Research funding

Ongoing funding projects

  • Main researcher 2022-2024 GAČR grant projectImpact of direct endoglin modulation on the development of major complications of metabolic syndrome: atherogenesis and non-alcoholic steatohepatitis.
  • GAUK: projects
  1. 2023-2025 GAUK Project: The impact of endoglin overexpression on endothelial dysfunction and nonalcoholic steatohepatitis development in mice
  2. 2022-2024 GAUK Project: The impact of dapagliflozin treatment on soluble endoglin-induced endothelial dysfunction in diabetic endothelial cells

Past funding projects

  • Main researcher 2017-2020 AZV grant projectThe relationship of soluble endoglin and hypercholesterolemia in patients with type 2 diabetes mellitus and the impact of therapeutical intervention.
  • 2015-2017 GACR project: Tissue and soluble endoglin and their importance in endothelial dysfunction and atherogenesis in vivo and in vitro.
  • 2012-2017 Charles University: UNCE project “Centre for investigation of toxic and protective effects of drugs on cardiovascular system” (UNCE 33/2012)
  • 2002 – 2004: post-doc project GACR „The comparison of the effect of various statins on the expression of cell adhesion molecules in the vessel after induction of hypercholesterolemia”

GAUK: projects

  • 2001 – 2003 „Study of cell adhesion molecules in large and middle sized blood vessels in various pathological situations”
  • 2008 – 2010 “The study of expression and function of endoglin in experimental atherogenesis”
  • 2010 – 2012 The study of potential antiatherogenic effect of Spirulina platensis in mice models of atherosclerosis.
  • 2011 – 2013 Study of cholesterol and statins effects on the expression and activation of endoglin/Smad cascade in endothelial and macrophage cell lines.
  • 2011 – 2013 Study of endoglin/Smad signaling cascade in different stages of atherogenesis and after statin treatment.
  • 2016-2018 GAUK Project: Soluble endoglin as a potential risk factor for the development of vascular diseases.
  • 2015-2017 GACR project: Tissue and soluble endoglin and their importance in endothelial dysfunction and atherogenesis in vivo and in vitro.
  • 2017-2019 GAUK Project: Monitoring of oxysterol, soluble endoglin and atorvastatin effects on the expression of endoglin and levels of soluble endoglin in endotelial cells
  • 2021-2023 GAUK Project: Carotuximab effects on endoglin expression and signaling, soluble endoglin levels in altered mouse liver
  • 2020-2022 GAUK Project: Carotuximab effects on endoglin expression, signaling and function in inflammation and oxysterol induced endothelial dysfunction in endothelial cells
  • 2019-2021 GAUK Project: Soluble endoglin as a risk factor of estrogen-induced cholestasis?

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