Publication on drugs acting on vascular smooth muscles / Články na léčiva působí na hladký cévní sval

Research group of Cardiovascular and respirator pharmacology and toxicology

Dias P, Salam R, Pourová J, Vopršalová M, Konečný L, Jirkovský E, Tebbens JD, Mladěnka P. The quercetin metabolite 4-methylcatechol causes vasodilation via voltage-gated potassium (KV) channels. Food Funct 2024;15: 11047-11059 (IF₂₀₂₃5.1, Q1_IF/AIS in FOOD SCIENCE & TECHNOLOGY)
Dias P, Salam R, Moravcová M, Saadat S, Pourová J, Vopršalová M, Jirkovský E, Tebbens JF & Mladěnka P. 3-methoxycatechol causes vasodilation likely via KV channels: Ex vivo, in silico docking and in vivo study. Vasc Pharmacol 2024;156: 107418 (IF₂₀₂₃3.5, Q2_IF/AIS in PHARMACOLOGY & PHARMACY)
Dias P, Pourová J, Vopršalová M, Nejmanová I, Mladěnka P. 3-Hydroxyphenylacetic Acid: A Blood Pressure-Reducing Flavonoid Metabolite. Nutrients. 2022; 14(2):328 /IF₂₀₂₀=5.7/ (Q2_2020/AIS in Nutrition & Dietetics)
Migkos T, Pourová J, Vopršalová M, Auger C, Schini-Kerth V & Mladěnka P. Biochanin A, the most potent of 16 isoflavones, iBiochanin A, the most potent of 16 isoflavones, induces relaxation of the coronary artery through the calcium channel and cGMP-dependent pathway. Planta Medica 2020; 86(10): 708-716 /IF₂₀₁₈=2.7/
Najmanová I, Pourová J & Mladěnka P. Mixture of phenolic metabolites of quercetin can decrease elevated blood pressure of spontaneously hypertensive rats even in low doses. Nutrients 2020;12(1): 213 /IF₂₀₁₈=4.2/
Pourová J, Najmanová I, Vopršalová M, Migkos T, Pilařová V, Applová L, Nováková L & Mladěnka P. Two flavonoid metabolites, 3,4-dihydroxyphenylacetic acid and 4-methylcatechol, relax arteries ex vivo and decrease blood pressure in vivo. Vasc Pharmacol 2018;111: 36-43 /IF₂₀₁₇=3.6/
Porcu EP, Cossu M, Rassu G, Giunchedi P, Cerri G, Pourová J, Najmanová I, Migkos T, Pilařová V, Nováková L, Mladěnka P & Gavini E. Aqueous injection of quercetin: an approach for confirmation of its direct in vivo cardiovascular effects. Int J Pharmaceut 2018;541(1-2):224-233 /IF₂₀₁₆=3.6/
Najmanová I, Pourová J, Vopršalová M, Pilařová V, Semecký V, Nováková L & Mladěnka P. The flavonoid metabolite 3-(3-hydroxyphenyl)propionic acid formed by human microflora decreases arterial blood pressure in rat. Mol Nutr Food Res 2016;60(5):981-91 /IF₂₀₁₄=4.6/
Najmanová I, Doseděl M, Hrdina R, Anzenbacher P, Filipský T, Říha M, Mladěnka P. Cardiovascular Effects of Coumarins Besides their Antioxidant Activity. Curr Top Med Chem. 2015;15(9):830-49 /IF₂₀₁₃=3.5/
Říha M, Vopršalová M, Pilařová V, Semecký V, Holečková M, Vávrová J, Palicka V, Filipský T, Hrdina R, Nováková L & Mladěnka P. Oral administration of quercetin is unable to protect against isoproterenol cardiotoxicity. Naunyn Schmiedeberg´s Arch Pharmacol 2014;387: 823-35 /IF₂₀₁₂=2.1/
Mladěnka P, Zatloukalová L, Filipský T, Hrdina R. Cardiovascular effects of flavonoids are not caused only by direct antioxidant activity. Free Radic Biol Med. 2010;49(6):963-75 /IF₂₀₀₉=6.1/