Group for study of drug resistance and drug interactions

Main areas of interest

Development of drug resistance in helminths

Drug resistance in parasitic worms becomes one of serious worldwide problems, especially in farm and free living animals. Induction of biotransformation enzymes in parasites and host can play important role in development of drug resistence in helminths. In our projects we focus on role of these enzymes in development of resistance in Barber’s pole worm (Haemonchus contortus) which parasitize in sheep (Ovis aries). Goal of our project is to find possibilities how to suppress drug resistance and increase efficiency of treatment.


Drug interaction with food supplements

Dietary supplements are intended to supplement the diet and provide nutrients, such as vitamins, minerals, fatty acids, or amino acids. In addition, dietary supplements contain numerous natural plant constituents and herbal extracts with proposed beneficial effects for individual’s health. Most people believe that supplements are innocuous substances, and they use them for added health benefits. Moreover, herbal supplements are often considered harmless as they are based on “natural plant” extracts and compounds. Therefore high-dose dietary supplements with natural/herbal constituents are widely used in our population. However consumption of food supplements can lead to induction or inhibition of some biotransformation enzymes and transport proteins and that can affect pharmacokinetics of simultaneously or subsequently administered drugs. Aim of this project is to study interactions between biologically active substances contained in food supplements (polyphenols, flavonoids, vitamins) and simultaneously or subsequently administered drugs. Goal is to point out the possible risks and adverse effects.


Isolation of tissue slices


© Charles University, Faculty of Pharmacy in Hradec Králové, Akademika Heyrovského 1203, 500 05 Hradec Králové, Czech Republic
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