Azaphthalocyanine group

The research group focuses on a wide range of aspects concerning phthalocyanines and, in particular, azaphthalocyanines. Synthetic approaches, photophysical and photochemical behavior are studied in several applications.

News

August 2018: We have opened a call for a new postdoc positon in our research group (for a fixed period (1 year) with the possibility of extension for the entire duration of the project, i.e. till 31^st December 2022). Details can be found at: https://portal.faf.cuni.cz/Careers/EFSA-CDN-Postdoc-researcher-201808/
May 2018: Monika Steklá won also Supranational round of the Student´s Science conference with her work studying in vitro activity of amphiphilic (aza)phthalocyanines under supervision of Miloslav Machacek. Congratulation to Monika!
April 2018: Great success of our diploma student Monika Steklá, who won the Biological section of XXVI. Students‘ Science Conference with her work entitled "In vitro evaluation of the photodynamic activity of novel amphiphilic (aza)phthalocyanines". Congratulation to her! She was selected for the Supranational round of the Student´s Science conference that will take place on 9^th May 2018 at Zentiva a.s.
February 2018: We have published a comprehensive review on the properties and application of tetrapyrazinoporphyrazines in the Coordination Chemistry Reviews (see Coordination Chemistry Reviews, 2018, 361: 1-73.). It is possible to download it for free until March 27, 2018.
June 2017: Great success of our two PhD students in the competition "Sanofi Prize For Pharmacy" arranged by French Embassy in the Czech Republic and Jean-Marie Lehn (laureate of Nobel Prize). Lukas Lochman ranked 2^nd place with his research work entitled "Study of recognition moieties of sensoric azaphthalocyanines" and Slavek Machacek took 3^rd place with research work "Study of the novel phthalocyanine and azaphthalocyanine photosensitizers for photodynamic therapy of cancer" (photo of Slavek and Lukas with Jean-Marie Lehn during the award ceremony)
for the news archives click here

Selected publications

Cidlina A, Miletin M, Fathi-Rasekh M, Nemykin V, Zimcik P, Novakova V, OFF-ON-OFF Red-Emitting Fluorescent Indicators for a Narrow pH Window, Chemistry - A European Journal, 2017, 23, 8, 1795-1804. Highlighted in Chemistry Views and selected for Front Cover and Cover Profile
Donzello MP, Ercolani C, Novakova V, Zimcik P, Stuzhin PA, Tetrapyrazinoporphyrazines and Their Metal Derivatives. Part I: Synthesis and Basic Structural Information, Coordination Chemistry Reviews, 2016; 309: 107-179.
Machacek M, Demuth J, Cermak P, Vavreckova M, Hruba L, Jedlickova A, Kubat P, Simunek T, Novakova V, Zimcik P, Tetra(3,4-pyrido)porphyrazines caught in the cationic cage: toward nanomolar active photosensitizers, Journal of Medicinal Chemistry, 2016, DOI: 10.1021/acs.jmedchem.6b01140. Open Access, ACS Author Choice
Novakova V, Lásková M, Vavřičková H, Zimcik P, Phenol Substituted Tetrapyrazinoporphyrazines: pH dependent fluorescence in basic media, Chemistry - A European Journal, 2015, 21 (41): 14382–14392.
Makhseed S, Machacek M, Alfadly W, Tuhl A, Vinodh M, Simunek T, Novakova V, Kubat P, Rudolf E, Zimcik P, Water soluble non-aggregating phthalocyanine and in vitro studies for photodynamic therapy, Chemical Communications, 2013; 49 (95): 11149-11151.
Novakova V, Lochman L, Zajícová I, Kopecky K, Miletin M, Lang K, Kirakci K, Zimcik P, Azaphthalocyanines: Red Fluorescent probes for Cations, Chemistry - A European Journal, 2013; 19 (16): 5025-5028.
Novakova V, Roh J, Gela P, Kuneš J, Zimcik P. Azaphthalocyanines with fused triazolo rings: formation of sterically stressed constitutional isomers. Chemical Communications. 2012; 48 (36): 4326-4328.