Research

Research group aims with the research in the field of dosage forms formulation, modified drug release and development of drug delivery systems for targeted distribution of drugs. This particularly include:

1. Fractal aspects of the flow and consolidation behaviour of pharmaceutical particulate materials (Hurychová et al 2018, Trpělková et al 2020).

2. Compaction process and its influencing by the excipients used, their properties and the methods of their production, e.g. co-processing and granulation (Beneš et al 2017a, 2017b; Mužíková et al. 2016, 2018, 2019; Vodáčková et al 2018).

Various methods are methodologically employed such as the flow & compaction equations, force-displacement method, stress relaxation kinetic, and kinetic of tablet disintegration. The results are successfully used in collaboration with pharmaceutical manufacturers such as Zentiva Group, a.s., Teva Czech Industries s.r.o. and others. The mathematical and statistical techniques (DoE, PCA, multiregression analysis) are performed to the experiments & results (collaboration with doc. dipl. mat. J. DuintjerTebbens).

3. The influence of drug bioavailability due to the preparation of the biodegradable solid dispersions and matrix systems with prolonged (Čupera et al. 2015, Komersová et al. 2016, 2018) or fasted (ODT) (Svačinová et al 2019, Mužíková et al 2019) release or targeted into colon as well as the improvement of solubility of drugs by preparation of interactive mixtures, liquisolid systems (Vraníková et al. 2020, Vraníková et al. 2015, 2017) and self-emulsifying systems.

4. The preparation of biodegradable micro- and nanoparticle drug delivery systems (DDS) from the commercially available and originally synthetized PLGA based polyesters having the linear or branched or block architecture (Snejdrova et al 2020,  Martiška et al 2019, Dittrich et al. 2014, Snejdrova et al 2016) for application on the mucosal (Berka P et al 2019, Jirásková et al 2015, Vrbata et al 2014) or the dermal tissue, or to be implanted; and the preparation of the lipid carriers for dermal and transdermal drug delivery (Vidlářová et al. 2016).

5. The development of oromucosal freeze-dried products for application of vaccines, immunoprotection and desenzitisation.

6. The formulation and stability studies of the extemporaneously compounded preparations, particularly for pediatric patients, in the hospital pharmacy with close relationships with National Pharmacopoeia and practice (Klovrzová et al 2016, Zahálka et al. 2018).

7. Study of rheological behaviour and bioadhesive properties of polymeric systems, drug carriers, and newly formulated generic preparations (Siska et al 2019).

© Charles University, Faculty of Pharmacy in Hradec Králové, Akademika Heyrovského 1203, 500 05 Hradec Králové, Czech Republic
Website information | Powered by Kentico