2022

We are happy to share with you our latest publication, where we explored the cellular handling and regulation of monoamine transporters during the phenotypic transitioning of cytotrophoblasts along the villous pathway. For this, we used multiple techniques and two complementary placental in vitro models: the primary trophoblast cells isolated from the human term placenta and the choriocarcinoma-derived cell line BeWo. Find out more here: Functional reorganization of monoamine transport systems during villous trophoblast differentiation: evidence of distinct differences between primary human trophoblasts and BeWo cells

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Take a look at our recently published paper in Scientific Reports where we show that the placenta provides an efficient clearance system for dopamine and norepinephrine from both maternal and fetal circulations. Read more here:  Functional characterization of dopamine and norepinephrine transport across the apical and basal plasma membranes of the human placental syncytiotrophoblast

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Our one and only Hanča Horáčková is on fire 👍During the 70th Czech-Slovak Pharmacological Days in Bratislava (22 - 24 June 2022), she received the award of the Czech Society for Experimental and Clinical Pharmacology and Toxicology for her publication in the field of toxicology (Effect of Selected Antidepressants on Placental Homeostasis of Serotonin: Maternal and Fetal Perspectives).  At the same time, her second (fist-author) paper on dopamine and norepinephrine homeostasis in the placenta got published in Scientific Reports.

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Our team attended the European Placenta Perfusion Workshop in Jena! Cilia and Rona presented our team by showing their latest results in placental tryptophan metabolism in preterm birth and prenatal inflammation. 

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We are thrilled to share that our team (led by Prof. Frantisek Staud) is a part of the National Institute for Neurological Research, one of the 5 special-purpose projects supported in the Programme for the Support of Excellent Research in Priority Areas of Public Interest in the Health Sector - EXCELES. The EXCELES program aims to increase the ability of research capacities in selected priority areas of research, development, and innovation. Our institute will be focused on neurosciences and the study of neurodegenerative and other types of neurological diseases. More info here: www.msmt.cz/research-and-development-1

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Our wonderful and energetic diploma student Anna Orbisová presented her work on “Effect of inflammation on serotonin pathway in the placenta” at the Student Science Conference held at the Univerzita Karlova, Farmaceutická fakulta v Hradci Králové. Her presentation received great feedback and Anna was awarded 3rd place in the Biological Section of the conference. 👏

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We are happy to announce that The Czech Health Research Council (Agentura pro zdravotnický výzkum České republiky) has decided to support our research proposal named “Placental NLRP3 inflammasome signaling in gestational diabetes and the therapeutic potential of metformin”. So, we are starting to believe in Santa after all 😉 

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Pleased to share our next paper on the regulation of placental transporters in response to trophoblast differentiation in vitro. This is another result of the wonderful collaboration with Christiane Albrecht's lab at the University of Bern in Switzerland. If you are interested in the topic, please check out the link below: Trophoblast Differentiation Affects Crucial Nutritive Functions of Placental Membrane Transporters


Happy faces after successful presentations! 🥳🍾 Yesterday our team attended the 12th Postgraduate and Postdoc Conference organized by the Univerzita Karlova, Farmaceutická fakulta v Hradci Králové where 6 of us presented our data (5 in person and 1 online). We recieved great feedback from the audience and engaged in a very fruitful discussion section after the presentations! Afterwards, we practiced our modeling skills in a photoshoot session 😆

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