermal delivery of antineoplastic and antiviral acyclic nucleoside phosphonate cPr‑PMEDAP. Pharm. Res. 2011; 28(12):3105-3115.

Janůšová B, Zbytovská J, Lorenc P, Vavrysová H, Palát K, Hrabálek A, Vávrová K. Effect of ceramide acyl chain length on skin permeability and thermotropic phase behavior of model stratum corneum lipid membranes. Biochim. Biophys. Acta Mol. Cell Biol. Lipids 2011; 1811(3):129-137.

Novotný M, Klimentová J, Janůšová B, Palát K. Hrabálek A, Vávrová K. Ammonium carbamates as highly active transdermal permeation enhancers with a dual mechanism of action. J. Control. Release 2011; 150(2):164-70.

Zbytovská J, Vávrová K. Neutron Scattering in Skin Research. In: Neutron Scattering Methods and Studies, Lyons MJ, ed. Nova Science Pub, 2011, ISBN-10: 1611225213, pp 89-110.

2010

Novotný M, Hrabálek A, Janůšová B, Novotný J, Vávrová K. Transkarbams as transdermal permeation enhancers; Effects of ester position and ammonium carbamate formation. Bioorg. Med. Chem. Lett. 2010; 20(9): 2726-8.

Novotný J, Hrabálek A, Vávrová K. Synthesis and Structure-Activity Relationships of Skin Ceramides. Curr. Med. Chem. 2010; 17(21):2301-24.

2009

Novotný J, Pospěchová K, Hrabálek A, Čáp R, Vávrová K. Synthesis of Fluorescent C24-Ceramide: Evidence for Acyl Chain Length Dependent Differences in Penetration of Exogenous NBD-Ceramides into Human Skin. Bioorg. Med. Chem. Lett. 2009; 19(24): 6975-6977.

Zbytovská J, Vávrová K, Kiselev MA, Lessieur P, Wartewig S, Neubert RHH. The effects of transdermal permeation enhancers on thermotropic phase behaviour of a stratum corneum lipid model. Col. Surf. A 2009; 351:30-37.

Novotný M, Hrabálek A, Janůšová B, Novotný J, Vávrová K. Dicarboxylic acid esters as transdermal permeation enhancers: effects of chain number and geometric isomers. Bioorg. Med. Chem. Lett. 2009; 19(2):344-347.

Novotný J, Kovaříková P, Novotný M, Janůšová B, Hrabálek A, Vávrová K. Dimethylamino acid esters as biodegradable and reversible transdermal permeation enhancers: effects of linking chain length, chirality and polyfluorination. Pharm. Res. 2009;26(4):811-21.

Novotný J, Janůšová B, Novotný M, Hrabálek A, Vávrová K. Short-Chain Ceramides Decrease Skin Barrier Properties. Skin Pharmacol. Physiol. 2009; 22(1):22-30.

2008

Vávrová K, Lorencová K, Novotný J, Holý A, Hrabálek A. Permeation enhancer dodecyl 6-(dimethylamino)hexanoate increases transdermal and topical delivery of adefovir; influence of pH, ion-pairing and skin species. Eur. J. Pharm. Biopharm. 2008; 70(3):901-7.

Klimentová J, Kosák P, Vávrová K, Holas T, Novotný J, Hrabálek A. Transkarbams with Terminal Branching as Transdermal Permeation Enhancers. Bioorg. Med. Chem. Lett. 2008; 18(5):1712-1715.

Vávrová K, Lorencová K, Klimentová J, Novotný J, Holý A, Hrabálek A. Transdermal and dermal delivery of adefovir; effects of pH and permeation enhancers. Eur. J. Pharm. Biopharm. 2008; 69(2):597-604.

2007

Vávrová K, Hrabálek A, Mac-Mary S, Humbert P, Muret P. Ceramide analogue 14S24 selectively recovers perturbed human skin barrier. Brit. J. Dermatol. 2007; 157 (4):704-712.

Vávrová K, Lorencová K, Klimentová J, Novotný J, Hrabálek A. HPLC method for determination of in vitro delivery through and into porcine skin of adefovir (PMEA). J. Chromatogr. B. 2007; 853(1-2):198-203.

Hrabálek A, Vávrová K. Historie a současný stav ve vývoji akcelerantů transdermální permeace na Farmaceutické fakultě UK v Hradci Králové – od esterů 6-aminohexanové kyseliny k transkarbamům (II. část). Praktické lékárenství 2007; 3(6):299-300.

Hrabálek A, Doležal P, Vávrová K. Historie a současný stav ve vývoji akcelerantů transdermální permeace na Farmaceutické fakultě UK v Hradci Králové – od esterů 6-aminohexanové kyseliny k transkarbamům (I. část). Praktické lékárenství 2007; 3(2):90-2.

2006

Klimentová J, Kosák P, Vávrová K, Holas T, Hrabálek A. Influence of terminal branching on the transdermal permeation-enhancing activity in fatty alcohols and acids. Bioorg. Med. Chem. 2006; 14(23):7681-7.

Holas T, Vávrová K, Šíma M, Klimentová J, Hrabálek A. Synthesis and transdermal permeation-enhancing activity of carbonate and carbamate analogs of Transkarbam 12. Bioorg. Med. Chem. 2006; 14(23):7671-80.

Hrabálek A, Doležal P, Vávrová K, Zbytovská J, Holas T, Klimentová J, Novotný J. Synthesis and Enhancing Effect of Transkarbam 12 on the Transdermal Delivery of Theophylline, Clotrimazole, Flobufen, and Griseofulvin. Pharm. Res. 2006; 23(5):912-8.

Klimentová J, Hrabálek A, Vávrová K, Holas T, Kroutil A. Synthesis and transdermal penetration-enhancing activity of carbonic and carbamic acid esters-comparison with transkarbam 12. Bioorg. Med. Chem. Lett. 2006; 16(7):1981-4.

Holas T, Vávrová K, Klimentová J, Hrabálek A. Synthesis and transdermal permeation-enhancing activity of ketone, amide, and alkane analogs of Transkarbam 12. Bioorg. Med. Chem. 2006; 14(9):2896-2903.

Holas T, Zbytovská J, Vávrová K, Berka P, Mádlová M, Klimentová J, Hrabálek A. Thermotropic phase behavior of long-chain alkylammonium-alkylcarbamates. Thermochim. Acta 2006; 441(2):116-123

Vávrová K, Hrabálek A. Role ceramidů v kůži. Praktické lékárenství 2006; 2:55-58.

2005

Vávrová K, Zbytovská J, Hrabálek A. Amphiphilic transdermal permeation enhancers: structure-activity relationships. Curr. Med. Chem. 2005; 12(19):2273-91.

Hrabálek A, Vávrová K, Doležal P, Macháček M. Esters of 6-aminohexanoic acid as skin permeation enhancers: The effect of branching in the alkanol moiety. J. Pharm. Sci. 2005; 94(7):1494-9.

Vávrová K, Hrabálek A, Doležal P, Holas T, Klimentová J. Biodegradable derivatives of tranexamic acid as transdermal permeation enhancers. J. Control. Release. 2005; 104(1):41-9.

Hrabálek A, Vávrová K. Lze překonat kožní bariéru? Praktické lékárenství 2005; 1:8-11.

2004

Vávrová K, Zbytovská J, Palát K, Holas T, Klimentová J, Hrabálek A, Doležal P. Ceramide analogue 14S24 ((S)-2-tetracosanoylamino-3-hydroxypropionic acid tetradecyl ester) is effective in skin barrier repair in vitro. Eur. J. Pharm. Sci. 2004; 21(5):581-7.

2003

Vávrová K, Hrabálek A, Doležal P, Šámalová L, Palát K, Zbytovská J, Holas T, Klimentová J. Synthetic ceramide analogues as skin permeation enhancers: structure-activity relationships. Bioorg. Med. Chem. 2003; 11(24):5381-90.

Vávrová K, Hrabálek A, Doležal P, Holas T, Zbytovská J. L-Serine and glycine based ceramide analogues as transdermal permeation enhancers: polar head size and hydrogen bonding. Bioorg. Med. Chem. Lett. 2003; 13(14):2351-3.

Doležal P, Hrabálek A, Svozil M, Vávrová K, Zbytovská J. In vitro studies on transkarbam 12 and laurocapram effect on transdermal permeation of butorphanol. Farmacevtski Vestnik 2003; 54 (Spec. Iss.):527-8.

2002

Vávrová K, Hrabálek A, Doležal P. Enhancement effects of (R) and (S) enantiomers and the racemate of a model enhancer on permeation of theophylline through human skin. Arch. Dermatol. Res. 2002; 294(8):383-5.

 

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