Group of pathology and pharmacology of cardiovascular system

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Varejckova M, Gallardo-Vara E, Vicen M, Vitverova B, Fikrova P, Dolezelova E, Rathouska J, Prasnicka A, Blazickova K, Micuda S, Bernabeu C, Nemeckova I, Nachtigal P. Soluble endoglin modulates the pro-inflammatory mediators nf-kappab and il-6 in cultured human endothelial cells. Life sciences. 2017;175:52-60 [IF= 2,936]. 

Rathouska J, Fikrova P, Mrkvicova A, Blazickova K, Varejckova M, Dolezelova E, Nemeckova I, Vitverova B, Peslova L, Gallardo-Vara E, Pericacho M, Nachtigal P. High soluble endoglin levels do not induce changes in structural parameters of mouse heart. Heart and vessels. 2017 [IF= 3,434]. 

Dolezelova E, Stein E, Derosa G, Maffioli P, Nachtigal P, Sahebkar A: Effect of ezetimibe on plasma adipokines: a systematic review and meta-analysis. British journal of clinical pharmacology 2017 [IF = 3,830]

Sahebkar A, Ferri C, Giorgini P, Bo S, Nachtigal P, Grassi D: Effects of pomegranate juice on blood pressure: A systematic review and meta-analysis of randomized controlled trials. Pharmacological research 2017;115:149-161. [IF= 4,408]


Jezkova K, Rathouska J, Nemeckova I, Fikrova P, Dolezelova E, Varejckova M, Vitverova B, Tysonova K, Serwadczak A, Buczek E, Bernabeu C, Lopez-Novoa JM, Chlopicki S, Nachtigal P. High Levels of Soluble Endoglin Induce a Proinflammatory and Oxidative-Stress Phenotype Associated with Preserved NO-Dependent Vasodilatation in Aortas from Mice Fed a High-Fat Diet. J Vasc Res 2016; 53:149-162. [IF = 2,186]

Sahebkar A, Simental-Mendia LE, Pedone C, Ferretti G, Nachtigal P, Bo S, Derosa G, Maffioli P, Watts GF: Statin therapy and plasma free fatty acids: a systematic review and meta-analysis of controlled clinical trials. British journal of clinical pharmacology 2016;81:807-818. [IF = 3,878]

Sahebkar A, Rathouska J, Simental-Mendia LE, Nachtigal P: Statin therapy and plasma cortisol concentrations: A systematic review and meta-analysis of randomized placebo-controlled trials. Pharmacological research 2016;103:17-25. [IF= 4,408]

Sahebkar A, Rathouska J, Derosa G, Maffioli P, Nachtigal P: Statin impact on disease activity and C-reactive protein concentrations in systemic lupus erythematosus patients: A systematic review and meta-analysis of controlled trials. Autoimmunity reviews 2016;15:344-353[IF = 8,490]

Marin V, Rosso N, Dal Ben M, Raseni A, Boschelle M, Degrassi C, Nemeckova I, Nachtigal P, Avellini C, Tiribelli C, Gazzin S: An Animal Model for the Juvenile Non-Alcoholic Fatty Liver Disease and Non-Alcoholic Steatohepatitis. PloS one 2016;11:e0158817[IF = 3,057]

Cermanova J, Prasnicka A, Dolezelova E, Rozkydalova L, Hroch M, Chládek J, Tomsik P, Kloeting I, Micuda S. Pharmacokinetics of boldine in control and Mrp2-deficient rats. Physiol Res. 2016; 65: 489-497. [IF = 1,643]


Rathouska J, Jezkova K, Nemeckova I, Nachtigal P. Soluble endoglin, hypercholesterolemia and endothelial dysfunction. Atherosclerosis. 2015;243:383-388 [IF = 3,994]

Kostogrys RB, Johann C, Czyzynska I, Franczyk-Zarow M, Drahun A, Maslak E, Jasztal A, Gajda M, Mateuszuk L, Wrobel TP, Baranska M, Wybranska I, Jezkova K, Nachtigal P, Chlopicki S. Characterisation of atherogenic effects of low carbohydrate, high protein diet (lchp) in apoe/ldlr-/- mice. The journal of nutrition, health & aging. 2015;19:710-718 [IF= 2.996]

Zemankova L, Varejckova M, Dolezalova E, Fikrova P, Jezkova K, Rathouska J, Cerveny L, Botella LM, Bernabeu C, Nemeckova I, Nachtigal P. Atorvastatin-induced endothelial nitric oxide synthase expression in endothelial cells is mediated by endoglin. J Physiol Pharmacol. 2015;66:403-413 [IF = 2,804]

Cermanova J, Kadova Z, Zagorova M, Hroch M, Tomsik P, Nachtigal P, Kudlackova Z, Pavek P, Dubecka M, Ceckova M, Staud F, Laho T, Micuda S. Boldine enhances bile production in rats via osmotic and farnesoid x receptor dependent mechanisms. Toxicol Appl Pharmacol. 2015;285:12-22 [IF = 3,705]

Nemeckova I, Serwadczak A, Oujo B, Jezkova K, Rathouska J, Fikrova P, Varejckova M, Bernabeu C, Lopez-Novoa JM, Chlopicki S, Nachtigal P. High soluble endoglin levels do not induce endothelial dysfunction in mouse aorta. PLoS One. 2015;10:e0119665 [IF = 3.057]

Rathouska J, Jezkova K, Nemeckova I, Zemankova L, Varejckova M, Nachtigal P. Endoglin is not expressed with cell adhesion molecules in aorta during atherogenesis in apoe-deficient mice. Histol Histopathol. 2015;30:233-244 [IF = 2.281]

Rathouska J, Nemeckova I, Zemankova L, Strasky Z, Jezkova K, Varejckova M, Nachtigal P. Cell adhesion molecules and enos expression in aorta of normocholesterolemic mice with different predispositions to atherosclerosis. Heart Vessels. 2015;30:241-248 [IF = 2.293]

Zagorova M, Prasnicka A, Kadova Z, Dolezelova E, Kazdova L, Cermanova J, Rozkydalova L, Hroch M, Mokry J, Micuda S. Boldine attenuates cholestasis associated with nonalcoholic fatty liver disease in hereditary hypertriglyceridemic rats fed by high-sucrose diet. Physiol Res. 2015; 64: 467-76. [IF = 2.544]

Muchova L, Vanova K, Suk J, Micuda S, Dolezelova E, Fuksa L, Cerny D, Farghali H, Zelenkova M, Lenicek M, Wong RJ, Vreman HJ, Vitek L. Protective effect of heme oxygenase induction in ethinylestradiol-induced cholestasis. J Cell Mol Med. 2015308: 388-99. [IF = 3.368]


Lenicek M, Duricova D, Hradsky O, Dusatkova P, Jiraskova A, Lukas M, Nachtigal P, Vitek L. The relationship between serum bilirubin and crohn's disease. Inflammatory bowel diseases. 2014;20:481-487 [IF= 5.119]


Strasky Z, Zemankova L, Nemeckova I, Rathouska J, Wong RJ, Muchova L, Subhanova I, Vanikova J, Vanova K, Vitek L, Nachtigal P. Spirulina platensis and phycocyanobilin activate atheroprotective heme oxygenase-1: A possible implication for atherogenesis. Food & function. 2013;4:1586-1594 [IF= 2.686]

Ahmadimoghaddam D, Zemankova L, Nachtigal P, Dolezelova E, Neumanova Z, Cerveny L, Ceckova M, Kacerovsky M, Micuda S, Staud F. Organic cation transporter 3 (oct3/slc22a3) and multidrug and toxin extrusion 1 (mate1/slc47a1) transporter in the placenta and fetal tissues: Expression profile and fetus protective role at different stages of gestation. Biol Reprod. 2013;88:55 [IF= 4.027]


Vitek L, Vanikova J, Nachtigal P. Letter by vitek et al regarding article, "niacin inhibits vascular inflammation via the induction of heme oxygenase-1". Circulation. 2012;126:e99 [IF = 15.202]

Vecerova L, Strasky Z, Rathouska J, Slanarova M, Brcakova E, Micuda S, Nachtigal P. Activation of tgf-beta receptors and smad proteins by atorvastatin is related to reduced atherogenesis in apoe/ldlr double knockout mice. J Atheroscler Thromb. 2012;19:115-126 [IF=2.933]

Nachtigal P, Zemankova Vecerova L, Rathouska J, Strasky Z. The role of endoglin in atherosclerosis. Atherosclerosis. 2012;224:4-11 [IF= 3.706]

Ahmadimoghaddam D, Hofman J, Zemankova L, Nachtigal P, Dolezelova E, Cerveny L, Ceckova M, Micuda S, Staud F. Synchronized activity of organic cation transporter 3 (oct3/slc22a3) and multidrug and toxin extrusion 1 (mate1/slc47a1) transporter in transplacental passage of mpp+ in rat. Toxicol Sci. 2012;128:471-481 [IF= 4.328]


Strasky Z, Vecerova L, Rathouska J, Slanarova M, Brcakova E, Kudlackova Z, Andrys C, Micuda S, Nachtigal P. Cholesterol effects on endoglin and its downstream pathways in apoe/ldlr double knockout mice. Circ J. 2011;75:1747-1755 [IF= 3.578]

Stejskalova L, Vecerova L, Perez LM, Vrzal R, Dvorak Z, Nachtigal P, Pavek P. Aryl hydrocarbon receptor and aryl hydrocarbon nuclear translocator expression in human and rat placentas and transcription activity in human trophoblast cultures. Toxicol Sci. 2011;123:26-36 [IF=4.328]

Rathouska J, Vecerova L, Strasky Z, Slanarova M, Brcakova E, Mullerova Z, Andrys C, Micuda S, Nachtigal P. Endoglin as a possible marker of atorvastatin treatment benefit in atherosclerosis. Pharmacol Res. 2011;64:53-59 [IF= 4.346]

Nachtigal P, Sterba M, Popelova O, Vecerova L, Kudlackova Z, Jirkovsky E, Gersl V. Daunorubicin does not induce immunohistochemically detectable endothelial dysfunction in rabbit aorta and femoral artery. Histol Histopathol. 2011;26:551-562 [IF= 2.281]

Kolouchova G, Brcakova E, Hirsova P, Cermanova J, Fuksa L, Mokry J, Nachtigal P, Lastuvkova H, Micuda S. Modification of hepatic iron metabolism induced by pravastatin during obstructive cholestasis in rats. Life Sci. 2011;89:717-724 [IF= 2.555]


Pospechova K, Rozehnal V, Stejskalova L, Vrzal R, Pospisilova N, Jamborova G, May K, Siegmund W, Dvorak Z, Nachtigal P, Semecky V, Pavek P. Expression and activity of vitamin d receptor in the human placenta and in choriocarcinoma bewo and jeg-3 cell lines. Mol Cell Endocrinol. 2009;299:178-187 [IF= 4.039]

Popelova O, Sterba M, Haskova P, Simunek T, Hroch M, Guncova I, Nachtigal P, Adamcova M, Gersl V, Mazurova Y. Dexrazoxane-afforded protection against chronic anthracycline cardiotoxicity in vivo: Effective rescue of cardiomyocytes from apoptotic cell death. Br J Cancer. 2009;101:792-802 [IF= 5.082]

Nachtigal P, Vecerova L, Pospisilova N, Micuda S, Brcakova E, Navarro Hernandez E, Pospechova K, Semecky V. Endoglin co-expression with enos, smad2 and phosphorylated smad2/3 in normocholesterolemic and hypercholesterolemic mice: An immunohistochemical study. Histol Histopathol. 2009;24:1499-1506 [IF=2.281]

Nachtigal P, Pospisilova N, Vecerova L, Micuda S, Brcakova E, Pospechova K, Semecky V. Atorvastatin increases endoglin, smad2, phosphorylated smad2/3 and enos expression in apoe/ldlr double knockout mice. J Atheroscler Thromb. 2009;16:265-274 [IF=2.933]

Mladenka P, Zatloukalova L, Simunek T, Bobrovova Z, Semecky V, Nachtigal P, Haskova P, Mackova E, Vavrova J, Holeckova M, Palicka V, Hrdina R. Direct administration of rutin does not protect against catecholamine cardiotoxicity. Toxicology. 2009;255:25-32 [IF= 4.017]

Mladenka P, Semecky V, Bobrovova Z, Nachtigal P, Vavrova J, Holeckova M, Palicka V, Mazurova Y, Hrdina R. The effects of lactoferrin in a rat model of catecholamine cardiotoxicity. Biometals. 2009;22:353-361 [IF= 3.284]

Mladenka P, Kalinowski DS, Haskova P, Bobrovova Z, Hrdina R, Simunek T, Nachtigal P, Semecky V, Vavrova J, Holeckova M, Palicka V, Mazurova Y, Jansson PJ, Richardson DR. The novel iron chelator, 2-pyridylcarboxaldehyde 2-thiophenecarboxyl hydrazone, reduces catecholamine-mediated myocardial toxicity. Chem Res Toxicol. 2009;22:208-217 [IF= 3.667]

Mladenka P, Hrdina R, Bobrovova Z, Semecky V, Vavrova J, Holeckova M, Palicka V, Mazurova Y, Nachtigal P. Cardiac biomarkers in a model of acute catecholamine cardiotoxicity. Hum Exp Toxicol. 2009;28:631-640 [IF= 1.453]


Sadlonova J, Kostal M, Smahelova A, Hendl J, Starkova J, Nachtigal P. Selected metabolic parameters and the risk for uterine fibroids. Int J Gynaecol Obstet. 2008;102:50-54 [IF=0.546]

Nachtigal P, Pospisilova N, Jamborova G, Pospechova K, Solichova D, Andrys C, Zdansky P, Micuda S, Semecky V. Atorvastatin has hypolipidemic and anti-inflammatory effects in apoe/ldl receptor-double-knockout mice. Life Sci. 2008;82:708-717 [IF=2.555]

Jamborova G, Pospisilova N, Semecky V, Hyspler R, Ticha A, Pospechova K, Solichova D, Maxova M, Briestensky J, Real KJ, Nachtigal P. Microdispersed oxidized cellulose as a novel potential substance with hypolipidemic properties. Nutrition. 2008;24:1174-1181 [IF= 2.859]


Syka J, Ouda L, Nachtigal P, Solichova D, Semecky V. Atorvastatin slows down the deterioration of inner ear function with age in mice. Neurosci Lett. 2007;411:112-116 [IF= 2.026]

Pospechova K, Kopecky M, Nachtigal P, Pospisilova N, Jamborova G, Semecky V. Changes in the expression of p-cadherin in the normal, cryptorchid and busulphan-treated rat testis. Int J Androl. 2007;30:430-438 [IF= 3.565]

Pavek P, Cerveny L, Svecova L, Brysch M, Libra A, Vrzal R, Nachtigal P, Staud F, Ulrichova J, Fendrich Z, Dvorak Z. Examination of glucocorticoid receptor alpha-mediated transcriptional regulation of p-glycoprotein, cyp3a4, and cyp2c9 genes in placental trophoblast cell lines. Placenta. 2007;28:1004-1011 [IF= 3.117]

Nachtigal P, Pospisilova N, Jamborova G, Pospechova K, Solichova D, Andrys C, Zdansky P, Semecky V. Endothelial expression of endoglin in normocholesterolemic and hypercholesterolemic c57bl/6j mice before and after atorvastatin treatment. Can J Physiol Pharmacol. 2007;85:767-773 [IF= 1.556]


Staud F, Vackova Z, Pospechova K, Pavek P, Ceckova M, Libra A, Cygalova L, Nachtigal P, Fendrich Z. Expression and transport activity of breast cancer resistance protein (bcrp/abcg2) in dually perfused rat placenta and hrp-1 cell line. J Pharmacol Exp Ther. 2006;319:53-62 [IF= 3.891]

Pospisilova N, Semecky V, Jamborova G, Pospechova K, Solichova D, Andrys C, Zdansky P, Nachtigal P. Endoglin expression in hyper-cholesterolemia and after atorvastatin treatment in apoe-deficient mice. J Pharm Pharm Sci. 2006;9:388-397 [IF= 2.198]

Nachtigal P, Pospisilova N, Pospechova K, Jamborova G, Kopecky M, Jaynes R, Briestensky J, Santar I, Smahelova A, Solichova D, Zdansky P, Semecky V. Mdoc and atorvastatin have potential antiinflammatory effects in vascular endothelium of apoe-/- mouse model of atherosclerosis. Life Sci. 2006;78:1983-1989 [IF=2.555]

Nachtigal P, Jamborova G, Pospisilova N, Pospechova K, Solichova D, Zdansky P, Semecky V. Atorvastatin has distinct effects on endothelial markers in different mouse models of atherosclerosis. J Pharm Pharm Sci. 2006;9:222-230 [IF=2.198]

Ceckova M, Libra A, Pavek P, Nachtigal P, Brabec M, Fuchs R, Staud F. Expression and functional activity of breast cancer resistance protein (bcrp, abcg2) transporter in the human choriocarcinoma cell line bewo. Clin Exp Pharmacol Physiol. 2006;33:58-65 [IF= 2.160]


Nachtigal P, Kopecky M, Solichova D, Zdansky P, Semecky V. The changes in the endothelial expression of cell adhesion molecules and inos in the vessel wall after the short-term administration of simvastatin in rabbit model of atherosclerosis. J Pharm Pharmacol. 2005;57:197-203 [IF= 2.033]

Kopecky M, Semecky V, Nachtigal P. Vimentin expression during altered spermatogenesis in rats. Acta Histochem. 2005;107:279-289 [IF= 1.608]


Nachtigal P, Semecky V, Kopecky M, Gojova A, Solichova D, Zdansky P, Zadak Z. Application of stereological methods for the quantification of vcam-1 and icam-1 expression in early stages of rabbit atherogenesis. Pathol Res Pract. 2004;200:219-229 [IF= 1.213]

Kopecky M, Semecky V, Trejtnar F, Laznicek M, Laznickova A, Nachtigal P, Decristoforo C, Mather SJ, Macke HR. Analysis of accumulation of 99mtc-octreotide and 99mtc-edda/hynic-tyr3-octreotide in the rat kidneys. Nucl Med Biol. 2004;31:231-239 [IF=2.517]


Nachtigal P, Semecky V, Gojova A, Kopecky M, Benes V, Juzkova R: The application of stereological methods for the quantitative analysis of the atherosclerotic lesions in rabbits. Image Analysis and Stereology, 2002;21:165-174


Nachtigal P, Gojova A, Semecky V. The role of epithelial and vascular-endothelial cadherin in the differentiation and maintenance of tissue integrity. Acta Medica (Hradec Kralove). 2001;44:83-87










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