Azaphthalocyanine group

The research group focuses on a wide range of aspects concerning phthalocyanines and, in particular, azaphthalocyanines. Synthetic approaches, photophysical and photochemical behavior are studied in several applications.

News

• April 2024: Posdoc position  available in our group !!! See details: Job Opening: FaF_VZ1_23: Researcher (junior), 0,8 FTE (project NETPHARM) | Farmaceutická fakulta Univerzity Karlovy (cuni.cz) Deadline for applciations 15th May 2024.

• PhD position available in our group !!! We are looking for a motivated student for a project dealing with the synthesis of acridine derivatives as DNA intercalators (see https://faf.cuni.cz/Study/Postgraduate/Dissertation-themes/260314/…). Deadline for applications is on 3^rd September 2023. PhD project will be a folow-up study on our recent paper in NAR.

• July 2023: Veronika Novakova succeeded with her project entitled "Smart photosensitizers: highly-efficient, activatable and aptamer-targeted (SPs-HEAT)" in the prestigious ERC-CZ. The aim of this programme is to support breakthrought czech projects that have succeeded in the European Research Council ("ERC") call for proposals and got A or B in the second round. Congrats!

• April 2023: our PhD student Filip Kostelansky, Ph.D. won prestigious Prize of Rector of Charles University and was awarded Prize of Mayor of Hradec Kralove for his research in the field of synthesis of new acridine derivatives that have the ability to stabilize DNA duplexes, which was done collaboration with the biotechnology company GENERI BIOTECH and recently published in Nucleic Acids Research.

• July 2022: Veronika Novakova was honoured with the SPP/JPP Young Investigator Award in 2022 by Society of Porphyrins and Phthalocyanines. Congrats!

• for the news archives click here

Selected publications

• Kociscakova L, Rando C, Kozlikova M, Machacek M, Novakova V, Šindelář V, Zimcik P, Monomerization of Phthalocyanines in Water via Their Supramolecular Interactions with Cucurbiturils, The Journal of Organic Chemistry, 2023, 88, 2, 988–1002.

• Kostelansky F, Miletin M, Havlinova Z, Szotakova B, Libra A, Kucera R, Novakova V, Zimcik P, Thermal stabilisation of the short DNA duplexes by acridine-4-carboxamide derivatives, Nucleic Acids Research, 2022, 50, 18, 10212-10229.

• Demuth J, Gallego L, Kozlikova M, Machacek M, Kucera R, Torres T, Martinez-Diaz MV, Novakova V, Subphthalocyanines as efficient photosensitizers with nanomolar photodynamic activity against cancer cells, Journal of Medicinal Chemistry, 2021, 64, 23, 17436–17447.

• Kollar J, Machacek M, Halaskova M, Lenco J, Kucera R, Demuth J, Rohlickova M, Hasonova K, Miletin M, Novakova V, Zimcik P, Cationic Versus Anionic Phthalocyanines for Photodynamic Therapy: What a Difference the Charge Makes, Journal of Medicinal Chemistry,  2020, 63, 7616-7632. 

• Cidlina A, Miletin M, Fathi-Rasekh M, Nemykin V, Zimcik P, Novakova V, OFF-ON-OFF Red-Emitting Fluorescent Indicators for a Narrow pH Window, Chemistry - A European Journal, 2017, 23, 8, 1795-1804. 
• Donzello MP, Ercolani C, Novakova V, Zimcik P, Stuzhin PA, Tetrapyrazinoporphyrazines and Their Metal Derivatives. Part I: Synthesis and Basic Structural Information, Coordination Chemistry Reviews, 2016; 309: 107-179.
• Machacek M, Demuth J,  Cermak P, Vavreckova M, Hruba L, Jedlickova A, Kubat P, Simunek T, Novakova V, Zimcik P, Tetra(3,4-pyrido)porphyrazines caught in the cationic cage: toward nanomolar active photosensitizers, Journal of Medicinal Chemistry, 2016, 59 (20): 9443–9456.
• Novakova V, Lásková M, Vavřičková H, Zimcik P, Phenol Substituted Tetrapyrazinoporphyrazines: pH dependent fluorescence in basic media, Chemistry - A European Journal, 2015, 21 (41): 14382–14392.
• Makhseed S, Machacek M, Alfadly W, Tuhl A, Vinodh M, Simunek T, Novakova V, Kubat P, Rudolf E, Zimcik P, Water soluble non-aggregating phthalocyanine and in vitro studies for photodynamic therapy, Chemical Communications, 2013; 49 (95): 11149-11151.
• Novakova V, Roh J, Gela P, Kuneš J, Zimcik P. Azaphthalocyanines with fused triazolo rings: formation of sterically stressed constitutional isomers. Chemical Communications. 2012; 48 (36): 4326-4328.