Research funding

Group of pathology and pharmacology of cardiovascular and metabolic disorders

Ongoing funding projects

Main researcher 2022-2024 GAČR grant project: Impact of direct endoglin modulation on the development of major complications of metabolic syndrome: atherogenesis and non-alcoholic steatohepatitis.
GAUK: projects

2023-2025 GAUK Project: The impact of endoglin overexpression on endothelial dysfunction and nonalcoholic steatohepatitis development in mice

2022-2024 GAUK Project: The impact of dapagliflozin treatment on soluble endoglin-induced endothelial dysfunction in diabetic endothelial cells

Past funding projects

Main researcher 2017-2020 AZV grant project: The relationship of soluble endoglin and hypercholesterolemia in patients with type 2 diabetes mellitus and the impact of therapeutical intervention.
2015-2017 GACR project: Tissue and soluble endoglin and their importance in endothelial dysfunction and atherogenesis in vivo and in vitro.
2012-2017 Charles University: UNCE project “Centre for investigation of toxic and protective effects of drugs on cardiovascular system” (UNCE 33/2012)
2002 – 2004: post-doc project GACR „The comparison of the effect of various statins on the expression of cell adhesion molecules in the vessel after induction of hypercholesterolemia”

GAUK: projects

2001 – 2003 „Study of cell adhesion molecules in large and middle sized blood vessels in various pathological situations”
2008 – 2010 “The study of expression and function of endoglin in experimental atherogenesis”
2010 – 2012 The study of potential antiatherogenic effect of Spirulina platensis in mice models of atherosclerosis.
2011 – 2013 Study of cholesterol and statins effects on the expression and activation of endoglin/Smad cascade in endothelial and macrophage cell lines.
2011 – 2013 Study of endoglin/Smad signaling cascade in different stages of atherogenesis and after statin treatment.
2016-2018 GAUK Project: Soluble endoglin as a potential risk factor for the development of vascular diseases.
2015-2017 GACR project: Tissue and soluble endoglin and their importance in endothelial dysfunction and atherogenesis in vivo and in vitro.
2017-2019 GAUK Project: Monitoring of oxysterol, soluble endoglin and atorvastatin effects on the expression of endoglin and levels of soluble endoglin in endotelial cells
2021-2023 GAUK Project: Carotuximab effects on endoglin expression and signaling, soluble endoglin levels in altered mouse liver
2020-2022 GAUK Project: Carotuximab effects on endoglin expression, signaling and function in inflammation and oxysterol induced endothelial dysfunction in endothelial cells
2019-2021 GAUK Project: Soluble endoglin as a risk factor of estrogen-induced cholestasis?