Publications on flavonoids / Články o flavonoidech

Research group of Cardiovascular and respirator pharmacology and toxicology

Dias P, Salam R, Pourová J, Vopršalová M, Konečný L, Jirkovský E, Tebbens JD, Mladěnka P. The quercetin metabolite 4-methylcatechol causes vasodilation via voltage-gated potassium (KV) channels. Food Funct 2024; 15: 11047-11059 (IF₂₀₂₃5.1, Q1_IF/AIS in FOOD SCIENCE & TECHNOLOGY)
Rassu G, Vlčková HK, Giunchedi P, Dias P, Cossu M, Pourová J, Harčárová P, Lomozová Z, Nováková L, Gavini E & Mladěnka P. A water-soluble preparation for intravenous administration of isorhamnetin and its pharmacokinetics in rats. Chem Biol Interact. 2024;396:111064 (IF₂₀₂₃5.1, Q1_IF in PHARMACOLOGY & PHARMACY)
Moravcová M, Lomozová Z, Kučera R, Mladěnka P. 3-hydroxyflavone is a mildly active and safe cobalt chelator while cobalt markedly enhances baicalein toxicity toward erythrocytes. RSC Adv 2023;13: 29242-29251 (IF₂₀₂₂3.9, Q2 in CHEMISTRY, MULTIDISCPIPLINARY)
Konečný L, Hrubša M, Karlíčková J, Carazo A, Javorská L, Matoušová K, Krčmová LK, Šmahelová A, Blaha V, Bláha M, Mladěnka P. The Effect of 4-Methylcatechol on Platelets in Familial Hypercholesterolemic Patients Treated with Lipid Apheresis and/or Proprotein Convertase Subtilisin Kexin 9 Monoclonal Antibodies. Nutrients. 2023; 15(8):1842 (IF₂₀₂₁ 6.7 Q1_2021/IF in Nutrition & Dietetics, Q2_2021/AIS in Nutrition & Dietetics)
Hrubša M, Konečný L, Paclíková M, Parvin MS, Skořepa P, Musil F, Karlíčková J, Javorská L, Matoušová K, Krčmová LK, Carazo A, Šmahelová A, Blaha V, Mladěnka P. The Antiplatelet Effect of 4-Methylcatechol in a Real Population Sample and Determination of the Mechanism of Action. Nutrients. 2022; 14(22):4798 (IF₂₀₂₁ 6.7 Q1_2021/IF in Nutrition & Dietetics, Q2_2021/AIS in Nutrition & Dietetics)
Lomozová Z, Hrubša M, Conte PF, Papastefanaki E, Moravcová M, Catapano MC, Proietti Silvestri I, Karlíčková J, Kučera R, Macáková K & Mladěnka P. The effect of flavonoids on the reduction of cupric ions, the copper-driven Fenton reaction and copper-triggered haemolysis. Food Chem 2022; 394: 13346 /IF₂₀₂₀ 7.5/ (1^th decile in Nutrition & Dietetics; Food Science & Technology and Chemistry, Applied)
Hrubša M, Tvrdý V, Kutý M, Valentová K, Křen V & Mladěnka M. Interaction of flavonoids with zinc and zinc-containing enzymes. J Agric Food Chem 2022;70(20): 6134–6144 /IF₂₀₂₀ = 5.3/ (Q1_2020/IF/AIS Food Science & Technology, 1^st decile_IF/2020 Agriculture, multidiscipilinary, Q1_IF/AIS/2020 Chemistry, applied)
Dias P, Pourová J, Vopršalová M, Nejmanová I, Mladěnka P. 3-Hydroxyphenylacetic Acid: A Blood Pressure-Reducing Flavonoid Metabolite. Nutrients. 2022; 14(2):328 /IF₂₀₂₀=5.7/ (Q2_2020/AIS in Nutrition & Dietetics)
Hrubša M, Alva R, Parvin MS, Macáková K, Karlíčková J, Fadraersada J, Konečný L, Moravcová M, Carazo A, Mladěnka P. Comparison of Antiplatelet Effects of Phenol Derivatives in Humans. Biomolecules. 2022; 12(1):117 /IF₂₀₂₀ 4.9/ (Q2_AIS,2020 in Biochemistry & Molecular Biology)
Tvrdý V, Hrubša M, Jirkovský E, Biedermann D, Kutý M, Valentová K, Křen V, Mladěnka P. Silymarin Dehydroflavonolignans Chelate Zinc and Partially Inhibit Alcohol Dehydrogenase. Nutrients 2021; 13(12):4238 /IF₂₀₁₉=5.7/ (Q2_2020/AIS in Nutrition & Dietetics)
Lomozová Z, Catapano MC, Hrubša M, Karlíčková J, Macáková K, Kučera R & Mladěnka P. Chelation of iron and copper by quercetin B-ring methyl metabolites, isorhamnetin and tamarixetin, and their effect on metal-based Fenton chemistry. J Agric Food Chem 2021;69(21):5926-5937 /IF₂₀₁₉ 4.2/ (1^st decile in Agriculture, mutlidisciplinary; Q1₂₀₁₉ in Food Science and Technology and Q1₂₀₁₉ Chemistry, applied)
Lomozová Z, Tvrdý V, Hrubša M, Catapano MC, Macáková K, Biedermann D, Kučera R, Křen V, Mladěnka P, Valentová K. Dehydroflavonolignans from Silymarin Potentiate Transition Metal Toxicity In Vitro but Are Protective for Isolated Erythrocytes Ex Vivo. Antioxidants 2021; 10(5):679 /IF₂₀₁₉ 5.0/
Tvrdý V, Pourová J, Jirkovský E, Křen V, Valentová K & Mladěnka P. Systematic review of pharmacokinetics and potential pharmacokinetic interactions of flavonolignans from silymarin. Med Res Rev 2021; 41: 2195-2246 /IF₂₀₁₉ 9.3/
Migkos T, Pourová J, Vopršalová M, Auger C, Schini-Kerth V & Mladěnka P. Biochanin A, the most potent of 16 isoflavones, iBiochanin A, the most potent of 16 isoflavones, induces relaxation of the coronary artery through the calcium channel and cGMP-dependent pathway. Planta Medica 2020; 86(10): 708-716 /IF₂₀₁₈=2.7/
Najmanová I, Pourová J & Mladěnka P. Mixture of phenolic metabolites of quercetin can decrease elevated blood pressure of spontaneously hypertensive rats even in low doses. Nutrients 2020;12(1): 213 /IF₂₀₁₈=4.2/
Najmanová I, Vopršalová M, Saso L & Mladěnka P. The pharmacokinetics of flavanones. Crit Rev Food Sci Nutr 2020; 60(18): 3155-3171 /IF₂₀₁₈=6.7/
Pourová J, Applová L, Macáková K, Vopršalová M, Migkos T, Bentanachs R, Biedermann D, Petrásková L, Tvrdý V, Hrubša M, Karlíčková J, Křen V, Valentová K & Mladěnka P. The Effect of Silymarin Flavonolignans and Their Sulfated Conjugates on Platelet Aggregation and Blood Vessels Ex Vivo. Nutrients 2019;11(10): 2286 /IF₂₀₁₈=4.2/
Applová L, Karlíčková J, Warncke P, Macáková K, Hrubša M, Macháček M, Tvrdý V, Fischer D, Mladěnka P. 4-Methylcatechol, a Flavonoid Metabolite with Potent Antiplatelet Effects. Mol Nutr Food Res. 2019; 63 (20): 1900261 /IF₂₀₁₇=5.2/
Migkos T, Applová L, Horký P, Tvrdý V, Karlíčková J, Macáková K, Hrubša M, Catapano MC, Tomanek M, Pour M, Mladěnka P. The influence of microbial isoflavonoid specific metabolites on platelets and transition metals iron and copper. Phytomedicine 2019;62:152974 /IF₂₀₁₇=3.6/
Pourová J, Najmanová I, Vopršalová M, Migkos T, Pilařová V, Applová L, Nováková L & Mladěnka P. Two flavonoid metabolites, 3,4-dihydroxyphenylacetic acid and 4-methylcatechol, relax arteries ex vivo and decrease blood pressure in vivo. Vasc Pharmacol 2018;111: 36-43 /IF₂₀₁₇=3.6/
Tvrdý V, Catapano MC, Rawlik T, Karlíčková J, Biedermann D, Křen V, Mladěnka P, Valentová K. Interaction of isolated silymarin flavonolignans with iron and copper. J Inorg Biochem 2018,189: 115-123 /IF₂₀₁₇=3.0/
Porcu EP, Cossu M, Rassu G, Giunchedi P, Cerri G, Pourová J, Najmanová I, Migkos T, Pilařová V, Nováková L, Mladěnka P & Gavini E. Aqueous injection of quercetin: an approach for confirmation of its direct in vivo cardiovascular effects. Int J Pharmaceut 2018;541(1-2): 224-233 /IF₂₀₁₆=3.6/
Catapano MC, Tvrdý V, Karlíčková J, Migkos T, Valentová K, Křen V, Mladěnka P. The Stoichiometry of Isoquercitrin Complex with Iron or Copper Is Highly Dependent on Experimental Conditions. Nutrients 2017, 9, 1193 /IF₂₀₁₆=3.6/
Applová L, Karlíčková J, Říha M, Filipský T, Macáková K, Spilková J, Mladěnka P. The isoflavonoid tectorigenin has better antiplatelet potential than acetylsalicylic acid. Phytomedicine 2017;35:11-7 /IF₂₀₁₆=3.5/
Filipský T, Říha M, Hašková P, Pilařová V, Nováková L, Semecký V, Vávrová J, Holečková M, Palicka V, Šimůnek T, Hrdina R & Mladěnka P. Intravenous rutin in rat exacerbates isoprenaline-induced cardiotoxicity likely due to intracellular oxidative stress. Redox Rep 2017;22(2):78-90 /IF₂₀₁₅=2.6/
Mladěnka P, Říha M, Martin J, Gorová B, Matějíček A & Spilková J. Fruit extracts of 10 varieties of elderberry (Sambucus nigra L.) interact differently with iron and copper. Phytochem Lett 2016; 18:232-8 /IF₂₀₁₅=1.4/
Najmanová I, Pourová J, Vopršalová M, Pilařová V, Semecký V, Nováková L & Mladěnka P. The flavonoid metabolite 3-(3-hydroxyphenyl)propionic acid formed by human microflora decreases arterial blood pressure in rat. Mol Nut Food Chem 2016;60(5):981-91 /IF₂₀₁₄=4.6/
Karlíčková J, Říha M, Filipský T, Macáková K, Hrdina R & Mladěnka P. Antiplatelet effects of flavonoids mediated by inhibition of arachidonic acid based pathway. Planta Med 2016;82(01/02):76-83 /IF₂₀₁₄=2.2/
Karlíčková J, Macáková K, Říha M, Pinheiro LMT, Filipský T, Horňasová V, Hrdina R & Mladěnka P. Isoflavones Reduce Copper with Minimal Impact on Iron In Vitro. Oxid Med Cell Longev 2015;2015: article ID 437381 /IF₂₀₁₄=3.5/
Říha M, Karlíčková J, Filipský T, Macáková K, Rocha L, Bovicelli P, Proietti Silvestri I, Saso L, Jahodář L, Hrdina R & Mladěnka P. In vitro evaluation of copper-chelating properties of flavonoids. RSC Adv 2014;4 (62): 32628 - 32638 /IF₂₀₁₃=3.7/
Mladěnka P, Hrdina R, Filipký T, Říha M & Palicka V. Is a Highly Linear Relationship Between the Dose of Quercetin and the Pharmacological Effect Possible? — A Comment on Liu, et al. Evaluation of Antioxidant and Immunity Activities of Quercetin in Isoproterenol-Treated Rats. Molecules 2012, 17, 4281–4291. Molecules 2014, 19(7), 9606-9609 /IF₂₀₁₂=2.4/
Říha M, Vopršalová M, Pilařová V, Semecký V, Holečková M, Vávrová J, Palicka V, Filipský T, Hrdina R, Nováková L & Mladěnka P. Oral administration of quercetin is unable to protect against isoproterenol cardiotoxicity. Naunyn Schmiedeberg´s Arch Pharmacol 2014;387: 823-35 /IF₂₀₁₂=2.1/
Macáková K, Mladěnka P, Filipský T, Říha M, Jahodář L, Trejtnar F, Bovicelli P, Proietti Silvestri I, Hrdina R, Saso L. Iron reduction potentiates hydroxyl radical formation only in flavonols. Food Chem 2012; 135(4): 2584–92 /IF₂₀₁₁=3.7/
Mladěnka P, Macáková K, Filipský T, Zatloukalová L, Jahodář L, Bovicelli P, Silvestri IP, Hrdina R, Saso L. In vitro analysis of iron chelating activity of flavonoids. J Inorg Biochem. 2011;105(5):693-701 /IF₂₀₁₀=3.3/
Mladenka P, Zatloukalová L, Filipský T, Hrdina R. Cardiovascular effects of flavonoids are not caused only by direct antioxidant activity. Free Radic Biol Med. 2010;49(6):963-75 /IF₂₀₀₉=6.1/
Mladěnka P, Zatloukalová L, Šimůnek T, Bobrovová Z, Semecký V, Nachtigal P, Hašková P, Macková E, Vávrová J, Holečková M, Palicka V, Hrdina R. Direct administration of rutin does not protect against catecholamine cardiotoxicity. Toxicology 2009;255:25-32 /IF₂₀₀₉=3.2/